Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health

Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus

(2020) Didier Ndeh et al.   Nature Communications

The Uptake, Trafficking, and Biodistribution of Bacteroides thetaiotaomicron Generated Outer Membrane Vesicles

(2020) Emily J. Jones et al.   Frontiers in Microbiology

Utilization of xylan-type polysaccharides in co-culture fermentations of Bifidobacterium and Bacteroides species

(2020) Nuket Zeybek et al.   CARBOHYDRATE POLYMERS

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

(2020) Steven Zhao et al.   NATURE

The crystal structure of the TonB-dependent transporter YncD reveals a positively charged substrate-binding site

(2020) Rhys Grinter et al.   Acta Crystallographica Section D-Structural Biology

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

(2020) Wenjing Yang et al.   Nature Communications

Novel strains of Bacteroides fragilis and Bacteroides ovatus alleviate the LPS-induced inflammation in mice

(2019) Huizi Tan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Architecture of type VI secretion system membrane core complex

(2019) Meng Yin et al.   CELL RESEARCH

Bacteroides vulgatus and Bacteroides dorei Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis

(2019) Naofumi Yoshida et al.   CIRCULATION

A Cell-Surface GH9 Endo-Glucanase Coordinates with Surface Glycan Binding Proteins to Mediate Xyloglucan Uptake in the Gut Symbiont Bacteroides ovatus

(2019) Matthew H. Foley et al.   JOURNAL OF MOLECULAR BIOLOGY

1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses

(2019) Yuanqiang Zou et al.   NATURE BIOTECHNOLOGY

Bacteroides thetaiotaomicron Starch Utilization Promotes Quercetin Degradation and Butyrate Production by Eubacterium ramulus

(2019) Gina Paola Rodriguez-Castaño et al.   Frontiers in Microbiology

Utilization of Complex Pectic Polysaccharides from New Zealand Plants (Tetragonia tetragonioides and Corynocarpus laevigatus) by Gut Bacteroides Species

(2019) Manuela Centanni et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Bacteroidetes use thousands of enzyme combinations to break down glycans

(2019) Pascal Lapébie et al.   Nature Communications

Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine

(2019) Girmay Desalegn et al.   Nature Communications

The Preparation and Structure Analysis Methods of Natural Polysaccharides of Plants and Fungi: A Review of Recent Development

(2019) Yan Ren et al.   MOLECULES

Streamlined Genetic Manipulation of Diverse Bacteroides and Parabacteroides Isolates from the Human Gut Microbiota

(2019) Leonor García-Bayona et al.   mBio

Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing Enterocolitis In Vitro and in a Neonatal Rat Model

(2019) Hongying Fan et al.   mSystems

Hybrid Two-Component Sensors for Identification of Bacterial Chemoreceptor Function

(2019) Rita A. Luu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Effects of polysaccharides on glycometabolism based on gut microbiota alteration

(2019) Qingying Fang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Insights into the genome structure of four acetogenic bacteria with specific reference to the Wood–Ljungdahl pathway

(2019) Alfonso Esposito et al.   MicrobiologyOpen

The Starch Utilization System Assembles around Stationary Starch-Binding Proteins

(2018) Hannah H. Tuson et al.   BIOPHYSICAL JOURNAL

Specificity of glycosaminoglycan–protein interactions

(2018) Lena Kjellén et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

TonB-dependent transport by the gut microbiota: novel aspects of an old problem

(2018) David N Bolam et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

How fine structural differences of xylo-oligosaccharides and arabinoxylo-oligosaccharides regulate differential growth of Bacteroides species

(2018) Mihiri Mendis et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Short-chain fatty acids administration is protective in colitis-associated colorectal cancer development

(2018) Yun Tian et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

SusE facilitates starch uptake independent of starch binding in B. thetaiotaomicron

(2018) Matthew H. Foley et al.   MOLECULAR MICROBIOLOGY

Bacteroides fragilis Protects Against Antibiotic-Associated Diarrhea in Rats by Modulating Intestinal Defenses

(2018) Wendi Zhang et al.   Frontiers in Immunology

Genetic Variation of the SusC/SusD Homologs from a Polysaccharide Utilization Locus Underlies Divergent Fructan Specificities and Functional Adaptation in Bacteroides thetaiotaomicron Strains

(2018) Payal Joglekar et al.   mSphere

Alpha- and beta-mannan utilization by marine Bacteroidetes

(2018) Jing Chen et al.   ENVIRONMENTAL MICROBIOLOGY

Bacteroides thetaiotaomicron Ameliorates Colon Inflammation in Preclinical Models of Crohn’s Disease

(2018) Margaret Delday et al.   INFLAMMATORY BOWEL DISEASES

Neutrophils Promote Amphiregulin Production in Intestinal Epithelial Cells through TGF-β and Contribute to Intestinal Homeostasis

(2018) Feidi Chen et al.   JOURNAL OF IMMUNOLOGY

Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention With a Volumetric Diet

(2018) David A. Muñiz Pedrogo et al.   MAYO CLINIC PROCEEDINGS

Bacteroides thetaiotaomicron

(2018) Nathan T. Porter et al.   TRENDS IN MICROBIOLOGY

Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins

(2018) Aaron G Wexler et al.   eLife

Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A

(2018) June L. Chan et al.   Mucosal Immunology

A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation

(2018) Alan Cartmell et al.   Nature Microbiology

The Protective Role of Bacteroides fragilis in a Murine Model of Colitis-Associated Colorectal Cancer

(2018) Yun Kyung Lee et al.   mSphere

Prioritization of polysaccharide utilization and control of regulator activation inBacteroides thetaiotaomicron

(2017) Nathan D. Schwalm et al.   MOLECULAR MICROBIOLOGY

Complex pectin metabolism by gut bacteria reveals novel catalytic functions

(2017) Didier Ndeh et al.   NATURE

Human genetic variation and the gut microbiome in disease

(2017) Andrew Brantley Hall et al.   NATURE REVIEWS GENETICS

How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans

(2017) Alan Cartmell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Navigating the Gut Buffet: Control of Polysaccharide Utilization in Bacteroides spp.

(2017) Nathan D. Schwalm et al.   TRENDS IN MICROBIOLOGY

Gut Symbiont Bacteroides fragilis Secretes a Eukaryotic-Like Ubiquitin Protein That Mediates Intraspecies Antagonism

(2017) Maria Chatzidaki-Livanis et al.   mBio

Molecular Mechanism by which Prominent Human Gut Bacteroidetes Utilize Mixed-Linkage Beta-Glucans, Major Health-Promoting Cereal Polysaccharides

(2017) Kazune Tamura et al.   Cell Reports

The Glycolytic Versatility of Bacteroides uniformis CECT 7771 and Its Genome Response to Oligo and Polysaccharides

(2017) Alfonso Benítez-Páez et al.   Frontiers in Cellular and Infection Microbiology

Bioluminescence Imaging to Track Bacteroides fragilis Inhibition of Vibrio parahaemolyticus Infection in Mice

(2017) Zhengchao Li et al.   Frontiers in Cellular and Infection Microbiology

Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides

(2017) Ana S. Luis et al.   Nature Microbiology

A Highly Active Endo-Levanase BT1760 of a Dominant Mammalian Gut Commensal Bacteroides thetaiotaomicron Cleaves Not Only Various Bacterial Levans, but Also Levan of Timothy Grass

(2017) Karin Mardo et al.   PLoS One

Butyrate enhances antibacterial effects while suppressing other features of alternative activation in IL-4-induced macrophages

(2016) Maria R. Fernando et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Feedback Control of Two-Component Regulatory Systems

(2016) Eduardo A. Groisman   Annual Review of Microbiology

Xylan degradation by the human gut Bacteroides xylanisolvens XB1AT involves two distinct gene clusters that are linked at the transcriptional level

(2016) Jordane Despres et al.   BMC GENOMICS

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

The Sus operon: a model system for starch uptake by the human gut Bacteroidetes

(2016) Matthew H. Foley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Formation of propionate and butyrate by the human colonic microbiota

(2016) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

Galactomannan Catabolism Conferred by a Polysaccharide Utilization Locus ofBacteroides ovatus

(2016) Viktoria Bågenholm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polysaccharide Degradation by the Intestinal Microbiota and Its Influence on Human Health and Disease

(2016) Darrell W. Cockburn et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional characterization of a gene locus from an uncultured gutBacteroidesconferring xylo-oligosaccharides utilization toEscherichia coli

(2016) Alexandra S. Tauzin et al.   MOLECULAR MICROBIOLOGY

Gut microbiota, diet, and obesity-related disorders-The good, the bad, and the future challenges

(2016) Kevin J. Portune et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

(2016) W Wu et al.   Mucosal Immunology

Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice

(2016) J-Y Yang et al.   Mucosal Immunology

The evolution of cooperation within the gut microbiota

(2016) Seth Rakoff-Nahoum et al.   NATURE

Cellulosomes: bacterial nanomachines for dismantling plant polysaccharides

(2016) Lior Artzi et al.   NATURE REVIEWS MICROBIOLOGY

Revised phylogeny of Bacteroidetes and proposal of sixteen new taxa and two new combinations including Rhodothermaeota phyl. nov.

(2016) Raul Munoz et al.   SYSTEMATIC AND APPLIED MICROBIOLOGY

Bacteroidales Secreted Antimicrobial Proteins Target Surface Molecules Necessary for Gut Colonization and Mediate Competition In Vivo

(2016) Kevin G. Roelofs et al.   mBio

Impact of oral consumption of heat-treated Bacteroides xylanisolvens DSM 23964 on the level of natural TFα-specific antibodies in human adults

(2016) P. Ulsemer et al.   Beneficial Microbes

Composition and temporal stability of the gut microbiota in older persons

(2015) Ian B Jeffery et al.   ISME Journal

Species-Specific Dynamic Responses of Gut Bacteria to a Mammalian Glycan

(2015) Varsha Raghavan et al.   JOURNAL OF BACTERIOLOGY

Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

(2015) Fiona Cuskin et al.   NATURE

Glycan complexity dictates microbial resource allocation in the large intestine

(2015) Artur Rogowski et al.   Nature Communications

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Automatic prediction of polysaccharide utilization loci in Bacteroidetes species

(2014) Nicolas Terrapon et al.   BIOINFORMATICS

Crystal structures of apparent saccharide sensors from histidine kinase receptors prevalent in a human gut symbiont

(2014) Zhen Zhang et al.   FEBS Journal

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Characterization of Glycosaminoglycan (GAG) Sulfatases from the Human Gut SymbiontBacteroides thetaiotaomicronReveals the First GAG-specific Bacterial Endosulfatase

(2014) Jonathan E. Ulmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium

(2014) Varsha Raghavan et al.   MOLECULAR MICROBIOLOGY

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes

(2014) Johan Larsbrink et al.   NATURE

Efficient utilization of complex N-linked glycans is a selective advantage for Bacteroides fragilis in extraintestinal infections

(2014) Y. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preferential Packing of Acidic Glycosidases and Proteases into Bacteroides Outer Membrane Vesicles

(2014) W. Elhenawy et al.   mBio

Polysaccharides utilization in human gut bacterium Bacteroides thetaiotaomicron: comparative genomics reconstruction of metabolic and regulatory networks

(2013) Dmitry A Ravcheev et al.   BMC GENOMICS

An Ecological Network of Polysaccharide Utilization among Human Intestinal Symbionts

(2013) Seth Rakoff-Nahoum et al.   CURRENT BIOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Effects of Diet on Resource Utilization by a Model Human Gut Microbiota Containing Bacteroides cellulosilyticus WH2, a Symbiont with an Extensive Glycobiome

(2013) Nathan P. McNulty et al.   PLOS BIOLOGY

A scissor blade-like closing mechanism implicated in transmembrane signaling in a Bacteroides hybrid two-component system

(2012) E. C. Lowe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Longitudinal Analysis of the Prevalence, Maintenance, and IgA Response to Species of the Order Bacteroidales in the Human Gut

(2011) Naamah Levy Zitomersky et al.   INFECTION AND IMMUNITY

SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor

(2011) Marco A. R. Vinolo et al.   PLoS One

Recognition and Degradation of Plant Cell Wall Polysaccharides by Two Human Gut Symbionts

(2011) Eric C. Martens et al.   PLOS BIOLOGY

Treatment of colitis with a commensal gut bacterium engineered to secrete human tgf-β1 under the control of dietary xylan

(2010) Zaed Z.R. Hamady et al.   INFLAMMATORY BOWEL DISEASES

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Coordinate Regulation of Glycan Degradation and Polysaccharide Capsule Biosynthesis by a Prominent Human Gut Symbiont

(2009) Eric C. Martens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla

(2009) M. A. Mahowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucosal Glycan Foraging Enhances Fitness and Transmission of a Saccharolytic Human Gut Bacterial Symbiont

(2008) Eric C. Martens et al.   Cell Host & Microbe

From cellulosomes to cellulosomics

(2008) Edward A. Bayer et al.   CHEMICAL RECORD

Structural and Functional Analysis of a Glycoside Hydrolase Family 97 Enzyme fromBacteroides thetaiotaomicron

(2008) Momoyo Kitamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium-Coupled Transport of the Short Chain Fatty Acid Butyrate by SLC5A8 and Its Relevance to Colon Cancer

(2008) Muthusamy Thangaraju et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Evolution of Mammals and Their Gut Microbes

(2008) R. E. Ley et al.   SCIENCE