Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain
出版年份 2018 全文链接
标题
Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain
作者
关键词
Amyloid β-protein, Automated live-cell imaging, iPSC-derived human neurons, Long-term potentiation, Neuritic dystrophy, Soluble aggregates
出版物
ACTA NEUROPATHOLOGICA
Volume 136, Issue 1, Pages 19-40
出版商
Springer Nature
发表日期
2018-04-23
DOI
10.1007/s00401-018-1846-7
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP
- (2017) Zemin Wang et al. JOURNAL OF NEUROSCIENCE
- Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease
- (2017) David L. Brody et al. Alzheimers Research & Therapy
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate
- (2016) Ting Yang et al. JOURNAL OF NEUROSCIENCE
- Soluble Amyloid-beta Aggregates from Human Alzheimer’s Disease Brains
- (2016) Thomas J. Esparza et al. Scientific Reports
- Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis
- (2015) Kirsten L. Viola et al. ACTA NEUROPATHOLOGICA
- The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species
- (2015) Jessica M. Mc Donald et al. Alzheimers & Dementia
- N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42
- (2015) Olga Szczepankiewicz et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- η-Secretase processing of APP inhibits neuronal activity in the hippocampus
- (2015) Michael Willem et al. NATURE
- Anti-Aβ antibodies incapable of reducing cerebral Aβ oligomers fail to attenuate spatial reference memory deficits in J20 mice
- (2015) Alexandra J. Mably et al. NEUROBIOLOGY OF DISEASE
- A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid
- (2015) Ting Yang et al. Alzheimers Research & Therapy
- Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration
- (2015) Peng Liu et al. Cell Reports
- Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity
- (2014) Alfred T. Welzel et al. BIOCHEMISTRY
- Open questions for Alzheimer’s disease immunotherapy
- (2014) Todd E Golde Alzheimers Research & Therapy
- Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer’s disease
- (2014) Lars Lannfelt et al. Alzheimers Research & Therapy
- Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells
- (2013) Yingsha Zhang et al. NEURON
- Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls
- (2012) Thomas J. Esparza et al. ANNALS OF NEUROLOGY
- The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain
- (2012) Jessica M. McDonald et al. BRAIN RESEARCH
- Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis
- (2012) Jungsu Kim et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
- (2012) Iryna Benilova et al. NATURE NEUROSCIENCE
- Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
- (2012) Ji Won Um et al. NATURE NEUROSCIENCE
- Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation
- (2012) Gilyana G. Borlikova et al. NEUROBIOLOGY OF AGING
- Epigenetic regulation of reelin and brain-derived neurotrophic factor genes in long-term potentiation in rat medial prefrontal cortex
- (2012) Li Sui et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Large Aggregates Are the Major Soluble Aβ Species in AD Brain Fractionated with Density Gradient Ultracentrifugation
- (2012) Dag Sehlin et al. PLoS One
- Alzheimer’s disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory
- (2012) Igor Klyubin et al. Molecular Brain
- Amyloid-β Annular Protofibrils Evade Fibrillar Fate in Alzheimer Disease Brain
- (2011) Cristian A. Lasagna-Reeves et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- High-molecular weight Aβ oligomers and protofibrils are the predominant Aβ species in the native soluble protein fraction of the AD brain
- (2011) Ajeet Rijal Upadhaya et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Alzheimer's Disease Brain-Derived Amyloid- -Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein
- (2011) A. E. Barry et al. JOURNAL OF NEUROSCIENCE
- Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift
- (2011) Todd E. Golde et al. NEURON
- Soluble amyloid -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
- (2011) M. Jin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites
- (2011) Darragh B. Freir et al. Nature Communications
- The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia
- (2010) Jessica M. Mc Donald et al. BRAIN
- Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease
- (2010) C. R. Jack et al. BRAIN
- β-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins
- (2010) Carlo Sala Frigerio et al. FEBS Journal
- Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species
- (2010) Asad Jan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Specification of Region-Specific Neurons Including Forebrain Glutamatergic Neurons from Human Induced Pluripotent Stem Cells
- (2010) Hui Zeng et al. PLoS One
- Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains
- (2009) Akihiko Noguchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alzheimer's disease: synaptic dysfunction and Aβ
- (2009) Ganesh M Shankar et al. Molecular Neurodegeneration
- Amyloid β-Protein Toxicity and the Pathogenesis of Alzheimer Disease
- (2008) Bruce A. Yankner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Classification of Toxic Amyloid Oligomers
- (2008) Charles G. Glabe JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
- (2008) Ganesh M Shankar et al. NATURE MEDICINE
- Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
- (2007) Fernanda G. De Felice et al. NEUROBIOLOGY OF AGING
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More