Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells
出版年份 2023 全文链接
标题
Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells
作者
关键词
-
出版物
Cell Metabolism
Volume -, Issue -, Pages -
出版商
Elsevier BV
发表日期
2023-10-18
DOI
10.1016/j.cmet.2023.09.013
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits
- (2023) Maria C. Costanzo et al. Cell Metabolism
- A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection
- (2023) Xuming Tang et al. NATURE CELL BIOLOGY
- An effector index to predict target genes at GWAS loci
- (2022) Vincenzo Forgetta et al. HUMAN GENETICS
- HNF1A Mutations and Beta Cell Dysfunction in Diabetes
- (2022) Yasutaka Miyachi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
- (2022) Anubha Mahajan et al. NATURE GENETICS
- Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology
- (2022) Zhidong Liu et al. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
- ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes
- (2022) Qing Ma et al. Nature Communications
- APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation
- (2022) Laurie Arnaud et al. Cell Reports
- 3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk
- (2022) Chun Su et al. Cell Metabolism
- DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism
- (2022) Zhenzhen Li et al. Cell Death & Disease
- Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management
- (2022) Svetlana Dinić et al. Frontiers in Endocrinology
- The UCSC Genome Browser database: 2023 update
- (2022) Luis R Nassar et al. NUCLEIC ACIDS RESEARCH
- SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism
- (2021) Väinö Lithovius et al. DIABETOLOGIA
- Twelve years of SAMtools and BCFtools
- (2021) Petr Danecek et al. GigaScience
- SARS-CoV-2 Infection Induces Beta Cell Transdifferentiation
- (2021) Xuming Tang et al. Cell Metabolism
- Groucho co-repressor proteins regulate β cell development and proliferation by repressing Foxa1 in the developing mouse pancreas
- (2021) Alexandra Theis et al. DEVELOPMENT
- Genetic effects on liver chromatin accessibility identify disease regulatory variants
- (2021) Kevin W. Currin et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Targeting β-cell dedifferentiation and transdifferentiation: opportunities and challenges
- (2021) Wenrui Wang et al. Endocrine Connections
- Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes
- (2021) Aimee M. Deaton et al. Scientific Reports
- TIGER: The gene expression regulatory variation landscape of human pancreatic islets
- (2021) Lorena Alonso et al. Cell Reports
- From Genetic Association to Molecular Mechanisms for Islet-cell Dysfunction in Type 2 Diabetes
- (2020) Katia K. Mattis et al. JOURNAL OF MOLECULAR BIOLOGY
- Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics
- (2020) Nicole A. J. Krentz et al. Nature Reviews Endocrinology
- High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation
- (2020) Mateusz Legut et al. Cell Reports
- SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro
- (2020) Leonardo Velazco-Cruz et al. Cell Reports
- Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis
- (2020) Jeffrey C. Davis et al. Cell Reports
- Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
- (2020) Marijana Vujkovic et al. NATURE GENETICS
- Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity
- (2020) Guy A. Rutter et al. DIABETOLOGIA
- Pathophysiology of Type 2 Diabetes Mellitus
- (2020) Unai Galicia-Garcia et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
- (2020) Ana Viñuela et al. Nature Communications
- Genetic mapping of etiologic brain cell types for obesity
- (2020) Pascal N Timshel et al. eLife
- Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes
- (2020) Lorella Marselli et al. Cell Reports
- Point mutations in the PDX1 transactivation domain impair human β-cell development and function
- (2019) Xianming Wang et al. Molecular Metabolism
- Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
- (2019) Jason Flannick et al. NATURE
- WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition
- (2019) Pouya Saeedi et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- CRISPRitz: rapid, high-throughput and variant-aware in silico off-target site identification for CRISPR genome editing
- (2019) Samuele Cancellieri et al. BIOINFORMATICS
- Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
- (2019) Om Prakash Dwivedi et al. NATURE GENETICS
- Single-cell ATAC-Seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signatures
- (2019) Vivek Rai et al. Molecular Metabolism
- Interactions between genetic variation and cellular environment in skeletal muscle gene expression
- (2018) D. Leland Taylor et al. PLoS One
- Discovery of a drug candidate for GLIS3-associated diabetes
- (2018) Sadaf Amin et al. Nature Communications
- The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates
- (2018) Violeta Georgieva Tsonkova et al. Molecular Metabolism
- Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes
- (2018) Yoon S. Oh et al. Frontiers in Endocrinology
- Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis
- (2018) Miriam S. Udler et al. PLOS MEDICINE
- Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
- (2018) Anubha Mahajan et al. NATURE GENETICS
- Serum copper, zinc, and iron levels, and markers of carbohydrate metabolism in postmenopausal women with prediabetes and type 2 diabetes mellitus
- (2017) Margarita G. Skalnaya et al. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
- Allele-specific expression reveals interactions between genetic variation and environment
- (2017) David A Knowles et al. NATURE METHODS
- An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues
- (2017) M Ryan Corces et al. NATURE METHODS
- DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma
- (2017) Y Zhou et al. ONCOGENE
- Genetic regulatory signatures underlying islet gene expression and type 2 diabetes
- (2017) Arushi Varshney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E
- (2017) Min Guo et al. Cell Reports
- GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells
- (2017) Amita Tiyaboonchai et al. Stem Cell Reports
- Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene
- (2017) Timothy J. Pullen et al. Frontiers in Genetics
- An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery
- (2016) Hui Zeng et al. Cell Stem Cell
- High-throughput allele-specific expression across 250 environmental conditions
- (2016) Gregory A. Moyerbrailean et al. GENOME RESEARCH
- Next-generation genotype imputation service and methods
- (2016) Sayantan Das et al. NATURE GENETICS
- QoRTs: a comprehensive toolset for quality control and data processing of RNA-Seq experiments
- (2015) Stephen W. Hartley et al. BMC BIOINFORMATICS
- High-Throughput Luminescent Reporter of Insulin Secretion for Discovering Regulators of Pancreatic Beta-Cell Function
- (2015) Sean M. Burns et al. Cell Metabolism
- The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas
- (2015) Patrick S. McGrath et al. DIABETES
- A global reference for human genetic variation
- (2015) Richard A. Gibbs et al. NATURE
- WASP: allele-specific software for robust molecular quantitative trait locus discovery
- (2015) Bryce van de Geijn et al. NATURE METHODS
- The Role of ARX in Human Pancreatic Endocrine Specification
- (2015) Blair K. Gage et al. PLoS One
- Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity
- (2014) Matthew T. Weirauch et al. CELL
- ADCY5 Couples Glucose to Insulin Secretion in Human Islets
- (2014) D. J. Hodson et al. DIABETES
- Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
- (2014) Alireza Rezania et al. NATURE BIOTECHNOLOGY
- Zinc transporter 8 (ZnT8) and β cell function
- (2014) Howard W. Davidson et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
- (2013) S. C. J. Parker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Detecting and Estimating Contamination of Human DNA Samples in Sequencing and Array-Based Genotype Data
- (2012) Goo Jun et al. AMERICAN JOURNAL OF HUMAN GENETICS
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Overexpression of Monocarboxylate Transporter-1 (Slc16a1) in Mouse Pancreatic -Cells Leads to Relative Hyperinsulinism During Exercise
- (2012) T. J. Pullen et al. DIABETES
- Effects of sequence variation on differential allelic transcription factor occupancy and gene expression
- (2012) T. E. Reddy et al. GENOME RESEARCH
- Molecular signatures database (MSigDB) 3.0
- (2011) A. Liberzon et al. BIOINFORMATICS
- FIMO: scanning for occurrences of a given motif
- (2011) Charles E. Grant et al. BIOINFORMATICS
- HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells
- (2011) A. DeLaForest et al. DEVELOPMENT
- INS GFP/w human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells
- (2011) S. J. Micallef et al. DIABETOLOGIA
- AlleleSeq: analysis of allele-specific expression and binding in a network framework
- (2011) J. Rozowsky et al. Molecular Systems Biology
- BEDTools: a flexible suite of utilities for comparing genomic features
- (2010) Aaron R. Quinlan et al. BIOINFORMATICS
- Motif Enrichment Analysis: a unified framework and an evaluation on ChIP data
- (2010) Robert C McLeay et al. BMC BIOINFORMATICS
- Accurate inference of transcription factor binding from DNA sequence and chromatin accessibility data
- (2010) R. Pique-Regi et al. GENOME RESEARCH
- ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
- (2010) K. Wang et al. NUCLEIC ACIDS RESEARCH
- Epistasis of Transcriptomes Reveals Synergism between Transcriptional Activators Hnf1α and Hnf4α
- (2010) Sylvia F. Boj et al. PLoS Genetics
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- Fast and accurate short read alignment with Burrows-Wheeler transform
- (2009) H. Li et al. BIOINFORMATICS
- An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol
- (2009) Huanting Liu et al. BMC BIOTECHNOLOGY
- Update of mutations in the genes encoding the pancreatic beta-cell KATPchannel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism
- (2008) Sarah E. Flanagan et al. HUMAN MUTATION
- Model-based Analysis of ChIP-Seq (MACS)
- (2008) Yong Zhang et al. GENOME BIOLOGY
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