标题
Molecular mechanisms of biological aging in intervertebral discs
作者
关键词
-
出版物
JOURNAL OF ORTHOPAEDIC RESEARCH
Volume 34, Issue 8, Pages 1289-1306
出版商
Wiley
发表日期
2016-02-18
DOI
10.1002/jor.23195
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Growth and Differentiation Factor-5 Contributes to the Structural and Functional Maintenance of the Intervertebral Disc
- (2015) Chencheng Feng et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Interleukin-1β in intervertebral disk degeneration
- (2015) Wei Yang et al. CLINICA CHIMICA ACTA
- Prolyl-4-hydroxylase Domain Protein 2 Controls NF-κB/p65 Transactivation and Enhances the Catabolic Effects of Inflammatory Cytokines on Cells of the Nucleus Pulposus
- (2015) Jun Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Age-dependency of glycosaminoglycan content in lumbar discs: A 3t gagcEST study
- (2015) Anja Müller-Lutz et al. JOURNAL OF MAGNETIC RESONANCE IMAGING
- MRI evaluation of spontaneous intervertebral disc degeneration in the alpaca cervical spine
- (2015) Dean K. Stolworthy et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Potential roles of cytokines and chemokines in human intervertebral disc degeneration: interleukin-1 is a master regulator of catabolic processes
- (2015) K.L.E. Phillips et al. OSTEOARTHRITIS AND CARTILAGE
- ISSLS Prize Winner
- (2015) Juhani H. Määttä et al. SPINE
- Low rate loading-induced convection enhances net transport into the intervertebral disc in vivo
- (2015) Sarah E. Gullbrand et al. Spine Journal
- Harnessing the Potential of Mesenchymal Stem Cells for IVD Regeneration
- (2015) Louise Clarke et al. Current Stem Cell Research & Therapy
- Tumor Necrosis Factor-α– and Interleukin-1β–Dependent Matrix Metalloproteinase-3 Expression in Nucleus Pulposus Cells Requires Cooperative Signaling via Syndecan 4 and Mitogen-Activated Protein Kinase–NF-κB Axis
- (2014) Xin Wang et al. AMERICAN JOURNAL OF PATHOLOGY
- Expression of Matrix Metalloproteinases is Positively Related to the Severity of Disc Degeneration and Growing Age in the East Asian Lumbar Disc Herniation Patients
- (2014) Haidong Xu et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Influence of maturity on nucleus–endplate integration in the ovine lumbar spine
- (2014) Kelly R. Wade et al. EUROPEAN SPINE JOURNAL
- Accelerated premature stress-induced senescence of young annulus fibrosus cells of rats by high glucose-induced oxidative stress
- (2014) Jong-Soo Park et al. INTERNATIONAL ORTHOPAEDICS
- The aging mouse partially models the aging human spine: lumbar and coccygeal disc height, composition, mechanical properties, and Wnt signaling in young and old mice
- (2014) Nilsson Holguin et al. JOURNAL OF APPLIED PHYSIOLOGY
- FIH-1-Mint3 Axis Does Not Control HIF-1α Transcriptional Activity in Nucleus Pulposus Cells
- (2014) Yuichiro Hirose et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Is post-contrast MRI a valuable method for the study of the nutrition of the intervertebral disc?
- (2014) Fabio Galbusera et al. JOURNAL OF BIOMECHANICS
- Temporal changes of mechanical signals and extracellular composition in human intervertebral disc during degenerative progression
- (2014) Qiaoqiao Zhu et al. JOURNAL OF BIOMECHANICS
- The catabolic effect of TNFα on bovine nucleus pulposus intervertebral disc cells and the restraining role of glucosamine sulfate in the TNFα-mediated up-regulation of MMP-3
- (2014) Eleni Mavrogonatou et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP
- (2014) Zariel I. Johnson et al. MATRIX BIOLOGY
- The role of senescent cells in ageing
- (2014) Jan M. van Deursen NATURE
- The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced Senescence
- (2014) Mehtap Kilic Eren et al. PLoS One
- Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus
- (2014) Christophe Merceron et al. PLoS One
- Simulation of the Progression of Intervertebral Disc Degeneration Due to Decreased Nutritional Supply
- (2014) Weiyong Gu et al. SPINE
- Link N and Mesenchymal Stem Cells Can Induce Regeneration of the Early Degenerate Intervertebral Disc
- (2014) Fackson Mwale et al. TISSUE ENGINEERING PART A
- Inflammatory Cytokines Associated with Degenerative Disc Disease Control Aggrecanase-1 (ADAMTS-4) Expression in Nucleus Pulposus Cells through MAPK and NF-κB
- (2013) Ye Tian et al. AMERICAN JOURNAL OF PATHOLOGY
- Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration
- (2013) Kate Louise Eve Phillips et al. ANNALS OF THE RHEUMATIC DISEASES
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
- (2013) Ana P. Gomes et al. CELL
- Age-Related Carbonylation of Fibrocartilage Structural Proteins Drives Tissue Degenerative Modification
- (2013) Brian Scharf et al. CHEMISTRY & BIOLOGY
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration
- (2013) Luigi A. Nasto et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints
- (2013) Nam Vo et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Age- and diabetes-related nonenzymatic crosslinks in collagen fibrils: Candidate amino acids involved in Advanced Glycation End-products
- (2013) Alfonso Gautieri et al. MATRIX BIOLOGY
- Role of cytokines in intervertebral disc degeneration: pain and disc content
- (2013) Makarand V. Risbud et al. Nature Reviews Rheumatology
- Intervertebral Disc Decompression Following Endplate Damage
- (2013) Patricia Dolan et al. SPINE
- Injection of human umbilical tissue–derived cells into the nucleus pulposus alters the course of intervertebral disc degeneration in vivo
- (2013) Steven K. Leckie et al. Spine Journal
- Ionizing radiation exposure and the development of intervertebral disc degeneration—no case to answer
- (2013) Fiona E. Mellor et al. Spine Journal
- Investigating the role of DNA damage in tobacco smoking-induced spine degeneration
- (2013) Luigi A. Nasto et al. Spine Journal
- Cells from Degenerative Intervertebral Discs Demonstrate Unfavorable Responses to Mechanical and Inflammatory Stimuli
- (2012) Gwendolyn A. Sowa et al. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
- The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: A population-based study
- (2012) Dino Samartzis et al. ARTHRITIS AND RHEUMATISM
- Notochordal Cells in the Adult Intervertebral Disc: New Perspective on an Old Question
- (2012) Makarand V. Risbud et al. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
- Expression of Prolyl Hydroxylases (PHDs) Is Selectively Controlled by HIF-1 and HIF-2 Proteins in Nucleus Pulposus Cells of the Intervertebral Disc
- (2012) Nobuyuki Fujita et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Prolyl Hydroxylase 3 (PHD3) Modulates Catabolic Effects of Tumor Necrosis Factor-α (TNF-α) on Cells of the Nucleus Pulposus through Co-activation of Nuclear Factor κB (NF-κB)/p65 Signaling
- (2012) Nobuyuki Fujita et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Quantitative analysis of exogenous IGF-1 administration of intervertebral disc through intradiscal injection
- (2012) C.-Y. Huang et al. JOURNAL OF BIOMECHANICS
- NF-κB inhibition delays DNA damage–induced senescence and aging in mice
- (2012) Jeremy S. Tilstra et al. JOURNAL OF CLINICAL INVESTIGATION
- Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity
- (2012) Marina Klawitter et al. Journal of Inflammation-London
- Dystrophin and utrophin “double knockout” dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities
- (2012) Christian Isaac et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Oxidative Damage, Platelet Activation, and Inflammation to Predict Mobility Disability and Mortality in Older Persons: Results From the Health Aging and Body Composition Study
- (2012) M. Cesari et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Increased intramuscular fatty infiltration without differences in lumbar muscle cross-sectional area during remission of unilateral recurrent low back pain
- (2012) Roseline D'hooge et al. MANUAL THERAPY
- Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs
- (2012) Luigi A. Nasto et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Spine degeneration in a murine model of chronic human tobacco smokers
- (2012) D. Wang et al. OSTEOARTHRITIS AND CARTILAGE
- Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update
- (2012) John M. Kyriakis et al. PHYSIOLOGICAL REVIEWS
- Part 2
- (2012) Chan Hong Moon et al. SPINE
- ISSLS Prize Winner
- (2012) Luigi A. Nasto et al. SPINE
- Height and torsional stiffness are most sensitive to annular injury in large animal intervertebral discs
- (2012) Arthur J. Michalek et al. Spine Journal
- Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
- (2012) Daisuke Sakai et al. Nature Communications
- Effects of Advanced Age on the Morphometry and Degenerative State of the Cervical Spine in a Rat Model
- (2011) Andrew C. Laing et al. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
- Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study
- (2011) G. Livshits et al. ANNALS OF THE RHEUMATIC DISEASES
- Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: Role of hypoxia-inducible factor proteins
- (2011) Shilpa S. Gogate et al. ARTHRITIS AND RHEUMATISM
- Is the spinal motion segment a diarthrodial polyaxial joint: What a nice nucleus like you doing in a joint like this?
- (2011) Irving M. Shapiro et al. BONE
- Effect of intervertebral disc degeneration on disc cell viability: a numerical investigation
- (2011) Fabio Galbusera et al. COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
- p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
- (2011) Adam Freund et al. EMBO JOURNAL
- Snapshot of degenerative aging of porcine intervertebral disc: a model to unravel the molecular mechanisms
- (2011) Hongsik Cho et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Novel ex-vivo mechanobiological intervertebral disc culture system
- (2011) Robert A. Hartman et al. JOURNAL OF BIOMECHANICS
- HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc
- (2011) Nobuyuki Fujita et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Exogenous and autocrine growth factors stimulate human intervertebral disc cell proliferation via the ERK and Akt pathways
- (2011) Harris Pratsinis et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Longitudinal Study of Radiographic Spinal Osteoarthritis in a Macaque Model
- (2011) Andrea E. Duncan et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Fracture of the vertebral endplates, but not equienergetic impact load, promotes disc degeneration in vitro
- (2011) Stefan Dudli et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- The Dog as an Animal Model for Intervertebral Disc Degeneration?
- (2011) Niklas Bergknut et al. SPINE
- Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model
- (2011) Steven K. Leckie et al. Spine Journal
- Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis
- (2011) Zhongying Zhang et al. ARTHRITIS RESEARCH & THERAPY
- Hypoxic Regulation of Nucleus Pulposus Cell Survival
- (2010) Makarand V. Risbud et al. AMERICAN JOURNAL OF PATHOLOGY
- Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression
- (2010) Akihiko Hiyama et al. ARTHRITIS AND RHEUMATISM
- Senescent vs. non-senescent cells in the human annulus in vivo: Cell harvest with laser capture microdissection and gene expression studies with microarray analysis
- (2010) Helen E Gruber et al. BMC BIOTECHNOLOGY
- Comparative anatomical dimensions of the complete human and porcine spine
- (2010) Iris Busscher et al. EUROPEAN SPINE JOURNAL
- Analysis of cell viability in intervertebral disc: Effect of endplate permeability on cell population
- (2010) A. Shirazi-Adl et al. JOURNAL OF BIOMECHANICS
- Multipotential Differentiation of Human Anulus Fibrosus Cells
- (2010) Gang Feng et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- Accelerated aging of intervertebral discs in a mouse model of progeria
- (2010) Nam Vo et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Human intervertebral disc internal strain in compression: The effect of disc region, loading position, and degeneration
- (2010) Grace D. O'Connell et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Effect of varying osmotic conditions on the response of bovine nucleus pulposus cells to growth factors and the activation of the ERK and Akt pathways
- (2010) Eleni Mavrogonatou et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- ADAMTS-5 and Intervertebral Disc Degeneration: The Results of Tissue Immunohistochemistry and In Vitro Cell Culture
- (2010) Chang-Qing Zhao et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Leg Amputation Accelerates Senescence of Rat Lumbar Intervertebral Discs
- (2010) Qiu-Juan Xing et al. SPINE
- The Effects of Exogenous Crosslinking on Hydration and Fluid Flow in the Intervertebral Disc Subjected to Compressive Creep Loading and Unloading
- (2010) Shih-Youeng Chuang et al. SPINE
- Isolation and Characterization of Mesenchymal Stromal Cells From Human Degenerated Nucleus Pulposus
- (2010) Juan F. Blanco et al. SPINE
- Region-Dependent Aggrecan Degradation Patterns in the Rat Intervertebral Disc Are Affected by Mechanical Loading In Vivo
- (2010) James C. latridis et al. SPINE
- Direct Application of the Tumor Necrosis Factor-α Inhibitor, Etanercept, Into a Punctured Intervertebral Disc Decreases Calcitonin Gene-Related Peptide Expression in Rat Dorsal Root Ganglion Neurons
- (2010) Manato Horii et al. SPINE
- Age-Related Variation in Cell Density of Human Lumbar Intervertebral Disc
- (2010) Thomas Liebscher et al. SPINE
- MAPK signaling in inflammation-associated cancer development
- (2010) Pengyu Huang et al. Protein & Cell
- Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
- (2009) Ludmila Pawlikowska et al. AGING CELL
- Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and Biosynthesis
- (2009) James C. Iatridis et al. Cellular and Molecular Bioengineering
- Pericellular Matrix Mechanics in the Anulus Fibrosus Predicted by a Three-Dimensional Finite Element Model and In Situ Morphology
- (2009) Li Cao et al. Cellular and Molecular Bioengineering
- Stress-Activated MAP Kinase Cascades in Cellular Senescence
- (2009) Junichi Maruyama et al. CURRENT MEDICINAL CHEMISTRY
- High osmolality activates the G1 and G2 cell cycle checkpoints and affects the DNA integrity of nucleus pulposus intervertebral disc cells triggering an enhanced DNA repair response
- (2009) Eleni Mavrogonatou et al. DNA REPAIR
- In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression
- (2009) Karin Wuertz et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Does Damage to DNA and Other Macromolecules Play a Role in Aging? If So, How?
- (2009) J. Campisi et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Ageing populations: the challenges ahead
- (2009) Kaare Christensen et al. LANCET
- Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
- (2009) Francis Rodier et al. NATURE CELL BIOLOGY
- Impact of Chronic Musculoskeletal Pathology on Older Adults: A Study of Differences between Knee OA and Low Back Pain
- (2009) Natalia E. Morone et al. PAIN MEDICINE
- Characterization of Intervertebral Disc Aging
- (2009) Gwendolyn Sowa et al. SPINE
- Absence of Biglycan Accelerates the Degenerative Process in Mouse Intervertebral Disc
- (2009) Takashi Furukawa et al. SPINE
- Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs
- (2009) Ki-Won Kim et al. Spine Journal
- Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc
- (2008) Amit Agrawal et al. ARTHRITIS AND RHEUMATISM
- Connective tissue growth factor expression in human intervertebral disc: implications for angiogenesis in intervertebral disc degeneration
- (2008) R Ali et al. BIOTECHNIC & HISTOCHEMISTRY
- Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
- (2008) Juan C. Acosta et al. CELL
- Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
- (2008) Leonard Guarente CELL
- Growth Factors in Intervertebral Disc Homeostasis
- (2008) Harris Pratsinis et al. CONNECTIVE TISSUE RESEARCH
- Gene therapy approach for disc degeneration and associated spinal disorders
- (2008) Kotaro Nishida et al. EUROPEAN SPINE JOURNAL
- p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1
- (2008) Rebecca K. Studer et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Intervertebral disc cell response to dynamic compression is age and frequency dependent
- (2008) Casey L. Korecki et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer
- (2008) T. Boutros et al. PHARMACOLOGICAL REVIEWS
- The Action of Resveratrol, a Phytoestrogen Found in Grapes, on the Intervertebral Disc
- (2008) Xin Li et al. SPINE
- Age-Related Changes in the Extracellular Matrix of Nucleus Pulposus and Anulus Fibrosus of Human Intervertebral Disc
- (2008) Kern Singh et al. SPINE
- Increased cell senescence is associated with decreased cell proliferation in vivo in the degenerating human annulus
- (2008) Helen E. Gruber et al. Spine Journal
- Autophagy and aging: keeping that old broom working
- (2008) Ana Maria Cuervo TRENDS IN GENETICS
- Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration
- (2008) Sarah Heathfield et al. ARTHRITIS RESEARCH & THERAPY
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
- Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan
- (2007) Laura J. Niedernhofer et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search