Insights Into the Role of Mortalin in Alzheimer’s Disease, Parkinson’s Disease, and HIV-1-Associated Neurocognitive Disorders

Main lymphocyte subpopulations in cerebrospinal fluid and peripheral blood in HIV-1 subtypes C and B

(2022) Sergio M. de Almeida et al.   JOURNAL OF NEUROVIROLOGY

Diversity in heat shock protein families: functional implications in virus infection with a comprehensive insight of their role in the HIV-1 life cycle

(2021) Kruthika Iyer et al.   CELL STRESS & CHAPERONES

Role of Heat Shock Proteins (HSP70 and HSP90) in Viral Infection

(2021) Anna Lubkowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The HIV-1 accessory protein Nef increases surface expression of the checkpoint receptor Tim-3 in infected CD4+ T cells

(2021) Rajesh Abraham Jacob et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A trio has turned into a quartet: DJ-1 interacts with the IP3R-Grp75-VDAC complex to control ER-mitochondria interaction

(2020) Valentina Basso et al.   CELL CALCIUM

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

(2020) Preston Ge et al.   Molecular Neurodegeneration

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Human Immunodeficiency Virus Type-1 and Methamphetamine Mediated Mitochondrial Damage and Neuronal Degeneration in Human Neurons

(2020) Carmen Teodorof-Diedrich et al.   JOURNAL OF VIROLOGY

Extracellular HIV-1 Tat Mediates Increased Glutamate in the CNS Leading to Onset of Senescence and Progression of HAND

(2020) Jamie Marino et al.   Frontiers in Aging Neuroscience

Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration

(2020) Andrey Y. Abramov et al.   Life-Basel

Genetics of Parkinson's disease

(2020) Ajith Cherian et al.   ACTA NEUROLOGICA BELGICA

Novel role of mortalin in attenuating HIV-1 Tat-mediated astrogliosis

(2020) Priyanka et al.   Journal of Neuroinflammation

Global prevalence and burden of HIV-associated neurocognitive disorder: a meta-analysis

(2020) Yunhe Wang et al.   NEUROLOGY

Neurotoxicity of HIV-1 Tat is attributed to its penetrating property

(2020) Xiaoli Tang et al.   Scientific Reports

Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20

(2020) Briana R. De Miranda et al.   npj Parkinsons Disease

Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells

(2019) Sujit Pujhari et al.   Emerging Microbes & Infections

HIV-1 and Compromised Adult Neurogenesis: Emerging Evidence for a New Paradigm of HAND Persistence

(2019) Raj Putatunda et al.   AIDS REVIEWS

Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells

(2019) Dmytro Starenki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention

(2019) Zvi Fishelson et al.   Frontiers in Immunology

Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion

(2019) Eman A. Taha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Peripheral versus central nervous system APOE in Alzheimer’s disease: Interplay across the blood-brain barrier

(2019) Dustin Chernick et al.   NEUROSCIENCE LETTERS

SMR peptide antagonizes mortalin promoted release of extracellular vesicles and affects mortalin protection from complement-dependent cytotoxicity in breast cancer cells and leukemia cells

(2019) Ming-Bo Huang et al.   Oncotarget

Heat-Shock Proteins in Neuroinflammation

(2019) Brigitta Dukay et al.   Frontiers in Pharmacology

Astrocytes: Role and Functions in Brain Pathologies

(2019) Rosalba Siracusa et al.   Frontiers in Pharmacology

DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

(2019) Mariaelena Repici et al.   Journal of Clinical Medicine

Dynamics of Dynamin-Related Protein 1 in Alzheimer’s Disease and Other Neurodegenerative Diseases

(2019) Darryll Oliver et al.   Cells

Infusion of HIV-1 Nef-expressing astrocytes into the rat hippocampus induces enteropathy and interstitial pneumonitis and increases blood–brain-barrier permeability

(2019) Jocelyn Rivera et al.   PLoS One

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

(2018) Franziska Kundel et al.   ACS Chemical Biology

Hsp70 at the membrane: driving protein translocation

(2018) Elizabeth A. Craig   BMC BIOLOGY

Heat shock factor 1 suppresses the HIV-induced inflammatory response by inhibiting nuclear factor-κB

(2018) Xiaoyan Pan et al.   CELLULAR IMMUNOLOGY

Serum Mortalin Correlated with α-Synuclein as Serum Markers in Parkinson’s Disease: A Pilot Study

(2018) Amrendra Pratap Singh et al.   NEUROMOLECULAR MEDICINE

Emerging Roles of Astrocytes in Neuro-Vascular Unit and the Tripartite Synapse With Emphasis on Reactive Gliosis in the Context of Alzheimer’s Disease

(2018) Cai-Yun Liu et al.   Frontiers in Cellular Neuroscience

Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses

(2018) Ryan P. McNamara et al.   mBio

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

Amyloid-β Plaques in Clinical Alzheimer’s Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity

(2018) Norelle C. Wildburger et al.   Frontiers in Neurology

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

(2018) Xiongwei Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

Human Immunodeficiency Virus Type-1 gp120 and Tat Induce Mitochondrial Fragmentation and Incomplete Mitophagy in Human Neurons

(2018) Carmen Teodorof-Diedrich et al.   JOURNAL OF VIROLOGY

GRP75 modulates oncogenic Dbl-driven endocytosis derailed via the CHIP-mediated ubiquitin degradation pathway

(2018) Xiuran Niu et al.   Cell Death & Disease

Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models

(2018) Era Taoufik et al.   Open Biology

Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases

(2018) Hao Chi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heat Shock Proteins Regulatory Role in Neurodevelopment

(2018) David J. Miller et al.   Frontiers in Neuroscience

Circulating mitochondrial stress 70 protein/mortalin and cytosolic Hsp70 in blood: Risk indicators in colorectal cancer

(2017) Ritta Jubran et al.   INTERNATIONAL JOURNAL OF CANCER

HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment

(2017) Christian Eggers et al.   JOURNAL OF NEUROLOGY

The heat shock response in neurons and astroglia and its role in neurodegenerative diseases

(2017) Rebecca San Gil et al.   Molecular Neurodegeneration

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

(2017) J.A. Obeso et al.   MOVEMENT DISORDERS

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HIV-1 Vpr disrupts mitochondria axonal transport and accelerates neuronal aging

(2017) Ying Wang et al.   NEUROPHARMACOLOGY

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity

(2017) A Sami Saribas et al.   Cell Death & Disease

Neuronal Mitophagy in Neurodegenerative Diseases

(2017) Marta Martinez-Vicente   Frontiers in Molecular Neuroscience

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

(2017) Rachel E. Lackie et al.   Frontiers in Neuroscience

Protein misfolding in neurodegenerative diseases: implications and strategies

(2017) Patrick Sweeney et al.   Translational Neurodegeneration

Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin

(2017) Yunxia Liu et al.   Scientific Reports

Stress Chaperone Mortalin Contributes to Epithelial-to-Mesenchymal Transition and Cancer Metastasis

(2016) Y. Na et al.   CANCER RESEARCH

Complement triggers relocation of Mortalin/GRP75 from mitochondria to the plasma membrane

(2016) Niv Mazkereth et al.   IMMUNOBIOLOGY

HIV-1 Tat Promotes Lysosomal Exocytosis in Astrocytes and Contributes to Astrocyte-mediated Tat Neurotoxicity

(2016) Yan Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells

(2016) Alison E. Mungenast et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mortalin is Expressed by Astrocytes and Decreased in the Midbrain of Parkinson's Disease Patients

(2015) Travis J. Cook et al.   BRAIN PATHOLOGY

The Contribution of Extracellular Nef to HIV-Induced Pathogenesis

(2015) Eleonora Olivetta et al.   CURRENT DRUG TARGETS

Mitochondrial Heat Shock Protein (Hsp) 70 and Hsp10 Cooperate in the Formation of Hsp60 Complexes

(2015) Lena Böttinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Mitochondrial Hsp70 (Mortalin): Shedding Light on ATPase Activity, Interaction with Adenosine Nucleotides, Solution Structure and Domain Organization

(2015) Paulo R. Dores-Silva et al.   PLoS One

Surviving apoptosis: life–death signaling in single cells

(2015) Deborah A. Flusberg et al.   TRENDS IN CELL BIOLOGY

Inhibition of HSP70 reduces porcine reproductive and respiratory syndrome virus replication in vitro

(2014) Jintao Gao et al.   BMC MICROBIOLOGY

Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease

(2014) Juhyun Song et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy

(2014) Pasquale Picone et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

(2014) L F Burbulla et al.   Cell Death & Disease

The activity of Nef on HIV-1 infectivity

(2014) Stéphane Basmaciogullari et al.   Frontiers in Microbiology

Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress

(2013) I. Tai-Nagara et al.   BLOOD

Down-regulation of Mortalin Exacerbates Aβ-mediated Mitochondrial Fragmentation and Dysfunction

(2013) So Jung Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Centenary of Lewy bodies (1912–2012)

(2013) Bernd Holdorff et al.   JOURNAL OF NEURAL TRANSMISSION

Mitochondrial Alterations near Amyloid Plaques in an Alzheimer's Disease Mouse Model

(2013) Hong Xie et al.   JOURNAL OF NEUROSCIENCE

Cerebrospinal fluid biomarkers in Parkinson disease

(2013) Lucilla Parnetti et al.   Nature Reviews Neurology

Mortalin mutations are not a frequent cause of early-onset Parkinson disease

(2013) Karen Freimann et al.   NEUROBIOLOGY OF AGING

Knockdown of Hsc70-5/mortalin Induces Loss of Synaptic Mitochondria in a Drosophila Parkinson’s Disease Model

(2013) Jun-yi Zhu et al.   PLoS One

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Parkinsonism Due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitochondrial Pathways

(2013) M. R. Cookson   Cold Spring Harbor Perspectives in Medicine

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

Astrocytic expression of HIV-1 Nef impairs spatial and recognition memory

(2012) Gladys Chompre et al.   NEUROBIOLOGY OF DISEASE

Brain Transcriptome-Wide Screen for HIV-1 Nef Protein Interaction Partners Reveals Various Membrane-Associated Proteins

(2012) Ellen C. Kammula et al.   PLoS One

HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase

(2012) H Lecoeur et al.   Cell Death & Disease

Nonmotor Symptoms in Parkinson’s Disease in 2012: Relevant Clinical Aspects

(2012) Anne Marie Bonnet et al.   Parkinsons Disease

Chronic Inflammation in Cancer Development

(2012) Gabriele Multhoff et al.   Frontiers in Immunology

Virus-Heat Shock Protein Interaction and a Novel Axis for Innate Antiviral Immunity

(2012) Mi Young Kim et al.   Cells

Mitochondrial dysfunction induced by knockdown of mortalin is rescued by Parkin

(2011) Hui Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mortalin–p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

(2011) W-J Lu et al.   CELL DEATH AND DIFFERENTIATION

Reciprocal Regulation of Human Immunodeficiency Virus-1 Gene Expression and Replication by Heat Shock Proteins 40 and 70

(2011) Manish Kumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Secretion Modification Region-Derived Peptide Disrupts HIV-1 Nef's Interaction with Mortalin and Blocks Virus and Nef Exosome Release

(2011) M. N. Shelton et al.   JOURNAL OF VIROLOGY

Mortalin inhibition in experimental Parkinson's disease

(2011) Davide Chiasserini et al.   MOVEMENT DISORDERS

HIV-1 Tat neurotoxicity: A model of acute and chronic exposure, and neuroprotection by gene delivery of antioxidant enzymes

(2011) Lokesh Agrawal et al.   NEUROBIOLOGY OF DISEASE

DJ-1 knock-down impairs astrocyte mitochondrial function

(2011) N.J. Larsen et al.   NEUROSCIENCE

Inhibition of mitochondrial permeability transition pore opening is involved in the protective effects of mortalin overexpression against beta-amyloid-induced apoptosis in SH-SY5Y cells

(2011) Mingyue Qu et al.   NEUROSCIENCE RESEARCH

Genetic Characterization of HIV Type 1 Nef-Induced Vesicle Secretion

(2010) Syed A. Ali et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Inflammation and survival pathways: Chronic lymphocytic leukemia as a model system

(2010) Lisa S. Chen et al.   BIOCHEMICAL PHARMACOLOGY

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

(2010) Zhen Hong et al.   BRAIN

Mortalin overexpression attenuates beta-amyloid-induced neurotoxicity in SH-SY5Y cells

(2010) Mingyue Qu et al.   BRAIN RESEARCH

Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis

(2010) Lena F. Burbulla et al.   HUMAN MOLECULAR GENETICS

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

(2010) L.-Y. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV and Mature Dendritic Cells: Trojan Exosomes Riding the Trojan Horse?

(2010) Nuria Izquierdo-Useros et al.   PLoS Pathogens

Targeting Trojan Horse leukocytes for HIV prevention

(2009) Deborah J Anderson et al.   AIDS

The progression of pathology in Parkinson's disease

(2009) Glenda Margaret Halliday et al.   Annals of the New York Academy of Sciences

Mutational screening of the mortalin gene (HSPA9) in Parkinson’s disease

(2009) Lorena De Mena et al.   JOURNAL OF NEURAL TRANSMISSION

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

(2009) Dennis W Dickson et al.   LANCET NEUROLOGY

From proliferative to neurological role of an hsp70 stress chaperone, mortalin

(2008) Custer C. Deocaris et al.   BIOGERONTOLOGY

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

(2008) Adrienne M. Gorman   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Overexpression of Mitochondrial Hsp70/Hsp75 in Rat Brain Protects Mitochondria, Reduces Oxidative Stress, and Protects from Focal Ischemia

(2008) Lijun Xu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

(2008) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Reduced cytosolic protein synthesis suppresses mitochondrial degeneration

(2008) Xiaowen Wang et al.   NATURE CELL BIOLOGY