Review
Biochemistry & Molecular Biology
Xuejun Shao, Shenghao Hua, Tao Feng, Dickson Kofi Wiredu Ocansey, Lei Yin
Summary: Hypoxic tumor-derived exosomes play a crucial role in the interaction between cancer cells and their microenvironment, influencing immune evasion and tumor progression. These exosomes educate immune cells and modulate factors that contribute to the immune-suppressive milieu of the tumor environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Gregg L. Semenza
Summary: This review summarizes recent reports on hypoxia-induced mechanisms of immune evasion in various types of cancer. These studies suggest novel therapeutic approaches to improve anti-tumor immunity and increase responses to immunotherapy.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Luying Zhang, Kamil Kuca, Li You, Yingying Zhao, Kamil Musilek, Eugenie Nepovimova, Qinghua Wu, Wenda Wu, Vojtech Adam
Summary: The underlying mechanism of tumor immune evasion, particularly the role of STAT3 in promoting tumor cell escape from immune surveillance through regulating autophagy molecules, immune factors, and immunosuppressive cell recruitment, is discussed in this review. The article also highlights the significance of the research on STAT3 signaling and tumor immune evasion in the development of targeted drugs for immunotherapy.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cell Biology
Yan Zhang, Ruimin Hu, Bixin Xi, Dimin Nie, Hanxiao Xu, Aiguo Liu
Summary: Low-dose chemotherapy induces senescence in neuroblastoma cells, promoting the shedding of NKG2D ligand MICA/B through the MALAT1/miR-92a/ADAM10 axis, thereby contributing to the formation of a suppressive immune microenvironment and promoting immune escape.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Mohammad Hossein Razizadeh, Alireza Zafarani, Mahsa Taghavi-Farahabadi, Hossein Khorramdelazad, Sara Minaeian, Mohammad Mahmoudi
Summary: This article initially examines the role of natural killer cells in various viral infections and the mechanisms used by viruses to evade these important immune system cells. Subsequently, it discusses the role of NK cell-derived exosomes in controlling various viral infections. Finally, it reviews the current position of these cells in the treatment of viral infections and the therapeutic potential of their exosomes.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Immunology
Pei-Yu Chen, Wen-Fei Wei, Hong-Zhen Wu, Liang-Sheng Fan, Wei Wang
Summary: CAFs are important and heterogeneous components of the tumor extracellular matrix, with different origins and biomarkers, playing a role in immune regulation of the tumor microenvironment and exerting immunosuppressive functions through various mechanisms. Inhibition of CAFs and targeted therapy against CAFs offer new adjuvant means for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Tong Ding, Ting Cheng, Xuerui Zhu, Wenwen Xiao, Sijin Xia, Liurong Fang, Puxian Fang, Shaobo Xiao
Summary: Porcine epidemic diarrhea virus (PEDV) is a highly pathogenic enteric coronavirus that causes severe enteritis and lethal watery diarrhea in suckling piglets. In this study, it was found that exosomes from PEDV-infected cells contain viral genomic RNA and viral nucleocapsid protein, and these exosomes can transmit the virus to both susceptible and non-susceptible cells. This study reveals a potential immune evasion mechanism utilized by PEDV and provides new insight into the transmission and infection of this important pathogen.
VETERINARY MICROBIOLOGY
(2023)
Article
Immunology
Sarthak Sahoo, Sonali Priyadarshini Nayak, Kishore Hari, Prithu Purkait, Susmita Mandal, Akash Kishore, Herbert Levine, Mohit Kumar Jolly
Summary: Recent research shows that cells with hybrid epithelial/mesenchymal characteristics can have high levels of PD-L1, important for immune evasion, without needing to fully undergo epithelial-mesenchymal transition. This cellular state in breast cancer is associated with resistance to anti-estrogen therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiaotu Ma, Meinan Yao, Yu Gao, Yale Yue, Yao Li, Tianjiao Zhang, Guangjun Nie, Xiao Zhao, Xiaolong Liang
Summary: Immune cell-derived exosomes have been engineered as radiotherapy sensitizers in order to enhance the efficacy of radiotherapy by modifying the immune microenvironment and increasing DNA damage repair inhibition.
Review
Toxicology
Li You, Yingying Zhao, Kamil Kuca, Xu Wang, Patrik Oleksak, Zofia Chrienova, Eugenie Nepovimova, Vesna Jacevic, Qinghua Wu, Wenda Wu
Summary: T-2 toxin and DON, as type A and B trichothecenes, widely occur as pollutants in food and crops, causing toxicities primarily based on oxidative stress mechanisms. Mitochondria play a significant role in apoptosis induced by oxidative stress from these toxins. Hypoxia and immune evasion are closely related to oxidative stress in this context.
ARCHIVES OF TOXICOLOGY
(2021)
Review
Chemistry, Medicinal
Li You, Wenda Wu, Xu Wang, Liurong Fang, Vojtech Adam, Eugenie Nepovimova, Qinghua Wu, Kamil Kuca
Summary: Hypoxia and HIF-1 are crucial in tumor immune evasion, suppressing the immune system to promote tumor growth and metastasis.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Genetics & Heredity
Kimberly A. Luddy, Jamie K. Teer, Audrey Freischel, Cliona O'Farrelly, Robert Gatenby
Summary: In an evolving population, fitness determines proliferation and the dominant population usually has the most well adapted phenotype. Negative selection provides crucial information about genes involved in essential cellular processes. Similar to immunoediting, evolutionary triage eliminates mutations in tumor cells that increase susceptibility to immune response while mutations that shield them from immune attack increase proliferation. This new approach can be used to investigate evolutionary triage in immune-related genes and potentially lead to new treatment options.
FRONTIERS IN GENETICS
(2022)
Review
Immunology
Senzhao Zhang, Yu He, Zhen Wu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Qun Gao, Di Sun, Ling Zhang, Yanling Yu, Shun Chen, Anchun Cheng
Summary: The Flavivirus genus comprises various viruses that cause severe diseases in humans. The NS1 glycoprotein, encoding a 352-amino-acid polypeptide, is highly conserved among flaviviruses and occurs in different forms. Intracellular dimeric NS1 is involved in viral replication and virion maturation, whereas extracellular sNS1 plays a critical role in immune evasion, pathogenesis, and interaction with natural hosts. This review provides an overview of recent research progress on flavivirus NS1, including its structure, secretory pathways, and multiple functions in viral replication and host interactions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Daan F. Boreel, Paul N. Span, Annemarie Kip, Milou Boswinkel, Johannes P. W. Peters, Gosse J. Adema, Johan Bussink, Sandra Heskamp
Summary: Limited oxygen diffusion and increased oxygen consumption in solid malignancies lead to chronic hypoxia, which induces radioresistance and an immunosuppressive microenvironment. This study aimed to develop a radiolabeled antibody to visualize chronic hypoxia and study immune cell populations in these hypoxic areas. The results showed that the radiotracer binds to CAIX-expressing cells in vitro and accumulates in CAIX+ areas in vivo. The technique can quantitatively distinguish between tumor models with varying CAIX+ fractions and identified less infiltration of immune cells in the CAIX+ areas.
MOLECULAR PHARMACEUTICS
(2023)
Review
Oncology
Judith Wienke, Miranda P. Dierselhuis, Godelieve A. M. Tytgat, Annette Kuenkele, Stefan Nierkens, Jan J. Molenaar
Summary: Immunotherapy shows promise in treating pediatric cancers, but faces challenges in pediatric oncology such as low treatment success rates and tumor immune evasion strategies.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Chiharu Sogawa, Takanori Eguchi, Manh Tien Tran, Masayuki Ishige, Kilian Trin, Yuka Okusha, Eman Ahmed Taha, Yanyin Lu, Hotaka Kawai, Norio Sogawa, Masaharu Takigawa, Stuart K. Calderwood, Kuniaki Okamoto, Ken-ichi Kozaki
Article
Biochemistry & Molecular Biology
Mariko Seyama, Kaya Yoshida, Kayo Yoshida, Natsumi Fujiwara, Kisho Ono, Takanori Eguchi, Hotaka Kawai, Jiajie Guo, Yao Weng, Yuan Haoze, Kenta Uchibe, Mika Ikegame, Akira Sasaki, Hitoshi Nagatsuka, Kuniaki Okamoto, Hirohiko Okamura, Kazumi Ozaki
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Manh Tien Tran, Yuka Okusha, Yunxia Feng, Masatoshi Morimatsu, Penggong Wei, Chiharu Sogawa, Takanori Eguchi, Tomoko Kadowaki, Eiko Sakai, Hirohiko Okamura, Keiji Naruse, Takayuki Tsukuba, Kuniaki Okamoto
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Editorial Material
Medicine, General & Internal
Takanori Eguchi
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Cell Biology
Chiharu Sogawa, Takanori Eguchi, Yuri Namba, Yuka Okusha, Eriko Aoyama, Kazumi Ohyama, Kuniaki Okamoto
Summary: Research has shown that tumoroids of metastatic colorectal cancer exhibit different responses to cisplatin, imatinib, and 5-fluorouracil in a 3D culture system, indicating that this system is useful for modeling drug resistance in cancer with enhanced stem cell properties.
Article
Cell Biology
Yanyin Lu, Takanori Eguchi, Chiharu Sogawa, Eman A. Taha, Manh Tien Tran, Toshiki Nara, Penggong Wei, Shiro Fukuoka, Takuya Miyawaki, Kuniaki Okamoto
Summary: Researchers developed a combination method to characterize different types of EVs and identified five types of EVs in the culture supernatant of macrophage-like cells. Through molecular transfer assays, it was confirmed that macrophage-secreted EXO-S and EXO-L were more efficient in transferring GFP to oral carcinoma cells, but also significantly reduced the cell viability of oral carcinoma cells.
Review
Chemistry, Multidisciplinary
Eman A. Taha, Joseph Lee, Akitsu Hotta
Summary: The discovery of CRISPR genome editing technology has provided a versatile approach for treating multiple diseases. However, the safe and effective delivery of genome-editing components remains a key challenge for in vivo genome editing therapy. Recent developments in transient delivery systems and ongoing clinical trials offer potential solutions and applications for in vivo genome editing therapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Tsukasa Shigehiro, Maho Ueno, Mayumi Kijihira, Ryotaro Takahashi, Chiho Umemura, Eman A. Taha, Chisaki Kurosaka, Megumi Asayama, Hiroshi Murakami, Ayano Satoh, Yoshimasa Nakamura, Junichiro Futami, Junko Masuda
Summary: mLNs play a role in the inflammatory immune conversion during breast cancer development, with T cells converting from a pro-inflammatory state to an anti-inflammatory state, and CD103(+)CD11b(+) dendritic cells potentially activating cancer-reactive T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Takanori Eguchi, Eva Csizmadia, Hotaka Kawai, Mona Sheta, Kunihiro Yoshida, Thomas L. Prince, Barbara Wegiel, Stuart K. Calderwood
Summary: The prostate epithelial transcription factor SCAND1 can reverse the mesenchymal and hybrid E/M phenotypes of cancer cells, inhibit their proliferation and migration, and promote an epithelial phenotype. SCAND1 achieves this by repressing the gene expression of EMT drivers and the MAP3K-MEK-ERK signaling pathway. Overexpression of SCAND1 has shown potential therapeutic value in reducing tumor cell proliferation and metastasis.
Review
Biology
Mona Sheta, Eman A. Taha, Yanyin Lu, Takanori Eguchi
Summary: Extracellular vesicles (EVs) are cell-derived membrane-surrounded vesicles that carry bioactive molecules and deliver them to recipient cells. They can be classified into classical EVs (exosomes, microvesicles, and apoptotic bodies) and additional types (autophagic EVs, matrix vesicles, and stressed EVs). EVs are involved in the communication between cancer cells and tumor-associated cells (TAC), leading to the establishment of immunosuppressive and chemoresistant microenvironments. Cancer EVs play important roles in immunosuppression, immune evasion, and cellular transformation, and can change hot tumors into cold ones.
Article
Cell Biology
Kisho Ono, Chiharu Sogawa, Hotaka Kawai, Manh Tien Tran, Eman A. Taha, Yanyin Lu, May Wathone Oo, Yuka Okusha, Hirohiko Okamura, Soichiro Ibaragi, Masaharu Takigawa, Ken-Ichi Kozaki, Hitoshi Nagatsuka, Akira Sasaki, Kuniaki Okamoto, Stuart K. Calderwood, Takanori Eguchi
JOURNAL OF EXTRACELLULAR VESICLES
(2020)
Article
Cell Biology
Yuka Okusha, Manh Tien Tran, Mami Itagaki, Chiharu Sogawa, Takanori Eguchi, Tatsuo Okui, Tomoko Kadowaki, Eiko Sakai, Takayuki Tsukuba, Kuniaki Okamoto
Review
Biology
Takanori Eguchi, Eman Ahmed Taha, Stuart K. Calderwood, Kisho Ono