A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

The Genetic Architecture of Human Complex Phenotypes is Modulated by Linkage Disequilibrium and Heterozygosity

(2021) Dominic Holland et al.   GENETICS

Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes

(2021) Jeremy Schwartzentruber et al.   NATURE GENETICS

A map of transcriptional heterogeneity and regulatory variation in human microglia

(2021) Adam M. H. Young et al.   NATURE GENETICS

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

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Quantifying genetic effects on disease mediated by assayed gene expression levels

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Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses

(2020) Chris Wallace   PLoS Genetics

A simple new approach to variable selection in regression, with application to genetic fine mapping

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Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer’s and Parkinson’s diseases

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Shifting paradigms: The central role of microglia in Alzheimer's disease

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Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture

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Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

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A modular analysis of microglia gene expression, insights into the aged phenotype

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An update on genetic frontotemporal dementia

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Genome Wide Association Study and Next Generation Sequencing: A Glimmer of Light Toward New Possible Horizons in Frontotemporal Dementia Research

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Genetic mapping of cell type specificity for complex traits

(2019) Kyoko Watanabe et al.   Nature Communications

The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion

(2019) Zeran Li et al.   ACTA NEUROPATHOLOGICA

The neuropathological diagnosis of Alzheimer’s disease

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Conserved cell types with divergent features in human versus mouse cortex

(2019) Rebecca D. Hodge et al.   NATURE

Mapping the Mouse Cell Atlas by Microwell-Seq

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A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex

(2018) Suijuan Zhong et al.   NATURE

Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response

(2018) Kaur Alasoo et al.   NATURE GENETICS

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

(2018) Andrew E. Jaffe et al.   NATURE NEUROSCIENCE

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

(2018) Yukihide Momozawa et al.   Nature Communications

A transcriptomic atlas of aged human microglia

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GWAS on family history of Alzheimer’s disease

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Inhibiting amyloid-ß cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design

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Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure

(2018) Christiaan A. de Leeuw et al.   Nature Communications

A Systematic Review and Meta-Analysis on the Prevalence of Dementia in Europe: Estimates from the Highest-Quality Studies Adopting the DSM IV Diagnostic Criteria

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Comprehensive functional genomic resource and integrative model for the human brain

(2018) Daifeng Wang et al.   SCIENCE

Systematic Analysis and Biomarker Study for Alzheimer’s Disease

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TNIP1 in Autoimmune Diseases: Regulation of Toll-like Receptor Signaling

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Leukocyte immunoglobulin-like receptors in human diseases: an overview of their distribution, function, and potential application for immunotherapies

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Case–control association mapping by proxy using family history of disease

(2017) Jimmy Z Liu et al.   NATURE GENETICS

Molecular and functional variation in iPSC-derived sensory neurons

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Massively parallel single-nucleus RNA-seq with DroNc-seq

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An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

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DrugBank 5.0: a major update to the DrugBank database for 2018

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Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Massively parallel digital transcriptional profiling of single cells

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C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis

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Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells

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Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

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Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice

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STRT-seq-2i: dual-index 5ʹ single cell and nucleus RNA-seq on an addressable microwell array

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LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

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Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

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Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens

(2016) Yohann Nédélec et al.   CELL

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

(2016) Hélène Quach et al.   CELL

Defeating Alzheimer's disease and other dementias: a priority for European science and society

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Identification of context-dependent expression quantitative trait loci in whole blood

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Gene expression elucidates functional impact of polygenic risk for schizophrenia

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A novel Alzheimer disease locus located near the gene encoding tau protein

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Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

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Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

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A survey of human brain transcriptome diversity at the single cell level

(2015) Spyros Darmanis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic modulators of gene expression in human neutrophils

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MAGMA: Generalized Gene-Set Analysis of GWAS Data

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UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

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The Molecular Signatures Database Hallmark Gene Set Collection

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Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins

(2014) Alfonso Buil et al.   NATURE GENETICS

Genetic variability in the regulation of gene expression in ten regions of the human brain

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Quality control and conduct of genome-wide association meta-analyses

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Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

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Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia

(2014) Fargol Mazaheri et al.   Nature Communications

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Sequence Kernel Association Tests for the Combined Effect of Rare and Common Variants

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

The microglial sensome revealed by direct RNA sequencing

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Software for Computing and Annotating Genomic Ranges

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Passive and active DNA methylation and the interplay with genetic variation in gene regulation

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The UCSC genome browser and associated tools

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Genetics of gene expression in primary immune cells identifies cell type–specific master regulators and roles of HLA alleles

(2012) Benjamin P Fairfax et al.   NATURE GENETICS

Interactions of Pathological Hallmark Proteins

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Coated-platelet levels and progression from mild cognitive impairment to Alzheimer disease

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LocusZoom: regional visualization of genome-wide association scan results

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ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

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Practical aspects of imputation-driven meta-analysis of genome-wide association studies

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