Article
Endocrinology & Metabolism
Changchun Tseng, Yingchao Han, Zhendong Lv, Qingxin Song, Kun Wang, Hongxing Shen, Zhi Chen
Summary: Emerging evidence suggests that type 2 diabetes mellitus (T2DM) is associated with inter-vertebral disc degeneration (IDD). However, the mechanism behind this association is still unclear. This study identified that the CBP-PGC-1 alpha-Runx2 complex is required for the activation of ADAMTS4/5 genes, and blocking this complex could prevent IDD in diabetic mice.
Article
Biotechnology & Applied Microbiology
Xin Huang, Changhong Chen, Yaofei Chen, Jun Xu, Lin Liu
Summary: This study found that Omentin-1 plays an important role in inhibiting inflammation-associated cellular aging in intervertebral disc degeneration, and may be a candidate for IVDD gene target therapy.
Article
Biochemistry & Molecular Biology
Yifan Zhou, Zhiqian Chen, Xiao Yang, Xiankun Cao, Zhihao Liang, Hui Ma, Jie Zhao
Summary: The study revealed that TXNIP promotes pyroptosis in NP cells via the NLRP3/Caspase-1/IL-10 signaling pathway, while Morin shows significant inhibitory effects on the TXNIP/NLRP3/Caspase-1 signaling pathway, potentially serving as an effective therapeutic agent for IDD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Rikuto Yoshimizu, Junsuke Nakase, Katsuhito Yoshioka, Kengo Shimozaki, Kazuki Asai, Mitsuhiro Kimura, Katsuhiko Kitaoka, Hiroyuki Tsuchiya
Summary: This study found that lumbar degeneration was common in children and adolescent weightlifters after 5 years, with 33% of participants showing lumbar disc herniation findings. Long-term high frequency weightlifting training during growth periods may increase the risk of developing low back pain.
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcus Raudner, Markus M. Schreiner, Tom Hilbert, Tobias Kober, Michael Weber, Anna Szelenyi, Reinhard Windhager, Vladimir Juras, Siegfried Trattnig
Summary: The study evaluated GRAPPATINI, an accelerated T-2 mapping sequence that combines undersampling and model-based reconstruction to facilitate clinical implementation of T-2 mapping of the lumbar intervertebral disc. Results showed that T2 values obtained using GRAPPATINI were significantly different for normal discs compared to bulging or herniated discs, as well as discs with and without annular tears. The study concluded that GRAPPATINI can be used as a quantitative imaging biomarker to detect disc pathologies while significantly reducing acquisition time.
EUROPEAN RADIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Honglei Kang, Yimin Dong, Renpeng Peng, Haiyang Liu, Qian Guo, Kehan Song, Meipeng Zhu, Kaixu Yu, Wei Wu, Feng Li
Summary: This study found that IRE1 plays an important role in the progression of IDD, and inhibition of the IRE1 pathway can suppress the degeneration of NP cells and prevent IDD in vivo. These findings suggest that IRE1 may be a potential target for IDD treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Orthopedics
S. Li, X. Pan, Y. Wu, Y. Tu, W. Hong, J. Ren, J. Miao, T. Wang, W. Xia, J. Lu, J. Chen, X. Hu, Y. Lin, X. Zhang, X. Wang
Summary: In this study, the protective effect of Interleukin-37 (IL-37) on intervertebral disc degeneration (IDD) was evaluated. IL-37 was found to decrease during the IDD process and the experimental results showed that IL-37 can suppress the SASP factors level and senescence phenotype in IL-1b treated cells. Animal experiments also demonstrated that IL-37 can alleviate IDD progression in a puncture-induced rat model. Mechanistic studies revealed that IL-37 inhibits IDD progression by downregulating the activation of the NF-kB pathway through the activation of IL-1R8.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Orthopedics
G. Chao-yang, C. Peng, Z. Hai-hong
Summary: This article summarizes the role of the NLRP3 inflammasome in the pathogenesis of IVDD and its application in treatment.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Biotechnology & Applied Microbiology
Ming Lei, Kangcheng Zhao, Wenbin Hua, Kun Wang, Shuai Li, Xinghuo Wu, Cao Yang
Summary: The study demonstrated that overexpression of c-Jun has a positive effect on the treatment of intervertebral disc degeneration, inhibiting the inflammatory response in vivo and potentially delaying the degeneration of the intervertebral disc.
Review
Medicine, Research & Experimental
Chao-yang Gong, Hai-hong Zhang
Summary: Autophagy plays a dual role in intervertebral disc degeneration, as inducing autophagy can slow down the process while excessive autophagy activation-mediated apoptosis may accelerate degeneration.
Review
Geriatrics & Gerontology
Hongtao Li, Xiaoqiang Wang, Hongyu Pan, Changming Xiao, Chenglong Wang, Sheng Guo, Longhai Long, Houyin Shi, Hui Chen, Sen Li
Summary: Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP) and disability in the elderly, resulting in a significant global public health and economic burden. The mechanisms of IDD are complex and the specific targets for reversing IDD remain unclear. Interleukin-1 beta (IL-1 beta), a key mediator of IDD, has been found to regulate IVD cell death through various mechanisms, including apoptosis, pyroptosis, and ferroptosis. Inhibition of IL-1 beta has shown promise as a biological therapy for IDD by inhibiting inflammatory processes and regulating ECM degradation. This article reviews the mechanisms and functions of IL-1 beta in IDD and explores advances in IL-1 beta inhibition as a potential biotherapeutic approach for disc degeneration.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Cell & Tissue Engineering
Wentao Zhang, Tianze Sun, Ying Li, Ming Yang, Yantao Zhao, Jing Liu, Zhonghai Li
Summary: Stem cell therapy for intervertebral disc degeneration is emerging as a potential treatment option, with evidence from in vitro, in vivo, and clinical trials showing its effectiveness in relieving pain and symptoms, reversing the degenerative cascade, delaying the aging process, and maintaining spinal function. Further research is needed to understand the mechanisms and effects of stem cells in IDD treatment.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Longlong Du, Xuefeng Li, Qimeng Gao, Puwei Yuan, Yindi Sun, Yingpu Chen, Bo Huang, Yu Deng, Baohui Wang
Summary: This study examines the role of long noncoding RNA NR2F1-AS1 in intervertebral disc degeneration. The results show that NR2F1-AS1 interacts with miR-145-5p and upregulates the FOXO1 pathway, promoting the progression of intervertebral disc degeneration.
Article
Immunology
Long Li, Kang Wei, Yifan Ding, Paerxiati Ahati, Haoran Xu, Huang Fang, Huan Wang
Summary: The study found CD206-positive cells in degenerated intervertebral disc tissues, M2a macrophages promoted the expression of catabolism genes in NP cells but suppressed the expression of anabolism genes. These effects were eliminated by CHI3L1 knockdown. Exposure to recombinant CHI3L1 promoted an extracellular matrix metabolic imbalance in NP cells via the IL-13R alpha 2 receptor, along with activation of the ERK and JNK MAPK signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tengfei Li, Ye Peng, Yufei Chen, Xiaogang Huang, Xiaojie Li, Zhenyu Zhang, Junjie Du
Summary: Our study reveals the crucial role of LINC00917 in intervertebral disc degeneration (IDD), where it restores nucleus pulposus cell (NPC) function and inhibits IDD progression through modulating the miR-149-5p/NLRP1 axis.
