Diversity in heat shock protein families: functional implications in virus infection with a comprehensive insight of their role in the HIV-1 life cycle

Comparative analysis of differential gene expression of HSP40 and HSP70 family isoforms during heat stress and HIV-1 infection in T-cells

(2021) Kailash Chand et al.   CELL STRESS & CHAPERONES

Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy

(2021) Emanuel Wyler et al.   iScience

COVID-19 spike-host cell receptor GRP78 binding site prediction

(2020) Ibrahim M. Ibrahim et al.   JOURNAL OF INFECTION

In Silico Discovery of Candidate Drugs against Covid-19

(2020) Claudia Cava et al.   Viruses-Basel

HSF1 inhibition attenuates HIV-1 latency reversal mediated by several candidate LRAs In Vitro and Ex Vivo

(2020) Andrew Timmons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Heat Shock Protein 70 Family of Chaperones Regulates All Phases of the Enterovirus A71 Life Cycle

(2020) Yu-Siang Su et al.   Frontiers in Microbiology

The stress-inducible molecular chaperone GRP78 as potential therapeutic target for coronavirus infection

(2020) Dat P. Ha et al.   JOURNAL OF INFECTION

Avian Chaperonin Containing TCP1 Subunit 5 Supports Influenza A Virus Replication by Interacting With Viral Nucleoprotein, PB1, and PB2 Proteins

(2020) Xiaohan Zhang et al.   Frontiers in Microbiology

Covid-19, heat shock proteins, and autoimmune bullous diseases: a potential link deserving further attention

(2020) Michael Kasperkiewicz   CELL STRESS & CHAPERONES

Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease

(2019) Shuhei Taguwa et al.   Cell Reports

Requirement of Cellular Protein CCT7 for the Replication of Fowl Adenovirus Serotype 4 (FAdV-4) in Leghorn Male Hepatocellular Cells Via Interaction with the Viral Hexon Protein

(2019) Junfeng Gao et al.   Viruses-Basel

Hsp27 responds to and facilitates enterovirus A71 replication through enhancing viral IRES-mediated translation

(2019) Xuelian Dan et al.   JOURNAL OF VIROLOGY

Mitochondrial Heat Shock Response Induced by Ectromelia Virus is Accompanied by Reduced Apoptotic Potential in Murine L929 Fibroblasts

(2019) Zbigniew Wyżewski et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Heat shock protein 105 peptide vaccine could induce antitumor immune reactions in a phase I clinical trial

(2019) Yasuhiro Shimizu et al.   CANCER SCIENCE

Small molecule grp94 inhibitors block dengue and Zika virus replication

(2019) Hussin A. Rothan et al.   ANTIVIRAL RESEARCH

Hsp110 mitigates α-synuclein pathology in vivo

(2019) Yumiko V. Taguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of 2-isoxazol-3-yl-acetamide analogues as heat shock protein 90 (HSP90) inhibitors with significant anti-HIV activity

(2019) Jay Trivedi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Host Heat Shock Protein MRJ/DNAJB6 Modulates Virus Infection

(2019) Shih-Han Ko et al.   Frontiers in Microbiology

Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation

(2018) Uri Mbonye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class 1-Selective Histone Deacetylase (HDAC) Inhibitors Enhance HIV Latency Reversal while Preserving the Activity of HDAC Isoforms Necessary for Maximal HIV Gene Expression

(2018) Thomas D. Zaikos et al.   JOURNAL OF VIROLOGY

Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature

(2018) Jean-François Gélinas et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Cellular Hsp27 interacts with classical swine fever virus NS5A protein and negatively regulates viral replication by the NF-κB signaling pathway

(2018) Shifeng Ling et al.   VIROLOGY

Heat shock–induced mitotic arrest requires heat shock protein 105 for the activation of spindle assembly checkpoint

(2018) Ayana Kakihana et al.   FASEB JOURNAL

Correction to: HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway

(2018) Shalini Swaroop et al.   Journal of Neuroinflammation

Heat Shock Proteins as Immunomodulants

(2018) Tawanda Zininga et al.   MOLECULES

HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells

(2018) Sebastien Z. Causse et al.   ONCOGENE

Heat Shock Proteins Regulatory Role in Neurodevelopment

(2018) David J. Miller et al.   Frontiers in Neuroscience

Small heat shock protein 27: An effective adjuvant for enhancement of HIV-1 Nef antigen-specific immunity

(2017) Alireza Milani et al.   IMMUNOLOGY LETTERS

Combination of cell penetrating peptides and heterologous DNA prime/protein boost strategy enhances immune responses against HIV-1 Nef antigen in BALB/c mouse model

(2017) Somayeh Kadkhodayan et al.   IMMUNOLOGY LETTERS

Quiescence Promotes Latent HIV Infection and Resistance to Reactivation from Latency with Histone Deacetylase Inhibitors

(2017) Mark M. Painter et al.   JOURNAL OF VIROLOGY

Heat Shock Protein 90 Ensures Efficient Mumps Virus Replication by Assisting with Viral Polymerase Complex Formation

(2017) Hiroshi Katoh et al.   JOURNAL OF VIROLOGY

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glucose-regulated protein 78 is an antiviral against hepatitis A virus replication

(2017) Xia Jiang et al.   Experimental and Therapeutic Medicine

HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma

(2017) Sheila N. López et al.   Oncotarget

Rabies viruses leader RNA interacts with host Hsc70 and inhibits virus replication

(2017) Ran Zhang et al.   Oncotarget

Ebola virus infection induces autoimmunity against dsDNA and HSP60

(2017) H. Fausther-Bovendo et al.   Scientific Reports

Mitochondrial injury and cognitive function in HIV infection and methamphetamine use

(2016) Susanna R. Var et al.   AIDS

Tyrosine phosphorylation modulates mitochondrial chaperonin Hsp60 and delays rotavirus NSP4-mediated apoptotic signaling in host cells

(2016) Shiladitya Chattopadhyay et al.   CELLULAR MICROBIOLOGY

Heat Shock Protein 90 Facilitates Latent HIV Reactivation through Maintaining the Function of Positive Transcriptional Elongation Factor b (p-TEFb) under Proteasome Inhibition

(2016) Xiao-Yan Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HSP90 Chaperoning in Addition to Phosphoprotein Required for Folding but Not for Supporting Enzymatic Activities of Measles and Nipah Virus L Polymerases

(2016) Louis-Marie Bloyet et al.   JOURNAL OF VIROLOGY

The co-chaperone Cdc37 regulates the rabies virus phosphoprotein stability by targeting to Hsp90AA1 machinery

(2016) Yunbin Xu et al.   Scientific Reports

HIV–host interactome revealed directly from infected cells

(2016) Yang Luo et al.   Nature Microbiology

Binding of the pathogen receptor HSP90AA1 to avibirnavirus VP2 induces autophagy by inactivating the AKT-MTOR pathway

(2015) Boli Hu et al.   Autophagy

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection

(2015) Shuhei Taguwa et al.   CELL

Quantitative proteomics of heat-treated human cells show an across-the-board mild depletion of housekeeping proteins to massively accumulate few HSPs

(2015) Andrija Finka et al.   CELL STRESS & CHAPERONES

Regulation and function of the human HSP90AA1 gene

(2015) Abbey D. Zuehlke et al.   GENE

Upregulation of Heat Shock Proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in Tumour Tissues Is Associated with Poor Outcomes from HBV-Related Early-Stage Hepatocellular Carcinoma

(2015) Zongguo Yang et al.   International Journal of Medical Sciences

A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum Membrane

(2015) Madhu Sudhan Ravindran et al.   PLoS Pathogens

HSPA5 is an essential host factor for Ebola virus infection

(2014) St. Patrick Reid et al.   ANTIVIRAL RESEARCH

Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo

(2014) Abhay P.S. Rathore et al.   ANTIVIRAL RESEARCH

VPS35 and DNAJC13 disease-causing variants in essential tremor

(2014) Alex Rajput et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Progression of colorectal cancers correlates with overexpression and loss of polarization of expression of the htid-1 tumor suppressor

(2014) Ursula Kurzik-Dumke et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Interaction of the Molecular Chaperone DNAJB6 with Growing Amyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation

(2014) Cecilia Månsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DnaJA1/Hsp40 Is Co-Opted by Influenza A Virus To Enhance Its Viral RNA Polymerase Activity

(2014) M. Cao et al.   JOURNAL OF VIROLOGY

Modulation of Kaposi's Sarcoma-Associated Herpesvirus Interleukin-6 Function by Hypoxia-Upregulated Protein 1

(2014) L. Giffin et al.   JOURNAL OF VIROLOGY

HIV Tat-Mediated Induction of Human Brain Microvascular Endothelial Cell Apoptosis Involves Endoplasmic Reticulum Stress and Mitochondrial Dysfunction

(2014) Rong Ma et al.   MOLECULAR NEUROBIOLOGY

Hepatitis C Virus Nonstructural Protein 5A Inhibits Thapsigargin-Induced Apoptosis

(2014) Xia Jiang et al.   PLoS One

Heat shock protein 90 controls HIV-1 reactivation from latency

(2014) I. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation

(2014) Alessia Landi et al.   Retrovirology

Heat shock proteins in neurodegenerative disorders and aging

(2014) Rehana K. Leak   Journal of Cell Communication and Signaling

Large Isoform of Mammalian Relative of DnaJ is a Major Determinant of Human Susceptibility to HIV-1 Infection

(2014) Yu-Ping Chiang et al.   EBioMedicine

Proteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasis

(2013) Andrija Finka et al.   CELL STRESS & CHAPERONES

The Hsp60 folding machinery is crucial for manganese superoxide dismutase folding and function

(2013) R. Magnoni et al.   FREE RADICAL RESEARCH

Novel Role of HSP40/DNAJ in the Regulation of HIV-1 Replication

(2013) Emiko Urano et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Cellular Chaperonin CCT  Contributes to Rabies Virus Replication during Infection

(2013) J. Zhang et al.   JOURNAL OF VIROLOGY

1918 Influenza Virus Hemagglutinin (HA) and the Viral RNA Polymerase Complex Enhance Viral Pathogenicity, but Only HA Induces Aberrant Host Responses in Mice

(2013) T. Watanabe et al.   JOURNAL OF VIROLOGY

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of Mitochondria in HIV Infection and Associated Metabolic Disorders: Focus on Nonalcoholic Fatty Liver Disease and Lipodystrophy Syndrome

(2013) P. Pérez-Matute et al.   Oxidative Medicine and Cellular Longevity

Heat Shock Protein 27 Mediated Signaling in Viral Infection

(2012) Jaya Rajaiya et al.   BIOCHEMISTRY

The role of molecular chaperones in spermatogenesis and the post-testicular maturation of mammalian spermatozoa

(2012) Matthew D. Dun et al.   HUMAN REPRODUCTION UPDATE

HSPB1 is an intracellular antiviral factor against hepatitis B virus

(2012) Shi-Wen Tong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inhibition of NF-κB activity by HIV-1 Vpr is dependent on Vpr binding protein

(2012) Michael Kogan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Identification of prohibitin as a Chikungunya virus receptor protein

(2012) Phitchayapak Wintachai et al.   JOURNAL OF MEDICAL VIROLOGY

Physical Chemistry of Polyglutamine: Intriguing Tales of a Monotonous Sequence

(2012) Ronald Wetzel   JOURNAL OF MOLECULAR BIOLOGY

Hsp70 Protein Positively Regulates Rabies Virus Infection

(2012) X. Lahaye et al.   JOURNAL OF VIROLOGY

Circulating Heat Shock Protein 60 Levels Are Elevated in HIV Patients and Are Reduced by Anti-Retroviral Therapy

(2012) Itaru Anraku et al.   PLoS One

Brain Transcriptome-Wide Screen for HIV-1 Nef Protein Interaction Partners Reveals Various Membrane-Associated Proteins

(2012) Ellen C. Kammula et al.   PLoS One

Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores

(2012) Pheroze Joshi et al.   VIROLOGY

Hyperthermia Stimulates HIV-1 Replication

(2012) Ferdinand Roesch et al.   PLoS Pathogens

Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber

(2011) Nicholai R. Douglas et al.   CELL

Human immunodeficiency virus-1 Nef suppresses Hsp70-mediated Tat activation

(2011) Ryuichi Sugiyama et al.   FEBS LETTERS

Impaired Infectivity of Ritonavir-resistant HIV Is Rescued by Heat Shock Protein 90AB1

(2011) Pheroze Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat Shock Protein 70 Inhibits HIV-1 Vif-mediated Ubiquitination and Degradation of APOBEC3G

(2011) Ryuichi Sugiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal Regulation of Human Immunodeficiency Virus-1 Gene Expression and Replication by Heat Shock Proteins 40 and 70

(2011) Manish Kumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Secretion Modification Region-Derived Peptide Disrupts HIV-1 Nef's Interaction with Mortalin and Blocks Virus and Nef Exosome Release

(2011) M. N. Shelton et al.   JOURNAL OF VIROLOGY

DnaJ homolog Hdj2 Facilitates Japanese Encephalitis Virus Replication

(2011) Robert Wang et al.   Virology Journal

BiP and Multiple DNAJ Molecular Chaperones in the Endoplasmic Reticulum Are Required for Efficient Simian Virus 40 Infection

(2011) E. C. Goodwin et al.   mBio

Identification and Characterization of the Host Protein DNAJC14 as a Broadly Active Flavivirus Replication Modulator

(2011) Zhigang Yi et al.   PLoS Pathogens

Inhibition of heat-shock protein 90 reduces Ebola virus replication

(2010) Darci R. Smith et al.   ANTIVIRAL RESEARCH

Hsp40 proteins modulate humoral and cellular immune response in rheumatoid arthritis patients

(2010) Stefan Tukaj et al.   CELL STRESS & CHAPERONES

Hsp110-Mediated Enhancement of CD4+T Cell Responses to the Envelope Glycoprotein of Members of the FamilyFlaviviridae In VitroDoes Not OccurIn Vivo

(2010) Kerry McLaughlin et al.   Clinical and Vaccine Immunology

Gyrase B Inhibitor Impairs HIV-1 Replication by Targeting Hsp90 and the Capsid Protein

(2010) Luciano Vozzolo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat Shock Protein 72 Is Associated with the Hepatitis C Virus Replicase Complex and Enhances Viral RNA Replication

(2010) Yin-Ju Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of heat-shock protein 90 in hepatitis E virus capsid trafficking

(2010) Z.-Z. Zheng et al.   JOURNAL OF GENERAL VIROLOGY

The Small Heat Shock Protein 27 Is a Key Regulator of CD8+CD57+ Lymphocyte Survival

(2010) K. L. Wood et al.   JOURNAL OF IMMUNOLOGY

Hepatitis B Virus Replication Could Enhance Regulatory T Cell Activity by Producing Soluble Heat Shock Protein 60 From Hepatocytes

(2010) Yasuteru Kondo et al.   JOURNAL OF INFECTIOUS DISEASES

Human Cytomegalovirus Induces the Endoplasmic Reticulum Chaperone BiP through Increased Transcription and Activation of Translation by Using the BiP Internal Ribosome Entry Site

(2010) N. J. Buchkovich et al.   JOURNAL OF VIROLOGY

Association of the Influenza Virus RNA Polymerase Subunit PB2 with the Host Chaperonin CCT

(2010) T. Fislova et al.   JOURNAL OF VIROLOGY

Identification of Essential Filovirion-associated Host Factors by Serial Proteomic Analysis and RNAi Screen

(2010) Kevin B. Spurgers et al.   MOLECULAR & CELLULAR PROTEOMICS

Gymnastics of Molecular Chaperones

(2010) Matthias P. Mayer   MOLECULAR CELL

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GRP94 in ER quality control and stress responses

(2010) Davide Eletto et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome via interaction with the viral NS5B protein

(2010) Yasushi Inoue et al.   VIROLOGY

Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway

(2010) Zhenhong Guan et al.   Protein & Cell

Chaperones and protein folding in the archaea

(2009) Andrew T. Large et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-α-mediated apoptosis

(2009) Su-Min Kang et al.   CANCER LETTERS

Multi-faceted role of HSP40 in cancer

(2009) Aparna Mitra et al.   CLINICAL & EXPERIMENTAL METASTASIS

Glycoprotein 96-Mediated Presentation of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Human Leukocyte Antigen Class I-Restricted Peptide and Humoral Immune Responses to HIV-1 p24

(2009) X. Gong et al.   Clinical and Vaccine Immunology

The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production

(2009) Oscar Gonzalez et al.   HEPATOLOGY

RNA interference mediated silencing of Hsp60 gene in human monocytic myeloma cell line U937 revealed decreased dengue virus multiplication

(2009) Y.S. Padwad et al.   IMMUNOBIOLOGY

Heat Shock Protein 60, via MyD88 Innate Signaling, Protects B Cells from Apoptosis, Spontaneous and Induced

(2009) M. Cohen-Sfady et al.   JOURNAL OF IMMUNOLOGY

High affinity binding between Hsp70 and the C-terminal domain of the measles virus nucleoprotein requires an Hsp40 co-chaperone

(2009) Marie Couturier et al.   JOURNAL OF MOLECULAR RECOGNITION

Modification and Reorganization of the Cytoprotective Cellular Chaperone Hsp27 during Herpes Simplex Virus Type 1 Infection

(2009) S. S. Mathew et al.   JOURNAL OF VIROLOGY

The Endoplasmic Reticulum Chaperone BiP/GRP78 Is Important in the Structure and Function of the Human Cytomegalovirus Assembly Compartment

(2009) N. J. Buchkovich et al.   JOURNAL OF VIROLOGY

Identification of Cellular Proteome Modifications in Response to West Nile Virus Infection

(2009) Boris Pastorino et al.   MOLECULAR & CELLULAR PROTEOMICS

Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

(2009) Frederic D. Bushman et al.   PLoS Pathogens

Chaperonins: The hunt for the Group II mechanism

(2008) Maria Giulia Bigotti et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Structural Basis for the Cooperation of Hsp70 and Hsp110 Chaperones in Protein Folding

(2008) Sigrun Polier et al.   CELL

Molecular Chaperones in Pathogen Virulence: Emerging New Targets for Therapy

(2008) Len Neckers et al.   Cell Host & Microbe

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Hsp27 Inhibits Bax Activation and Apoptosis via a Phosphatidylinositol 3-Kinase-dependent Mechanism

(2008) Andrea Havasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY