Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

A Ring-Distortion Strategy from Marine Natural Product Ilimaquinone Leads to Quorum Sensing Modulators

(2018) Laurent Evanno et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Directed C–H Bond Oxidation of (+)-Pleuromutilin

(2018) Xiaoshen Ma et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (+)-Pleuromutilin

(2018) Elliot P. Farney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Topologically Complex Scaffold Derived from Alkaloid Haemanthamine

(2018) Karthik Govindaraju et al.   MOLECULES

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Chemical probes and drug leads from advances in synthetic planning and methodology

(2018) Christopher J. Gerry et al.   NATURE REVIEWS DRUG DISCOVERY

Ferroptosis-inducing agents compromise in vitro human islet viability and function

(2018) Antonio Bruni et al.   Cell Death & Disease

Reagent-controlled regiodivergent ring expansions of steroids

(2018) Manwika Charaschanya et al.   Nature Communications

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

(2018) Jan Lewerenz et al.   Frontiers in Neuroscience

Preparation of Structurally Diverse Compounds from the Natural Product Lycorine

(2018) Sarah Z. Tasker et al.   ORGANIC LETTERS

Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis

(2017) Eduardo Reynoso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

(2017) Trang Thi Mai et al.   Nature Chemistry

A modular and enantioselective synthesis of the pleuromutilin antibiotics

(2017) Stephen K. Murphy et al.   SCIENCE

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine

(2016) Alfredo Garcia et al.   ORGANIC LETTERS

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

(2015) Rahul Palchaudhuri et al.   Cell Reports

Synthesis of Bridged Oxafenestranes from Pleuromutilin

(2014) Robert W. Hicklin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Dual Small-Molecule Targeting of Procaspase-3 Dramatically Enhances Zymogen Activation and Anticancer Activity

(2014) Rachel C. Botham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Efficient NQO1 Substrates are Potent and Selective Anticancer Agents

(2013) Elizabeth I. Parkinson et al.   ACS Chemical Biology

Synthesis of Complex and Diverse Compounds through Ring Distortion of Abietic Acid

(2013) Ryan J. Rafferty et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis

(2013) BO RA YOU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

1,3,5-Triazine as a Modular Scaffold for Covalent Inhibitors with Streamlined Target Identification

(2013) Ranjan Banerjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural products as starting points for the synthesis of complex and diverse compounds

(2013) Karen C. Morrison et al.   NATURAL PRODUCT REPORTS

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products

(2013) Robert W. Huigens III et al.   Nature Chemistry

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The secret ally: immunostimulation by anticancer drugs

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

The synthesis of C-13 functionalized pleuromutilins via C–H amidation and subsequent novel rearrangement product

(2011) Daniel P. Uccello et al.   TETRAHEDRON LETTERS

A concise synthesis of the molecular framework of pleuromutilin

(2010) Junjia Liu et al.   CHEMICAL COMMUNICATIONS

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

(2010) Warren R.J.D. Galloway et al.   Nature Communications

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Process Development for A Novel Pleuromutilin-Derived Antibiotic

(2009) Yemane Andemichael et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Targeting airway inflammation: PMX464 and the epithelial bulls eye

(2008) D W Sexton   BRITISH JOURNAL OF PHARMACOLOGY

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Retapamulin

(2008) Lily P H Yang et al.   DRUGS

A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines

(2007) A Mukherjee et al.   BRITISH JOURNAL OF PHARMACOLOGY

The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome

(2003) Susan M. Poulsen et al.   MOLECULAR MICROBIOLOGY