High throughput screening for rapid and reliable prediction of monovalent antibody binding behavior in flowthrough mode

Standardized method for mechanistic modeling of multimodal anion exchange chromatography in flow through operation

(2023) Rudger Hess et al.   JOURNAL OF CHROMATOGRAPHY A

A multiscale modeling method for therapeutic antibodies in ion exchange chromatography

(2022) David Saleh et al.   BIOTECHNOLOGY AND BIOENGINEERING

Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography

(2021) David Saleh et al.   BIOTECHNOLOGY AND BIOENGINEERING

Automation and Miniaturization: Enabling tools for fast High Throughput Process Development in Integrated Continuous Biomanufacturing

(2021) Tiago Castanheira Silva et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Separation of charge variants of a monoclonal antibody by overloaded ion exchange chromatography

(2021) Krystian Baran et al.   JOURNAL OF CHROMATOGRAPHY A

Process‐wide control and automation of an integrated continuous manufacturing platform for antibodies

(2020) Fabian Feidl et al.   BIOTECHNOLOGY AND BIOENGINEERING

The effect of pH on antibody retention in multimodal cation exchange chromatographic systems

(2020) Julie Robinson et al.   JOURNAL OF CHROMATOGRAPHY A

Effects of molecule size and resin structure on protein adsorption on multimodal anion exchange chromatography media

(2020) Joey A. Roberts et al.   JOURNAL OF CHROMATOGRAPHY A

Optimizing selectivity of anion hydrophobic multimodal chromatography for purification of a single‐chain variable fragment

(2019) Laila I. Sakhnini et al.   ENGINEERING IN LIFE SCIENCES

Monoclonal antibody purification and its progression to commercial scale

(2019) Digamber Singh Chahar et al.   BIOLOGICALS

Modeling the Downstream Processing of Monoclonal Antibodies Reveals Cost Advantages for Continuous Methods for a Broad Range of Manufacturing Scales

(2018) Jonathan Hummel et al.   Biotechnology Journal

Defining the mechanistic binding of viral particles to a multi-modal anion exchange resin

(2018) Matthew R. Brown et al.   BIOTECHNOLOGY PROGRESS

Domain contributions to antibody retention in multimodal chromatography systems

(2018) Julie Robinson et al.   JOURNAL OF CHROMATOGRAPHY A

Integrated flow-through purification for therapeutic monoclonal antibodies processing

(2018) Takamitsu Ichihara et al.   mAbs

Modeling the Downstream Processing of Monoclonal Antibodies Reveals Cost Advantages for Continuous Methods for a Broad Range of Manufacturing Scales

(2018) Jonathan Hummel et al.   Biotechnology Journal

Polishing approach with fully connected flow-through purification for therapeutic monoclonal antibody

(2018) Takamitsu Ichihara et al.   ENGINEERING IN LIFE SCIENCES

Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation

(2016) Tomoyuki Igawa et al.   IMMUNOLOGICAL REVIEWS

The rapid identification of elution conditions for therapeutic antibodies from cation-exchange chromatography resins using high-throughput screening

(2016) Paul McDonald et al.   JOURNAL OF CHROMATOGRAPHY A

High throughput chromatography strategies for potential use in the formal process characterization of a monoclonal antibody

(2015) Matthew G. Petroff et al.   BIOTECHNOLOGY AND BIOENGINEERING

Investigation of protein selectivity in multimodal chromatography usingin silicodesigned Fab fragment variants

(2015) Hanne Sophie Karkov et al.   BIOTECHNOLOGY AND BIOENGINEERING

Evaluation of selectivity in homologous multimodal chromatographic systems using in silico designed antibody fragment libraries

(2015) Hanne Sophie Karkov et al.   JOURNAL OF CHROMATOGRAPHY A

Robust high-throughput batch screening method in 384-well format with optical in-line resin quantification

(2015) Jörg Kittelmann et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Alternative molecular formats and therapeutic applications for bispecific antibodies

(2015) Christoph Spiess et al.   MOLECULAR IMMUNOLOGY

Continuous Processing for Production of Biopharmaceuticals

(2015) Anurag S. Rathore et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

Purification of monoclonal antibodies by hydrophobic interaction chromatography under no-salt conditions

(2013) Sanchayita Ghose et al.   mAbs

Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent

(2013) M. Merchant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput isotherm determination and thermodynamic modeling of protein adsorption on mixed mode adsorbents

(2010) Beckley K. Nfor et al.   JOURNAL OF CHROMATOGRAPHY A

Separation of oxidized variants of a monoclonal antibody by anion-exchange

(2010) Glen Teshima et al.   JOURNAL OF CHROMATOGRAPHY A

Recovery and purification process development for monoclonal antibody production

(2010) Hui F. Liu et al.   mAbs

Aggregation-Prone Motifs in Human Immunoglobulin G

(2009) Naresh Chennamsetty et al.   JOURNAL OF MOLECULAR BIOLOGY

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Volumetric interpretation of protein adsorption: Ion-exchange adsorbent capacity, protein pI, and interaction energetics☆

(2008) Hyeran Noh et al.   BIOMATERIALS

High-throughput screening of chromatographic separations: II. Hydrophobic interaction

(2008) Jack F. Kramarczyk et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-throughput screening of chromatographic separations: IV. Ion-exchange

(2008) Brian D. Kelley et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-throughput screening of chromatographic separations: III. Monoclonal antibodies on ceramic hydroxyapatite

(2008) David L. Wensel et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-throughput screening of chromatographic separations: I. Method development and column modeling

(2008) Jonathan L. Coffman et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-Throughput Process Development: Determination of Dynamic Binding Capacity Using Microtiter Filter Plates Filled with Chromatography Resin

(2008) T. Bergander et al.   BIOTECHNOLOGY PROGRESS

High Throughput Screening for the Design and Optimization of Chromatographic Processes – Miniaturization, Automation and Parallelization of Breakthrough and Elution Studies

(2008) M. Wiendahl et al.   CHEMICAL ENGINEERING & TECHNOLOGY