BRPF1-KAT6A/KAT6B Complex: Molecular Structure, Biological Function and Human Disease

BRPF1 ‐associated syndrome: A patient with congenital ptosis, neurological findings, and normal intellectual development

(2022) Josiane Souza et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Discovery, optimization and evaluation of 1-(indolin-1-yl)ethan-1-ones as novel selective TRIM24/BRPF1 bromodomain inhibitors

(2022) Qiuping Xiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Whole Exome Sequencing in Coloboma/Microphthalmia: Identification of Novel and Recurrent Variants in Seven Genes

(2021) Patricia Haug et al.   Genes

Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains

(2021) Mengmeng Zhang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Clinically relevant copy-number variants in exome sequencing data of patients with dystonia

(2021) Michael Zech et al.   PARKINSONISM & RELATED DISORDERS

First case of pan-suture craniosynostosis due to de novo mosaic KAT6A mutation

(2021) Nisha Korakavi et al.   CHILDS NERVOUS SYSTEM

Deficiency of intellectual disability-related gene Brpf1 reduced inhibitory neurotransmission in MGE-derived GABAergic interneurons

(2021) Jingli Cao et al.   G3-Genes Genomes Genetics

Insights into the Molecular Mechanisms of Histone Code Recognition by the BRPF3 Bromodomain

(2021) Soumen Barman et al.   Chemistry-An Asian Journal

The histone acetyltransferase HBO1 (KAT7) promotes efficient tip cell sprouting during angiogenesis

(2021) Zoe L. Grant et al.   DEVELOPMENT

HBO1 overexpression is important for hepatocellular carcinoma cell growth

(2021) Wenhui Zhong et al.   Cell Death & Disease

Deficiency of Intellectual Disability-Related Gene Brpf1 Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability

(2021) Weiwei Xian et al.   Frontiers in Cell and Developmental Biology

Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer

(2021) Carol Lai-Hung Cheng et al.   Communications Biology

A de novo heterozygous variant in KAT6A is associated with a newly named neurodevelopmental disorder Arboleda-Tham syndrome—a case report

(2021) Mingyan Jiang et al.   Translational Pediatrics

The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal

(2021) Yuqing Yang et al.   BLOOD

Identification of a novel KAT6A variant in an infant presenting with facial dysmorphism and developmental delay: a case report and literature review

(2021) Soyoung Bae et al.   BMC Medical Genomics

ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer

(2021) Anna Melekhova et al.   Cells

Transcriptional Networks Identify BRPF1 as a Potential Drug Target Based on Inflammatory Signature in Primary Lower-Grade Gliomas

(2021) Mingyang Xia et al.   Frontiers in Oncology

Tapping on the crucial role of Asp1116 in selective Drug targeting of CREB-cAMP- responsive element-binding protein Implicated in Prostate Cancer

(2020) Oluwayimika E. Akinsiku et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Five new cases of syndromic intellectual disability due to KAT6A mutations: widening the molecular and clinical spectrum

(2020) Roser Urreizti et al.   Orphanet Journal of Rare Diseases

Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer

(2020) Kezhi Yan et al.   Science Advances

The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer

(2020) Carla Solé et al.   Cancers

Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1

(2020) Ehab Ghazy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel Missense Variant in Heterozygous State in the BRPF1 Gene Leading to Intellectual Developmental Disorder With Dysmorphic Facies and Ptosis

(2020) Muhammad Imran Naseer et al.   Frontiers in Genetics

BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells

(2020) Hye In Cho et al.   CELL DEATH AND DIFFERENTIATION

A de novo BRPF1 variant in a case of Sudden Unexplained Death in Childhood

(2020) Christine Keywan et al.   European Journal of Medical Genetics

Diagnosis of Arboleda-Tham syndrome by whole genome sequencing in an Asian boy with severe developmental delay

(2020) Yung-Feng Lin et al.   Molecular Genetics and Metabolism Reports

Advancements in the Development of non-BET Bromodomain Chemical Probes

(2019) Michael A. Clegg et al.   ChemMedChem

ING5 inhibits lung cancer invasion and epithelial-mesenchymal transition by inhibiting the WNT/β-catenin pathway

