Article
Biochemistry & Molecular Biology
Randy E. Strauss, Louisa Mezache, Rengasayee Veeraraghavan, Robert G. Gourdie
Summary: The alpha CT1 peptide, originally designed to inhibit Cx43/ZO1 interaction, was found to protect endothelium from thrombin-induced breakdown in cell-cell contacts by remodeling the F-actin cytoskeleton and promoting the border localization of endothelial barrier-associated proteins, suggesting a therapeutic potential in treating vascular edema.
Article
Biochemistry & Molecular Biology
Clare Rogerson, Duncan J. Wotherspoon, Cristina Tommasi, Robert W. Button, Ryan F. L. O'Shaughnessy
Summary: The study shows that the dispersal of phosphorylated Lamin A/C in differentiating keratinocytes is Akt1-dependent and involves the cytoskeletal proteins actin, Arp3, and Myh9. Disruption of actin filament polymerisation, nucleation, or myosin IIa activity prevents cytoplasmic Lamin A/C structure formation. Live imaging reveals a rapid nuclear volume reduction step before final destruction, dependent on Akt1 and cytoskeleton-associated proteins.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Dermatology
Ali Narangifard, Christian L. Wennberg, Lianne den Hollander, Ichiro Iwai, HongMei Han, Magnus Lundborg, Sergej Masich, Erik Lindahl, Bertil Daneholt, Lars Norlen
Summary: This study reveals two cryo-electron microscopy patterns representing intermediate stages in the skin lipid lamellae's maturation process, contributing to a tentative molecular model for the complete skin barrier formation process.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Dermatology
Yoshikazu Uchida, Kyungho Park
Summary: Ceramides play crucial roles in forming the epidermal permeability barrier and regulating cellular functions, with implications in various skin diseases. Dysregulation of ceramide metabolism is associated with disease pathogenesis, highlighting their therapeutic potential in treating skin disorders.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2021)
Review
Neurosciences
Jacob R. Mann, Christopher J. Donnelly
Summary: Aggregation of RNA-binding proteins is a pathological hallmark of neurodegenerative disorders like ALS and FTD. Recent studies suggest liquid-liquid phase separation may be a critical step in the formation of pathological inclusions. RNA, a common ligand of disease-linked RBPs, plays a crucial role in regulating RBP phase transitions, although it can also antagonize RBP phase behavior in certain conditions.
Article
Biodiversity Conservation
Ji Chen, Yong Zhang, Yakov Kuzyakov, Dong Wang, Jorgen Eivind Olesen
Summary: Soil microbiology has entered the era of big data, but faces challenges in integrating laboratory, field, and model-based studies. The limitations of laboratory experiments ignore the interactions of various environmental drivers, leading to discrepancies between laboratory and field studies. The upscaling of soil microbiology research from laboratory to ecosystems is a grand challenge with the potential to inform climate-smart and resource-efficient ecosystems. Understanding the gaps between laboratory and field studies and the issues in bridging observations and model predictions is crucial for interdisciplinary collaboration and knowledge advancement.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Cell Biology
Fang-Lei Duan, Hong Yang, Xiaojin Gong, Zuo Zuo, Sheng Qin, Juan Ji, Chengmin Zhou, Jie Dai, Peng Guo, Yang Liu
Summary: This study evaluated the clinicopathological features, immunophenotype, differential diagnosis, molecular genetic features, and prognosis of spindle cell rhabdomyosarcoma with TFCP2 rearrangement. Through histological observation, immunohistochemistry, fluorescence in-situ hybridization, and high-throughput gene sequencing, two cases of spindle cell rhabdomyosarcoma with FET::TFCP2 gene fusion were analyzed. The tumor tissues mainly consisted of spindle cells and epithelioid cells, expressing striated muscle markers and exhibiting high expression levels of CK and ALK protein markers. Molecular detection confirmed the fusion of the FET::TFCP2 gene. A rare case with a double fusion of TIMP3::ALK and FUS::TFCP2 was also observed. This study provides important information on the molecular characteristics of spindle cell rhabdomyosarcoma with FET::TFCP2 fusion, which is characterized by aggressive behavior, poor prognosis, and limited response to therapy. Further exploration of targeted therapy for ALK should be conducted through clinical studies.
Article
Biochemistry & Molecular Biology
Menachem Hanani, David C. Spray, Tian-Ying Huang
Summary: This study focused on age-related changes in dorsal root ganglia (DRG) neurons and satellite glial cells (SGCs) in mice. It was found that in aged mice, there was a higher level of coupling between DRG neurons and SGCs, and the membrane excitability of DRG neurons increased with age. These changes may be caused by low-grade inflammation associated with aging and contribute to pain behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Miao Liu, Yang Li, Le Sun, Ziyin Du, Wencheng Li, Lin Zhang, Jinniu Wang, Ji Chen
Summary: Based on the investigation of plant adaptive strategies across the Tibetan Plateau, it was found that plant functional traits increased with elevation, and the control of these traits was more stable in alpine meadows compared to alpine steppes.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Oncology
Peng Guo, Xinhua Wang, Luhua Xia, Nadiremu Shawureding, Zhiheng Hu
Summary: This study investigates the prognostic value of lymph node ratio (LNR) and preoperative thyroglobulin (Tg) in thyroid papillary carcinoma (PTC). The results suggest that LNR and preoperative Tg levels are significantly associated with the prognosis of PTC patients with lymph node metastasis.
Article
Agriculture, Multidisciplinary
Tong Heng, Cecilie Hermansen, Lis Wollesen de Jonge, Ji Chen, Lili Yang, Li Zhao, Xinlin He
Summary: Salinization poses a global threat to farmland sustainability in arid areas. This study examined the direct and indirect responses of soil physicochemical and microbial properties to soil nutrients in salinized farmlands in northwest China. It was found that soil urease activity, nitrogen-fixing genes, alkali hydrolyzable nitrogen, soil organic carbon, and microbial biomass nitrogen content were higher at low-salinity sites compared to medium and high-salinity sites. The study also showed that improving microbial metabolic activity through reclamation measures is crucial for salinity management.
AGRICULTURE ECOSYSTEMS & ENVIRONMENT
(2023)
Article
Agriculture, Multidisciplinary
Peng Wu, Fu Liu, Yongze Zhao, Yanqian Bai, Biao Feng, Yanyan Li, Weige Nan, Ji Chen, Tie Cai, Peng Zhang, Zhikuan Jia
Summary: Assessing the potential uptake of methane (CH4) in dryland farming and its contribution to global warming mitigation by understanding CH4 migration characteristics in the soil profile is crucial. In this study, we applied fertilizers at different soil depths (5, 15, 25, and 35 cm) before planting maize in the Loess Plateau region of China. Our results showed that the dryland soil acted as a sink for CH4, with a cumulative uptake of 1.54 kg ha-1 without fertilization. Fertilization inhibited CH4 uptake by the soil, but deep fertilization promoted its uptake. The highest CH4 uptake flux was observed at a soil depth of 25 cm. These findings provide valuable insights into CH4 production, consumption, diffusion, and uptake in dryland farming areas.
AGRICULTURE ECOSYSTEMS & ENVIRONMENT
(2023)
Article
Engineering, Chemical
Shaobo Yang, Qiufei Chen, Jie Liu, Peng Miao, Chunhua Wang, Peng Guo, Xiaoxu Wang
Summary: Large-tow carbon fibers have high production capacity and processing efficiency, but the heat accumulation within the bundle during the stabilization reaction affects process control and reduces product performance stability. The configuration of the filament bundle, such as tow size and tow spreading width, strongly influences the thermal behavior and structural transformation of the fibers during stabilization. The center temperature of large-tow bundles rises slowly due to poor heat conductivity, leading to significant structural heterogeneities within the bundle. A processing model is proposed for product quality assurance.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Immunology
Peng Guo, Han Yi, Mingming Han, Xinxin Liu, Kemin Chen, Jie Qing, Fengrui Yang
Summary: Dexmedetomidine protects myocardium from ischemia/reperfusion (I/R) injury by suppressing miR-34b-3p to activate Jagged1-mediated Notch signaling pathway. Our findings reveal a novel mechanism underlying the effects of Dex on myocardial I/R injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Roberta Fabbri, Diletta Spennato, Giorgia Conte, Aikaterini Konstantoulaki, Chiara Lazzarini, Emanuela Saracino, Grazia Paola Nicchia, Antonio Frigeri, Roberto Zamboni, David C. Spray, Valentina Benfenati
Summary: This article introduces the concept of Glioception and focuses on the process by which glial cells sense, interpret, and integrate information about the inner state of the organism. Glial cells act as sensors and integrators of various interoceptive signals, and they can trigger regulatory responses by modulating the activity of neuronal networks in both physiological and pathological conditions. Understanding and manipulating glioceptive processes and underlying molecular mechanisms are believed to be a key path for the development of new therapies for the prevention and alleviation of devastating interoceptive dysfunctions, with a particular emphasis on pain.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Pei-Jing Li, Shu-Zhen Lai, Ting Jin, Hang-Jie Ying, Ya-Mei Chen, Peng Zhang, Qing-Qing Hang, Huan Deng, Lei Wang, Jian-Guo Feng, Xiao-Zhong Chen, Peng Guo, Ming Chen, Ye Tian, Yuan-Yuan Chen
Summary: In this preclinical study, we found that radiotherapy combined with anlotinib could be a potential treatment for glioblastoma (GBM). Anlotinib effectively inhibits the JAK3/STAT3 pathway, slows down tumor growth, and induces apoptosis. It also sensitizes GBM cells to radiation and increases the distribution of anlotinib in the central nervous system by weakening the blood-brain barrier.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Liang Guo, Xiaowei Liu, Juha M. Alatalo, Chuanyao Wang, Jianchu Xu, Haiying Yu, Ji Chen, Qiang Yu, Changhui Peng, Junhu Dai, Eike Luedeling
Summary: This study provides an extensive synthesis of warming effects on flower-leaf time intervals in China. It reveals that while the timing of both leaf-out and flowering events has advanced due to warming, the inter-stage intervals between them remain relatively stable. However, some species show significant changes in these intervals, which can be explained by differences in temperature sensitivity and species type. These changes have important ecological and evolutionary consequences for species fitness and ecosystem dynamics.
Article
Computer Science, Cybernetics
Yiyu Bu, Peng Guo
Summary: Speech-based HCI, as a popular form of interaction, allows people to communicate verbally with machines. However, current speech-based HCI fails to comprehend deeper pointing information. This paper proposes Oriennet, which identifies the orientation of human voice with 95% accuracy in determining whether people are facing the device or not.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2023)
Article
Engineering, Electrical & Electronic
HaiFei Liu, Peng Guo, JianXin Liu, Rong Liu, TieGang Tong
Summary: The representation of spatial discrete data is crucial in various fields such as meteorology, agriculture, and geological exploration. The multiquadric (MQ) method is widely used for scattered data interpolation, but it has accuracy and efficiency limitations. This study proposes an algorithm that integrates the MQ method with trend surface analysis to overcome these limitations, and it is validated on synthetic and real-world datasets, showing improved efficiency and comparable accuracy to other methods.
IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING
(2023)
Article
Plant Sciences
Taiki Mori, Senhao Wang, Cong Wang, Ji Chen, Cheng Peng, Mianhai Zheng, Juan Huang, Faming Wang, Zhanfeng Liu, Jiangming Mo, Wei Zhang
Summary: Soil microorganisms in tropical forests can adapt to P-poor conditions by altering the activity ratios of different types of phosphatases. A 10-year P addition experiment was conducted in three tropical forests to test the effect on PME:PDE ratio. The results showed that long-term P addition did not alter the ratio in primary and secondary forests, but increased it in planted forests.
JOURNAL OF PLANT ECOLOGY
(2023)