Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson’s disease and other synucleinopathies
出版年份 2022 全文链接
标题
Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson’s disease and other synucleinopathies
作者
关键词
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出版物
npj Parkinsons Disease
Volume 8, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-07-22
DOI
10.1038/s41531-022-00357-0
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Fluid markers of synapse degeneration in synucleinopathies
- (2022) Alba Cervantes González et al. JOURNAL OF NEURAL TRANSMISSION
- Exosomes in Parkinson: Revisiting Their Pathologic Role and Potential Applications
- (2022) Yassamine Ouerdane et al. Pharmaceuticals
- Comparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms
- (2022) Lara Petricca et al. Journal of Parkinsons Disease
- A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity
- (2022) Senthil T. Kumar et al. Science Advances
- Cerebrospinal Fluid α-Synuclein Species in Cognitive and Movements Disorders
- (2021) Vasilios C. Constantinides et al. Brain Sciences
- Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study
- (2021) Alex Iranzo et al. LANCET NEUROLOGY
- Preanalytical Stability of CSF Total and Oligomeric Alpha-Synuclein
- (2021) Ilham Y. Abdi et al. Frontiers in Aging Neuroscience
- Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies
- (2021) Inês C. Brás et al. Cells
- α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy
- (2021) Suman Dutta et al. ACTA NEUROPATHOLOGICA
- Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607
- (2021) Yang Shi et al. ACTA NEUROPATHOLOGICA
- α‐Synuclein in Plasma‐Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease
- (2021) Anne Stuendl et al. MOVEMENT DISORDERS
- Cerebrospinal α‐Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort
- (2021) Nour K. Majbour et al. MOVEMENT DISORDERS
- The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy
- (2021) Tim E. Moors et al. ACTA NEUROPATHOLOGICA
- Systematic Assessment of 10 Biomarker Candidates Focusing on α‐Synuclein‐Related Disorders
- (2021) Isabel Schulz et al. MOVEMENT DISORDERS
- Investigation of α-Synuclein Species in Plasma Exosomes and the Oligomeric and Phosphorylated α-Synuclein as Potential Peripheral Biomarker of Parkinson’s Disease
- (2021) Hengxing Zheng et al. NEUROSCIENCE
- Alpha-Synuclein as a Biomarker of Parkinson’s Disease: Good, but Not Good Enough
- (2021) Upasana Ganguly et al. Frontiers in Aging Neuroscience
- Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease
- (2021) Luis M. A. Oliveira et al. npj Parkinsons Disease
- Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies
- (2021) Ilaria Poggiolini et al. BRAIN
- Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies
- (2021) Galina Limorenko et al. CHEMICAL SOCIETY REVIEWS
- Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?
- (2021) Hilal A. Lashuel CURRENT OPINION IN CHEMICAL BIOLOGY
- Neuropathology and molecular diagnosis of Synucleinopathies
- (2021) Shunsuke Koga et al. Molecular Neurodegeneration
- Structure-based classification of tauopathies
- (2021) Yang Shi et al. NATURE
- Structure of pathological TDP-43 filaments from ALS with FTLD
- (2021) Diana Arseni et al. NATURE
- To target Tau pathologies, we must embrace and reconstruct their complexities
- (2021) Galina Limorenko et al. NEUROBIOLOGY OF DISEASE
- Association of Neurofibrillary Tangle Distribution With Age at Onset–Related Clinical Heterogeneity in Alzheimer Disease
- (2021) Denis S. Smirnov et al. NEUROLOGY
- Opinion: Independent third-party entities as a model for validation of commercial antibodies
- (2021) Carl Laflamme et al. New Biotechnology
- High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease
- (2021) Marco J. Russo et al. Acta Neuropathologica Communications
