Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20

A trio has turned into a quartet: DJ-1 interacts with the IP3R-Grp75-VDAC complex to control ER-mitochondria interaction

(2020) Valentina Basso et al.   CELL CALCIUM

Mitochondrial and Nuclear DNA Oxidative Damage in Physiological and Pathological Aging

(2020) Marta Kowalska et al.   DNA AND CELL BIOLOGY

α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo

(2020) Victor S. Van Laar et al.   Redox Biology

LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease

(2019) Emily M. Rocha et al.   NEUROBIOLOGY OF DISEASE

Determinants of dopaminergic neuron loss in Parkinson's disease

(2018) D.James Surmeier   FEBS Journal

Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease

(2018) Briana R. De Miranda et al.   NEUROBIOLOGY OF DISEASE

Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease

(2018) Emily M. Rocha et al.   NEUROBIOLOGY OF DISEASE

Serum Mortalin Correlated with α-Synuclein as Serum Markers in Parkinson’s Disease: A Pilot Study

(2018) Amrendra Pratap Singh et al.   NEUROMOLECULAR MEDICINE

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease

(2018) Diego Grassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 activation in idiopathic Parkinson’s disease

(2018) Roberto Di Maio et al.   Science Translational Medicine

Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson’s disease

(2018) Sandra Franco-Iborra et al.   Cell Death & Disease

Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease

(2017) Maria Pia Giannoccaro et al.   MOVEMENT DISORDERS

Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain

(2017) Poonam Thakur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Involvement of mortalin/GRP75/mthsp70 in the mitochondrial impairments induced by A53T mutant α-synuclein

(2015) Feng-tao Liu et al.   BRAIN RESEARCH

Post-translational modification of α-synuclein in Parkinson׳s disease

(2015) Paul J. Barrett et al.   BRAIN RESEARCH

shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model

(2015) Alevtina D. Zharikov et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons

(2015) Emily M. Rocha et al.   NEUROBIOLOGY OF DISEASE

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

(2014) Amy Reeve et al.   AGEING RESEARCH REVIEWS

Mitochondrial genome maintenance in health and disease

(2014) William C. Copeland et al.   DNA REPAIR

Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease

(2014) Laurie H. Sanders et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

(2014) L F Burbulla et al.   Cell Death & Disease

Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System

(2013) Sara E. Gombash et al.   PLoS One

Automated imaging system for fast quantitation of neurons, cell morphology and neurite morphometry in vivo and in vitro

(2012) Victor Tapias et al.   NEUROBIOLOGY OF DISEASE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Enhanced function in the good forelimb of hemi-parkinson rats: Compensatory adaptation for contralateral postural instability?

(2008) Martin T. Woodlee et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY