Human Mitochondrial Hsp70 (Mortalin): Shedding Light on ATPase Activity, Interaction with Adenosine Nucleotides, Solution Structure and Domain Organization

In vitrocharacterization of bacterial and chloroplast Hsp70 systems reveals an evolutionary optimization of the co-chaperones for their Hsp70 partner

(2014) Daniel Veyel et al.   BIOCHEMICAL JOURNAL

Conformational Changes in Human Hsp70 Induced by High Hydrostatic Pressure Produce Oligomers with ATPase Activity but without Chaperone Activity

(2014) Thaı́s L. S. Araujo et al.   BIOCHEMISTRY

Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone

(2014) Joseph Amick et al.   PROTEIN SCIENCE

GENFIT: software for the analysis of small-angle X-ray and neutron scattering data of macromolecules in solution

(2014) Francesco Spinozzi et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein

(2013) Anna Rodina et al.   CHEMISTRY & BIOLOGY

Structural and stability studies of the human mtHsp70-escort protein 1: An essential mortalin co-chaperone

(2013) P.R. Dores-Silva et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Structural and functional studies of Leishmania braziliensis Hsp90

(2012) K.P. Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity

(2011) Peng Zhai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of nucleotide-induced changes on the quaternary structure of human 70 kDa heat shock protein Hsp70.1 by analytical ultracentrifugation

(2011) Julio C. Borges et al.   BMB Reports

Analysis of Molecular Targets of Mycobacterium tuberculosis by Analytical Ultracentrifugation

(2011) J. C. Borges et al.   CURRENT MEDICINAL CHEMISTRY

Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones

(2011) Aikaterini Rousaki et al.   JOURNAL OF MOLECULAR BIOLOGY

The Molecular Chaperone Hsp70 Family Members Function by a Bidirectional Heterotrophic Allosteric Mechanism

(2011) Kelly P. da Silva et al.   PROTEIN AND PEPTIDE LETTERS

Function of Cytosolic Chaperones in Tom70-Mediated Mitochondrial Import

(2011) Anna C.Y. Fan et al.   PROTEIN AND PEPTIDE LETTERS

The DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9

(2011) Michael T. Vu et al.   PROTEIN SCIENCE

Mortalin overexpression attenuates beta-amyloid-induced neurotoxicity in SH-SY5Y cells

(2010) Mingyue Qu et al.   BRAIN RESEARCH

Kinetic and structural characterization of human mortalin

(2010) Wen-I Luo et al.   PROTEIN EXPRESSION AND PURIFICATION

Functional characterization of the DnaK chaperone system from the archaeonMethanothermobacter thermautotrophicusΔH

(2009) Simone L. Popp et al.   FEBS LETTERS

The role of molecular chaperones in human misfolding diseases

(2009) Sarah A. Broadley et al.   FEBS LETTERS

Combining structure and dynamics: non-denaturing high-pressure effect on lysozyme in solution

(2009) M. G. Ortore et al.   Journal of the Royal Society Interface

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Human Escort Protein Hep Binds to the ATPase Domain of Mitochondrial Hsp70 and Regulates ATP Hydrolysis

(2008) Peng Zhai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of Mitochondrial Hsp70/Hsp75 in Rat Brain Protects Mitochondria, Reduces Oxidative Stress, and Protects from Focal Ischemia

(2008) Lijun Xu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Modern analytical ultracentrifugation in protein science: A tutorial review

(2002) Jacob Lebowitz et al.   PROTEIN SCIENCE