The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance
出版年份 2020 全文链接
标题
The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance
作者
关键词
-
出版物
Cancers
Volume 12, Issue 10, Pages 2860
出版商
MDPI AG
发表日期
2020-10-05
DOI
10.3390/cancers12102860
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Integrin Signaling in Glioma Pathogenesis: From Biology to Therapy
- (2020) Aleksandra Ellert-Miklaszewska et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
- (2020) Pearl Lee et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Dissecting the role of crosstalk between glioblastoma subpopulations in tumor cell spreading
- (2020) Maria R. Jubran et al. Oncogenesis
- Involvement of the Gap Junction Protein, Connexin43, in the Formation and Function of Invadopodia in the Human U251 Glioblastoma Cell Line
- (2020) Amandine Chepied et al. Cells
- Accelerator-based boron neutron capture therapy for malignant glioma: a pilot neutron irradiation study using boron phenylalanine, sodium borocaptate and liposomal borocaptate with a heterotopic U87 glioblastoma model in SCID mice
- (2020) Evgenii Zavjalov et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions
- (2020) Patrick Y Wen et al. NEURO-ONCOLOGY
- Increased expression of connexin 43 in a mouse model of spinal motoneuronal loss
- (2020) Federica Maria Spitale et al. Aging-US
- Intercellular communication and ion channels in neuropathic pain chronicization
- (2020) Nunzio Vicario et al. INFLAMMATION RESEARCH
- SRC Tyrosine Kinase Inhibitor and X-rays Combined Effect on Glioblastoma Cell Lines
- (2020) Filippo Torrisi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeting the DNA Damage Response to Overcome Cancer Drug Resistance in Glioblastoma
- (2020) Alessandra Ferri et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance
- (2020) Silvia Valtorta et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- SRC Kinase in Glioblastoma: News from an Old Acquaintance
- (2020) Claudia Cirotti et al. Cancers
- Kill painting of hypoxic tumors with multiple ion beams
- (2019) Olga Sokol et al. PHYSICS IN MEDICINE AND BIOLOGY
- PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity
- (2019) Shiv K. Gupta et al. Frontiers in Oncology
- Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation
- (2019) Mutsuko Minata et al. Cell Reports
- The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts
- (2019) Mansour Alsaleem et al. MODERN PATHOLOGY
- An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
- (2019) Cyril Neftel et al. CELL
- A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor
- (2019) Anna Lucia Fallacara et al. Cancers
- Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line
- (2019) Francesco P Cammarata et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- ACTR-24. A RANDOMIZED PHASE II TRIAL OF VELIPARIB (V), RADIOTHERAPY (RT) AND TEMOZOLOMIDE (TMZ) IN PATIENTS (PTS) WITH UNMETHYLATED MGMT (uMGMT) GLIOBLASTOMA (GBM): THE VERTU STUDY
- (2019) Mustafa Khasraw et al. NEURO-ONCOLOGY
- Survival benefits of hypofractionated radiotherapy combined with temozolomide or temozolomide plus bevacizumab in elderly patients with glioblastoma aged ≥ 75 years
- (2019) Makoto Ohno et al. Radiation Oncology
- Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway
- (2019) Pauline Deshors et al. Cell Death & Disease
- Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response
- (2019) Shamir Cassim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells
- (2018) Catherine J. Libby et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- A Study of the Focal Adhesion Kinase Inhibitor GSK2256098 in Patients with Recurrent Glioblastoma with Evaluation of Tumor Penetration of [11C]GSK2256098
- (2018) Nicholas F Brown et al. NEURO-ONCOLOGY
- Proinvasive extracellular matrix remodeling in tumor microenvironment in response to radiation
- (2018) Ki-Chun Yoo et al. ONCOGENE
- Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies
- (2018) Zhenyi An et al. ONCOGENE
- First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness
- (2018) G. A. P. Cirrone et al. Scientific Reports
- MerTK mediates STAT3–KRAS/SRC-signaling axis for glioma stem cell maintenance
- (2018) Hyojin Eom et al. Artificial Cells Nanomedicine and Biotechnology
- Human Glioma Migration and Infiltration Properties as a Target for Personalized Radiation Medicine
- (2018) Michaela Wank et al. Cancers
- EGFR and EGFRvIII Promote Angiogenesis and Cell Invasion in Glioblastoma: Combination Therapies for an Effective Treatment
- (2017) Stefanie Keller et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inhibition of Cx43 mediates protective effects on hypoxic/reoxygenated human neuroblastoma cells
- (2017) Nunzio Vicario et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- In Vivo Relationship Between Hypoxia and Angiogenesis in Human Glioblastoma: A Multimodal Imaging Study
- (2017) Keven Ferreira da Ponte et al. JOURNAL OF NUCLEAR MEDICINE
- Role of AHR and HIF-1α in Glioblastoma Metabolism
- (2017) Galina Gabriely et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Interest of integrins targeting in glioblastoma according to tumor heterogeneity and cancer stem cell paradigm: an update
- (2017) Laure Malric et al. Oncotarget
- Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes hypoxia-induced glioma migration and invasion
- (2017) Yangyang Xu et al. Oncotarget
- The Role of Hypoxia in Glioblastoma Invasion
- (2017) Ana Monteiro et al. Cells
- The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
- (2016) David N. Louis et al. ACTA NEUROPATHOLOGICA
- Hypoxic tumor microenvironment: Opportunities to develop targeted therapies
- (2016) Akhil Patel et al. BIOTECHNOLOGY ADVANCES
- Myc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma
- (2016) K. Tateishi et al. CLINICAL CANCER RESEARCH
- Caspase-8 expression and its Src-dependent phosphorylation on Tyr380 promote cancer cell neoplastic transformation and resistance to anoikis
- (2016) G. Fianco et al. EXPERIMENTAL CELL RESEARCH
- Imaging of brain oxygenation with magnetic resonance imaging: A validation with positron emission tomography in the healthy and tumoural brain
- (2016) Samuel Valable et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells
- (2016) Alessia Calgani et al. MOLECULAR CANCER THERAPEUTICS
- Boron Neutron Capture Therapy for Malignant Brain Tumors
- (2016) Shin-Ichi MIYATAKE et al. NEUROLOGIA MEDICO-CHIRURGICA
- Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin
- (2016) Timothy P. Kegelman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glioblastoma multiforme: Effect of hypoxia and hypoxia inducible factors on therapeutic approaches
- (2016) Wen-Juan Huang et al. Oncology Letters
- Standards and Methodologies for Characterizing Radiobiological Impact of High-Z Nanoparticles
- (2016) Anna Subiel et al. Theranostics
- Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α–ZEB1 axis
- (2015) Justin V. Joseph et al. CANCER LETTERS
- Effects of indirect actions and oxygen on relative biological effectiveness: estimate of DSB induction and conversion induced by gamma rays and helium ions
- (2015) Ju-Ying Tsai et al. JOURNAL OF RADIATION RESEARCH
- Src family kinases differentially influence glioma growth and motility
- (2015) Laura J. Lewis-Tuffin et al. Molecular Oncology
- Phase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627)
- (2015) Andrew B. Lassman et al. NEURO-ONCOLOGY
- Cytotoxic and radiosensitizing effects of FAK targeting in human glioblastoma cells in vitro
- (2015) KATJA STORCH et al. ONCOLOGY REPORTS
- Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors
- (2015) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Effect of cancer-associated fibroblasts on the migration of glioma cells in vitro
- (2015) Jana Trylcova et al. TUMOR BIOLOGY
- EGFRvIII/integrin β3 interaction in hypoxic and vitronectinenriching microenvironment promote GBM progression and metastasis
- (2015) Zhaoyu Liu et al. Oncotarget
- Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe
- (2015) Elodie A. Pérès et al. Oncotarget
- Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection
- (2014) Julie A. Reisz et al. ANTIOXIDANTS & REDOX SIGNALING
- Radiation promotes malignant phenotypes through SRC in breast cancer cells
- (2014) Rae-Kwon Kim et al. CANCER SCIENCE
- The role of Src family kinases in growth and migration of glioma stem cells
- (2014) XIAOSI HAN et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Cilengitide treatment of newly diagnosed glioblastoma patients does not alter patterns of progression
- (2014) Günter Eisele et al. JOURNAL OF NEURO-ONCOLOGY
- Sustained Radiosensitization of Hypoxic Glioma Cells after Oxygen Pretreatment in an Animal Model of Glioblastoma and In Vitro Models of Tumor Hypoxia
- (2014) Ryon H. Clarke et al. PLoS One
- Ionizing Radiation and Glioblastoma Exosomes: Implications in Tumor Biology and Cell Migration
- (2014) W. Tris Arscott et al. Translational Oncology
- The prospective application of a hypoxic radiosensitizer, doranidazole to rat intracranial glioblastoma with blood brain barrier disruption
- (2013) Hironobu Yasui et al. BMC CANCER
- The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance
- (2013) Florian A. Siebzehnrubl et al. EMBO Molecular Medicine
- Radiobiological description of the LET dependence of the cell survival of oxic and anoxic cells irradiated by carbon ions
- (2013) L. Antonovic et al. JOURNAL OF RADIATION RESEARCH
- Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion
- (2013) Deborah Huveldt et al. PLoS One
- Inhibition of MMP14 potentiates the therapeutic effect of temozolomide and radiation in gliomas
- (2013) Ilya Ulasov et al. Cancer Medicine
- Ionizing Radiation in Glioblastoma Initiating Cells
- (2013) Maricruz Rivera et al. Frontiers in Oncology
- Imaging hypoxia in gliomas
- (2012) I Mendichovszky et al. BRITISH JOURNAL OF RADIOLOGY
- Phase 1 trial of dasatinib plus erlotinib in adults with recurrent malignant glioma
- (2012) David A. Reardon et al. JOURNAL OF NEURO-ONCOLOGY
- Involvement of connexin43 hemichannel in ATP release after -irradiation
- (2012) Y. Ohshima et al. JOURNAL OF RADIATION RESEARCH
- Active Efflux of Dasatinib from the Brain Limits Efficacy against Murine Glioblastoma: Broad Implications for the Clinical Use of Molecularly Targeted Agents
- (2012) S. Agarwal et al. MOLECULAR CANCER THERAPEUTICS
- EORTC 26083 phase I/II trial of dasatinib in combination with CCNU in patients with recurrent glioblastoma
- (2012) E. Franceschi et al. NEURO-ONCOLOGY
- Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury
- (2011) Edouard I. Azzam et al. CANCER LETTERS
- Directed cell invasion and migration during metastasis
- (2011) Jose Javier Bravo-Cordero et al. CURRENT OPINION IN CELL BIOLOGY
- Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma
- (2011) Olivier Keunen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Theoretical analysis of the dose dependence of the oxygen enhancement ratio and its relevance for clinical applications
- (2011) Tatiana Wenzl et al. Radiation Oncology
- Molecular Imaging–Based Dose Painting: A Novel Paradigm for Radiation Therapy Prescription
- (2011) Søren M. Bentzen et al. SEMINARS IN RADIATION ONCOLOGY
- Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
- (2010) Roel G.W. Verhaak et al. CANCER CELL
- Targeting SRC in glioblastoma tumors and brain metastases: Rationale and preclinical studies
- (2010) Manmeet S. Ahluwalia et al. CANCER LETTERS
- The Src Family of Protein Tyrosine Kinases: A New and Promising Target for Colorectal Cancer Therapy
- (2010) Christopher Lieu et al. Clinical Colorectal Cancer
- Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer
- (2010) Jun-Lin Guan IUBMB LIFE
- Effects of irradiation on tumor cell survival, invasion and angiogenesis
- (2010) Odysseas Kargiotis et al. JOURNAL OF NEURO-ONCOLOGY
- Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres
- (2010) Olga Méndez et al. Molecular Cancer
- Serum angiogenic profile of patients with glioblastoma identifies distinct tumor subtypes and shows that TIMP-1 is a prognostic factor
- (2010) M. Crocker et al. NEURO-ONCOLOGY
- Misregulated E-Cadherin Expression Associated with an Aggressive Brain Tumor Phenotype
- (2010) Laura J. Lewis-Tuffin et al. PLoS One
- The dual kinase complex FAK-Src as a promising therapeutic target in cancer
- (2010) Victoria Bolós OncoTargets and Therapy
- Expression of Integrin α6β1 Enhances Tumorigenesis in Glioma Cells
- (2009) Estelle Delamarre et al. AMERICAN JOURNAL OF PATHOLOGY
- Glioma Stem Cells: Not All Created Equal
- (2009) Howard A. Fine CANCER CELL
- v 3/ v 5 Integrins-FAK-RhoB: A Novel Pathway for Hypoxia Regulation in Glioblastoma
- (2009) N. Skuli et al. CANCER RESEARCH
- Adhesion signaling - crosstalk between integrins, Src and Rho
- (2009) S. Huveneers et al. JOURNAL OF CELL SCIENCE
- Low expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in glioblastoma predicts longer patient survival
- (2009) Charlotte Aaberg-Jessen et al. JOURNAL OF NEURO-ONCOLOGY
- The Role of Src in Solid Tumors
- (2009) D. L. Wheeler et al. ONCOLOGIST
- Paxillin comes of age
- (2008) N. O. Deakin et al. JOURNAL OF CELL SCIENCE
- Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2
- (2008) Fusun Baumann et al. NEURO-ONCOLOGY
- Cadherins and cancer: how does cadherin dysfunction promote tumor progression?
- (2008) A Jeanes et al. ONCOGENE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started