A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders

Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS

(2021) Wouter J. Peyrot et al.   NATURE GENETICS

Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes

(2021) Jeremy Schwartzentruber et al.   NATURE GENETICS

GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression

(2021) Yeda Wu et al.   Nature Communications

Genetic evidence for different adiposity phenotypes and their opposing influence on ectopic fat and risk of cardiometabolic disease

(2021) Susan Martin et al.   DIABETES

Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett’s oesophagus and provides insights into clinical heterogeneity in reflux diagnosis

(2021) Jue-Sheng Ong et al.   GUT

Parkinson mice show functional and molecular changes in the gut long before motoric disease onset

(2021) Manuela Gries et al.   Molecular Neurodegeneration

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

(2021) Douglas P. Wightman et al.   NATURE GENETICS

A review of the mechanisms underlying selected comorbidities in Alzheimer’s disease

(2021) Karolina Maciejewska et al.   Pharmacological Reports

Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways

(2021) E O Adewuyi et al.   HUMAN REPRODUCTION

No Association Linking Short-Term Proton Pump Inhibitor Use to Dementia

(2020) Muhammad Ali Khan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Lipids and Alzheimer’s Disease

(2020) Yu-Chia Kao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alzheimer’s disease and gastrointestinal microbiota; impact of Helicobacter pylori infection involvement

(2020) Michael Doulberis et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Reciprocal association between depression and peptic ulcers: Two longitudinal follow-up studies using a national sample cohort

(2020) So Young Kim et al.   Scientific Reports

Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity

(2020) Emmanuel O. Adewuyi et al.   Genes

Phosphodiesterase 4B: Master Regulator of Brain Signaling

(2020) Amy J. Tibbo et al.   Cells

Genome‐wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology

(2020) Kwangsik Nho et al.   Alzheimers & Dementia

Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study

(2020) Bing Zhang et al.   GUT

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

(2020) Tiantian Guo et al.   Molecular Neurodegeneration

Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality

(2020) Emmanuel O. Adewuyi et al.   HUMAN GENETICS

Acid suppressants use and the risk of dementia: A population-based propensity score-matched cohort study

(2020) Chia-Liang Wu et al.   PLoS One

Association between serum cholesterol levels and Alzheimer’s disease in China: a case-control study

(2019) Hui Chen et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap

(2019) Jüri Reimand et al.   Nature Protocols

Brain-Gut-Microbiota Axis in Alzheimer’s Disease

(2019) Karol Kowalski et al.   Journal of Neurogastroenterology and Motility

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

(2019) Philip R. Jansen et al.   NATURE GENETICS

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

(2019) Uku Raudvere et al.   NUCLEIC ACIDS RESEARCH

A global overview of pleiotropy and genetic architecture in complex traits

(2019) Kyoko Watanabe et al.   NATURE GENETICS

Helicobacter pylori eradication increases the serum high density lipoprotein cholesterol level in the infected patients with chronic gastritis: A single-center observational study

(2019) Naoto Iwai et al.   PLoS One

The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer's Disease—A Review

(2019) Annelien C van den Brink et al.   Advances in Nutrition

Proton pump inhibitors use and dementia risk: a meta-analysis of cohort studies

(2019) Yun Zhang et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases

(2019) Jiyuan An et al.   Nature Communications

Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

(2018) Carolina Pellegrini et al.   ACTA NEUROPATHOLOGICA

A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence

(2018) W. D. Hill et al.   MOLECULAR PSYCHIATRY

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

(2018) James J. Lee et al.   NATURE GENETICS

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

(2018) Gail Davies et al.   Nature Communications

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease

(2018) Ahmed Moustafa et al.   Clinical and Translational Gastroenterology

Linking CD1-Restricted T Cells With Autoimmunity and Dyslipidemia: Lipid Levels Matter

(2018) Sreya Bagchi et al.   Frontiers in Immunology

The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms

(2018) Bob G. Schultz et al.   Translational Neurodegeneration

Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer’s Disease Development

(2018) Changan Liu et al.   Frontiers in Genetics

Statins and gastroduodenal endoscopic lesions

(2018) Monica Pantea et al.   MEDICINE

Distinguishing genetic correlation from causation across 52 diseases and complex traits

(2018) Luke J. O’Connor et al.   NATURE GENETICS

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases

(2018) Heng Li et al.   Frontiers in Pharmacology

Coexistence of Multiple Sclerosis and Alzheimer's disease: A review

(2018) Pauline Luczynski et al.   Multiple Sclerosis and Related Disorders

PDE4 Inhibition and Inflammatory Bowel Disease: A Novel Therapeutic Avenue

(2017) Marco Spadaccini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Gut Microbiota and Alzheimer’s Disease

(2017) Chunmei Jiang et al.   JOURNAL OF ALZHEIMERS DISEASE

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

(2017) Katrina M de Lange et al.   NATURE GENETICS

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Statin Therapy Is Associated with Reduced Risk of Peptic Ulcer Disease in the Taiwanese Population

(2017) Chun-Jung Lin et al.   Frontiers in Pharmacology

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Mendelian Randomization as an Approach to Assess Causality Using Observational Data

(2016) P. Sekula et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genome-wide association study identifies 74 loci associated with educational attainment

(2016) Aysu Okbay et al.   NATURE

The effect of host genetics on the gut microbiome

(2016) Marc Jan Bonder et al.   NATURE GENETICS

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Association of Proton Pump Inhibitors With Risk of Dementia

(2016) Willy Gomm et al.   JAMA Neurology

Irritable Bowel Syndrome Is Associated with an Increased Risk of Dementia: A Nationwide Population-Based Study

(2016) Chien-Hua Chen et al.   PLoS One

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

(2015) G Davies et al.   MOLECULAR PSYCHIATRY

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Gastritis May Boost Odds of Dementia

(2014) Yadollah Abolfathi Momtaz et al.   American Journal of Alzheimers Disease and Other Dementias

SECA: SNP effect concordance analysis using genome-wide association summary results

(2014) Dale R. Nyholt   BIOINFORMATICS

PDE4 as a target for cognition enhancement

(2013) Wito Richter et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Identification of Genetic Loci Associated With Helicobacter pylori Serologic Status

(2013) Julia Mayerle et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

The Proton-Pump Inhibitor Lansoprazole Enhances Amyloid Beta Production

(2013) Nahuai Badiola et al.   PLoS One

Randomised clinical trial: simvastatin as adjuvant therapy improves significantly the Helicobacter pylori eradication rate - a placebo-controlled study

(2012) W. Nseir et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Role of theHelicobacter pylori-Induced inflammatory response in the development of gastric cancer

(2012) Acacia Lamb et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Random-Effects Model Aimed at Discovering Associations in Meta-Analysis of Genome-wide Association Studies

(2011) Buhm Han et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Complement Regulator CD46 Is Bactericidal to Helicobacter pylori and Blocks Urease Activity

(2011) Rahma Basmarke–Wehelie et al.   GASTROENTEROLOGY

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Therapeutic potential of lipase inhibitor orlistat in Alzheimer’s disease

(2009) Jing Du et al.   MEDICAL HYPOTHESES