Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease

Hsp90 and its co‐chaperone Sti1 control TDP‐43 misfolding and toxicity

(2021) Lilian Tsai‐Wei Lin et al.   FASEB JOURNAL

Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation

(2021) Jinge Gu et al.   CELL RESEARCH

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau

(2020) Luca Ferrari et al.   Nature Communications

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

(2020) Eliana Nachman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mechanism of Hsp90-induced oligomerizaton of Tau

(2020) S. Weickert et al.   Science Advances

Proteostasis is adaptive: Balancing chaperone holdases against foldases

(2020) Adam MR de Graff et al.   PLoS Computational Biology

Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles

(2019) Richard M. Meade et al.   Molecular Neurodegeneration

On the nature of the optimal form of the holdase‐type chaperone stress response

(2019) Damien Hall   FEBS LETTERS

HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation

(2019) Alessandro Arosio et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Regulation of α-synuclein by chaperones in mammalian cells

(2019) Björn M. Burmann et al.   NATURE

HSP70 and HSP90 in neurodegenerative diseases

(2019) Abha Gupta et al.   NEUROSCIENCE LETTERS

Structural Insights Into TDP-43 and Effects of Post-translational Modifications

(2019) Liberty François-Moutal et al.   Frontiers in Molecular Neuroscience

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

(2018) Franziska Kundel et al.   ACS Chemical Biology

The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein

(2018) Isabelle R. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dancing with the Diva: Hsp90–Client Interactions

(2018) Martina Radli et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular chaperone HSP70 prevents formation of inclusion bodies of the 25-kDa C-terminal fragment of TDP-43 by preventing aggregate accumulation

(2018) Akira Kitamura et al.   CELL STRESS & CHAPERONES

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

(2018) Javier Oroz et al.   Nature Communications

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

(2017) Rachel E. Lackie et al.   Frontiers in Neuroscience

Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling

(2016) Veronika Csizmok et al.   CHEMICAL REVIEWS

The C-terminal α-helices of mammalian Hsc70 play a critical role in the stabilization of α-synuclein binding and inhibition of aggregation

(2016) Ali Chaari et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

(2016) K. A. Verba et al.   SCIENCE

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders

(2016) Martin Ingelsson   Frontiers in Neuroscience

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

(2015) Emma L. Scotter et al.   Neurotherapeutics

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

(2014) G. Elif Karagöz et al.   CELL

Accelerating the Conformational Sampling of Intrinsically Disordered Proteins

(2014) Trang Nhu Do et al.   Journal of Chemical Theory and Computation

Modulation of the Hsp90 Chaperone Cycle by a Stringent Client Protein

(2014) Oliver Robin Lorenz et al.   MOLECULAR CELL

Casein Kinase II Induced Polymerization of Soluble TDP-43 into Filaments Is Inhibited by Heat Shock Proteins

(2014) Yari Carlomagno et al.   PLoS One

Hsp90 Inhibits α-Synuclein Aggregation by Interacting with Soluble Oligomers

(2013) Soumya Daturpalli et al.   JOURNAL OF MOLECULAR BIOLOGY

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Cdc37/Hsp90 Protein Complex Disruption Triggers an Autophagic Clearance Cascade for TDP-43 Protein

(2012) Umesh K. Jinwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperone networks in protein disaggregation and prion propagation

(2012) Juliane Winkler et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

Molecular Chaperones, Alpha-Synuclein, and Neurodegeneration

(2012) Stephan N. Witt   MOLECULAR NEUROBIOLOGY

Heat Shock Protein 70 Prevents both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport

(2011) Kristina R. Patterson et al.   BIOCHEMISTRY

Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D2concept

(2010) Vladimir N Uversky   Expert Review of Proteomics

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Molecular Chaperone Hsp90 Modulates Intermediate Steps of Amyloid Assembly of the Parkinson-related Protein α-Synuclein

(2009) S. Fabio Falsone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

(2009) U. K. Jinwal et al.   JOURNAL OF NEUROSCIENCE

Hsp70 Structure, Function, Regulation and Influence on Yeast Prions

(2009) Deepak Sharma et al.   PROTEIN AND PEPTIDE LETTERS

Interactions between Hsp70 and the Hydrophobic Core of α-Synuclein Inhibit Fibril Assembly†

(2008) Kelvin C. Luk et al.   BIOCHEMISTRY

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone

(2008) Mitul Sarkar et al.   JOURNAL OF NEUROSCIENCE RESEARCH