- Phosphorylated α-synuclein in diluted human serum a biomarker for Parkinson's disease
- (2021) W.R. Chen et al. Biomedical Journal
- Identification of cerebrospinal fluid biomarkers for parkinsonism using a proteomics approach
- (2021) Tainá M. Marques et al. npj Parkinsons Disease
- Optimizing red blood cell protein extraction for biomarker quantitation with mass spectrometry
- (2020) Stephan Klatt et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy
- (2020) Mohammad Shahnawaz et al. NATURE
- Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies
- (2020) Marcello Rossi et al. ACTA NEUROPATHOLOGICA
- The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies
- (2020) Anke Van der Perren et al. ACTA NEUROPATHOLOGICA
- Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease
- (2020) Min Guo et al. BRAIN
- New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy
- (2020) Ricardo Guerrero-Ferreira et al. CURRENT OPINION IN NEUROBIOLOGY
- A longitudinal study on α‐synuclein in plasma neuronal exosomes as a biomarker for Parkinson’s disease development and progression
- (2020) M. Niu et al. EUROPEAN JOURNAL OF NEUROLOGY
- Serum neuronal exosomes predict and differentiate Parkinson’s disease from atypical parkinsonism
- (2020) Cheng Jiang et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Structures of α-synuclein filaments from multiple system atrophy
- (2020) Manuel Schweighauser et al. NATURE
- Exosomal α-synuclein as a biomarker for Parkinson disease
- (2020) Sarah Lemprière Nature Reviews Neurology
- Increased alpha-synuclein tear fluid levels in patients with Parkinson’s disease
- (2020) Fabian Maass et al. Scientific Reports
- Parkinson’s Disease in African Americans: A Review of the Current Literature
- (2020) Meagan Bailey et al. Journal of Parkinsons Disease
- Development of a novel method for the quantification of tyrosine 39 phosphorylated α- and β-synuclein in human cerebrospinal fluid
- (2020) Chan Hyun Na et al. Clinical Proteomics
- CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers
- (2020) Nour K. Majbour et al. Translational Neurodegeneration
- Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease
- (2020) Simon Dujardin et al. NATURE MEDICINE
- A novel SNCA E83Q mutation in a case of dementia with Lewy bodies and atypical frontotemporal lobar degeneration
- (2020) Alifiya Kapasi et al. NEUROPATHOLOGY
- Facile Impedimetric Analysis of Neuronal Exosome Markers in Parkinson’s Disease Diagnostics
- (2020) Ying Fu et al. ANALYTICAL CHEMISTRY
- Blinded RT‐QuIC Analysis of α‐Synuclein Biomarker in Skin Tissue from Parkinson's Disease Patients
- (2020) Sireesha Manne et al. MOVEMENT DISORDERS
- Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease
- (2020) Zerui Wang et al. JAMA Neurology
- Exosomes in Parkinson disease
- (2020) Jennifer R. Pinnell et al. JOURNAL OF NEUROCHEMISTRY
- Oligomeric α-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson's disease
- (2020) Cristina Agliardi et al. NEUROBIOLOGY OF DISEASE
- How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology
- (2020) Senthil T. Kumar et al. NEUROBIOLOGY OF DISEASE
- Increased DJ-1 and α-Synuclein in Plasma Neural-Derived Exosomes as Potential Markers for Parkinson’s Disease
- (2019) Zhen-Hua Zhao et al. Frontiers in Aging Neuroscience
- Salivary alpha-synuclein in the diagnosis of Parkinson's disease and Progressive Supranuclear Palsy
- (2019) Giorgio Vivacqua et al. PARKINSONISM & RELATED DISORDERS
- Comparative study of cerebrospinal fluid α-synuclein seeding aggregation assays for diagnosis of Parkinson's disease
- (2019) Un Jung Kang et al. MOVEMENT DISORDERS
- Mass Spectrometric Analysis of Lewy Body-Enriched α-Synuclein in Parkinson’s Disease
- (2019) Payel Bhattacharjee et al. JOURNAL OF PROTEOME RESEARCH
- Central Nervous System-Derived Exosomal Alpha-Synuclein in Serum May Be a Biomarker in Parkinson’s Disease
- (2019) Xiaoli Si et al. NEUROSCIENCE
- The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases
- (2019) Jiaming Zhang et al. Frontiers in Neuroscience
- Erythrocytic α-Synuclein as a potential biomarker for Parkinson’s disease
- (2019) Chen Tian et al. Translational Neurodegeneration
- Oligomeric α-synuclein is increased in basal tears of Parkinson’s patients
- (2019) Sarah F Hamm-Alvarez et al. Biomarkers in Medicine
- Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease
- (2019) Hidetomo Murakami et al. BMC Neurology
- Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations
- (2019) Xiaodan Ni et al. JOURNAL OF MOLECULAR BIOLOGY
- Parkinson’s disease biomarkers based on α‐synuclein
- (2019) Muneera Fayyad et al. JOURNAL OF NEUROCHEMISTRY
- CSF and blood biomarkers for Parkinson's disease
- (2019) Lucilla Parnetti et al. LANCET NEUROLOGY
- Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease
- (2019) Sangjune Kim et al. NEURON
- Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification
- (2019) Alexis Fenyi et al. NEUROBIOLOGY OF DISEASE
- Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay
- (2019) Cristina Cariulo et al. Frontiers in Neuroscience
- Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy
- (2019) Chiara Maria Giulia De Luca et al. Translational Neurodegeneration
- Pathological Influences on Clinical Heterogeneity in Lewy Body Diseases
- (2019) David G. Coughlin et al. MOVEMENT DISORDERS
- Bridging the gaps: More inclusive research needed to fully understand Parkinson's disease
- (2019) Rebecca M. Gilbert et al. MOVEMENT DISORDERS
- CSF or serum neurofilament light added to α‐Synuclein panel discriminates Parkinson's from controls
- (2019) Linda P. Oosterveld et al. MOVEMENT DISORDERS
- Neuronal exosomes in saliva of Parkinson's disease patients: A pilot study
- (2019) Komal Rani et al. PARKINSONISM & RELATED DISORDERS
- Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue
- (2019) Marius Kollmer et al. Nature Communications
- α‐Synuclein in blood cells differentiates Parkinson’s disease from healthy controls
- (2019) Suaad Abd Elhadi et al. Annals of Clinical and Translational Neurology
- Plasma pS129-α-Synuclein Is a Surrogate Biofluid Marker of Motor Severity and Progression in Parkinson’s Disease
- (2019) Lin et al. Journal of Clinical Medicine
- Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy
- (2019) Ricardo Guerrero-Ferreira et al. eLife
- Cytotoxic Oligomers and Fibrils Trapped in a Gel-like State of α-Synuclein Assemblies
- (2018) Rakesh Kumar et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Amyloid blood biomarker detects Alzheimer's disease
- (2018) Andreas Nabers et al. EMBO Molecular Medicine
- The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson’s disease mouse model
- (2018) Saebom Lee et al. HUMAN MOLECULAR GENETICS
- Sensitivity and specificity of phospho-Ser129 α-synuclein monoclonal antibodies
- (2018) Vedad Delic et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Vibrational spectroscopy: a promising approach to discriminate neurodegenerative disorders
- (2018) Maria Paraskevaidi et al. Molecular Neurodegeneration
- Alpha-synuclein dimerization in erythrocytes of patients with genetic and non-genetic forms of Parkinson’s Disease
- (2018) Nikolaos Papagiannakis et al. NEUROSCIENCE LETTERS
- Cryo-EM structure of alpha-synuclein fibrils
- (2018) Ricardo Guerrero-Ferreira et al. eLife
- α-Synuclein Heterocomplexes with β-Amyloid Are Increased in Red Blood Cells of Parkinson’s Disease Patients and Correlate with Disease Severity
- (2018) Simona Daniele et al. Frontiers in Molecular Neuroscience
- Real-Time In Situ Secondary Structure Analysis of Protein Monolayer with Mid-Infrared Plasmonic Nanoantennas
- (2018) Dordaneh Etezadi et al. ACS Sensors
- Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study
- (2018) Brit Mollenhauer et al. JOURNAL OF NEUROCHEMISTRY
- Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells
- (2018) Gabriel Gustafsson et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies
- (2018) Inger van Steenoven et al. MOVEMENT DISORDERS
- Quantification of brain-derived extracellular vesicles in plasma as a biomarker to diagnose Parkinson's and related diseases
- (2018) Takuma Ohmichi et al. PARKINSONISM & RELATED DISORDERS
- The vermiform appendix impacts the risk of developing Parkinson’s disease
- (2018) Bryan A. Killinger et al. Science Translational Medicine
- α-Synuclein in salivary extracellular vesicles as a potential biomarker of Parkinson’s disease
- (2018) Zhentang Cao et al. NEUROSCIENCE LETTERS
- Quantitative Analysis of Human Red Blood Cell Proteome
- (2017) Agata H. Bryk et al. JOURNAL OF PROTEOME RESEARCH
- Dementia in Parkinson's disease
- (2017) Hasmet A. Hanagasi et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Revisiting biomarker discovery by plasma proteomics
- (2017) Philipp E Geyer et al. Molecular Systems Biology
- A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations
- (2017) Brit Mollenhauer et al. MOVEMENT DISORDERS
- Diagnostic utility of cerebrospinal fluid α-synuclein in Parkinson's disease: A systematic review and meta-analysis
- (2017) Paolo Eusebi et al. MOVEMENT DISORDERS
- Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease
- (2017) Zhentao Zhang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease
- (2017) Zhentao Zhang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Synucleinopathies: Twenty Years On
- (2017) Michel Goedert et al. Journal of Parkinsons Disease
- Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid
- (2017) Mohammad Shahnawaz et al. JAMA Neurology
- Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection
- (2017) Dordaneh Etezadi et al. Light-Science & Applications
- Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes
- (2017) Maja Mustapic et al. Frontiers in Neuroscience
- CSF α-Synuclein Does Not Discriminate Dementia with Lewy Bodies from Alzheimer's Disease
- (2017) Fransje E. Reesink et al. JOURNAL OF ALZHEIMERS DISEASE
- α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients
- (2017) Birger Victor Dieriks et al. Scientific Reports
- Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease
- (2017) Hugo Vicente Miranda et al. Scientific Reports
- Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations
- (2016) Igor Dikiy et al. ACS Chemical Biology
- Amyloid-β-Secondary Structure Distribution in Cerebrospinal Fluid and Blood Measured by an Immuno-Infrared-Sensor: A Biomarker Candidate for Alzheimer’s Disease
- (2016) Andreas Nabers et al. ANALYTICAL CHEMISTRY
- Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
- (2016) Nour K. Majbour et al. Molecular Neurodegeneration
- Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression
- (2016) Nour K. Majbour et al. MOVEMENT DISORDERS
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Monitoring of 30 marker candidates in early Parkinson disease as progression markers
- (2016) Brit Mollenhauer et al. NEUROLOGY
- Accuracy of clinical diagnosis of Parkinson disease
- (2016) Giovanni Rizzo et al. NEUROLOGY
- Autosomal dominant Parkinson's disease caused by SNCA duplications
- (2016) Takuya Konno et al. PARKINSONISM & RELATED DISORDERS
- Phenotypic spectrum of alpha-synuclein mutations: New insights from patients and cellular models
- (2016) Simona Petrucci et al. PARKINSONISM & RELATED DISORDERS
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson’s Disease
- (2016) Dan Lindholm et al. Frontiers in Aging Neuroscience
- Nilotinib Effects in Parkinson’s disease and Dementia with Lewy bodies
- (2016) Fernando Pagan et al. Journal of Parkinsons Disease
- Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?
- (2016) Abid Oueslati Journal of Parkinsons Disease
- Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies
- (2016) Graham Fairfoul et al. Annals of Clinical and Translational Neurology
- Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes
- (2016) Nicola J. Rutherford et al. Acta Neuropathologica Communications
- Abnormal Salivary Total and Oligomeric Alpha-Synuclein in Parkinson’s Disease
- (2016) Giorgio Vivacqua et al. PLoS One
- Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson’s disease patients
- (2016) Wenyan Kang et al. Scientific Reports
- Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
- (2015) Toshiki Uchihara et al. ACTA NEUROPATHOLOGICA
- Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies
- (2015) Anne Stuendl et al. BRAIN
- Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson’s Disease via Protein Semisynthesis and Mutagenesis
- (2015) Ritwik Burai et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation
- (2015) Aoife P. Kiely et al. Molecular Neurodegeneration
- Alpha-synuclein in gastric and colonic mucosa in Parkinson's disease: Limited role as a biomarker
- (2015) Sun Ju Chung et al. MOVEMENT DISORDERS
- Detection of α-synuclein oligomers in red blood cells as a potential biomarker of Parkinson’s disease
- (2015) Xuemei Wang et al. NEUROSCIENCE LETTERS
- Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
- (2015) Niklas K. U. Koehler et al. PLoS One
- Total and Proteinase K-Resistant α-Synuclein Levels in Erythrocytes, Determined by their Ability to Bind Phospholipids, Associate with Parkinson’s Disease
- (2015) Suaad Abd-Elhadi et al. Scientific Reports
- Phosphorylated α-synuclein in Parkinson’s disease: correlation depends on disease severity
- (2015) Tessandra Stewart et al. Acta Neuropathologica Communications
- Decrease in Plasma Levels of α-Synuclein Is Evident in Patients with Parkinson’s Disease after Elimination of Heterophilic Antibody Interference
- (2015) Ryotaro Ishii et al. PLoS One
- Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease
- (2014) Min Shi et al. ACTA NEUROPATHOLOGICA
- Cutaneous neuropathy in Parkinson’s disease: a window into brain pathology
- (2014) Kathrin Doppler et al. ACTA NEUROPATHOLOGICA
- Purification of α-Synuclein from Human Brain Reveals an Instability of Endogenous Multimers as the Protein Approaches Purity
- (2014) Eric S. Luth et al. BIOCHEMISTRY
- c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease
- (2014) Anne-Laure Mahul-Mellier et al. HUMAN MOLECULAR GENETICS
- Cerebrospinal fluid alpha-synuclein as a biomarker for Parkinson's disease diagnosis: a systematic review and meta-analysis
- (2014) Liang Gao et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Acceleration of α-Synuclein Aggregation by Exosomes
- (2014) Marie Grey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directions
- (2014) Nadia Magdalinou et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease
- (2014) Lucilla Parnetti et al. MOVEMENT DISORDERS
- Reduced alpha-synuclein in cerebrospinal fluid in synucleinopathies: Evidence from a meta-analysis
- (2014) Wataru Sako et al. MOVEMENT DISORDERS
- Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates
- (2014) Laura A Volpicelli-Daley et al. Nature Protocols
- A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
- (2014) Petra Pasanen et al. NEUROBIOLOGY OF AGING
- Intramuscular injection of -synuclein induces CNS -synuclein pathology and a rapid-onset motor phenotype in transgenic mice
- (2014) A. N. Sacino et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry
- (2014) John F. Kellie et al. Scientific Reports
- Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson’s disease with dementia and dementia with Lewy bodies compared to Alzheimer’s disease
- (2014) Oskar Hansson et al. Alzheimers Research & Therapy
- Differential role of CSF alpha-synuclein species, tau, and Aβ42 in Parkinson's Disease
- (2014) Lucilla Parnetti et al. Frontiers in Aging Neuroscience
- α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?
- (2013) Aoife P. Kiely et al. ACTA NEUROPATHOLOGICA
- G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome
- (2013) Suzanne Lesage et al. ANNALS OF NEUROLOGY
- May the Evaluation of Nitrosative Stress Through Selective Increase of 3-Nitrotyrosine Proteins Other Than Nitroalbumin and Dominant Tyrosine-125/136 Nitrosylation of Serum α-Synuclein Serve for Diagnosis of Sporadic Parkinson's Disease?
- (2013) Emilio Fernández et al. ANTIOXIDANTS & REDOX SIGNALING
- Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of -synuclein in Parkinson's disease models
- (2013) M. L. Hebron et al. HUMAN MOLECULAR GENETICS
- Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies
- (2013) Adrien W. Schmid et al. MOLECULAR & CELLULAR PROTEOMICS
- Serum from Parkinson’s disease patients presents excess of protein halogenation and nitrosylation, with anomalous nitrosylation of serum α-synuclein as potentially etiological factor
- (2013) Emilio Fernandez et al. Molecular Neurodegeneration
- Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
- (2013) Silke Appel-Cresswell et al. MOVEMENT DISORDERS
- Neuroprotective Efficacy of a New Brain-Penetrating C-Abl Inhibitor in a Murine Parkinson’s Disease Model
- (2013) Syed Z. Imam et al. PLoS One
- Synthetic polyubiquitinated -Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology
- (2013) M. Haj-Yahya et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease
- (2013) Penelope G. Foulds et al. Scientific Reports
- Critical Role of Truncated α-Synuclein and Aggregates in Parkinson's Disease and Incidental Lewy Body Disease
- (2012) Kavita Prasad et al. BRAIN PATHOLOGY
- α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer
- (2012) Bruno Fauvet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Elevated Levels of α-Synuclein Oligomer in the Cerebrospinal Fluid of Drug-Naïve Patients with Parkinson's Disease
- (2012) Min Jeong Park et al. Journal of Clinical Neurology
- Elucidating the Role of C-Terminal Post-Translational Modifications Using Protein Semisynthesis Strategies: α-Synuclein Phosphorylation at Tyrosine 125
- (2012) Mirva Hejjaoui et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation
- (2012) Nitzan Shabek et al. MOLECULAR CELL
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson’s disease
- (2012) H. Pouclet et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Total CSF α-synuclein is lower in de novo Parkinson patients than in healthy subjects
- (2012) Brit Mollenhauer et al. NEUROSCIENCE LETTERS
- α-Synuclein Levels in Blood Plasma from LRRK2 Mutation Carriers
- (2012) Ana Gorostidi et al. PLoS One
- Salivary α-synuclein and DJ-1: potential biomarkers for Parkinson's disease
- (2011) Ivana Devic et al. BRAIN
- Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease
- (2011) Penelope G. Foulds et al. FASEB JOURNAL
- Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease
- (2011) S. Z. Imam et al. JOURNAL OF NEUROSCIENCE
- α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study
- (2011) Brit Mollenhauer et al. LANCET NEUROLOGY
- Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias
- (2011) Lucilla Parnetti et al. MOVEMENT DISORDERS
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
- (2011) Tim Bartels et al. NATURE
- Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies
- (2011) P.G. Foulds et al. NEUROBIOLOGY OF DISEASE
- Identification of Novel α-Synuclein Isoforms in Human Brain Tissue by using an Online NanoLC-ESI-FTICR-MS Method
- (2011) Annika Öhrfelt et al. NEUROCHEMICAL RESEARCH
- α-synuclein phosphorylation and truncation are normal events in the adult human brain
- (2011) G. Muntané et al. NEUROSCIENCE
- α-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson's Disease Patients
- (2011) Kiran Yanamandra et al. PLoS One
- Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
- (2010) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- Abnormal Neurites Containing C-Terminally Truncated α-Synuclein Are Present in Alzheimer's Disease without Conventional Lewy Body Pathology
- (2010) Karen A. Lewis et al. AMERICAN JOURNAL OF PATHOLOGY
- Towards Elucidation of the Role of Ubiquitination in the Pathogenesis of Parkinson’s Disease with Semisynthetic Ubiquitinated α-Synuclein
- (2010) Mirva Hejjaoui et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease
- (2010) Zhen Hong et al. BRAIN
- Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions
- (2010) K. E. Paleologou et al. JOURNAL OF NEUROSCIENCE
- Plasma α-synuclein in patients with Parkinson's disease with and without treatment
- (2010) Raquel Duran et al. MOVEMENT DISORDERS
- Detection of elevated levels of -synuclein oligomers in CSF from patients with Parkinson disease
- (2010) T. Tokuda et al. NEUROLOGY
- Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease
- (2010) Min Shi et al. NEUROSCIENCE LETTERS
- Brain α-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation
- (2009) Junchao Tong et al. BRAIN
- Characterization of antibodies that selectively detect α-synuclein in pathological inclusions
- (2008) Elisa A. Waxman et al. ACTA NEUROPATHOLOGICA
- Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
- (2008) Brit Mollenhauer et al. EXPERIMENTAL NEUROLOGY
- Parkinson's disease: clinical features and diagnosis
- (2008) J Jankovic JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood
- (2008) Robin Barbour et al. Neurodegenerative Diseases
- The solubility of α-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease
- (2003) Bruce C. V. Campbell et al. JOURNAL OF NEUROCHEMISTRY
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