Biochemical Mechanisms of Sirtuin-Directed Protein Acylation in Hepatic Pathologies of Mitochondrial Dysfunction

Focus on Molecular Functions of Anti-Aging Deacetylase SIRT3

(2022) Jarmila Nahálková   BIOCHEMISTRY-MOSCOW

Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice

(2022) Dhaval P. Bhatt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice

(2022) Brenna Osborne et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer

(2021) Yashira L. Negrón Abril et al.   ONCOGENE

Chronic liver disease: Global perspectives and future challenges to delivering quality health care

(2021) Wai-Kay Seto et al.   PLoS One

Pilot Clinical Trial of Time-Restricted Eating in Patients with Metabolic Syndrome

(2021) Iwona Świątkiewicz et al.   Nutrients

Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy

(2021) Johanna C. Arroyave-Ospina et al.   Antioxidants

The Roles of Post-Translational Modifications on mTOR Signaling

(2021) Shasha Yin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirtuin 2 Regulates Protein LactoylLys Modifications

(2021) Erin Q. Jennings et al.   CHEMBIOCHEM

Mitochondria: A critical hub for hepatic stellate cells activation during chronic liver diseases

(2021) Devaraj Ezhilarasan   Hepatobiliary & Pancreatic Diseases International

NAD + and NAFLD – Caution, Causality, and Careful Optimism

(2021) Morten Dall et al.   JOURNAL OF PHYSIOLOGY-LONDON

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

(2021) Mihoko Yoshino et al.   SCIENCE

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

(2021) Patrick C. Bradshaw   Antioxidants

Time-restricted eating for the prevention and management of metabolic diseases

(2021) Emily N Manoogian et al.   ENDOCRINE REVIEWS

A 10-hour time-restricted eating intervention to address cancer-related fatigue among cancer survivors.

(2021) Amber Kleckner et al.   JOURNAL OF CLINICAL ONCOLOGY

Disturbed mitochondrial acetylation in accordance with the availability of acetyl groups in hepatocellular carcinoma

(2021) Xiaowen Hu et al.   MITOCHONDRION

Dihydromyricetin attenuates palmitic acid-induced oxidative stress by promoting autophagy via SIRT3-ATG4B signaling in hepatocytes

(2021) Li Huang et al.   Nutrition & Metabolism

Restoration of energy homeostasis by SIRT6 extends healthy lifespan

(2021) A. Roichman et al.   Nature Communications

Alcohol Abstinence Rescues Hepatic Steatosis and Liver Injury via Improving Metabolic Reprogramming in Chronic Alcohol-Fed Mice

(2021) Aiwen Pi et al.   Frontiers in Pharmacology

The Endless Sources of Hepatocellular Carcinoma Heterogeneity

(2021) Marina Barcena-Varela et al.   Cancers

Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma

(2021) Ho-Yeop Lee et al.   Cells

Molecular aspects of fructose metabolism and metabolic disease

(2021) Mark A. Herman et al.   Cell Metabolism

Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis–like phenotypes

(2021) Morten Dall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical genesis of enzymatic and non-enzymatic post-translational modifications

(2021) Erin Q. Jennings et al.   MOLECULAR ASPECTS OF MEDICINE

Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation

(2021) Sophie Trefely et al.   MOLECULAR CELL

Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression

(2021) Feroza K. Choudhury   Antioxidants

The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase

(2021) Kai-Min Niu et al.   Frontiers in Nutrition

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Alcohol Makes Its Epigenetic Marks

(2020) Subhash C. Pandey et al.   Cell Metabolism

NAFLD 2020: The State of the Disease

(2020) Thomas G. Cotter et al.   GASTROENTEROLOGY

Antrodan Alleviates High-Fat and High-Fructose Diet-Induced Fatty Liver Disease in C57BL/6 Mice Model via AMPK/Sirt1/SREBP-1c/PPARγ Pathway

(2020) Charng-Cherng Chyau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Compartmentalized acyl-CoA metabolism and roles in chromatin regulation

(2020) Sophie Trefely et al.   Molecular Metabolism

Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells

(2020) Hanhee Jo et al.   BMC CANCER

Vitexin protects against ethanol-induced liver injury through Sirt1/p53 signaling pathway

(2020) Huiqi Yuan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging

(2020) Daniel C. Levine et al.   MOLECULAR CELL

Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation

(2020) Anyuan He et al.   MOLECULAR CELL

Comprehensive analysis of posttranslational protein modifications in aging of subcellular compartments

(2020) Tim Baldensperger et al.   Scientific Reports

Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma

(2020) Kishor Pant et al.   Cells

Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer

(2020) Daniela Tomaselli et al.   Frontiers in Oncology

No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial

(2020) Marlies de Ligt et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Sirt3 promotes hepatocellular carcinoma cells sensitivity to regorafenib through the acceleration of mitochondrial dysfunction

(2020) Ruobing Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation

(2020) Anyuan He et al.   Autophagy

Cystathionine gamma-lyase/H2S system suppresses hepatic acetyl-CoA accumulation and nonalcoholic fatty liver disease in mice

(2020) Amr Ali et al.   LIFE SCIENCES

Ethanol metabolism: The good, the bad, and the ugly

(2020) David F. Wilson et al.   MEDICAL HYPOTHESES

SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2

(2020) Emma Barroso et al.   Cell Communication and Signaling

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

(2020) Alba Luengo et al.   MOLECULAR CELL

Efficacy of resveratrol supplementation on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis

(2020) Shumin Wei et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Efficacy of resveratrol supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials

(2020) Sahar Rafiee et al.   Complementary Therapies in Clinical Practice

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

(2019) Rebecca Bertolio et al.   Nature Communications

The Circadian Clock and Liver Function in Health and Disease

(2019) Atish Mukherji et al.   JOURNAL OF HEPATOLOGY

Role of SIRT-3, p-mTOR and HIF-1α in Hepatocellular Carcinoma Patients Affected by Metabolic Dysfunctions and in Chronic Treatment with Metformin

(2019) Serena De Matteis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients

(2019) Nunzia D’Onofrio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3

(2019) Xi Xu et al.   FASEB JOURNAL

Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation

(2019) Parvin Farzanegi et al.   European Journal of Sport Science

Spatial heterogeneity in the mammalian liver

(2019) Shani Ben-Moshe et al.   Nature Reviews Gastroenterology & Hepatology

Effect of resveratrol on metabolic syndrome components: A systematic review and meta-analysis

(2019) Sedigheh Asgary et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway

(2019) Jie Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins

(2019) Samir Softic et al.   Cell Metabolism

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway

(2019) Xue-Yang Chen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The Roles of Sirtuin Family Proteins in Cancer Progression

(2019) Erhu Zhao et al.   Cancers

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

(2018) Ole L Dollerup et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dihydromyricetin Ameliorates Nonalcoholic Fatty Liver Disease by Improving Mitochondrial Respiratory Capacity and Redox Homeostasis Through Modulation of SIRT3 Signaling

(2018) Xianglong Zeng et al.   ANTIOXIDANTS & REDOX SIGNALING

The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications

(2018) Chris Carrico et al.   Cell Metabolism

The Global Epidemic of the Metabolic Syndrome

(2018) Mohammad G. Saklayen   CURRENT HYPERTENSION REPORTS

Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism

(2018) Russell P. Goodman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

(2018) Xinjian Li et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression

(2018) Yang Q. Xia et al.   Frontiers in Pharmacology

Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway

(2018) Sufan Wang et al.   Redox Biology

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

(2018) Sung Min Son et al.   Cell Metabolism

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Acetylation of Mitochondrial Proteins in the Heart: The Role of SIRT3

