Distinct dynamical features of plasmodial and human HSP70-HSP110 highlight the divergence in their chaperone-assisted protein folding

Synthetic Small Molecule Modulators of Hsp70 and Hsp40 Chaperones as Promising Anticancer Agents

(2023) Bianca Nitzsche et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A first-in-class inhibitor of Hsp110 molecular chaperones of pathogenic fungi

(2023) Liqing Hu et al.   Nature Communications

Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease

(2022) Benjamin S. Rutledge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets

(2022) Julian Barth et al.   Frontiers in Molecular Biosciences

Mutation of GGMP Repeat Segments of Plasmodium falciparum Hsp70-1 Compromises Chaperone Function and Hop Co-Chaperone Binding

(2021) Stanley Makumire et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterisation of a unique linker segment of the Plasmodium falciparum cytosol localised Hsp110 chaperone

(2021) Graham Chakafana et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

Dynamic View of Allosteric Regulation in the Hsp70 Chaperones by J-Domain Cochaperone and Post-Translational Modifications: Computational Analysis of Hsp70 Mechanisms by Exploring Conformational Landscapes and Residue Interaction Networks

(2020) Lindy Astl et al.   Journal of Chemical Information and Modeling

The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species

(2020) Jessica Tittelmeier et al.   EMBO JOURNAL

Comparative Characterization of Plasmodium falciparum Hsp70-1 Relative to E. coli DnaK Reveals the Functional Specificity of the Parasite Chaperone

(2020) Charity Mekgwa Lebepe et al.   Biomolecules

Structural–functional diversity of malaria parasite's PfHSP70-1 and PfHSP40 chaperone pair gives an edge over human orthologs in chaperone-assisted protein folding

(2020) Mohammad Anas et al.   BIOCHEMICAL JOURNAL

Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy

(2019) Gustavo J. Gozzi et al.   CELL DEATH AND DIFFERENTIATION

Smyd2 conformational changes in response to p53 binding: role of the C‐terminal domain

(2019) Balasubramanian Chandramouli et al.   Molecular Oncology

Protein quality control machinery in intracellular protozoan parasites: hopes and challenges for therapeutic targeting

(2019) Mohammad Anas et al.   CELL STRESS & CHAPERONES

Partners in Mischief: Functional Networks of Heat Shock Proteins of Plasmodium falciparum and Their Influence on Parasite Virulence

(2019) Michael O. Daniyan et al.   Biomolecules

Inter‐domain communication suppressing high intrinsic ATPase activity of Sse1 is essential for its co‐dissaggregase activity with Ssa1

(2019) Vignesh Kumar et al.   FEBS Journal

The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite

(2019) Jemma Day et al.   FASEB JOURNAL

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein–Protein Interactions with Heat Shock Protein 70 (Hsp70)

(2018) Hao Shao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural and biochemical characterization of Plasmodium falciparum Hsp70-x reveals functional versatility of its C-terminal EEVN motif

(2018) Blessing Mabate et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Intrinsically Disordered Proteins: The Dark Horse of the Dark Proteome

(2018) Prakash Kulkarni et al.   PROTEOMICS

Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: Role of the Acidic Subdomain

(2018) Yovana Cabrera et al.   JOURNAL OF MOLECULAR BIOLOGY

The Hsp70 interdomain linker is a dynamic switch that enables allosteric communication between two structured domains

(2017) Charles A. English et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinated Hsp110 and Hsp104 Activities Power Protein Disaggregation in Saccharomyces cerevisiae

(2017) Jayasankar Mohanakrishnan Kaimal et al.   MOLECULAR AND CELLULAR BIOLOGY

The Hsp40 J-domain modulates Hsp70 conformation and ATPase activity with a semi-elliptical spring

(2017) Neil Andrew D. Bascos et al.   PROTEIN SCIENCE

Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion

(2016) Tawanda Zininga et al.   CELL STRESS & CHAPERONES

Probing Allosteric Inhibition Mechanisms of the Hsp70 Chaperone Proteins Using Molecular Dynamics Simulations and Analysis of the Residue Interaction Networks

(2016) Gabrielle Stetz et al.   Journal of Chemical Information and Modeling

HSP110 promotes colorectal cancer growth through STAT3 activation

(2016) K Berthenet et al.   ONCOGENE

Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity inDrosophila

(2016) Pedro Fernandez-Funez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

An atomistic view of Hsp70 allosteric crosstalk: from the nucleotide to the substrate binding domain and back

(2016) Federica Chiappori et al.   Scientific Reports

MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories

(2015) Robert T. McGibbon et al.   BIOPHYSICAL JOURNAL

How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions

(2015) Eugenia M. Clerico et al.   JOURNAL OF MOLECULAR BIOLOGY

Dancing through Life: Molecular Dynamics Simulations and Network-Centric Modeling of Allosteric Mechanisms in Hsp70 and Hsp110 Chaperone Proteins

(2015) Gabrielle Stetz et al.   PLoS One

Unexpected features of the dark proteome

(2015) Nelson Perdigão et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Co-evolutionary analysis implies auxiliary functions of HSP110 inPlasmodium falciparum

(2015) Deeksha Bhartiya et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Pathways of allosteric regulation in Hsp70 chaperones

(2015) Roman Kityk et al.   Nature Communications

Automatic Identification of Mobile and Rigid Substructures in Molecular Dynamics Simulations and Fractional Structural Fluctuation Analysis

(2015) Leandro Martínez   PLoS One

Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein

(2015) Tawanda Zininga et al.   PLoS One

ATPase Subdomain IA Is a Mediator of Interdomain Allostery in Hsp70 Molecular Chaperones

(2014) Ignacio J. General et al.   PLoS Computational Biology

Binding of Human Nucleotide Exchange Factors to Heat Shock Protein 70 (Hsp70) Generates Functionally Distinct Complexesin Vitro

(2013) Jennifer N. Rauch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp110 Is aBona FideChaperone Using ATP to Unfold Stable Misfolded Polypeptides and Reciprocally Collaborate with Hsp70 to Solubilize Protein Aggregates

(2013) Rayees U. H. Mattoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

(2013) Ruifeng Qi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain

(2013) Francesco A. Aprile et al.   PLoS One

Asparagine Repeats in Plasmodium falciparum Proteins: Good for Nothing?

(2013) Vasant Muralidharan et al.   PLoS Pathogens

Conformational dynamics of full-length inducible human Hsp70 derived from microsecond molecular dynamics simulations in explicit solvent

(2012) Adrien Nicolaï et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Simulation of the Opening and Closing of Hsp70 Chaperones by Coarse-Grained Molecular Dynamics

(2012) Ewa Gołaś et al.   Journal of Chemical Theory and Computation

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

Plasmodium falciparum  heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers

(2012) Vasant Muralidharan et al.   Nature Communications

Molecular Mechanism of Allosteric Communication in Hsp70 Revealed by Molecular Dynamics Simulations

(2012) Federica Chiappori et al.   PLoS Computational Biology

Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1

(2011) Ingrid L. Cockburn et al.   BIOLOGICAL CHEMISTRY

Unique Peptide Substrate Binding Properties of 110-kDa Heat-shock Protein (Hsp110) Determine Its Distinct Chaperone Activity

(2011) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MDAnalysis: A toolkit for the analysis of molecular dynamics simulations

(2011) Naveen Michaud-Agrawal et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The Four Hydrophobic Residues on the Hsp70 Inter-Domain Linker Have Two Distinct Roles

(2011) Divya Prasanna Kumar et al.   JOURNAL OF MOLECULAR BIOLOGY

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

(2011) James Shorter   PLoS One

Human Inducible Hsp70: Structures, Dynamics, and Interdomain Communication from All-Atom Molecular Dynamics Simulations

(2010) Adrien Nicolaï et al.   Journal of Chemical Theory and Computation

Interaction of the Hsp110 Molecular Chaperones from S. cerevisiae with Substrate Protein

(2010) Sigrun Polier et al.   JOURNAL OF MOLECULAR BIOLOGY

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78

(2010) Magdalena Wisniewska et al.   PLoS One

Role of Hsp70 ATPase Domain Intrinsic Dynamics and Sequence Evolution in Enabling its Functional Interactions with NEFs

(2010) Ying Liu et al.   PLoS Computational Biology

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for the Cooperation of Hsp70 and Hsp110 Chaperones in Protein Folding

(2008) Sigrun Polier et al.   CELL

Targeted Disruption of Hsp110/105 Gene Protects Against Ischemic Stress

(2008) Junji Nakamura et al.   STROKE