Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer’s Disease, ALS, and Harmful Stress Conditions

Amyotrophic Lateral Sclerosis, Neuroinflammation, and Cromolyn

(2020) Theoharis C. Theoharides et al.   CLINICAL THERAPEUTICS

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice

(2020) Nur Jury et al.   Clinical Epigenetics

The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

(2020) Yevgeniya A. Abramzon et al.   Frontiers in Neuroscience

Glial connexins and pannexins in the healthy and diseased brain

(2020) Christian BA Giaume et al.   PHYSIOLOGICAL REVIEWS

Effects of Chronic Masitinib Treatment in APPPS1dE9 Transgenic Mice Modeling Alzheimer’s Disease

(2020) Tengfei Li et al.   JOURNAL OF ALZHEIMERS DISEASE

The interplay between α7 nicotinic acetylcholine receptors, pannexin‐1 channels and P2X7 receptors elicit exocytosis in chromaffin cells

(2020) María C. Maldifassi et al.   JOURNAL OF NEUROCHEMISTRY

Stretch-Induced Activation of Pannexin 1 Channels Can Be Prevented by PKA-Dependent Phosphorylation

(2020) Ximena López et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neurotransmitter and neuropeptide regulation of mast cell function: a systematic review

(2020) Huaping Xu et al.   Journal of Neuroinflammation

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

(2019) Angelique di Domenico et al.   Stem Cell Reports

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

(2019) André Varcianna et al.   EBioMedicine

Anaphylactic Degranulation of Mast Cells: Focus on Compound Exocytosis

(2019) Ofir Klein et al.   Journal of Immunology Research

Connexin Hemichannels in Astrocytes: Role in CNS Disorders

(2019) LingYan Xing et al.   Frontiers in Molecular Neuroscience

Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders?

(2019) Theoharis C. Theoharides et al.   Expert Review of Clinical Immunology

Mast Cells in Neurodegenerative Disease

(2019) Michael K. Jones et al.   Frontiers in Cellular Neuroscience

New insights on the disease contribution of neuroinflammation in amyotrophic lateral sclerosis

(2019) Aude Chiot et al.   CURRENT OPINION IN NEUROLOGY

Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial

(2019) Jesus S. Mora et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Cromolyn sodium delays disease onset and is neuroprotective in the SOD1G93A Mouse Model of amyotrophic lateral sclerosis

(2019) Eric J. Granucci et al.   Scientific Reports

Pannexin-1 Channels Are Essential for Mast Cell Degranulation Triggered During Type I Hypersensitivity Reactions

(2019) Paloma A. Harcha et al.   Frontiers in Immunology

Schwann cells orchestrate peripheral nerve inflammation through the expression of CSF1, IL‐34, and SCF in amyotrophic lateral sclerosis

(2019) Emiliano Trias et al.   GLIA

Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity

(2019) Anastasya Birger et al.   EBioMedicine

Diverse exocytic pathways for mast cell mediators

(2018) Hao Xu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Gap junction gene and protein families: Connexins, innexins, and pannexins

(2018) Eric C. Beyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

New roles and controls of mast cells

(2018) Eric Espinosa et al.   CURRENT OPINION IN IMMUNOLOGY

Astroglial Connexins as a Therapeutic Target for Alzheimer's Disease

(2018) Chenju Yi et al.   CURRENT PHARMACEUTICAL DESIGN

Non-IgE mediated mast cell activation

(2018) Frank A. Redegeld et al.   IMMUNOLOGICAL REVIEWS

Mast cells as sources of cytokines, chemokines, and growth factors

(2018) Kaori Mukai et al.   IMMUNOLOGICAL REVIEWS

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

(2018) Stephen D. Skaper et al.   Frontiers in Cellular Neuroscience

Mast cells as protectors of health

(2018) Anne Dudeck et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease

(2017) Chenju Yi et al.   GLIA

αVβ3 Integrin regulates astrocyte reactivity

(2017) Raúl Lagos-Cabré et al.   Journal of Neuroinflammation

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

(2017) Carolina Cunha et al.   MOLECULAR NEUROBIOLOGY

Amyloid β Peptides Trigger CD47-Dependent Mast Cell Secretory and Phagocytic Responses

(2017) N. Niederhoffer et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Corticotropin-Releasing Hormone, Microglia and Mental Disorders

(2017) S.K. Kritas et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

P2X7-pannexin-1 and amyloid β-induced oxysterol input in human retinal cell: Role in age-related macular degeneration?

(2016) Elodie Olivier et al.   BIOCHIMIE

Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer’s disease

(2016) C Yi et al.   CELL DEATH AND DIFFERENTIATION

High glucocorticoid levels during gestation activate the inflammasome in hippocampal oligodendrocytes of the offspring

(2016) Carola J. Maturana et al.   Developmental Neurobiology

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

(2016) A. Verkhratsky et al.   EMBO JOURNAL

Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis

(2016) Akshata A. Almad et al.   GLIA

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

(2016) Emiliano Trias et al.   Journal of Neuroinflammation

FGF-1 Triggers Pannexin-1 Hemichannel Opening in Spinal Astrocytes of Rodents and Promotes Inflammatory Responses in Acute Spinal Cord Slices

(2016) J. M. Garre et al.   JOURNAL OF NEUROSCIENCE

Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP

(2016) Y. Hong et al.   JOURNAL OF NEUROSCIENCE

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Next-Generation Connexin and Pannexin Cell Biology

(2016) Jessica L. Esseltine et al.   TRENDS IN CELL BIOLOGY

Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions

(2016) Rosario Gajardo-Gómez et al.   Frontiers in Molecular Neuroscience

Masitinib for the treatment of mild to moderate Alzheimer’s disease

(2015) Jaume Folch et al.   Expert Review of Neurotherapeutics

Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes

(2015) Verónica Abudara et al.   GLIA

Hemichannels Are Required for Amyloid  -Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice

(2015) P. A. Harcha et al.   JOURNAL OF NEUROSCIENCE

C-kit is important for SOD1G93A mouse survival independent of mast cells

(2015) K.A. Staats et al.   NEUROSCIENCE

Restraint stress increases hemichannel activity in hippocampal glial cells and neurons

(2015) Juan A. Orellana et al.   Frontiers in Cellular Neuroscience

Astrocytes in Neurodegenerative Disease: Table 1.

(2015) Hemali Phatnani et al.   Cold Spring Harbor Perspectives in Biology

The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis

(2015) Burcin Ikiz et al.   Cell Reports

Masitinib for the treatment of mild to moderate Alzheimer’s disease

(2015) Jaume Folch et al.   Expert Review of Neurotherapeutics

Role of Connexin/Pannexin containing channels in infectious diseases

(2014) Eliseo A. Eugenin   FEBS LETTERS

Hunting for connexin hemichannels

(2014) Juan C. Sáez et al.   FEBS LETTERS

Mechanosensitive release of adenosine 5′-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A mechanism for purinergic involvement in chronic strain

(2014) Jonathan M. Beckel et al.   GLIA

Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model

(2014) Yiwen Cui et al.   Journal of Neuroinflammation

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

(2014) Benjamin D. McNeil et al.   NATURE

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

(2014) Diane B. Re et al.   NEURON

Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases

(2014) Hideyuki Takeuchi et al.   Frontiers in Cellular Neuroscience

Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress

(2014) Fabiola Rojas et al.   Frontiers in Cellular Neuroscience

Vesicular Trafficking and Signaling for Cytokine and Chemokine Secretion in Mast Cells

(2014) Ulrich Blank et al.   Frontiers in Immunology

Mast Cell Mediators: Their Differential Release and the Secretory Pathways Involved

(2014) Tae Chul Moon et al.   Frontiers in Immunology

Effect of stress on brain inflammation and multiple sclerosis

(2013) Anna Karagkouni et al.   AUTOIMMUNITY REVIEWS

Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability

(2013) Elsa Fritz et al.   JOURNAL OF NEUROPHYSIOLOGY

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

The epidemiology of ALS: a conspiracy of genes, environment and time

(2013) Ammar Al-Chalabi et al.   Nature Reviews Neurology

The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels

(2013) Manuel A. Riquelme et al.   NEUROPHARMACOLOGY

Pannexin1 Channel Proteins in the Zebrafish Retina Have Shared and Unique Properties

(2013) Sarah Kurtenbach et al.   PLoS One

Ionotropic receptors and ion channels in ischemic neuronal death and dysfunction

(2012) Nicholas L Weilinger et al.   ACTA PHARMACOLOGICA SINICA

Paracrine signaling through plasma membrane hemichannels

(2012) Nan Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study

(2012) Patrick Vermersch et al.   BMC Neurology

Microenvironmental regulation of inducible nitric oxide synthase expression and nitric oxide production in mouse bone marrow-derived mast cells

(2012) T. C. Moon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Anoxia-Induced NMDA Receptor Activation Opens Pannexin Channels via Src Family Kinases

(2012) N. L. Weilinger et al.   JOURNAL OF NEUROSCIENCE

The SNARE Machinery in Mast Cell Secretion

(2012) Axel Lorentz et al.   Frontiers in Immunology

Glial connexin expression and function in the context of Alzheimer's disease

(2011) Annette Koulakoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Modulatory effects of connexin-43 expression on gap junction intercellular communications with mast cells and fibroblasts

(2011) Ashley L. Pistorio et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease

(2011) Hideyuki Takeuchi et al.   PLoS One

Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

(2011) P. Diaz-Amarilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity

(2011) Feng Qiu et al.   Purinergic Signalling

Cerebral Mast Cells Mediate Blood-Brain Barrier Disruption in Acute Experimental Ischemic Stroke Through Perivascular Gelatinase Activation

(2011) Olli S. Mattila et al.   STROKE

Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial

(2011) François Piette et al.   Alzheimers Research & Therapy

Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice

(2010) A. Florence Keller et al.   EXPERIMENTAL NEUROLOGY

Meningeal Mast Cells Affect Early T Cell Central Nervous System Infiltration and Blood-Brain Barrier Integrity through TNF: A Role for Neutrophil Recruitment?

(2010) B. A. Sayed et al.   JOURNAL OF IMMUNOLOGY

IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients

(2010) Milan Fiala et al.   Journal of Neuroinflammation

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice

(2010) X. Mei et al.   NEUROSCIENCE

Pannexins, distant relatives of the connexin family with specific cellular functions?

(2009) Catheleyne D'hondt et al.   BIOESSAYS

Activation of CD47 receptors causes histamine secretion from mast cells

(2009) E. Sick et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The potassium channel subunit Kvβ3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials

(2009) Stefanie Bunse et al.   FEBS Journal

IgE-FcεRI Interactions Determine HIV Coreceptor Usage and Susceptibility to Infection during Ontogeny of Mast Cells

(2009) J. Bruce Sundstrom et al.   JOURNAL OF IMMUNOLOGY

Microglial VEGF Receptor Response Is an Integral Chemotactic Component in Alzheimer's Disease Pathology

(2009) J. K. Ryu et al.   JOURNAL OF NEUROSCIENCE

Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

(2009) Patrice Dubreuil et al.   PLoS One

P2X7 receptor-Pannexin1 complex: pharmacology and signaling

(2008) R. Iglesias et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP

(2008) Feng Qiu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

IgE-induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors

(2008) Natsuko Kageyama-Yahara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mast cells populations fluctuate along the spinal dura mater of the developing rat

(2008) Helen Michaloudi et al.   BRAIN RESEARCH

Acute Effects of Calvarial Damage on Dural Mast Cells, Pial Vascular Permeability, and Cerebral Cortical Histamine Levels in Rats and Mice

(2008) Martha E. Stokely et al.   JOURNAL OF NEUROTRAUMA

Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms

(2008) N. Puri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropeptides activate human mast cell degranulation and chemokine production

(2007) Marianna Kulka et al.   IMMUNOLOGY