Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species

Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors

(2021) Giulia Fani et al.   ACS Chemical Neuroscience

Calcium Dyshomeostasis in Alzheimer’s Disease Pathogenesis

(2021) Roberta Cascella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation

(2020) Francisca García et al.   Marine Drugs

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Calcium signaling in Alzheimer's disease & therapies

(2018) Benjamin Chun-Kit Tong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload

(2017) Roberta Cascella et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide

(2017) Anthony Bosson et al.   Molecular Neurodegeneration

Ginsenoside Rg1 inhibits high-voltage-activated calcium channel currents in hippocampal neurons of beta-amyloid peptide-exposed rat brain slices

(2016) Qian-kun Quan et al.   Chinese Journal of Integrative Medicine

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Local and Use-Dependent Effects of β-Amyloid Oligomers on NMDA Receptor Function Revealed by Optical Quantal Analysis

(2016) Brooke L. Sinnen et al.   JOURNAL OF NEUROSCIENCE

Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases

(2016) Elisa Evangelisti et al.   Scientific Reports

Impact of Phosphatidylethanolamine on the Antioxidant Activity of α-Tocopherol and Trolox in Bulk Oil

(2015) Leqi Cui et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to  -Amyloid Oligomer-Related Neurotoxicity and Memory Impairment

(2015) V. G. Ostapchenko et al.   JOURNAL OF NEUROSCIENCE

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism

(2014) Ilie-Cosmin Stancu et al.   Molecular Neurodegeneration

TDP-43 Inclusion Bodies Formed in Bacteria Are Structurally Amorphous, Non-Amyloid and Inherently Toxic to Neuroblastoma Cells

(2014) Claudia Capitini et al.   PLoS One

Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro

(2013) Roberta Cascella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Calcium channelopathies and Alzheimer's disease: Insight into therapeutic success and failures

(2013) Shreaya Chakroborty et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively

(2013) A. Bobba et al.   MITOCHONDRION

Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N

(2013) Francesca Tatini et al.   NEUROBIOLOGY OF AGING

Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer's disease

(2013) Fernando J. Sepúlveda et al.   NEUROBIOLOGY OF AGING

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

(2012) Kristina Leuner et al.   ANTIOXIDANTS & REDOX SIGNALING

Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers

(2012) E. Evangelisti et al.   JOURNAL OF CELL SCIENCE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

(2010) Elena Alberdi et al.   CELL CALCIUM

A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells

(2010) Mariagioia Zampagni et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane

(2010) Mariagioia Zampagni et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid-β peptide oligomers

(2010) Helena Decker et al.   JOURNAL OF NEUROCHEMISTRY

A causative link between the structure of aberrant protein oligomers and their toxicity

(2010) Silvia Campioni et al.   Nature Chemical Biology

Oxidative stress in Alzheimer disease: A possibility for prevention

(2010) David J. Bonda et al.   NEUROPHARMACOLOGY

Oxidative stress in Alzheimer disease

(2010) Alejandro Gella et al.   Cell Adhesion & Migration

Amyloid-beta Leads to Impaired Cellular Respiration, Energy Production and Mitochondrial Electron Chain Complex Activities in Human Neuroblastoma Cells

(2009) V. Rhein et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Small molecule blockers of the Alzheimer A  calcium channel potently protect neurons from A  cytotoxicity

(2009) J. C. Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccination with soluble Aβ oligomers generates toxicity-neutralizing antibodies

(2003) Mary P. Lambert et al.   JOURNAL OF NEUROCHEMISTRY