期刊
MOLECULES
卷 19, 期 12, 页码 20295-20313出版社
MDPI AG
DOI: 10.3390/molecules191220295
关键词
sirtuins; cancer; apoptosis; autophagy
资金
- Japan Society for the Promotion of Science
- Fukuoka Foundation for Sound Health Cancer Research Fund
- Central Research Institute of Fukuoka University [141043]
Sirtuins are nicotinamide adenine dinucleotide(+)-dependent deacetylases of which there are seven isoforms (SIRT1-7). Sirtuin activity is linked to gene expression, lifespan extension, neurodegeneration, and age-related disorders. Numerous studies have suggested that sirtuins could be of great significance with regard to both antiaging and tumorigenesis, depending on its targets in specific signaling pathways or in specific cancers. Recent studies have identified small chemical compounds that modulate sirtuins, and these modulators have enabled a greater understanding of the biological function and molecular mechanisms of sirtuins. This review highlights the possibility of sirtuins, especially SIRT1 and SIRT2, for cancer therapy targets, and focuses on the therapeutic potential of sirtuin modulators both in cancer prevention and treatment.
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