Article
Psychology, Multidisciplinary
Adriana Boettcher, Alexis Zarucha, Theresa Koebe, Malo Gaubert, Angela Hoeppner, Slawek Altenstein, Claudia Bartels, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Silka Dawn Freiesleben, Ingo Frommann, John Dylan Haynes, Daniel Janowitz, Ingo Kilimann, Luca Kleineidam, Christoph Laske, Franziska Maier, Coraline Metzger, Matthias H. J. Munk, Robert Perneczky, Oliver Peters, Josef Priller, Boris-Stephan Rauchmann, Nina Roy, Klaus Scheffler, Anja Schneider, Annika Spottke, Stefan J. Teipel, Jens Wiltfang, Steffen Wolfsgruber, Renat Yakupov, Emrah Duezel, Frank Jessen, Sandra Roeske, Michael Wagner, Gerd Kempermann, Miranka Wirth
Summary: This study examines the association between musical instrument playing, cognitive abilities, and brain morphology in older adults. Results show that participants with musical activity perform better in various cognitive domains and have greater gray matter volume in certain brain areas.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Geriatrics & Gerontology
Qu Tian, Brendan A. Mitchell, Guray Erus, Christos Davatzikos, Ruin Moaddel, Susan M. Resnick, Luigi Ferrucci
Summary: Lipids are important for brain structure and function, and studies show that men experience greater brain atrophy than women with aging. This study investigated the sex-specific associations between circulating lipids and brain atrophy in a sample of cognitively normal older adults. Results revealed sex differences in the associations between specific lipid profiles and accelerated brain aging. The findings suggest the need for further investigation into the mechanisms underlying these sex-specific lipid profiles.
NEUROBIOLOGY OF AGING
(2023)
Article
Multidisciplinary Sciences
Jing Lu, Aline Moussard, Sijia Guo, Yunjo Lee, Gavin M. Bidelman, Sylvain Moreno, Cassandra Skrotzki, Jennifer Bugos, Dawei Shen, Dezhong Yao, Claude Alain
Summary: There is growing interest in developing training programs to mitigate cognitive decline associated with normal aging. This study found that music training had an effect on theta brain waves and functional connectivity in older adults. These findings contribute to a better understanding of inhibitory control ability in older adults and the neuroplastic effects of music interventions.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Cell Biology
Adam Krzystyniak, Malgorzata Wesierska, Gregory Petrazzo, Agnieszka Gadecka, Magdalena Dudkowska, Anna Bielak-Zmijewska, Grazyna Mosieniak, Izabela Figiel, Jakub Wlodarczyk, Ewa Sikora
Summary: By conducting experiments on aged rats, it was found that the use of senolytic agents D+Q can improve the learning and memory abilities of aged rats, reduce peripheral inflammation, and regulate the structure of hippocampal neurons and histone modifications. Moreover, the benefits of this treatment are long-lasting, even after the cessation of drug administration.
Review
Immunology
Eduardo Dominguez-Rivas, Evangelina Avila-Munoz, Stephan W. Schwarzacher, Angelica Zepeda
Summary: Continuous generation of new neurons occurs in at least two well-defined niches in the adult rodent brain, with one of them being the subgranular zone of the dentate gyrus. Hippocampal neurogenesis is essential for pattern separation and involves the activation of neural stem cells and integration of newly generated neurons into hippocampal circuits. The neurogenic process is modulated by intrinsic factors like neuroinflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Megan M. Marron, Eric S. Orwoll, Peggy M. Cawthon, Nancy E. Lane, Anne B. Newman, Jane A. Cauley
Summary: In this study, the researchers found that certain metabolites associated with polyunsaturated fatty acids are correlated with muscle mass, gait speed, and other physical performance measures in older men. These findings suggest that these specific oxylipins may have anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Maria Karlgren, Heather Hulme, Elva Fridjonsdottir, Per Svenningsson, Per E. Andren
Summary: This study utilized advanced technology to simultaneously observe multiple metabolic changes in specific brain regions of mice, revealing the impact of aging on brain function, particularly in mitochondrial function, neurotransmission, and lipid signaling. The findings indicate that age-induced metabolic perturbations are not always attenuated by specific pharmacological interventions, such as acetylcholinesterase inhibition.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Neurosciences
Marco Ghibaudi, Nicole Marchetti, Elena Vergnano, Chiara La Rosa, Bruno Benedetti, Sebastien Couillard-Despres, Stefano Farioli-Vecchioli, Luca Bonfanti
Summary: The recent discovery of cortical immature neurons (cINs) in the piriform cortex raises questions about their maintenance or reduction throughout the lifespan. Unlike most brain structural plasticity forms, which decline with age due to stem cell depletion, all cINs are produced during embryogenesis and retain their immaturity until they fully mature and integrate into neural circuits. This study analyzed the abundance, maturation stage, and expression of markers of maturity/immaturity in cINs in the mouse piriform cortex from postnatal to advanced ages. The results show that while the number of cINs decreases with age, a small population of highly immature cINs persists in advanced ages.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Immunology
Edubiel A. Alpizar-Sosa, Yasmine Kumordzi, Wenbin Wei, Phillip D. Whitfield, Michael P. Barrett, Paul W. Denny
Summary: With the global spread of the neglected tropical disease leishmaniasis, the validation of new drug targets in the causative insect vector is crucial. Using CRISPR Cas9 technology, a study reveals the essentiality of a gene and the possibility of simultaneous deletion of two genes, providing insights into the physiological process of the parasite.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Physiology
Shruthi Hamsanathan, Aditi U. Gurkar
Summary: Lipids play a crucial role in cellular senescence and its regulation. Changes in lipid composition and levels can impact cell function and are associated with aging and inflammation. While there is some understanding of lipid metabolism in cellular senescence, the link between key regulators and lipid changes is still not fully understood.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cell Biology
Mauricio G. Martin, Carlos G. Dotti
Summary: One characteristic of aging is a decline in cell responsiveness to external stimuli, particularly in pathways controlled by hormones. This decline is associated with reduced receptor response to ligands, and it has been observed for hormones such as insulin, leptin, thyroid hormones, and glucocorticoids. This age-related resistance is also seen in adrenergic receptors, adenosine A2B receptor, and other G-protein-coupled receptors. The loss of receptors and changes in lipid composition of neuronal plasma membrane are proposed mechanisms for the decreased sensitivity to hormones and neurotransmitters. The altered membrane properties may contribute to physiological decline, decreased brain function, and increased vulnerability to neuropathology in aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ulkan Kilic, Birsen Elibol, Ahmet Burak Caglayan, Mustafa Caglar Beker, Merve Beker, Burcugul Altug-Tasa, Omer Uysal, Bayram Yilmaz, Ertugrul Kilic
Summary: In this study, the effects of melatonin on cell survival and apoptosis after stroke were investigated. The results showed that melatonin delayed neurological recovery and improved motor coordination. It also enhanced neuronal survival and reduced apoptosis at the cellular level. Furthermore, melatonin promoted brain remodeling and neuronal regeneration, especially in the contralateral hemisphere during the later stages of recovery.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Maxime Perron, Josee Vaillancourt, Pascale Tremblay
Summary: Limited evidence suggests that musical activities like choral singing can alleviate age-related speech perception difficulties. This study reveals that amateur choral singing is associated with structural plasticity in auditory and dorsal speech regions, leading to better SPiN performance in aging. The relationship between singing practice and SPiN may depend on practice conditions and intensity.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Multidisciplinary Sciences
Giorgia Dellaferrera, Stanislaw Wozniak, Giacomo Indiveri, Angeliki Pantazi, Evangelos Eleftheriou
Summary: The article proposes a brain-inspired optimizer based on mechanisms of synaptic integration and strength regulation for improved performance of both artificial and spiking neural networks.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Qiong Wu, Isabelle Ripp, Monica Emch, Kathrin Koch
Summary: The study found that working memory training has a certain impact on the morphology of the brain, mainly manifested in increased cortical gyrification, volume and thickness, as well as changes in surface area. Particularly, the affected brain regions, especially the parietal regions, may provide a better brain processing environment for higher working memory load.
HUMAN BRAIN MAPPING
(2021)
Article
Biochemistry & Molecular Biology
Enrique Gabande-Rodriguez, Azucena Perez-Canamas, Beatriz Soto-Huelin, Daniel N. Mitroi, Sara Sanchez-Redondo, Elena Martinez-Saez, Cesar Venero, Hector Peinado, Maria Dolores Ledesma
Review
Neurosciences
Maria F. Harman, Mauricio G. Martin
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Daniel N. Mitroi, Guadalupe Pereyra-Gomez, Beatriz Soto-Huelin, Fernando Senovilla, Toshihide Kobayashi, Jose A. Esteban, Maria Dolores Ledesma
Review
Neurosciences
Ana Toledano-Zaragoza, Maria Dolores Ledesma
Article
Medicine, Research & Experimental
Adrian Bartoll, Ana Toledano-Zaragoza, Josefina Casas, Manuel Guzman, Edward H. Schuchman, Maria Dolores Ledesma
EMBO MOLECULAR MEDICINE
(2020)
Article
Neurosciences
Silvia de Vidania, Irene Palomares-Perez, Ana Frank-Garcia, Takashi Saito, Takaomi C. Saido, Jonathan Draffin, Maria Szaruga, Lucia Chavez-Gutierrez, Miguel Calero, Miguel Medina, Francesc X. Guix, Carlos G. Dotti
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Behavioral Sciences
M. L. Perea Vega, M. S. Sanchez, G. Fernandez, M. G. Paglini, M. Martin, S. R. de Barioglio
Summary: The study reveals that ghrelin, an orexigenic peptide, modulates various brain functions through its specific receptor GHSR-1a, mainly enriched in the pituitary, cortex, and hippocampus. Ghrelin affects excitability and synaptic plasticity in the hippocampus, while also increasing dendritic spine density and selectively enhancing the expression of BDNF-mRNA.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Biology
Francesc X. Guix, Ana Marrero Capitan, Alvaro Casadome-Perales, Irene Palomares-Perez, Ines Lopez del Castillo, Veronica Miguel, Leigh Goedeke, Mauricio G. Martin, Santiago Lamas, Hector Peinado, Carlos Fernandez-Hernando, Carlos G. Dotti
Summary: As neurons age, their ability to degrade proteins and membranes decreases, leading to reduced cell function and survival. Aging neurons in culture secrete more small extracellular vesicles filled with cholesterol, which may negatively impact neighboring and distant cells.
LIFE SCIENCE ALLIANCE
(2021)
Article
Biochemistry & Molecular Biology
Daniel Almansa, Hector Peinado, Raquel Garcia-Rodriguez, Alvaro Casadome-Perales, Carlos G. Dotti, Francesc X. Guix
Summary: Research showed that EVs from neural cells cultured for 14 days could reduce the reactivity of astrocytes, while EVs from cells cultured for 21 days did not have the same effect. These findings in an in vitro model provide insights for further evaluating potential in vivo effects and underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Mauricio G. Martin, Carlos G. Dotti
Summary: One characteristic of aging is a decline in cell responsiveness to external stimuli, particularly in pathways controlled by hormones. This decline is associated with reduced receptor response to ligands, and it has been observed for hormones such as insulin, leptin, thyroid hormones, and glucocorticoids. This age-related resistance is also seen in adrenergic receptors, adenosine A2B receptor, and other G-protein-coupled receptors. The loss of receptors and changes in lipid composition of neuronal plasma membrane are proposed mechanisms for the decreased sensitivity to hormones and neurotransmitters. The altered membrane properties may contribute to physiological decline, decreased brain function, and increased vulnerability to neuropathology in aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Gabriel G. Cataldi, Setiembre D. Elorza, Ana Toledano-Zaragoza, Soledad de Olmos, Andrea B. Cragnolini, Mauricio G. Martin
Summary: In this study, the expression pattern of CYP46 in the brains of old mice was investigated using immunohistochemistry and immunofluorescence. The results showed that CYP46 is mainly localized in the hippocampus, cortical layers, and Purkinje neurons of the cerebellum. Increased expression of CYP46 was observed in reactive astrocytes stimulated by proinflammatory signals. This study provides insights into the specific expression characteristics of CYP46 in old individuals and its regulation by inflammatory signals.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
N. Zlocowski, L. d Sosa, B. De la Cruz-Thea, C. B. Guido, M. G. Martin, J. H. Mukdsi, A. Torres, J. P. Petiti
Summary: The study examines the involvement of the EZH2/H3K27me3 axis in the proliferation of lactotroph tumor cells. The levels of EZH2 and H3K27me3 were found to be increased in murine experimental prolactin tumors, while p21 mRNA levels were low. H3K27me3 enrichment was observed in the promoter region of GH3 tumor cells. Inhibition of the EZH2/H3K27me3 axis blocked the proliferation of primary tumor cells and GH3 cells, suggesting it as a potential therapeutic target for prolactin pituitary neuroendocrine tumors (PitNETs).
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Cell Biology
Angel Gaudioso, Xuntian Jiang, Josefina Casas, Edward H. Schuchman, Maria Dolores Ledesma
Summary: Acid sphingomyelinase deficiency (ASMD) is a lysosomal storage disorder caused by mutations in the SMPD1 gene. High levels of brain sphingomyelin (SM), specifically SM16:0, lead to neurodegeneration in ASMD. Targeting lysosomes and silencing Ceramide Synthase 5 can prevent disease phenotypes in ASMko neurons and mice. SM16:0 levels in plasma correlate strongly with those in the brain, making it a potential biomarker and therapeutic target for ASMD brain pathology.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Xin Zhang, Tian Yuan, Xuhui Chen, Xuebo Liu, Jun Hu, Zhigang Liu
Summary: The prevalence of Alzheimer's disease is increasing due to aging population, and ApoE4 allele is identified as the primary genetic risk factor. However, emerging research suggests that dietary factors, such as DHA, can modify the risk of AD. The interplay between DHA and ApoE genotype within the brain needs further investigation. Early DHA supplementation may benefit cognitively normal older adults carrying the ApoE4 gene, while its effectiveness for AD patients is limited.
PROGRESS IN LIPID RESEARCH
(2024)
Review
Biochemistry & Molecular Biology
Chen Wu, Haiqin Chen, Yongchao Mei, Bo Yang, Jianxin Zhao, Catherine Stanton, Wei Chen
Summary: This review summarizes the recent advances in microbial conjugated linoleic acid (CLA) production, including the mechanisms of linoleic acid conversion to CLA, factors influencing CLA production and isomer composition, and strategies for enhancing CLA content and nutritional value in fermented products using microorganisms. The review aims to serve as a reference for microbial CLA production and expand the understanding of the potential probiotic role of microbial CLA producers.
PROGRESS IN LIPID RESEARCH
(2024)
