Review
Pathology
Rui Ran, Hai-yang Liao, Zhi-qiang Wang, Chao-yang Gong, Kai-sheng Zhou, Hai-hong Zhang
Summary: Intervertebral disc degeneration is a crucial pathological process in the development of low back pain, and the changes in the life process of nucleus pulposus cells play a major role. Long noncoding RNAs have emerged as important regulators in IDD, influencing cellular signaling pathways and cellular activities. Understanding lncRNAs can aid in discovering new therapeutic targets and treatment strategies for IDD.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Cell Biology
Yulin Huang, Jiaming Yang, Xizhe Liu, Xiaoshuai Wang, Kai Zhu, Zemin Ling, Baozhu Zeng, Ningning Chen, Shaoyu Liu, Fuxin Wei
Summary: Enhancer RNAs (eRNAs) play an important role in the progression of intervertebral disc degeneration (IDD), and could be a potential therapeutic target for alleviation of IDD. Delivery of LINC02569 siRNA to nucleus pulposus cells significantly alleviated inflammatory response and cell senescence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chengcong Zhou, Sai Yao, Fangda Fu, Yishan Bian, Zhiguo Zhang, Huihao Zhang, Huan Luo, Yuying Ge, Yuying Chen, Weifeng Ji, Kun Tian, Ming Yue, Hongting Jin, Peijian Tong, Chengliang Wu, Hongfeng Ruan
Summary: Morroniside protects against NP cell senescence to alleviate IVDD progression by inhibiting the ROS-Hippo-p53 pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jiongnan Xu, Ting Shao, Jianfen Lou, Jun Zhang, Chen Xia
Summary: Intervertebral disc degeneration (IVDD) is the aging and degenerative diseases of intervertebral disc components and is the main cause of chronic low back pain. Many researchers have focused on the degeneration of nucleus pulposus (NP) cells in IVDD, which is caused by oxidative stress, inflammatory response, apoptosis, abnormal proliferation, and autophagy. The senescence of NP cells has been found to be closely related to the progression of NP degeneration. Targeted therapies for IVDD, including anti-aging drugs, have been explored to inhibit NP cells senescence.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Hongze Chang, Hongzhang Wang, Xiaolong Yang, Kemin You, Mingwei Jiang, Feng Cai, Yan Zhang, Liang Liu, Hui Liu, Xiaodong Liu
Summary: This study identified the important role of circular RNAs in regulating NP cell functions under glucose deprivation conditions during intervertebral disc degeneration (IDD). Specifically, circ_0075062 was upregulated in NP cells and potentially influenced the balance of extracellular matrix synthesis and degradation. These findings provide insights into the underlying mechanisms of IDD and suggest circ_0075062 as a promising therapeutic target for IDD.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Xiangheng Dai, Yu Chen, Zihan Yu, Congrui Liao, Zhongyuan Liu, Jianting Chen, Qian Wu
Summary: This study found that AOPPs induce senescence in AF cells through a NOX4-dependent and MAPK-mediated pathway, thereby accelerating IVDD.
Article
Pharmacology & Pharmacy
Honglei Kang, Yimin Dong, Renpeng Peng, Haiyang Liu, Qian Guo, Kehan Song, Meipeng Zhu, Kaixu Yu, Wei Wu, Feng Li
Summary: This study found that IRE1 plays an important role in the progression of IDD, and inhibition of the IRE1 pathway can suppress the degeneration of NP cells and prevent IDD in vivo. These findings suggest that IRE1 may be a potential target for IDD treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cell Biology
Bolin Chen, Runjiu Zhu, Hao Hu, Mingbin Zhan, Tingxuan Wang, Fangli Huang, Fuxin Wei, Yu Chai, Zemin Ling, Xuenong Zou
Summary: Senolytics selectively eliminate senescent cells and ameliorate senescence-associated diseases. These drugs have been shown to rejuvenate various cell types in different human organs by clearing senescent cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Orthopedics
Q. Guo, D. Zhu, Y. Wang, Z. Miao, Z. Chen, Z. Lin, J. Lin, C. Huang, L. Pan, L. Wang, S. Zeng, J. Wang, X. Zheng, Y. Lin, X. Zhang, Y. Wu
Summary: STING upregulation in degenerated NP tissues promotes ECM degradation, apoptosis, and senescence, contributing to IVDD progression. Mechanistically, STING activates IRF3 pathway to exert its effects on IVDD development.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Biochemistry & Molecular Biology
Rongjin Luo, Huaizhen Liang, Weifeng Zhang, Gaocai Li, Kangcheng Zhao, Wenbin Hua, Yu Song, Cao Yang
Summary: The study demonstrates that RETREG1-mediated ER-phagy plays a protective role in response to glucose deprivation treatment, with ER stress being suggested as an upstream event of ER-phagy. By modulating ER stress, ER-phagy can protect human nucleus pulposus cells against cell injury induced by GD treatment.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Medicine, Research & Experimental
Chao Song, Yan Zhou, Kang Cheng, Fei Liu, Weiye Cai, Daqian Zhou, Rui Chen, Houyin Shi, Zhijiang Fu, Jingwen Chen, Zongchao Liu
Summary: Intervertebral disc degeneration (IVDD) is a chronic condition that causes significant discomfort to patients and economic burden on society. Understanding the pathophysiology of IVDD is crucial, and recent research has shown that cellular senescence, particularly in nucleus pulposus cells, may play a significant role.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Hosni Cherif, Matthew Mannarino, Alain Sarabia Pacis, Jiannis Ragoussis, Oded Rabau, Jean A. Ouellet, Lisbet Haglund
Summary: In this study, single-cell transcriptomic analysis was used to identify new biomarkers for nucleus pulposus (NP) and inner annulus fibrosis (iAF) cells in intervertebral discs (IVD). The analysis also provided insights into the cell populations within non-degenerating and degenerating IVD. The findings suggest potential functional differences linked to degeneration and among NP and iAF subpopulations, and also propose specific cell type and predictive IVD degeneration genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Zhenxuan Shao, Libin Ni, Sunli Hu, Tianzhen Xu, Zaher Meftah, Zupo Yu, Naifeng Tian, Yaosen Wu, Liaojun Sun, Aimin Wu, Zongyou Pan, Linwei Chen, Weiyang Gao, Yifei Zhou, Xiaolei Zhang, Xiangyang Wang
Summary: This study suggests that HuR may suppress senescence through autophagy activation via stabilizing Atg7 in diabetic NP cells. Overexpression of Atg7, but not HuR, may serve as a potential therapeutic target for DB-IVDD.
CELL PROLIFERATION
(2021)
Article
Geriatrics & Gerontology
Xiao-Hu Wang, Jia-Wei Gao, Jun-Ping Bao, Lei Zhu, Zhi-Yang Xie, Lu Chen, Xin Peng, Cong Zhang, Xiao-Tao Wu
Summary: This study found that GATA4 promotes senescence in nucleus pulposus cells and is involved in the regulation through the NF-KB signaling pathway. These findings suggest that GATA4 may be a potential target for the treatment of intervertebral disc degeneration in the future.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Biotechnology & Applied Microbiology
Xin Huang, Changhong Chen, Yaofei Chen, Jun Xu, Lin Liu
Summary: This study found that Omentin-1 plays an important role in inhibiting inflammation-associated cellular aging in intervertebral disc degeneration, and may be a candidate for IVDD gene target therapy.