Intercellular communication and ion channels in neuropathic pain chronicization

Neuromuscular Plasticity in a Mouse Neurotoxic Model of Spinal Motoneuronal Loss

(2019) Rosario Gulino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

(2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist

(2019) Lorella Pasquinucci et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain

(2019) Nunzio Vicario et al.   MOLECULAR NEUROBIOLOGY

Role of Connexins in Chronic Pain and Their Potential as Therapeutic Targets for Next-Generation Analgesics

(2019) Norimitsu Morioka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Voltage gated sodium channels as therapeutic targets for chronic pain

(2019) Renee Siu Yu Ma et al.   Journal of Pain Research

Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice

(2018) Ryan S. Tonkin et al.   EXPERIMENTAL NEUROLOGY

Inhibition of Connexin 43 and Phosphorylated NR2B in Spinal Astrocytes Attenuates Bone Cancer Pain in Mice

(2018) Hui Yang et al.   Frontiers in Cellular Neuroscience

NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury

(2018) Perrine Inquimbert et al.   Cell Reports

Evaluation of RGD functionalization in hybrid hydrogels as 3D neural stem cell culture systems

(2018) Emanuele Mauri et al.   Biomaterials Science

Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors

(2018) Shannon D. Shields et al.   JOURNAL OF NEUROSCIENCE

The role of spinal interleukin-1β and astrocyte connexin 43 in the development of mirror-image pain in an inflammatory pain model

(2017) Hoon-Seong Choi et al.   EXPERIMENTAL NEUROLOGY

Inhibition of Cx43 mediates protective effects on hypoxic/reoxygenated human neuroblastoma cells

(2017) Nunzio Vicario et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Carbon Monoxide-Releasing Molecule-2 Inhibits Connexin 43-Hemichannel Activity in Spinal Cord Astrocytes to Attenuate Neuropathic Pain

(2017) Hui Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Ion channels and neuronal hyperexcitability in chemotherapy-induced peripheral neuropathy

(2017) Kelly A Aromolaran et al.   Molecular Pain

Gap junctions, pannexins and pain

(2017) David C. Spray et al.   NEUROSCIENCE LETTERS

Inflammation in the pathophysiology of neuropathic pain

(2017) Claudia Sommer et al.   PAIN

Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets

(2017) Nunzio Vicario et al.   Frontiers in Physiology

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis

(2016) Akshata A. Almad et al.   GLIA

Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents

(2016) Ian A. Clark et al.   Journal of Neuroinflammation

Repeated activation of delta opioid receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain

(2016) Nunzio Vicario et al.   Molecular Pain

The Effectiveness and Risks of Long-Term Opioid Therapy for Chronic Pain: A Systematic Review for a National Institutes of Health Pathways to Prevention Workshop

(2015) Roger Chou et al.   ANNALS OF INTERNAL MEDICINE

Battle of the hemichannels – Connexins and Pannexins in ischemic brain injury

(2015) J.O. Davidson et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Dysregulation of Kv3.4 Channels in Dorsal Root Ganglia Following Spinal Cord Injury

(2015) D. M. Ritter et al.   JOURNAL OF NEUROSCIENCE

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

(2015) Nanna B Finnerup et al.   LANCET NEUROLOGY

The Role of Nav1.9 Channel in the Development of Neuropathic Orofacial Pain Associated with Trigeminal Neuralgia

(2015) Ana Paula Lulz et al.   Molecular Pain

Spinal astrocyte gap junction and glutamate transporter expression contributes to a rat model of bortezomib-induced peripheral neuropathy

(2015) C.R. Robinson et al.   NEUROSCIENCE

Emerging potassium channel targets for the treatment of pain

(2015) Christoforos Tsantoulas   Current Opinion in Supportive and Palliative Care

Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation

(2014) Mounir Belkouch et al.   Journal of Neuroinflammation

Basic Anatomy and Physiology of Pain Pathways

(2014) Sarah Bourne et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy

(2014) Simon Haroutounian et al.   PAIN

Chronic Neuropathic Pain in SCI

(2014) Elizabeth Roy Felix   Physical Medicine and Rehabilitation Clinics of North America

Functional Upregulation of Nav1.8 Sodium Channels on the Membrane of Dorsal Root Ganglia Neurons Contributes to the Development of Cancer-Induced Bone Pain

(2014) Xiao-Dan Liu et al.   PLoS One

Peripheral input and its importance for central sensitization

(2013) Ralf Baron et al.   ANNALS OF NEUROLOGY

Pharmacological Inhibition of Voltage-gated Ca2+ Channels for Chronic Pain Relief

(2013) Bentham Science Publisher Bentham Science Publisher   Current Neuropharmacology

Kv2 dysfunction after peripheral axotomy enhances sensory neuron responsiveness to sustained input

(2013) Christoforos Tsantoulas et al.   EXPERIMENTAL NEUROLOGY

Cognitive and emotional control of pain and its disruption in chronic pain

(2013) M. Catherine Bushnell et al.   NATURE REVIEWS NEUROSCIENCE

The glutamatergic system as a target for neuropathic pain relief

(2012) Maria Osikowicz et al.   EXPERIMENTAL PHYSIOLOGY

Expression of Nav1.7 in DRG Neurons Extends from Peripheral Terminals in the Skin to Central Preterminal Branches and Terminals in the Dorsal Horn

(2012) Joel A Black et al.   Molecular Pain

Role of Astrocytes in Pain

(2012) C.-Y. Chiang et al.   NEUROCHEMICAL RESEARCH

T-type voltage-gated calcium channels as targets for the development of novel pain therapies

(2011) Slobodan M Todorovic et al.   BRITISH JOURNAL OF PHARMACOLOGY

Purinergic system, microglia and neuropathic pain

(2011) Makoto Tsuda et al.   CURRENT OPINION IN PHARMACOLOGY

Neuronal Hyperexcitability: A Substrate for Central Neuropathic Pain After Spinal Cord Injury

(2011) Young Seob Gwak et al.   Current Pain and Headache Reports

Role of gap junctions in chronic pain

(2011) Ann Wu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

GABA and central neuropathic pain following spinal cord injury

(2011) Young S. Gwak et al.   NEUROPHARMACOLOGY

The Roles of Sodium Channels in Nociception: Implications for Mechanisms of Neuropathic Pain

(2011) Min Liu et al.   PAIN MEDICINE

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Calcium channel functions in pain processing

(2010) John Park et al.   Channels

Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

(2009) Michael Costigan et al.   Annual Review of Neuroscience

Pregabalin in the Treatment of Chronic Pain

(2009) S. Chiechio et al.   CLINICAL DRUG INVESTIGATION

Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels

(2009) Juan A. Orellana et al.   GLIA

Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons

(2009) X. X. Chi et al.   JOURNAL OF CELL SCIENCE

The Increased Trafficking of the Calcium Channel Subunit  2 -1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the  2  Ligand Pregabalin

(2009) C. S. Bauer et al.   JOURNAL OF NEUROSCIENCE

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Physiological and pathological functions of P2X7 receptor in the spinal cord

(2009) Maria Luisa Cotrina et al.   Purinergic Signalling

Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration

(2008) Juan A. Orellana et al.   ANTIOXIDANTS & REDOX SIGNALING

Gliopathy ensures persistent inflammation and chronic pain after spinal cord injury

(2008) Claire E. Hulsebosch   EXPERIMENTAL NEUROLOGY

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE

Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury

(2008) Michael Cronin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE