Review
Cell Biology
Claudia Alia, Daniele Cangi, Verediana Massa, Marco Salluzzo, Livia Vignozzi, Matteo Caleo, Cristina Spalletti
Summary: Ischemic damage in brain tissue leads to plastic changes in cell-to-cell interactions, influencing a wide range of molecular and structural interactions. Understanding and manipulating these intercellular connections is crucial for post-stroke neurorehabilitation.
Review
Neurosciences
Khaled S. Abd-Elrahman, Shaarika Sarasija, Stephen S. G. Ferguson
Summary: This review discusses the disruption of neuroglial homeostasis by β-amyloid and hyperphosphorylated tau, and their contribution to the pathophysiology of Alzheimer's Disease.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Julie Bigarreau, Nathalie Rouach, Anselme L. Perrier, Franck Mouthon, Mathieu Charveriat
Summary: Neuroglial interactions play a crucial role in the study of neurological disorders, and the discovery of human induced pluripotent stem cells has provided a new avenue for research in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Herbert Renz-Polster, Marie-Eve Tremblay, Dorothee Bienzle, Joachim E. Fischer
Summary: The pathobiological processes of ME/CFS may be unified by neuroglial dysfunction, which is characterized by impaired or pathologically reactive astrocytes, microglia, and oligodendrocytes. This hypothesis suggests that the dysfunction of the central nervous system due to neuroglial dysfunction may be the common denominator of ME/CFS. The findings may also be relevant to a subset of patients with post-acute sequelae COVID who exhibit similar key features as ME/CFS.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Ming Zhao, Xue-Fan Jiang, Hui-Qin Zhang, Jia-Hui Sun, Hui Pei, Li-Na Ma, Yu Cao, Hao Li
Summary: Alzheimer's disease is an irreversible neurodegenerative disorder with no satisfying curative therapies currently available. Dysfunction of the blood-brain barrier contributes to the onset and progression of AD, yet the pathogenesis caused by BBB injury remains unclear. Glial cells play a crucial role in maintaining the integrity of BBB and neuronal function.
AGEING RESEARCH REVIEWS
(2021)
Review
Neurosciences
Yao Liu, Xi Shen, Yuhan Zhang, Xiaoli Zheng, Carlos Cepeda, Yao Wang, Shumin Duan, Xiaoping Tong
Summary: The mammalian brain is composed of neurons, glial cells, and numerous synapses. Neurons form the complex circuitry of the brain, while glial cells, especially astrocytes and microglia, play essential roles in supporting and regulating neuronal activity. This review summarizes the latest research on how glial cells impact and remodel synapses, with a focus on microglia and oligodendrocytes. The review highlights the cellular and molecular mechanisms of neuron-glia crosstalk and provides insights into how disrupted synaptic communication between neurons and glia may contribute to neural pathologies.
Review
Biochemistry & Molecular Biology
Olga V. Galkina, Oleg V. Vetrovoy, Irina E. Krasovskaya, Nataliya D. Eschenko
Summary: Lipids are a diverse group of compounds with various biological functions. They are not only important structural components of cells, but also play a role in intracellular and intercellular signaling. This review discusses the role of lipids and their metabolites in glial cell communication with neurons, focusing on lipid signal molecules and their involvement in synaptic plasticity and neuroplasticity. These findings greatly expand our understanding of the regulatory functions of lipids in neuroglial relationships.
BIOCHEMISTRY-MOSCOW
(2023)
Review
Cell Biology
Xinxin Yu, Shihao Wang, Wenzheng Wu, Hongyuan Chang, Pufan Shan, Lin Yang, Wenjie Zhang, Xiaoyu Wang
Summary: Depression is a prevalent neuropsychiatric disorder characterized by recurrent depressed mood, pain and despair, pessimism and anxiety, and even suicidal tendencies. It is often associated with the development of other diseases and is believed to be influenced by genetic, psychological, environmental, and biological factors. Recent evidence suggests that viral infections may play a role in the development of depression by affecting glial cells and leading to neuroinflammation.
Article
Neurosciences
Kalee N. Holloway, James C. Douglas, Tonya M. Rafferty, Ania K. Majewska, Cynthia J. M. Kane, Paul D. Drew
Summary: Fetal alcohol spectrum disorders (FASD) are neurodevelopmental disorders caused by alcohol exposure during pregnancy. This study investigates the transcriptomic changes in the cerebellum of postnatal mice exposed to ethanol for 1 or 2 days, shedding light on early changes associated with FASD. Ethanol exposure alters pathways related to immune function, cytokine signaling, and the cell cycle. It also affects the expression of genes associated with neurodegenerative microglia and reactive astrocytes. These findings improve our understanding of FASD mechanisms and may contribute to the development of new interventions and therapeutics.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Vishal Chavda, Kavita Singh, Vimal Patel, Meerambika Mishra, Awdhesh Kumar Mishra
Summary: This review examines the role of glial cells in neurodegenerative diseases and discusses different interactions and important factors related to Alzheimer's disease.
Article
Pharmacology & Pharmacy
Ying Zhang, Hai-Yan Yin, Patrizia Rubini, Peter Illes, Yong Tang
Summary: There is a dispute about whether CNS neurons possess ATP-sensitive P2X7 receptors. By genetically deleting P2X7 receptors in astrocytes and oligodendrocytes, it was found that these receptors indirectly modulate the neuronal input to neighboring neurons.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Neurosciences
Hao Huang, Wanjun He, Tao Tang, Mengsheng Qiu
Summary: Glial cells in the CNS, including oligodendrocytes, astrocytes, and microglia, are vital for neural development and functioning. Proper use of cell- or stage-specific molecular markers is crucial for studying their fate specification, differentiation, and functional diversification. This article provides an updated overview of immunological markers for labeling central glia and discusses their cell-type specificity and stage dependency.
NEUROSCIENCE BULLETIN
(2023)
Review
Biochemistry & Molecular Biology
Hariprasath Ragupathy, Manasvi Vukku, Sandeep Kumar Barodia
Summary: Neurodegeneration is a progressive phenomenon associated with aging, where activated microglia and neuroinflammation play crucial roles. Mitochondrial dysfunction and excessive neuroinflammatory responses are important factors contributing to age-dependent neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Xinguo Zhang, Ruiqi Zhang, Maher Un Nisa Awan, Jie Bai
Summary: Parkinson's disease is a neurodegenerative disease that primarily affects elderly people. The onset and progression mechanism is unknown, and there are currently no effective treatment strategies. In addition to the loss of midbrain dopaminergic neurons, glia cells also play a role in brain tissue homeostasis, defense, and repair in PD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Barbora Salcman, Karen Affleck, Silvia Bulfone-Paus
Summary: Localisation of mast cells at the abluminal side of blood vessels in the brain promotes their interaction with other brain cells, leading to the release of inflammatory mediators. Furthermore, activation of P2X receptors in mast cells and glial cells plays a crucial role in regulating neuroinflammation.
Article
Obstetrics & Gynecology
M. Ferrer-Buitrago, L. Dhaenens, Y. Lu, D. Bonte, F. Vanden Meerschaut, P. De Sutter, L. Leybaert, B. Heindryckx
HUMAN REPRODUCTION
(2018)
Article
Biochemistry & Molecular Biology
Sara Crespo Yanguas, Tereza C. da Silva, Isabel V. A. Pereira, Joost Willebrords, Michael Maes, Marina Sayuri Nogueira, Inar Alves de Castro, Isabelle Leclercq, Guilherme R. Romualdo, Luis F. Barbisan, Luc Leybaert, Bruno Cogliati, Mathieu Vinken
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tinneke Delvaeye, Leonie Wyffels, Steven Deleye, Kelly Lemeire, Amanda Goncalves, Elke Decrock, Steven Staelens, Luc Leybaert, Peter Vandenabeele, Dmitri V. Krysko
JOURNAL OF NUCLEAR MEDICINE
(2018)
Article
Developmental Biology
Yuechao Lu, Davina Bonte, Minerva Ferrer-Buitrago, Mina Popovic, Jitesh Neupane, Margot Van der Jeught, Luc Leybaert, Petra De Sutter, Bjorn Heindryckx
REPRODUCTION FERTILITY AND DEVELOPMENT
(2018)
Review
Biochemistry & Molecular Biology
Delphine Hoorelbeke, Elke Decrock, Valerie Van Haver, Marijke De Bock, Luc Leybaert
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2018)
Review
Developmental Biology
Minerva Ferrer-Buitrago, Davina Bonte, Petra De Sutter, Luc Leybaert, Bjorn Heindryckx
Article
Immunology
Moises Freitas-Andrade, Nan Wang, John F. Bechberger, Marijke De Bock, Paul D. Lampe, Luc Leybaert, Christian C. Naus
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Review
Physiology
Christian Giaume, Christian C. Naus, Juan C. Saez, Luc Leybaert
Summary: Over the past few decades, research has shown that glial cells interact dynamically with neurons, impacting their activity and survival. Connexins and pannexins play a key role in these interactions, and understanding their function can provide insights into neuronal behavior and aid in the development of therapeutic strategies for brain diseases.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Alessio Lissoni, Nan Wang, Timur Nezlobinskii, Maarten De Smet, Alexander V. Panfilov, Nele Vandersickel, Luc Leybaert, Katja Witschas
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Raghda Ramadan, Sarah Baatout, An Aerts, Luc Leybaert
Summary: Radiation therapy is effective in treating breast cancer and other thoracic tumors, but can lead to secondary cardiovascular diseases due to radiation exposure of the heart and large arteries. Radiation-induced coronary artery atherosclerosis is a major cardiovascular complication in thoracic radiotherapy-treated patients, with complex biological and molecular mechanisms that are not fully understood. Ionizing radiation exposure can damage the vascular endothelium, leading to atherosclerosis through various mechanisms such as DNA damage, oxidative stress, cellular senescence, and inflammation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Laura Walrave, Mathieu Vinken, Luc Leybaert, Ilse Smolders
Correction
Biochemistry & Molecular Biology
Raghda Ramadan, Sarah Baatout, An Aerts, Luc Leybaert
Summary: A correction to this paper has been published.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Neurosciences
Steffi Schumacher, Hanane Tahiri, Pascal Ezan, Nathalie Rouach, Katja Witschas, Luc Leybaert
Summary: Therapeutic brain irradiation induces reorganization of astrocytic vesicular transport, leading to VEGF-A release and barrier leakage, and this process can be inhibited by targeting astrocyte connexin 43 (Cx43).
Article
Biochemistry & Molecular Biology
Alessio Lissoni, Siyu Tao, Rosalie Allewaert, Katja Witschas, Luc Leybaert
Summary: Cx43 hemichannels (HCs) and Panx1 channels, two genetically distant protein families, have been debated for their similarities in expression, membrane topology, and electrical properties. This study used mimetic peptides Gap19 and (10)Panx1 to investigate their cross-effects on Cx43 HCs and Panx1 channels. The results showed that Gap19 significantly inhibited Panx1 channels, while high concentrations of (10)Panx1 significantly reduced the activity of Cx43 HCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Luc Leybaert, Maarten A. J. De Smet, Alessio Lissoni, Rosalie Allewaert, H. Llewelyn Roderick, Geert Bultynck, Mario Delmar, Karin R. Sipido, Katja Witschas
Summary: This paragraph mainly discusses the role of connexins in cardiac function. Connexins form hemichannels and gap junctions, and gap junctions are responsible for transmitting electrical and chemical signals between myocardial cells and specialized conduction system cells to synchronize the cardiac cycle and control cardiac pump function. Under pathological conditions, gap junctions close and hemichannels open, leading to disruption of cardiac function and homeostasis. Current evidence shows that hemichannels play an emerging role in myocardial ischemia and arrhythmia, and there are now tools available to selectively inhibit hemichannels without inhibiting gap junctions, as well as to stimulate the incorporation of hemichannels into gap junctions. We review experimental evidence for the contribution of hemichannels to pro-arrhythmic events in ventricular and atrial cardiomyocytes, and link these findings to the molecular control of connexin-43-based hemichannel opening. We conclude that a double-edged approach of both preventing hemichannel opening and preserving gap junctional function will be crucial for further research and development of new connexin-based experimental approaches for treating heart disease.
JOURNAL OF CLINICAL INVESTIGATION
(2023)