Dynamics of Dynamin-Related Protein 1 in Alzheimer’s Disease and Other Neurodegenerative Diseases

Molecular Basis of Alzheimer’s Disease: Focus on Mitochondria

(2019) Darryll M.A. Oliver et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

(2019) P. Hemachandra Reddy et al.   Cells

Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington's disease

(2018) Anne Jessica Roe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1

(2018) A. Mallat et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis

(2018) Amit U Joshi et al.   EMBO Molecular Medicine

Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer’s Disease

(2018) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of Cdk5-mediated Drp1 phosphorylation in Aβ1-42 induced mitochondrial fission and neuronal apoptosis

(2018) Miao-Yu Guo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation

(2018) Dong Hwan Ho et al.   Experimental Neurobiology

Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases

(2018) Zhihao Qi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis

(2017) Fucheng Luo et al.   EXPERIMENTAL NEUROLOGY

Aqua-soluble DDQ reduces the levels of Drp1 and Aβ and inhibits abnormal interactions between Aβ and Drp1 and protects Alzheimer’s disease neurons from Aβ- and Drp1-induced mitochondrial and synaptic toxicities

(2017) Chandra Sekhar Kuruva et al.   HUMAN MOLECULAR GENETICS

Inhibition of mitochondrial fragmentation protects against Alzheimer’s disease in rodent model

(2017) Wenzhang Wang et al.   HUMAN MOLECULAR GENETICS

Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals

(2017) Chenxia Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria-Division Inhibitor 1 Protects Against Amyloid-β induced Mitochondrial Fragmentation and Synaptic Damage in Alzheimer’s Disease

(2017) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

(2017) Jonathon L. Burman et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

(2017) Seung Hyun Baek et al.   JOURNAL OF NEUROSCIENCE

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

(2017) Anil Rana et al.   Nature Communications

Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP

(2017) Jarmon G. Lees et al.   Stem Cells International

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

(2017) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson’s disease

(2017) Simone Bido et al.   Scientific Reports

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

(2016) Ramesh Kandimalla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer’s disease

(2016) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease

(2016) Xiangling Yin et al.   HUMAN MOLECULAR GENETICS

PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

(2016) Kenneth R. Pryde et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson’s disease model induced by MPTP

(2016) Emily Filichia et al.   Scientific Reports

PARK2/Parkin becomes critical when DNM1L/Drp1 is absent

(2015) Madhuparna Roy et al.   Autophagy

Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion

(2015) Christof Osman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis

(2015) Francesco Tafuri et al.   Frontiers in Cellular Neuroscience

Drp1-Mediated Mitochondrial Abnormalities Link to Synaptic Injury in Diabetes Model

(2014) Shengbin Huang et al.   DIABETES

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Parkin and PINK1: much more than mitophagy

(2014) Leslie A. Scarffe et al.   TRENDS IN NEUROSCIENCES

Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo

(2014) Phillip M. Rappold et al.   Nature Communications

Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice

(2013) Ke Cao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Function in Pluripotent Stem Cells and Cellular Reprogramming

(2013) Raul Bukowiecki et al.   GERONTOLOGY

A Calcineurin Docking Motif (LXVP) in Dynamin-related Protein 1 Contributes to Mitochondrial Fragmentation and Ischemic Neuronal Injury

(2013) Andrew M. Slupe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration

(2013) Xing Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynasore Protects Mitochondria and Improves Cardiac Lusitropy in Langendorff Perfused Mouse Heart

(2013) Danchen Gao et al.   PLoS One

Functional Mapping of Human Dynamin-1-Like GTPase Domain Based on X-ray Structure Analyses

(2013) Julia Wenger et al.   PLoS One

Genome-wide RNAi screen reveals a role for the ESCRT complex in rotavirus cell entry

(2013) D. Silva-Ayala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation

(2013) S. Din et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies

(2012) Maria Manczak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

The axonal transport of mitochondria

(2012) W. M. Saxton et al.   JOURNAL OF CELL SCIENCE

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity

(2012) X. Qi et al.   JOURNAL OF CELL SCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease

(2011) R K Dagda et al.   CELL DEATH AND DIFFERENTIATION

Impaired Mitochondrial Biogenesis Precedes Heart Failure in Right Ventricular Hypertrophy in Congenital Heart Disease

(2011) Georgios Karamanlidis et al.   Circulation-Heart Failure

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Secretion of IL-1β triggered by dynasore in murine peritoneal macrophages

(2011) Michèle Seil et al.   Innate Immunity

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

(2011) H.-F. Jheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

(2010) P. Hemachandra Reddy et al.   BRAIN RESEARCH REVIEWS

Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes

(2010) A. Makino et al.   DIABETOLOGIA

Perturbations in Mitochondrial Dynamics Induced by Human Mutant PINK1 Can Be Rescued by the Mitochondrial Division Inhibitor mdivi-1

(2010) Mei Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

(2009) P. Hemachandra Reddy   EXPERIMENTAL NEUROLOGY

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

(2009) Junko Wakabayashi et al.   JOURNAL OF CELL BIOLOGY

Local control of mitochondrial membrane potential, permeability transition pore and reactive oxygen species by calcium and calmodulin in rat ventricular myocytes

(2009) Keiichi Odagiri et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease

(2009) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology

(2008) Xiao-Jian Han et al.   JOURNAL OF CELL BIOLOGY

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

(2008) Adrienne M. Gorman   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondria Are Linked to Calcium Stores in Striated Muscle by Developmentally Regulated Tethering Structures

(2008) Simona Boncompagni et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial Medicine for Aging and Neurodegenerative Diseases

(2008) P. Hemachandra Reddy   NEUROMOLECULAR MEDICINE

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA