Article
Evolutionary Biology
Pablo Mier, Miguel A. Andrade-Navarro
Summary: Polyglutamine (polyQ) regions are consecutive runs of glutamine residues, which are associated with various diseases. Studies suggest that polyQ may serve as a motif for modulation of protein-protein interactions. However, long polyQ regions could lead to an excess of interactions and the formation of aggregates.
GENOME BIOLOGY AND EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Rachel S. Fisher, Rosa Meyo Jimenez, Elizabeth Soto, Darin Kalev, Shana Elbaum-Garfinkle
Summary: Using microscopy, researchers found that polyQ aggregates in aging C. elegans neurons exhibit a core/shell structure, with decreased intensity in the center as the worm ages.
Article
Multidisciplinary Sciences
Hong-Wei Yue, Jun-Ye Hong, Shu-Xian Zhang, Lei-Lei Jiang, Hong-Yu Hu
Summary: The study reveals that polyglutamine (polyQ) proteins can disrupt cellular proteostasis of endogenous ataxin-3 (Atx3) by sequestering the co-chaperone HSJ1, leading to the imbalance and aggregation of Atx3 proteins. This finding sheds light on a potential mechanism underlying proteinopathies caused by PQE proteins.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Chandan Kumar Maurya, Madhu G. Tapadia
Summary: In this study, the authors simulated the phenotype of Huntington's disease in neuronal cells of Drosophila eye and identified sarco-endoplasmic reticulum calcium ATPase (SERCA) as a genetic modifier of neurodegenerative phenotype. The results showed that polyglutamine aggregates interact with SERCA, altering calcium dynamics and causing toxicity. Manipulating SERCA activity can be a potential therapeutic approach for treating neurodegeneration caused by expanded polyglutamine repeats.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2023)
Article
Biology
Tien-Ying Tsai, Chun-Yu Chen, Tien-Wei Lin, Tien-Chang Lin, Feng-Lan Chiu, Orion Shih, Yu-Chun Lin, An-Chung Su, Chiung-Mei Chen, U-Ser Jeng, Hung-Chih Kuo, Chi-Fon Chang, Yun-Ru Chen
Summary: This study reveals the molecular mechanism of SERF1a and mutant Httex1 in facilitating therapeutic development for Huntington's disease. SERF1a induces aggregation of mutated TrxHttex1 through α-helical regions, leading to the formation of β-sheet enriched conformation, exacerbating polyQ-induced toxicity. The interaction between SERF1a and Httex1 is intensified by enhancing α-helical content.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jun-Ye Hong, Jian-Yang Wang, Hong-Wei Yue, Xiang-Le Zhang, Shu-Xian Zhang, Lei-Lei Jiang, Hong-Yu Hu
Summary: This study investigates the heterologous coaggregation of four polyQ-containing proteins and its impact on cellular proteostasis. The results show that the N-terminal fragment of polyQ-expanded Atx7 or Htt can coaggregate with and sequester AR and Atx3 into insoluble aggregates or inclusions through their respective polyQ tracts. This coaggregation is mediated by polyQ-tract interactions and depletes the cellular availability of AR, impairing its transactivation function.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Acoustics
Tiehua Zhang, Yanli Zhao, Xiner Tian, Jing Liu, Haiqing Ye, Xue Shen
Summary: It was found that pretreatment of WPISA with high-intensity ultrasound increased the content and crosslinking degree of high-molecular-weight polymers, improving particle size, fluorescence intensity, and hydrophobicity. This process also enhanced the apparent viscosity and consistency index of WPISA, as well as its water holding capacity and gel strength.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Chemistry, Applied
Yu Zhang, Jiang-lan Yuan, Chao Fan, Ping Yan, Xu Kang
Summary: Porcine plasma protein (PPP) cold-set gel was successfully prepared using GDL and MTGase as synergistic inducers, with the optimum concentrations found to be 0.3% and 0.2%, respectively. The gel exhibited excellent texture and a water holding capacity (WHC) close to 75%. The main force in the gel network was determined to be the covalent crosslinking catalyzed by MTGase, which required the formation of GDL-mediated aggregates with appropriate structures.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Applied
Yuxuan Wang, Qipu Xin, Yujia Miao, Xianming Zeng, Hao Li, Kai Shan, Yingqun Nian, Di Zhao, Juqing Wu, Chunbao Li
Summary: The study found that TG treatment can affect the gastric digestion rate of proteins, with a greater impact on soybean protein isolate (SPI). Analysis of peptide composition after digestion revealed that TG treatment leads to the loss of lysine residues and release of bioactive peptides.
Article
Thermodynamics
Guanglei Li, Yahui Cui, Lihua Wang, Lei Meng
Summary: This paper proposes a robot inverse kinematics method based on ELM-SSA-SCA, which achieves faster convergence rate, higher precision, and better timeliness by optimizing the initial inverse solution and using ELM for prediction.
ADVANCES IN MECHANICAL ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Ioannis Gkekas, Anna Gioran, Marina Kleopatra Boziki, Nikolaos Grigoriadis, Niki Chondrogianni, Spyros Petrakis
Summary: Neurodegenerative polyglutamine (polyQ) disorders are caused by trinucleotide repeat expansions within disease-causing genes, leading to protein inclusions and oxidative stress. The interplay between oxidative stress, neurodegeneration, and neuroinflammation in polyQ diseases is discussed, with potential pharmaceutical interventions to delay disease progression.
Article
Medicine, Research & Experimental
Jessica Panes-Fernandeza, Pamela A. Godoy, Javiera Gavilan, Oscar Ramirez-Molina, Carlos Felipe Burgos, Ana Marileo, Oscar Flores-Nunez, Patricio A. Castro, Gustavo Moraga-Cid, Gonzalo E. Yevenes, Carola Munoz-Montesino, Jorge Fuentealba
Summary: Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by cognitive impairment in the elderly. Transglutaminase type 2 (TG2) has been found to promote aggregation of the amyloid beta peptide (Aβ) and contribute to cellular damage and synaptic failure. This study demonstrates that TG2 enhances calcium overload and disrupts mitochondrial-endoplasmic reticulum contacts, leading to neuronal damage and dysfunctional synapses. Inhibition of TG2 reverses these effects, highlighting the potential of TG2 inhibitors as a therapeutic strategy for AD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Anja Schulze-Krebs, Fabio Canneva, Judith Stemick, Anne-Christine Plank, Julia Harrer, Gillian P. Bates, Daniel Aeschlimann, Joan S. Steffan, Stephan von Hoersten
Summary: This study investigated the expression, distribution, and activity of transglutaminases in Huntington disease models, particularly focusing on the role of TG6 in disease progression. Results demonstrated a physical interaction between TG6 and (mutant) huntingtin, as well as the involvement of TG6 in mHTT aggregate formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Leonardo E. Dionisio, X. William Yang
Summary: In this study, the authors utilize AP-MS and complementary approaches to define high-confidence polyglutamine-dependent huntingtin interaction partners and categorize them based on their abundance and stability. The findings reveal that these toxic gain-of-function partners are a consistent feature of HD pathogenesis.
Article
Engineering, Electrical & Electronic
Yang Lu
Summary: This paper investigates the secrecy energy efficiency (SEE) performance in RIS-assisted MISO networks and proposes an algorithm to solve the SEE maximization problem. Numerical results show that the proposed algorithm is more computationally efficient than the benchmark algorithm, and the use of RIS greatly enhances SEE.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2023)
Article
Genetics & Heredity
Wenting Dai, Jiayu Wu, Yaguang Zhao, Fang Jiang, Ruizhi Zheng, Dan-Na Chen, Meichao Men, Jia-Da Li
Article
Medicine, Research & Experimental
Meichao Men, Wu Li, Hongsheng Chen, Jiayu Wu, Yong Feng, Hui Guo, Jia-Da Li
Article
Multidisciplinary Sciences
Xiaoliang Xing, Jing Zhang, Kunyang Wu, Beibei Cao, Xianfeng Li, Fang Jiang, Zhengmao Hu, Kun Xia, Jia-Da Li
SCIENTIFIC REPORTS
(2019)
Article
Endocrinology & Metabolism
Fangfang Li, Dengfeng Li, Huadie Liu, Bei-Bei Cao, Fang Jiang, Dan-Na Chen, Jia-Da Li
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Obstetrics & Gynecology
Meichao Men, Jiayu Wu, Yaguang Zhao, Xiaoliang Xing, Fang Jiang, Ruizhi Zheng, Jia-Da Li
FERTILITY AND STERILITY
(2020)
Article
Endocrinology & Metabolism
Jia-Da Li, Jiayu Wu, Yaguang Zhao, Xinying Wang, Fang Jiang, Qiao Hou, Dan-Na Chen, Ruizhi Zheng, Renhe Yu, Wei Zhou, Meichao Men
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Genetics & Heredity
Wenting Dai, Jia-Da Li, Yaguang Zhao, Jiayu Wu, Fang Jiang, Dan-Na Chen, Ruizhi Zheng, Meichao Men
Article
Neurosciences
Xiaoliang Xing, Kunyang Wu, Yufan Dong, Yimei Zhou, Jing Zhang, Fang Jiang, Wang-Ping Hu, Jia-Da Li
Article
Cell Biology
Zongyang Lu, Zhen Liu, Wei Mao, Xinying Wang, Xiaoguo Zheng, Shanshan Chen, Beibei Cao, Shisheng Huang, Xuliang Zhang, Tao Zhou, Yu Zhang, Xingxu Huang, Qiang Sun, Jia-Da Li
CELL DEATH & DISEASE
(2020)
Article
Genetics & Heredity
Meichao Men, Xinying Wang, Jiayu Wu, Wang Zeng, Fang Jiang, Ruizhi Zheng, Jia-Da Li
Summary: The study investigated genotypic and phenotypic spectra of DUSP6, IL17RD, and SPRY4 in a large cohort of Chinese patients with IHH. Mutations in DUSP6 alone could cause IHH in an autosomal dominant manner, while IL17RD or SPRY4 mutations may synergistically lead to IHH phenotypes with variants in other IHH-associated genes.
JOURNAL OF MEDICAL GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Renbin Lu, Yufan Dong, Jia-Da Li
NUCLEIC ACIDS RESEARCH
(2020)
Article
Endocrinology & Metabolism
Qiao Hou, Jiayu Wu, Yaguang Zhao, Xinying Wang, Fang Jiang, Dan-Na Chen, Ruizhi Zheng, Meichao Men, Jia-Da Li
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Multidisciplinary Sciences
Ye Liang, JingJing Huan, Jia-Da Li, CanHua Jiang, ChangYun Fang, YongGang Liu
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Dengfeng Li, Fangfang Li, Lanlan Meng, Huafang Wei, Qianjun Zhang, Fang Jiang, Dan-Na Chen, Wei Li, Yue-Qiu Tan, Jia-Da Li
Summary: The study demonstrated that RNF216 plays a crucial role in regulation of meiosis during spermatogenesis in mice, with its deficiency leading to incomplete arrest of zygotene spermatocytes and apoptosis at the pachytene stage. Additionally, RNF216 was shown to interact with PRKACB and promote its degradation, resulting in elevated PKA activity in the testes.
Article
Multidisciplinary Sciences
Xinyu Li, Yufeng Cai, Yinghe Ding, Jia-Da Li, Guoqing Huang, Ye Liang, Linyong Xu
Summary: This study aimed to estimate the demand for isolation beds during the COVID-19 pandemic. A discrete simulation model was established to analyze the impact of various factors such as incubation period, hospital response speed, disease healing time, and population mobility on the epidemic and medical resource occupation. Multiple linear regression was used to predict the number of isolation beds, and the results showed that these factors significantly influenced the demand and number of beds.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)