(2019) Xin-Li Liu et al.   Thoracic Cancer

BRPF1 ‐associated intellectual disability, ptosis, and facial dysmorphism in a multiplex family

(2019) Naomi Pode‐Shakked et al.   Molecular Genetics & Genomic Medicine

Brpf1 Haploinsufficiency Impairs Dendritic Arborization and Spine Formation, Leading to Cognitive Deficits

(2019) Yan Su et al.   Frontiers in Cellular Neuroscience

Deciphering structure, function and mechanism of lysine acetyltransferase HBO1 in protein acetylation, transcription regulation, DNA replication and its oncogenic properties in cancer

(2019) Rongfeng Lan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin

(2019) Brianna J. Klein et al.   STRUCTURE

HBO1 is required for the maintenance of leukaemia stem cells

(2019) Laura MacPherson et al.   NATURE

Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma

(2019) Giuseppe Aiello et al.   Cell Reports

Structure-based discovery of selective BRPF1 bromodomain inhibitors

(2018) Jian Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A KAT6A variant in a family with autosomal dominantly inherited microcephaly and developmental delay

(2018) Joanne Trinh et al.   JOURNAL OF HUMAN GENETICS

The Kat in the HAT: The Histone Acetyl Transferase Kat6b (MYST4) Is Downregulated in Murine Macrophages in Response to LPS

(2018) Smita Shukla et al.   MEDIATORS OF INFLAMMATION

KAT6A Syndrome: genotype–phenotype correlation in 76 patients with pathogenic KAT6A variants

(2018) Joanna Kennedy et al.   GENETICS IN MEDICINE

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

(2018) Jonathan B. Baell et al.   NATURE

Novel truncating variants expand the phenotypic spectrum of KAT6B -related disorders

(2018) Alejandro Brea-Fernández et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Splicing and Chromatin Factors Jointly Regulate Epidermal Differentiation

(2018) Sabine E.J. Tanis et al.   Cell Reports

Increased expression of a novel miRNA in peripheral blood is negatively correlated with hippocampal volume in patients with major depressive disorder

(2018) Liansheng Zhao et al.   JOURNAL OF AFFECTIVE DISORDERS

Biological function and histone recognition of family IV bromodomain-containing proteins

(2017) Jonathan T. Lloyd et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains

(2017) Léa Bouché et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins

(2017) Niall Igoe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2

(2017) Ye Tao et al.   NUCLEIC ACIDS RESEARCH

ING5 activity in self-renewal of glioblastoma stem cells via calcium and follicle stimulating hormone pathways

(2017) F Wang et al.   ONCOGENE

Expression of ING4 is negatively correlated with cellular proliferation and microvessel density in human glioma

(2017) Bin Shao et al.   Oncology Letters

Association between the expression of inhibitor of growth family member 4 and the progression of clear cell renal carcinoma

(2017) Yuxin Ren et al.   Oncology Letters

INGs are potential drug targets for cancer

(2016) Runyun Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

BRPF1 is essential for development of fetal hematopoietic stem cells

(2016) Linya You et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential role for the histone acetyltransferase KAT7 in T cell development, fitness, and survival

(2016) Dane M. Newman et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chemical probes and inhibitors of bromodomains outside the BET family

(2016) Moses Moustakim et al.   MedChemComm

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain

(2016) Paul Bamborough et al.   ACS Medicinal Chemistry Letters

ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer

(2016) Yansu Chen et al.   Oncotarget

Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells

(2016) Kyoung Ah Kang et al.   Oncotarget

Dominant Mutations in KAT6A Cause Intellectual Disability with Recognizable Syndromic Features

(2015) Emma Tham et al.   AMERICAN JOURNAL OF HUMAN GENETICS

De Novo Nonsense Mutations in KAT6A, a Lysine Acetyl-Transferase Gene, Cause a Syndrome Including Microcephaly and Global Developmental Delay

(2015) Valerie A. Arboleda et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MOZ and MORF acetyltransferases: Molecular interaction, animal development and human disease