(2018) Rebecca M. Parodi-Rullán et al.   Frontiers in Physiology

Alcoholic liver disease

(2018) Helmut K. Seitz et al.   Nature Reviews Disease Primers

Modulation of Insulin Resistance in NAFLD

(2018) Reenam Khan et al.   HEPATOLOGY

Identification of a cellularly active SIRT6 allosteric activator

(2018) Zhimin Huang et al.   Nature Chemical Biology

Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals

(2018) Marcos C. Carreira et al.   Oxidative Medicine and Cellular Longevity

Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose

(2018) Jesse G. Meyer et al.   PLoS One

Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction

(2017) Samer Tohme et al.   HEPATOLOGY

No Beneficial Effects of Resveratrol on the Metabolic Syndrome: A Randomized Placebo-Controlled Clinical Trial

(2017) Thomas Nordstrøm Kjær et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway

(2017) Ling-Fang Wang et al.   Lipids in Health and Disease

SIRT3 functions as a tumor suppressor in hepatocellular carcinoma

(2017) Xianchun Zeng et al.   TUMOR BIOLOGY

Metabolic Syndrome Prevalence by Race/Ethnicity and Sex in the United States, National Health and Nutrition Examination Survey, 1988–2012

(2017) Justin Xavier Moore et al.   Preventing Chronic Disease

Non-enzymatic N -acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S -acetylated Thiol Intermediate Sensitive to Glyoxalase II

(2017) Andrew M. James et al.   Cell Reports

The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat

(2017) David Long et al.   Scientific Reports

Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

(2016) Aneesa Ansari et al.   AGING CELL

Liver glucose metabolism in humans

(2016) M. M. Adeva-Andany et al.   BIOSCIENCE REPORTS

Hepatic NAD+deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing

(2016) Can-Can Zhou et al.   BRITISH JOURNAL OF PHARMACOLOGY

SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth

(2016) Seong-Hoon Park et al.   CANCER RESEARCH

Post-translational modifications in mitochondria: protein signaling in the powerhouse

(2016) Amanda R. Stram et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Challenges and issues with streptozotocin-induced diabetes – A clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics

(2016) Sameer N. Goyal et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Hepatic glucose and lipid metabolism

(2016) John G. Jones   DIABETOLOGIA

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

(2016) Samir Softic et al.   DIGESTIVE DISEASES AND SCIENCES

The role of sirtuins in cellular homeostasis

(2016) Wioleta Kupis et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones

(2016) Jing Jin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway

(2016) Na-Na Tao et al.   Oncotarget

SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis

(2016) Yuming Li et al.   Oncotarget

SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2

(2016) Matthew D. Hirschey et al.   Aging-US

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

(2016) Samuel A.J. Trammell et al.   Scientific Reports

Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial

(2015) Shihui Chen et al.   DIGESTIVE AND LIVER DISEASE

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism

(2015) Hyunbae Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3β/BCL2-associated X protein-dependent apoptotic pathway

(2015) C-L Song et al.   ONCOGENE

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

(2015) Xiao-Hong Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of autophagy and mitophagy by nutrient availability and acetylation

(2014) Bradley R. Webster et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

SnapShot: Mammalian Sirtuins

(2014) Kristin A. Anderson et al.   CELL

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Coumestrol Induces Mitochondrial Biogenesis by Activating Sirt1 in Cultured Skeletal Muscle Cells

(2014) Dae-Bang Seo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anticancer Agents Targeted to Sirtuins

(2014) Tomohiro Kozako et al.   MOLECULES

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

(2014) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Sirtuins: guardians of mammalian healthspan

(2014) William Giblin et al.   TRENDS IN GENETICS

Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria

(2014) Kyriakos N. Papanicolaou et al.   Frontiers in Physiology

Functions of autophagy in normal and diseased liver

(2013) Mark J. Czaja et al.   Autophagy

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling

(2013) Juan Chen et al.   HEPATOLOGY

SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling

(2013) Juan L. García-Rodríguez et al.   HEPATOLOGY

Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site

(2013) Sivakama S. Bharathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Forkhead box class O transcription factors in liver function and disease

(2013) Irina Tikhanovich et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity

(2013) Alexander R. Moschen et al.   JOURNAL OF HEPATOLOGY

Tissue Specific Phosphorylation of Mitochondrial Proteins Isolated from Rat Liver, Heart Muscle, and Skeletal Muscle

(2013) Steffen Bak et al.   JOURNAL OF PROTEOME RESEARCH

Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation

(2013) João Soeiro Teodoro et al.   MITOCHONDRION

Activation of the Aryl Hydrocarbon Receptor Sensitizes Mice to Nonalcoholic Steatohepatitis by Deactivating Mitochondrial Sirtuin Deacetylase Sirt3

(2013) J. He et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization

(2013) Lei Lv et al.   MOLECULAR CELL

Evolution and functional cross-talk of protein post-translational modifications

(2013) Pedro Beltrao et al.   Molecular Systems Biology

Mouse model of chronic and binge ethanol feeding (the NIAAA model)

(2013) Adeline Bertola et al.   Nature Protocols

Early bioenergetic evolution

(2013) F. L. Sousa et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Ethanol Metabolism Modifies Hepatic Protein Acylation in Mice

(2013) Kristofer S. Fritz et al.   PLoS One

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

Multiple Regulatory Layers of SREBP1/2 by SIRT6

(2013) Sivan Elhanati et al.   Cell Reports

Protein Lysine Acylation and Cysteine Succination by Intermediates of Energy Metabolism

(2012) Hening Lin et al.   ACS Chemical Biology

Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b

(2012) Jeong Kyu Kim et al.   HEPATOLOGY

Mitochondrial Protein Acylation and Intermediary Metabolism: Regulation by Sirtuins and Implications for Metabolic Disease

(2012) John C. Newman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Acetylome Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice

(2012) Kristofer S. Fritz et al.   JOURNAL OF PROTEOME RESEARCH

Fructose-rich diet leads to reduced aerobic capacity and to liver injury in rats

(2012) José Botezelli et al.   Lipids in Health and Disease

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions

(2012) Alexander Laemmle et al.   PLoS One

Low SIRT3 Expression Correlates with Poor Differentiation and Unfavorable Prognosis in Primary Hepatocellular Carcinoma

(2012) Chris Zhiyi Zhang et al.   PLoS One

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth

(2011) J. Chen et al.   CANCER RESEARCH

Regulation of hepatic lipin-1 by ethanol: Role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice

(2011) Ming Hu et al.   HEPATOLOGY

The Metabolic Syndrome—from Insulin Resistance to Obesity and Diabetes

(2011) Emily Jane Gallagher et al.   MEDICAL CLINICS OF NORTH AMERICA

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

The metabolic footprint of aging in mice

(2011) Riekelt H. Houtkooper et al.   Scientific Reports

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

(2010) Agnieszka A. Kendrick et al.   BIOCHEMICAL JOURNAL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity

(2010) Jianjun Bao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intracellular Nicotinamide Phosphoribosyltransferase Protects against Hepatocyte Apoptosis and Is Down-Regulated in Nonalcoholic Fatty Liver Disease

(2010) Tuva B. Dahl et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

(2010) Julien Bricambert et al.   JOURNAL OF CLINICAL INVESTIGATION

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Chronic Ethanol Consumption Induces Global Hepatic Protein Hyperacetylation

(2009) Blythe D. Shepard et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Transcriptional coactivator p300 regulates glucose-induced gene expression in endothelial cells

(2009) Shali Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Harmonizing the Metabolic Syndrome

(2009) K.G.M.M. Alberti et al.   CIRCULATION

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Alcohol-induced protein hyperacetylation: Mechanisms and consequences

(2009) Blythe-D Shepard   WORLD JOURNAL OF GASTROENTEROLOGY

Resveratrol alleviates alcoholic fatty liver in mice

(2008) Joanne M. Ajmo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function

(2008) Charles S. Lieber et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ethanol intoxication increases hepatic N-lysyl protein acetylation

(2008) Matthew J. Picklo   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA