Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases?

Tau Phosphorylation by cdk5 and Fyn in Response to Amyloid Peptide Aβ25–35: Involvement of Lipid Rafts

(2017) Paula Hernandez et al.   JOURNAL OF ALZHEIMERS DISEASE

Sporadic and hereditary amyotrophic lateral sclerosis (ALS)

(2015) Senda Ajroud-Driss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse

(2015) Seán T. Anderson et al.   BRAIN BEHAVIOR AND IMMUNITY

Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson׳s disease

(2015) Shaoxia Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Membrane protein oxidation determines neuronal degeneration

(2015) Parvana Hajieva et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Fractalkine Over Expression Suppresses α-Synuclein-mediated Neurodegeneration

(2015) Kevin R Nash et al.   MOLECULAR THERAPY

Systemic Inflammation and the Brain: Novel Roles of Genetic, Molecular, and Environmental Cues as Drivers of Neurodegeneration

(2015) Roman Sankowski et al.   Frontiers in Cellular Neuroscience

Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice, an animal model of Alzheimer's disease

(2014) Minho Moon et al.   JOURNAL OF NEUROCHEMISTRY

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Transglutaminase 6 interacts with polyQ proteins and promotes the formation of polyQ aggregates

(2013) Wen-Juan Guan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Fluid—Mosaic Model of Membrane Structure: Still relevant to understanding the structure, function and dynamics of biological membranes after more than 40years

(2013) Garth L. Nicolson   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone

(2013) Sae-Hun Park et al.   CELL

Activation of innate immunity by lysozyme fibrils is critically dependent on cross-β sheet structure

(2013) Adelin Gustot et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Activation of microglia induces symptoms of Parkinson’s disease in wild-type, but not in IL-1 knockout mice

(2013) Sachiko Tanaka et al.   Journal of Neuroinflammation

Cellular distribution of copper to superoxide dismutase involves scaffolding by membranes

(2013) C. R. Pope et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Interaction of Tau Protein with Model Lipid Membranes Induces Tau Structural Compaction and Membrane Disruption

(2012) Emmalee M. Jones et al.   BIOCHEMISTRY

Effect of oxidative stress on plasma membrane fluidity of THP-1 induced macrophages

(2012) Carlos de la Haba et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells

(2012) Martina Malnar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Neuronal Membranes are Key to the Pathogenesis of Alzheimers Disease: the Role of Both Raft and Non-Raft Membrane Domains

(2012) R. Williamson et al.   Current Alzheimer Research

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

(2012) Dimitrije Krstic et al.   Journal of Neuroinflammation

Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study

(2012) Karen Barnett et al.   LANCET

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

(2012) Juxue Li et al.   NATURE CELL BIOLOGY

Deciphering the mechanism underlying late-onset Alzheimer disease

(2012) Dimitrije Krstic et al.   Nature Reviews Neurology

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

The Generation of Antimicrobial Peptide Activity: A Trade-off between Charge and Aggregation?

(2011) Marc Torrent et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis

(2011) Catherine Marquer et al.   FASEB JOURNAL

CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

(2011) Seo-Hyun Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The frontotemporal dementia mutation R406W blocks tau’s interaction with the membrane in an annexin A2–dependent manner

(2011) Anne Gauthier-Kemper et al.   JOURNAL OF CELL BIOLOGY

α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding

(2011) Iwona M. Pranke et al.   JOURNAL OF CELL BIOLOGY

Allostery in a Disordered Protein: Oxidative Modifications to α-Synuclein Act Distally To Regulate Membrane Binding

(2011) Eva Sevcsik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of Membrane Interaction and Disruption by α-Synuclein

(2011) Nicholas P. Reynolds et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of G protein-coupled receptors in the pathology of Alzheimer's disease

(2011) Amantha Thathiah et al.   NATURE REVIEWS NEUROSCIENCE

Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons

(2011) Andrew D. Kraft et al.   NEUROBIOLOGY OF AGING

Proinflammatory cytokines, sickness behavior, and Alzheimer disease

(2011) C. Holmes et al.   NEUROLOGY

Connecting Peptide Physicochemical and Antimicrobial Properties by a Rational Prediction Model

(2011) Marc Torrent et al.   PLoS One

Lipid changes in the aged brain: Effect on synaptic function and neuronal survival

(2011) María Dolores Ledesma et al.   PROGRESS IN LIPID RESEARCH

Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems

(2010) Sara M. Butterfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

(2010) Pavan K. Auluck et al.   Annual Review of Cell and Developmental Biology

The Role of the Lipid Bilayer in Tau Aggregation

(2010) Shana Elbaum-Garfinkle et al.   BIOPHYSICAL JOURNAL

A cellular perspective on conformational disease: the role of genetic background and proteostasis networks

(2010) Tali Gidalevitz et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Early and Late Events Induced by PolyQ-expanded Proteins

(2010) Alessandra Bertoni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pieces of the Parkinson's puzzle

(2010) Yukie Ozawa   NATURE REVIEWS NEUROSCIENCE

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

Impact of phospholipid bilayer saturation on amyloid-β protein aggregation intermediate growth: A quartz crystal microbalance analysis

(2009) J.A. Kotarek et al.   ANALYTICAL BIOCHEMISTRY

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Proteomic characterization of lipid raft proteins in amyotrophic lateral sclerosis mouse spinal cord

(2009) Jianjun Zhai et al.   FEBS Journal

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Striatal Neuroinflammation Promotes Parkinsonism in Rats

(2009) Dong-Young Choi et al.   PLoS One

Lipid Raft-Mediated Regulation of G-Protein Coupled Receptor Signaling by Ligands which Influence Receptor Dimerization: A Computational Study

(2009) Mohammad Fallahi-Sichani et al.   PLoS One

Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

(2009) C. M. Karch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-electrostatic binding and self-association of amyloid β-peptide on the surface of tightly packed phosphatidylcholine membranes

(2008) Mayumi Yoda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Membrane phospholipids, lipoxidative damage and molecular integrity: A causal role in aging and longevity

(2008) Reinald Pamplona   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells

(2008) Maria C.N. Marchetto et al.   Cell Stem Cell

How cytokines can influence the brain: A role for chemokines?

(2008) Alice Guyon et al.   JOURNAL OF NEUROIMMUNOLOGY

Soluble TNF receptors are associated with Aβ metabolism and conversion to dementia in subjects with mild cognitive impairment

(2008) Peder Buchhave et al.   NEUROBIOLOGY OF AGING

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

(2008) M. F. M. Engel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA