Ferroptosis: Environmental causes, biological redox signaling responses, cancer and other health consequences

The glutathione peroxidase family: Discoveries and mechanism

(2022) Leopold Flohé et al.   FREE RADICAL BIOLOGY AND MEDICINE

ATF4 protects against sorafenib-induced cardiotoxicity by suppressing ferroptosis

(2022) Hui Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell-cycle arrest and senescence in TP53-wild type renal carcinoma by enhancer RNA-P53-bound enhancer regions 2 (p53BER2) in a p53-dependent pathway

(2021) Haibiao Xie et al.   Cell Death & Disease

Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium

(2021) Armin Salek Maghsoudi et al.   International Journal of Nanomedicine

pH-Sensitive Polymeric Vesicles for GOx/BSO Delivery and Synergetic Starvation-Ferroptosis Therapy of Tumor

(2021) Yang Luo et al.   BIOMACROMOLECULES

Cadmium induces ferroptosis and apoptosis by modulating miR ‐34a‐5p/Sirt1axis in PC12 cells

(2021) Rili Hao et al.   ENVIRONMENTAL TOXICOLOGY

Endoplasmic reticulum stress-mediated autophagy activation is involved in cadmium-induced ferroptosis of renal tubular epithelial cells

(2021) Caijun Zhao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion

(2021) Ling Zeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bone Formation Ability and Cell Viability Enhancement of MC3T3-E1 Cells by Ferrostatin-1 a Ferroptosis Inhibitor of Cancer Cells

(2021) Alireza Valanezhad et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Is aggregated synthetic amorphous silica toxicologically relevant?

(2020) Sivakumar Murugadoss et al.   Particle and Fibre Toxicology

The Impact of PM2.5 on the Host Defense of Respiratory System

(2020) Liyao Yang et al.   Frontiers in Cell and Developmental Biology

Arsenite induces testicular oxidative stress in vivo and in vitro leading to ferroptosis

(2020) Pan Meng et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease

(2020) Ningning Tao et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death

(2020) Anna Martina Battaglia et al.   Cells

Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis

(2020) Sen Wei et al.   ENVIRONMENTAL RESEARCH

Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases

(2020) Marcus Conrad et al.   TRENDS IN MOLECULAR MEDICINE

Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium

(2020) Fumiya Ito et al.   Redox Biology

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

(2020) Cadiele Oliana Reichert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles

(2019) Aldenor G. Santos et al.   Scientific Reports

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Identification of PRDX6 as a regulator of ferroptosis

(2019) Bin Lu et al.   ACTA PHARMACOLOGICA SINICA

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

(2019) Evijola Llabani et al.   Nature Chemistry

The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival

(2019) Joseph A. Combs et al.   Cancers

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

(2019) Masahiro Yoshida et al.   Nature Communications

Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis

(2019) Zhou Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway

(2019) Sen Wei et al.   JOURNAL OF HAZARDOUS MATERIALS

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Acetyl- l -carnitine attenuates arsenic-induced liver injury by abrogation of mitochondrial dysfunction, inflammation, and apoptosis in rats

(2018) Vida Bodaghi-Namileh et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells

(2018) Fengyi Gao et al.   JOURNAL OF CELL BIOLOGY

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

The Role of Ferroptosis in Cancer Development and Treatment Response

(2018) Bin Lu et al.   Frontiers in Pharmacology

Iron and Cancer

(2018) Suzy V. Torti et al.   Annual Review of Nutrition

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury

(2018) Elizabeth M. Kenny et al.   CRITICAL CARE MEDICINE

Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: Toward the era of mesothelioma prevention

(2018) Shinya Toyokuni   FREE RADICAL BIOLOGY AND MEDICINE

Invasion and migration of MDA-MB-231 cells are inhibited by block of AhR and NFAT: role of AhR/NFAT1/β4 integrin signaling

(2018) Amir Shadboorestan et al.   JOURNAL OF APPLIED TOXICOLOGY

Biochemical and molecular evidence on the role of vaspin in early detection of the insulin resistance in a rat model of high-fat diet and use of diazinon

(2018) Armin Salek-Maghsoudi et al.   TOXICOLOGY

Whole cigarette smoke condensates induce ferroptosis in human bronchial epithelial cells

(2018) Eun-Jung Park et al.   TOXICOLOGY LETTERS

Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis

(2017) Shinya Toyokuni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases

(2017) Kathleen A. Hershberger et al.   Nature Reviews Nephrology

Mitochondrial Sirtuins and Molecular Mechanisms of Aging

(2017) Robert A.H. van de Ven et al.   TRENDS IN MOLECULAR MEDICINE

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner

(2016) Hiroki Daijo et al.   Scientific Reports

Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect

(2015) Andrew J. Ghio et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Ferroptosis is Involved in Acetaminophen Induced Cell Death

(2015) Tamás Lőrincz et al.   PATHOLOGY & ONCOLOGY RESEARCH

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

(2015) R. J. A. Bell et al.   SCIENCE

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

GABP Transcription Factor (Nuclear Respiratory Factor 2) Is Required for Mitochondrial Biogenesis

(2014) Z.-F. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Hypoxia Exerts Dualistic Effects on Inflammatory and Proliferative Responses of Healthy and Asthmatic Primary Human Bronchial Smooth Muscle Cells

(2014) Laura Keglowich et al.   PLoS One

Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species

(2013) Rajitha T Kolamunne et al.   Redox Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes

(2012) Marco Mariotti et al.   PLoS One

Mitochondrial Mayhem: The Mitochondrion as a Modulator of Iron Metabolism and Its Role in Disease

(2011) Michael Li-Hsuan Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of iron transport and the role of transferrin

(2011) Konstantinos Gkouvatsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

(2011) Richard J Bridges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of cigarette smoke and hypoxia on pulmonary circulation in the guinea pig

(2011) E. Ferrer et al.   EUROPEAN RESPIRATORY JOURNAL

Effects of cigarette smoke and chronic hypoxia on airways remodeling and resistance. Clinical significance

(2011) Elena Olea et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice

(2010) Junghee Lee et al.   ACTA NEUROPATHOLOGICA

Transcription factor GABP/NRF-2 controlling biogenesis of mitochondria regulates basal expression of peroxiredoxin V but the mitochondrial function of peroxiredoxin V is dispensable in the dog

(2010) Nadezhda Usmanova et al.   BIOCHIMIE

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyridine Nucleotide Cycling and Control of Intracellular Redox State in Relation to Poly (ADP-Ribose) Polymerase Activity and Nuclear Localization of Glutathione during Exponential Growth of Arabidopsis Cells in Culture

(2009) Till K. Pellny et al.   Molecular Plant

Particulate Matter in Cigarette Smoke Alters Iron Homeostasis to Produce a Biological Effect

(2008) Andrew J. Ghio et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Assessment of Endoplasmic Reticulum Glutathione Redox Status Is Confounded by Extensive Ex Vivo Oxidation

(2008) Brian M. Dixon et al.   ANTIOXIDANTS & REDOX SIGNALING

Epigenetic Control of rDNA Loci in Response to Intracellular Energy Status

(2008) Akiko Murayama et al.   CELL

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

(2008) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Glutathione and apoptosis

(2008) Magdalena L. Circu et al.   FREE RADICAL RESEARCH

Endothelial Protein C Receptor-Assisted Transport of Activated Protein C across the Mouse Blood—Brain Barrier

(2008) Rashid Deane et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

A Novel Strategy Involved Anti-Oxidative Defense: The Conversion of NADH into NADPH by a Metabolic Network

(2008) Ranji Singh et al.   PLoS One

Phosphorylation Regulates SIRT1 Function

(2008) Tsutomu Sasaki et al.   PLoS One

A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines

(2007) A Mukherjee et al.   BRITISH JOURNAL OF PHARMACOLOGY