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A calcium-sensitive antibody isolates soluble amyloid-β aggregates and fibrils from Alzheimer’s disease brain

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Cryo-EM structures of amyloid-β 42 filaments from human brains

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Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer’s Disease Neuropathology

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Bioactive human Alzheimer brain soluble Aβ: pathophysiology and therapeutic opportunities

(2022) Shaomin Li et al.   MOLECULAR PSYCHIATRY

Lipid Homeostasis and Its Links With Protein Misfolding Diseases

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Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species

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Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro

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Molecular structure of a prevalent amyloid-β fibril polymorph from Alzheimer's disease brain tissue

(2021) Ujjayini Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice

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Sensitivity-Enhanced Solid-State NMR Detection of Structural Differences and Unique Polymorphs in Pico- to Nanomolar Amounts of Brain-Derived and Synthetic 42-Residue Amyloid-β Fibrils

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Structural differences in amyloid-β fibrils from brains of nondemented elderly individuals and Alzheimer's disease patients

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Recent High-Resolution Structures of Amyloids Involved in Neurodegenerative Diseases

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A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Ab oligomers from Alzheimer brain

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The Toxicity and Polymorphism of β-Amyloid Oligomers

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N‐terminal heterogeneity of parenchymal and vascular amyloid‐β deposits in Alzheimer’s disease

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Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage

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Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer’s brain

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Molecular structure of an N-terminal phosphorylated β-amyloid fibril

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Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

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Human amyloid-β enriched extracts: evaluation of in vitro and in vivo internalization and molecular characterization

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Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

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Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain

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NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

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Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition

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Amyloid fibril polymorphism: a challenge for molecular imaging and therapy

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Molecular and Clinical Aspects of Protein Aggregation Assays in Neurodegenerative Diseases

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Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer’s disease

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An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease

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Distinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer’s disease

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Postsynaptic Proteome of Non-Demented Individuals with Alzheimer’s Disease Neuropathology

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Surveying the Energy Landscapes of Αβ Fibril Polymorphism

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Synaptotoxicity in Alzheimer's Disease Involved a Dysregulation of Actin Cytoskeleton Dynamics through Cofilin 1 Phosphorylation

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Amyloid β-Derived Diffusible Ligands (ADDLs) Induce Abnormal Autophagy Associated with Aβ Aggregation Degree

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Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

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Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease

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Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain

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Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

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Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

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Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

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Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

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The Three-Dimensional Structures of Amyloids

(2016) Roland Riek   Cold Spring Harbor Perspectives in Biology

Phosphorylation modifies the molecular stability of β-amyloid deposits

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The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

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Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity

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Rapidly progressive Alzheimer’s disease features distinct structures of amyloid-β

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Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Amyloid Polymorphism: Structural Basis and Neurobiological Relevance

(2015) Robert Tycko   NEURON

The keystone of Alzheimer pathogenesis might be sought in Aβ physiology

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(2015) Matthias Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity

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Atomic-Resolution Three-Dimensional Structure of Amyloid β Fibrils Bearing the Osaka Mutation

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The remarkable properties of amyloid-β derived from human Alzheimer’s disease brain: swinging the streetlight

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Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease

(2014) Ajeet Rijal Upadhaya et al.   BRAIN

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Amyloid Beta: Multiple Mechanisms of Toxicity and Only Some Protective Effects?

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Distinct synthetic A  prion strains producing different amyloid deposits in bigenic mice

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(2014) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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The amyloid-cell membrane system. The interplay between the biophysical features of oligomers/fibrils and cell membrane defines amyloid toxicity

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Brain amyloid-β oligomers in ageing and Alzheimer’s disease

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Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue

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Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

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The Amyloid State of Proteins in Human Diseases

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Protein Misfolded Oligomers: Experimental Approaches, Mechanism of Formation, and Structure-Toxicity Relationships

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Phosphorylation of Amyloid-β Peptide at Serine 8 Attenuates Its Clearance via Insulin-degrading and Angiotensin-converting Enzymes

(2012) Sathish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antiparallel  -sheet architecture in Iowa-mutant  -amyloid fibrils

(2012) W. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

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Soluble A  Seeds Are Potent Inducers of Cerebral  -Amyloid Deposition

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Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

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The Unique Alzheimer’s β-Amyloid Triangular Fibril Has a Cavity along the Fibril Axis under Physiological Conditions

(2011) Yifat Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

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Capillary CAA and perivascular Aβ-deposition: Two distinct features of Alzheimer's disease pathology

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A causative link between the structure of aberrant protein oligomers and their toxicity

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Structural polymorphism of Alzheimer Aβ and other amyloid fibrils

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Molecular Structures of Quiescently Grown and Brain-Derived Polymorphic Fibrils of the Alzheimer Amyloid Aβ9-40 Peptide: A Comparison to Agitated Fibrils

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Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains

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 -Amyloid Monomers Are Neuroprotective

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Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

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Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

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Seeded growth of  -amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

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Structure-neurotoxicity relationships of amyloid  -protein oligomers

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An Analytical Solution to the Kinetics of Breakable Filament Assembly

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Soluble aggregates of the amyloid-β protein selectively stimulate permeability in human brain microvascular endothelial monolayers

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Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death

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Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

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Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation

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