(2015) Xiang-Jiao Yang   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development

(2015) B. N. Sheikh et al.   BLOOD

BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation

(2015) Y. Feng et al.   EMBO JOURNAL

The histone acetyltransferase Myst2 regulatesNanogexpression, and is involved in maintaining pluripotency and self-renewal of embryonic stem cells

(2015) Min Seong Kim et al.   FEBS LETTERS

SCFJFKis a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer

(2015) Ruorong Yan et al.   GENES & DEVELOPMENT

The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival

(2015) Kezhi Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chromatin Regulator Brpf1 Regulates Embryo Development and Cell Proliferation

(2015) Linya You et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of the Chromatin Regulator Brpf1 Causes Abnormal Brain Development

(2015) Linya You et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

(2015) James Bennett et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

(2015) Wylie S. Palmer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors

(2015) F. Anthony Romero et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

(2015) Jiajun Zhu et al.   NATURE

Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation

(2015) Brianna J. Klein et al.   NUCLEIC ACIDS RESEARCH

MOZ and BMI1 play opposing roles duringHoxgene activation in ES cells and in body segment identity specification in vivo

(2015) Bilal N. Sheikh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An individual with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) and additional features expands the phenotype associated with mutations inKAT6B

(2014) Hung-Chun Yu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

Expression atlas of the multivalent epigenetic regulator Brpf1 and its requirement for survival of mouse embryos

(2014) Linya You et al.   Epigenetics

Further delineation of the KAT6B molecular and phenotypic spectrum

(2014) Tamsin Gannon et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain

(2014) Mulu Y. Lubula et al.   FEBS LETTERS

The MOZ Histone Acetyltransferase in Epigenetic Signaling and Disease

(2014) Samuel Carlson et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development

(2014) Yuta Mishima et al.   Nature Communications

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

(2014) Robert Huether et al.   Nature Communications

ING5 Is a Tip60 Cofactor That Acetylates p53 in Response to DNA Damage

(2013) N. Liu et al.   CANCER RESEARCH

Interplay between the Cancer Genome and Epigenome

(2013) Hui Shen et al.   CELL

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity

(2013) M.-E. Lalonde et al.   GENES & DEVELOPMENT

The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis

(2013) Flor M. Perez-Campo et al.   IMMUNOLOGY

Molecular Insights into the Recognition of N-Terminal Histone Modifications by the BRPF1 Bromodomain

(2013) Amanda Poplawski et al.   JOURNAL OF MOLECULAR BIOLOGY

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

The double PHD finger domain of MOZ/MYST3 induces  -helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification

(2013) I. Dreveny et al.   NUCLEIC ACIDS RESEARCH

ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth

(2013) A Moreno et al.   ONCOGENE

MOZ-Mediated Repression ofp16INK4aIs Critical for the Self-Renewal of Neural and Hematopoietic Stem Cells

(2013) Flor M. Perez-Campo et al.   STEM CELLS

De Novo Mutations of the Gene Encoding the Histone Acetyltransferase KAT6B Cause Genitopatellar Syndrome

(2012) Michael A. Simpson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in KAT6B, Encoding a Histone Acetyltransferase, Cause Genitopatellar Syndrome

(2012) Philippe M. Campeau et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

(2012) Jueng Soo You et al.   CANCER CELL

Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription

(2012) Y. Qiu et al.   GENES & DEVELOPMENT

TheKAT6B-related disorders genitopatellar syndrome and Ohdo/SBBYS syndrome have distinct clinical features reflecting distinct molecular mechanisms

(2012) Philippe M. Campeau et al.   HUMAN MUTATION

Querkopf is a key marker of self-renewal and multipotency of adult neural stem cells

(2012) B. N. Sheikh et al.   JOURNAL OF CELL SCIENCE

Diverse epigenetic strategies interact to control epidermal differentiation

(2012) Klaas W. Mulder et al.   NATURE CELL BIOLOGY

MicroRNA-193 Pro-Proliferation Effects for Bone Mesenchymal Stem Cells After Low-Level Laser Irradiation Treatment Through Inhibitor of Growth Family, Member 5

(2012) Jue Wang et al.   STEM CELLS AND DEVELOPMENT

Whole-Exome-Sequencing Identifies Mutations in Histone Acetyltransferase Gene KAT6B in Individuals with the Say-Barber-Biesecker Variant of Ohdo Syndrome

(2011) Jill Clayton-Smith et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis

(2011) Y. Mishima et al.   BLOOD

Recognition of Unmodified Histone H3 by the First PHD Finger of Bromodomain-PHD Finger Protein 2 Provides Insights into the Regulation of Histone Acetyltransferases Monocytic Leukemic Zinc-finger Protein (MOZ) and MOZ-related factor (MORF)

(2011) Su Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome–like phenotype and hyperactivated MAPK signaling in humans and mice

(2011) Michael Kraft et al.   JOURNAL OF CLINICAL INVESTIGATION

Exome sequencing supports a de novo mutational paradigm for schizophrenia

(2011) Bin Xu et al.   NATURE GENETICS

Structural and Histone Binding Ability Characterizations of Human PWWP Domains

(2011) Hong Wu et al.   PLoS One

The p53 Tumor Suppressor Is Stabilized by Inhibitor of Growth 1 (ING1) by Blocking Polyubiquitination

(2011) Subhash Thalappilly et al.   PLoS One

HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation

(2010) P Gaub et al.   CELL DEATH AND DIFFERENTIATION

MYST-family histone acetyltransferases: beyond chromatin

(2010) Vasileia Sapountzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Maintenance of Neuronal Laterality in Caenorhabditis elegans Through MYST Histone Acetyltransferase Complex Components LSY-12, LSY-13 and LIN-49

(2010) M. M. O'Meara et al.   GENETICS

The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas☆

(2010) Hua-chuan Zheng et al.   HUMAN PATHOLOGY

Decreased nuclear expression and increased cytoplasmic expression of ING5 may be linked to tumorigenesis and progression in human head and neck squamous cell carcinoma

(2010) Xiaohan Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development

(2010) A. J. Kueh et al.   MOLECULAR AND CELLULAR BIOLOGY

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1

(2010) Alessandro Vezzoli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibitor of growth-4 promotes I B promoter activation to suppress NF- B signaling and innate immunity

(2010) A. H. Coles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Support of association between BRD1 and both schizophrenia and bipolar affective disorder

(2009) Mette Nyegaard et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Loss of Inhibitor of Growth (ING-4) is Implicated in the Pathogenesis and Progression of Human Astrocytomas

(2009) George Klironomos et al.   BRAIN PATHOLOGY

Brpf1, a subunit of the MOZ histone acetyl transferase complex, maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons

(2009) Kenta Hibiya et al.   DEVELOPMENTAL BIOLOGY

Moz and Retinoic Acid Coordinately Regulate H3K9 Acetylation, Hox Gene Expression, and Segment Identity

(2009) Anne K. Voss et al.   DEVELOPMENTAL CELL

Histone acetyltransferase Hbo1: Catalytic activity, cellular abundance, and links to primary cancers

(2009) Masayoshi Iizuka et al.   GENE

ING4 Mediates Crosstalk between Histone H3 K4 Trimethylation and H3 Acetylation to Attenuate Cellular Transformation

(2009) Tiffany Hung et al.   MOLECULAR CELL

The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity

(2008) K. Laue et al.   DEVELOPMENT

HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1

(2008) B. Miotto et al.   GENES & DEVELOPMENT

Molecular Basis of Histone H3K4me3 Recognition by ING4

(2008) Alicia Palacios et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia

(2008) K Nebral et al.   LEUKEMIA

The ING4 Tumor Suppressor Attenuates NF- B Activity at the Promoters of Target Genes

(2008) S. Nozell et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Architecture of Quartet MOZ/MORF Histone Acetyltransferase Complexes

(2008) M. Ullah et al.   MOLECULAR AND CELLULAR BIOLOGY

Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing

(2008) Z.-Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide

(2008) Karen S. Champagne et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS