Connexins Signatures of the Neurovascular Unit and Their Physio-Pathological Functions

Pericyte Progenitor Coupling to the Emerging Endothelium During Vasculogenesis via Connexin 43

(2022) Laura Beth Payne et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain

(2022) Nunzio Vicario et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions

(2022) Eszter Császár et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cx43 hemichannels contribute to astrocyte-mediated toxicity in sporadic and familial ALS

(2022) Akshata A. Almad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation

(2022) Amanda C. Filiberto et al.   Nature Communications

Inhibition of Connexin 43 reverses ox-LDL-mediated inhibition of autophagy in VSMC by inhibiting the PI3K/Akt/mTOR signaling pathway

(2022) Xuqing Qin et al.   PeerJ

The Hallmarks of Glioblastoma: Heterogeneity, Intercellular Crosstalk and Molecular Signature of Invasiveness and Progression

(2022) Filippo Torrisi et al.   Biomedicines

Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer’s Disease, ALS, and Harmful Stress Conditions

(2021) Paloma A. Harcha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Connexin43 promotes angiogenesis through activating the HIF-1α/VEGF signaling pathway under chronic cerebral hypoperfusion

(2021) Weiwei Yu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice

(2021) Antonio Cibelli et al.   Frontiers in Cellular Neuroscience

In Vitro Model for Ischemic Stroke: Functional Analysis of Vascular Smooth Muscle Cells

(2021) Melissa Mariana et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The many ways astroglial connexins regulate neurotransmission and behavior

(2021) David Mazaud et al.   GLIA

Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing

(2021) Nunzio Vicario et al.   Cell Death & Disease

Neurovascular Coupling in Development and Disease: Focus on Astrocytes

(2021) Teresa L. Stackhouse et al.   Frontiers in Cell and Developmental Biology

Connexin 43 and Sonic Hedgehog Pathway Interplay in Glioblastoma Cell Proliferation and Migration

(2021) Filippo Torrisi et al.   Biology-Basel

Modulation of Vascular Smooth Muscle Cell Multiplication, Apoptosis, and Inflammatory Damage by miR-21 in Coronary Heart Disease

(2021) Wei Liu et al.   Computational and Mathematical Methods in Medicine

Cx43 carboxyl terminal domain determines AQP4 and Cx30 endfoot organization and blood brain barrier permeability

(2021) Antonio Cibelli et al.   Scientific Reports

Gap Junctions and Hemichannels Composed of Connexins and Pannexins Mediate the Secondary Brain Injury Following Intracerebral Hemorrhage

(2021) Yan Zhang et al.   Biology-Basel

Ixazomib Improves Bone Remodeling and Counteracts Sonic Hedgehog Signaling Inhibition Mediated by Myeloma Cells

(2020) Daniele Tibullo et al.   Cancers

Danegaptide Enhances Astrocyte Gap Junctional Coupling and Reduces Ischemic Reperfusion Brain Injury in Mice

(2020) Moises Freitas-Andrade et al.   Biomolecules

Glial connexins and pannexins in the healthy and diseased brain

(2020) Christian BA Giaume et al.   PHYSIOLOGICAL REVIEWS

A Steric “Ball-and-Chain” Mechanism for pH-Mediated Regulation of Gap Junction Channels

(2020) Ali K. Khan et al.   Cell Reports

Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia

(2020) Maiko T. Uemura et al.   Frontiers in Aging Neuroscience

Mitochondrial Functions, Energy Metabolism and Protein Glycosylation are Interconnected Processes Mediating Resistance to Bortezomib in Multiple Myeloma Cells

(2020) Daniele Tibullo et al.   Biomolecules

Increased expression of connexin 43 in a mouse model of spinal motoneuronal loss

(2020) Federica Maria Spitale et al.   Aging-US

Astroglial connexins in neurological, neuropsychological disorders and radiation exposure

(2020) Yuan Duo Liu et al.   CURRENT MEDICINAL CHEMISTRY

Intercellular communication and ion channels in neuropathic pain chronicization

(2020) Nunzio Vicario et al.   INFLAMMATION RESEARCH

Prostaglandin E2 breaks down pericyte–endothelial cell interaction via EP1 and EP4-dependent downregulation of pericyte N-cadherin, connexin-43, and R-Ras

(2020) Carole Y. Perrot et al.   Scientific Reports

Opposing modulation of Cx26 gap junctions and hemichannels by CO 2

(2020) Sarbjit Nijjar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Increased Immunosignals of Collagen IV and Fibronectin Indicate Ischemic Consequences for the Neurovascular Matrix Adhesion Zone in Various Animal Models and Human Stroke Tissue

(2020) Dominik Michalski et al.   Frontiers in Physiology

Iron regulates myeloma cell/macrophage interaction and drives resistance to bortezomib

(2020) Giuseppina Camiolo et al.   Redox Biology

The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance

(2020) Filippo Torrisi et al.   Cancers

Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation

(2020) Mengzhou Xue et al.   LANCET NEUROLOGY

The thermodynamics of thinking: connections between neural activity, energy metabolism and blood flow

(2020) Richard B. Buxton   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells

(2019) Maria Elena Silva et al.   Frontiers in Cellular Neuroscience

Middle-aged healthy women and Alzheimer's disease patients present an overlapping of brain cell transcriptional profile

(2019) Cristina Sanfilippo et al.   NEUROSCIENCE

Safety and efficacy of oncolytic HSV-1 G207 inoculated into the cerebellum of mice

(2019) Joshua D. Bernstock et al.   CANCER GENE THERAPY

Clobetasol Modulates Adult Neural Stem Cell Growth via Canonical Hedgehog Pathway Activation

(2019) Nunzio Vicario et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain

(2019) Nunzio Vicario et al.   MOLECULAR NEUROBIOLOGY

Endothelial NMDA receptors mediate activity-dependent brain hemodynamic responses in mice

(2019) Adam D. Hogan-Cann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Connexins in Chronic Pain and Their Potential as Therapeutic Targets for Next-Generation Analgesics

(2019) Norimitsu Morioka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Impairment of pericyte-endothelium crosstalk leads to blood-brain barrier dysfunction following traumatic brain injury

(2019) Saurav Bhowmick et al.   EXPERIMENTAL NEUROLOGY

Basement membrane collagens and disease mechanisms

(2019) Anna Gatseva et al.   Essays in Biochemistry

The Neurovascular Unit: Focus on the Regulation of Arterial Smooth Muscle Cells

(2019) Patrícia Quelhas et al.   CURRENT NEUROVASCULAR RESEARCH

Connexin 43 deletion in astrocytes promotes CNS remyelination by modulating local inflammation

(2019) Tao Li et al.   GLIA

Brain endothelial cell junctions after cerebral hemorrhage: Changes, mechanisms and therapeutic targets

(2018) Richard F Keep et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of Astrocyte Connexin 43 Channels Facilitates the Differentiation of Oligodendrocyte Precursor Cells Under Hypoxic Conditions In Vitro

(2018) Qiong Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Cell adhesion and matricellular support by astrocytes of the tripartite synapse

(2018) Anne E.J. Hillen et al.   PROGRESS IN NEUROBIOLOGY

Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases

(2018) Yinan Zhao et al.   NEURAL PLASTICITY

Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway

(2018) Yingzhu Chen et al.   Frontiers in Cellular Neuroscience

Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment

(2018) Chad M. Glen et al.   Nature Communications

Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks

(2018) Ang Li et al.   Nature Communications

Basement membrane and blood–brain barrier

(2018) Lingling Xu et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice

(2018) Beilei Chen et al.   BRAIN RESEARCH BULLETIN

Inhibition of Cx43 mediates protective effects on hypoxic/reoxygenated human neuroblastoma cells

(2017) Nunzio Vicario et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The vascular basement membrane in the healthy and pathological brain

(2017) Maj S Thomsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

(2017) Kassandra Kisler et al.   NATURE REVIEWS NEUROSCIENCE

Connexin Channels at the Glio-Vascular Interface: Gatekeepers of the Brain

(2017) Marijke De Bock et al.   NEUROCHEMICAL RESEARCH

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Connexin-Dependent Neuroglial Networking as a New Therapeutic Target

(2017) Mathieu Charvériat et al.   Frontiers in Cellular Neuroscience

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

(2017) Alerie Guzman De La Fuente et al.   Cell Reports

Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets

(2017) Nunzio Vicario et al.   Frontiers in Physiology

Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis

(2016) Akshata A. Almad et al.   GLIA

Connexin-based channels contribute to metabolic pathways in the oligodendroglial lineage

(2016) Jianqin Niu et al.   JOURNAL OF CELL SCIENCE

Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone

(2016) J.A. Filosa et al.   NEUROSCIENCE

C-reactive protein can upregulate VEGF expression to promote ADSC-induced angiogenesis by activating HIF-1α via CD64/PI3k/Akt and MAPK/ERK signaling pathways

(2016) JiaYuan Chen et al.   Stem Cell Research & Therapy

Microvascular endothelial cells-derived microvesicles imply in ischemic stroke by modulating astrocyte and blood brain barrier function and cerebral blood flow

(2016) Qunwen Pan et al.   Molecular Brain

Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions

(2016) Rosario Gajardo-Gómez et al.   Frontiers in Molecular Neuroscience

Protection of erythropoietin against ischemic neurovascular unit injuries through the effects of connexin43

(2015) Ziyi Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Connexin 43 Inhibition Sensitizes Chemoresistant Glioblastoma Cells to Temozolomide

(2015) S. F. Murphy et al.   CANCER RESEARCH

Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?

(2015) Elke Decrock et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Analytical approaches to the diagnosis and treatment of aging and aging-related disease: redox status and proteomics

(2015) V. Calabrese et al.   FREE RADICAL RESEARCH

What is a pericyte?

(2015) David Attwell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroactive molecules and growth factors modulate cytoskeletal protein expression during astroglial cell proliferation and differentiation in culture

(2015) Vincenzo Bramanti et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Astrocytes promote glioma invasion via the gap junction protein connexin43

(2015) W C Sin et al.   ONCOGENE

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Control of the neurovascular coupling by nitric oxide-dependent regulation of astrocytic Ca2+ signaling

(2015) Manuel F. Muñoz et al.   Frontiers in Cellular Neuroscience

The Sarcoglycan complex is expressed in the cerebrovascular system and is specifically regulated by astroglial Cx30 channels

(2015) Anne-Cécile Boulay et al.   Frontiers in Cellular Neuroscience

The neurovascular unit - concept review

(2014) V. Muoio et al.   Acta Physiologica

NO, via its target Cx37, modulates calcium signal propagation selectively at myoendothelial gap junctions

(2014) Kristin Pogoda et al.   Cell Communication and Signaling

In Rasmussen Encephalitis, Hemichannels Associated with Microglial Activation are linked to Cortical Pyramidal Neuron Coupling: A Possible Mechanism for Cellular Hyperexcitability

(2014) Carlos Cepeda et al.   CNS Neuroscience & Therapeutics

Basal CD38/cyclic ADP-ribose-dependent signaling mediates ATP release and survival of microglia by modulating connexin 43 hemichannels

(2014) Yingxin Ma et al.   GLIA

Astroglial connexin 43 sustains glutamatergic synaptic efficacy

(2014) O. Chever et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Oligodendrocyte Precursor Cells Support Blood-Brain Barrier Integrity via TGF-β Signaling

(2014) Ji Hae Seo et al.   PLoS One

Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex

(2014) Anna R. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemichannels: new roles in astroglial function

(2014) Juan A. Orellana et al.   Frontiers in Physiology

Immunolocalization of Wilms’ Tumor protein (WT1) in developing human peripheral sympathetic and gastroenteric nervous system

(2013) Rosalba Parenti et al.   ACTA HISTOCHEMICA

ATP Is Required and Advances Cytokine-Induced Gap Junction Formation in Microglia In Vitro

(2013) Pablo J. Sáez et al.   MEDIATORS OF INFLAMMATION

Specificity in the participation of connexin proteins in flow-induced endothelial gap junction communication

(2013) Eno E. Ebong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Astrocyte-induced cortical vasodilation is mediated by D-serine and endothelial nitric oxide synthase

(2013) J. L. L. Stobart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles

(2013) Christian Giaume et al.   Frontiers in Pharmacology

Dye coupling and connexin expression by cortical radial glia in the early postnatal subventricular zone

(2012) Andressa S. Freitas et al.   Developmental Neurobiology

Impact of vegf on astrocytes: Analysis of gap junctional intercellular communication, proliferation, and motility

(2012) Ricarda Wuestefeld et al.   GLIA

Disruption of oligodendrocyte gap junctions in experimental autoimmune encephalomyelitis

(2012) Kyriaki Markoullis et al.   GLIA

The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS

(2012) Dorothy P. Schafer et al.   GLIA

Making Connexons in the Neurovascular Unit

(2012) Lester R Drewes   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Deletion of Astroglial Connexins Weakens the Blood–Brain Barrier

(2012) Pascal Ezan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glial cells in (patho)physiology

(2012) Vladimir Parpura et al.   JOURNAL OF NEUROCHEMISTRY

Microglia: actively surveying and shaping neuronal circuit structure and function

(2012) Hiroaki Wake et al.   TRENDS IN NEUROSCIENCES

Glial gap junctional communication involvement in hippocampal damage after middle cerebral artery occlusion

(2011) Minjie Xie et al.   ANNALS OF NEUROLOGY

Hemichannels in the Neurovascular Unit and White Matter Under Normal and Inflamed Conditions

(2011) Juan A. Orellana et al.   CNS & Neurological Disorders-Drug Targets

Electrical activity patterns and the functional maturation of the neocortex

(2011) Werner Kilb et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor

(2011) Soo-Hyun Kim et al.   JOURNAL OF ENDOCRINOLOGY

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

Knock-down of endothelial connexins impairs angiogenesis

(2011) Christiane Gärtner et al.   PHARMACOLOGICAL RESEARCH

Astroglial networks scale synaptic activity and plasticity

(2011) U. Pannasch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Contributions of astrocytes to synapse formation and maturation — Potential functions of the perisynaptic extracellular matrix

(2010) Andreas Faissner et al.   BRAIN RESEARCH REVIEWS

Connexin32 protects against vascular inflammation by modulating inflammatory cytokine expression by endothelial cells

(2010) Takayuki Okamoto et al.   EXPERIMENTAL CELL RESEARCH

Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity

(2010) Rosalba Parenti et al.   GLIA

Oligodendrocytes in mouse corpus callosum are coupled via gap junction channels formed by connexin47 and connexin32

(2010) Marta Maglione et al.   GLIA

Neurovascular Coupling in Rat Brain Operates Independent of Hemoglobin Deoxygenation

(2010) Ute Lindauer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Regulation of synaptic connectivity by glia

(2010) Cagla Eroglu et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Astroglial networks: a step further in neuroglial and gliovascular interactions

(2010) Christian Giaume et al.   NATURE REVIEWS NEUROSCIENCE

Expression of connexin29 and 32 in the penumbra region after traumatic brain injury of mice

(2010) Younghye Moon et al.   NEUROREPORT

Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice

(2010) X. Mei et al.   NEUROSCIENCE

Connexin32 is expressed in vascular endothelial cells and participates in gap-junction intercellular communication

(2009) Takayuki Okamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Connexin-related signaling in cell death: to live or let die?

(2009) E Decrock et al.   CELL DEATH AND DIFFERENTIATION

Ischemia Alters the Expression of Connexins in the Aged Human Brain

(2009) Taizen Nakase et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

An Oligovascular Niche: Cerebral Endothelial Cells Promote the Survival and Proliferation of Oligodendrocyte Precursor Cells

(2009) K. Arai et al.   JOURNAL OF NEUROSCIENCE

Deletion of Astrocyte Connexins 43 and 30 Leads to a Dysmyelinating Phenotype and Hippocampal CA1 Vacuolation

(2009) S. E. Lutz et al.   JOURNAL OF NEUROSCIENCE

ATP release by way of connexin 36 hemichannels mediates ischemic tolerance in vitro

(2008) Sarah C. Schock et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pericytes: Pluripotent Cells of the Blood Brain Barrier

(2008) Paula Dore-Duffy   CURRENT PHARMACEUTICAL DESIGN

Neurons control the expression of connexin 30 and connexin 43 in mouse cortical astrocytes

(2008) Annette Koulakoff et al.   GLIA

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON