A multiscale modeling method for therapeutic antibodies in ion exchange chromatography

A Descriptor Set for Quantitative Structure‐property Relationship Prediction in Biologics

(2022) Kannan Sankar et al.   Molecular Informatics

Towards in silico Process Modeling for Vaccines

(2021) Antonio Gaetano Cardillo et al.   TRENDS IN BIOTECHNOLOGY

Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography

(2021) David Saleh et al.   BIOTECHNOLOGY AND BIOENGINEERING

Knowledge transfer across cell lines using hybrid Gaussian process models with entity embedding vectors

(2021) Clemens Hutter et al.   BIOTECHNOLOGY AND BIOENGINEERING

A roadmap to AI-driven in silico process development: bioprocessing 4.0 in practice

(2021) Moritz von Stosch et al.   Current Opinion in Chemical Engineering

The effect of pH on antibody retention in multimodal cation exchange chromatographic systems

(2020) Julie Robinson et al.   JOURNAL OF CHROMATOGRAPHY A

Improved protein structure prediction using potentials from deep learning

(2020) Andrew W. Senior et al.   NATURE

Fresh from the biotech pipeline—2019

(2020) Chris Morrison   NATURE BIOTECHNOLOGY

Developing therapeutic monoclonal antibodies at pandemic pace

(2020) Brian Kelley   NATURE BIOTECHNOLOGY

Towards a Digital Bioprocess Replica: Computational Approaches in Biopharmaceutical Development and Manufacturing

(2020) Jens Smiatek et al.   TRENDS IN BIOTECHNOLOGY

Exploring the trade-offs between electric heating policy and carbon mitigation in China

(2020) Jianxiao Wang et al.   Nature Communications

OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules

(2019) Katarina Roos et al.   Journal of Chemical Theory and Computation

Cross interaction chromatography based QSAR model for early stage screening to facilitate enhanced developability of monoclonal antibody therapeutics

(2019) Arathi Kizhedath et al.   Biotechnology Journal

Structure of a Therapeutic Full-Length Anti-NPRA IgG4 Antibody: Dissecting Conformational Diversity

(2019) Michaela Blech et al.   BIOPHYSICAL JOURNAL

Bioprocessing in the Digital Age: The Role of Process Models

(2019) Harini Narayanan et al.   Biotechnology Journal

Exploiting mAb structure characteristics for a directed QbD implementation in early process development

(2018) Micael Karlberg et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

AggScore: Prediction of aggregation-prone regions in proteins based on the distribution of surface patches

(2018) Kannan Sankar et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Estimation of adsorption isotherm and mass transfer parameters in protein chromatography using artificial neural networks

(2017) Gang Wang et al.   JOURNAL OF CHROMATOGRAPHY A

An orientation sensitive approach in biomolecule interaction quantitative structure–activity relationship modeling and its application in ion-exchange chromatography

(2017) Jörg Kittelmann et al.   JOURNAL OF CHROMATOGRAPHY A

Orientation of monoclonal antibodies in ion-exchange chromatography: A predictive quantitative structure–activity relationship modeling approach

(2017) Jörg Kittelmann et al.   JOURNAL OF CHROMATOGRAPHY A

Calibration-free inverse modeling of ion-exchange chromatography in industrial antibody purification

(2015) Tobias Hahn et al.   ENGINEERING IN LIFE SCIENCES

UV absorption-based inverse modeling of protein chromatography

(2015) Tobias Hahn et al.   ENGINEERING IN LIFE SCIENCES

Double-peak elution profile of a monoclonal antibody in cation exchange chromatography is caused by histidine-protonation-based charge variants

(2015) Haibin Luo et al.   JOURNAL OF CHROMATOGRAPHY A

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

(2015) Giovanna Scapin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

(2015) Giovanna Scapin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effects of salt-induced reversible self-association on the elution behavior of a monoclonal antibody in cation exchange chromatography

(2014) Haibin Luo et al.   JOURNAL OF CHROMATOGRAPHY A

Modeling and robust pooling design of a preparative cation-exchange chromatography step for purification of monoclonal antibody monomer from aggregates

(2014) Niklas Borg et al.   JOURNAL OF CHROMATOGRAPHY A

Mutual Information between Discrete and Continuous Data Sets

(2014) Brian C. Ross   PLoS One

Antibody structure determination using a combination of homology modeling, energy-based refinement, and loop prediction

(2014) Kai Zhu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Modeling of salt and pH gradient elution in ion-exchange chromatography

(2013) Michael Schmidt et al.   JOURNAL OF SEPARATION SCIENCE

Ab initiostructure prediction of the antibody hypervariable H3 loop

(2013) Kai Zhu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Evaluation of protein adsorption and preferred binding regions in multimodal chromatography using NMR

(2010) W. K. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances in large-scale production of monoclonal antibodies and related proteins

(2010) Abhinav A. Shukla et al.   TRENDS IN BIOTECHNOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY

Chromatographic separation of three monoclonal antibody variants using multicolumn countercurrent solvent gradient purification (MCSGP)

(2008) Thomas Müller-Späth et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quality by design—Thermodynamic modelling of chromatographic separation of proteins

(2007) Jørgen M. Mollerup et al.   JOURNAL OF CHROMATOGRAPHY A