标题
Sirtuins as regulators of metabolism and healthspan
作者
关键词
-
出版物
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 13, Issue 4, Pages 225-238
出版商
Springer Nature
发表日期
2012-03-07
DOI
10.1038/nrm3293
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
- (2016) Orsolya M. Palacios et al. Aging-US
- Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition
- (2012) Rui-Hong Wang et al. International Journal of Biological Sciences
- Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis
- (2011) Pablo J Fernandez-Marcos et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Sirtuin 1 in lipid metabolism and obesity
- (2011) Thaddeus T. Schug et al. ANNALS OF MEDICINE
- SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
- (2011) Lydia W.S. Finley et al. CANCER CELL
- NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function
- (2011) Hiroyasu Yamamoto et al. CELL
- Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
- (2011) Silvie Timmers et al. Cell Metabolism
- Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice
- (2011) Jun Yoshino et al. Cell Metabolism
- PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
- (2011) Péter Bai et al. Cell Metabolism
- Fine Tuning Our Cellular Factories: Sirtuins in Mitochondrial Biology
- (2011) Lei Zhong et al. Cell Metabolism
- PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
- (2011) Péter Bai et al. Cell Metabolism
- CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
- (2011) Lilia G Noriega et al. EMBO REPORTS
- Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
- (2011) Yu Li et al. FASEB JOURNAL
- Exposure to resveratrol triggers pharmacological correction of fatty acid utilization in human fatty acid oxidation-deficient fibroblasts
- (2011) J. Bastin et al. HUMAN MOLECULAR GENETICS
- Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Controls Transcription of theSirt3Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype
- (2011) Albert Giralt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sirtuin 1 (SIRT1) Deacetylase Activity Is Not Required for Mitochondrial Biogenesis or Peroxisome Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation following Endurance Exercise
- (2011) Andrew Philp et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
- (2011) Simon Schenk et al. JOURNAL OF CLINICAL INVESTIGATION
- Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
- (2011) Rui-Hong Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development
- (2011) Peter Mulligan et al. MOLECULAR CELL
- SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome
- (2011) Matthew D. Hirschey et al. MOLECULAR CELL
- Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase
- (2011) Wenqing Jiang et al. MOLECULAR CELL
- Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
- (2011) Mohan Viswanathan et al. NATURE
- Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
- (2011) Camilla Burnett et al. NATURE
- Sirtuins, Aging, and Medicine
- (2011) Leonard Guarente NEW ENGLAND JOURNAL OF MEDICINE
- Design, synthesis and biological characterization of novel inhibitors of CD38
- (2011) Min Dong et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity
- (2011) Lydia W. S. Finley et al. PLoS One
- Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling
- (2011) B. Beirowski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
- (2011) E. Jing et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
- (2011) J. Du et al. SCIENCE
- SRT1720 improves survival and healthspan of obese mice
- (2011) Robin K. Minor et al. Scientific Reports
- Mammalian Sirtuins: Biological Insights and Disease Relevance
- (2010) Marcia C. Haigis et al. Annual Review of Pathology-Mechanisms of Disease
- Mitochondrial sirtuins
- (2010) Jing-Yi Huang et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose
- (2010) Lei Tong et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
- (2010) Shinichi Someya et al. CELL
- The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
- (2010) Lei Zhong et al. CELL
- Metabolic Networks of Longevity
- (2010) Riekelt H. Houtkooper et al. CELL
- Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation
- (2010) Xiaolei Qiu et al. Cell Metabolism
- SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production
- (2010) Tadahiro Shimazu et al. Cell Metabolism
- Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
- (2010) Simon A. Hawley et al. Cell Metabolism
- Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis
- (2010) Hyun-Seok Kim et al. Cell Metabolism
- Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
- (2010) Carles Cantó et al. Cell Metabolism
- AMP-activated protein kinase and its downstream transcriptional pathways
- (2010) Carles Cantó et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Genetic control ofde novolipogenesis: role in diet-induced obesity
- (2010) Maggie S. Strable et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity
- (2010) J. Rutanen et al. DIABETES
- PPARβ/δ regulates the human SIRT1 gene transcription via Sp1
- (2010) Mizuho Okazaki et al. ENDOCRINE JOURNAL
- The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways
- (2010) Riekelt H. Houtkooper et al. ENDOCRINE REVIEWS
- Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/−Mice: A Role of Lipid Mobilization and Inflammation
- (2010) Fen Xu et al. ENDOCRINOLOGY
- Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
- (2010) A. K. Walker et al. GENES & DEVELOPMENT
- SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism
- (2010) Bhaskar Ponugoti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells
- (2010) Nargis Nasrin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
- (2010) Xiumei Guo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
- (2010) Michelle Pacholec et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition
- (2010) Jiyoung Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
- (2010) Carlos Escande et al. JOURNAL OF CLINICAL INVESTIGATION
- Metabolomic Analysis of Livers and Serum from High-Fat Diet Induced Obese Mice
- (2010) Hyun-Jin Kim et al. JOURNAL OF PROTEOME RESEARCH
- Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
- (2010) Satoru Hayashida et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
- (2010) Raga Krishnakumar et al. MOLECULAR CELL
- Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
- (2010) Ji-Hong Lim et al. MOLECULAR CELL
- SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
- (2010) Matthew D. Hirschey et al. NATURE
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
- (2010) Limin Han et al. NUCLEIC ACIDS RESEARCH
- Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity
- (2010) B. Schwer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Extending Healthy Life Span--From Yeast to Humans
- (2010) L. Fontana et al. SCIENCE
- Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
- (2010) Eric Verdin et al. TRENDS IN BIOCHEMICAL SCIENCES
- Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
- (2010) Daniel Herranz et al. Nature Communications
- Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice
- (2009) Yu Yamazaki et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
- (2009) Takashi Nakagawa et al. CELL
- Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
- (2009) Aparna Purushotham et al. Cell Metabolism
- Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity
- (2009) Dirk Beher et al. Chemical Biology & Drug Design
- Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes
- (2009) Shweta Rane et al. CIRCULATION RESEARCH
- PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
- (2009) Carles Cantó et al. CURRENT OPINION IN LIPIDOLOGY
- AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol
- (2009) J.-H. Um et al. DIABETES
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
- (2009) Carles Cantó et al. NATURE
- Regulatory enzymes of mitochondrial β-oxidation as targets for treatment of the metabolic syndrome
- (2009) M. Schreurs et al. Obesity Reviews
- JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity
- (2009) Nargis Nasrin et al. PLoS One
- Resveratrol alleviates alcoholic fatty liver in mice
- (2008) Joanne M. Ajmo et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
- (2008) Ying Li et al. Cell Metabolism
- Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span
- (2008) Kevin J. Pearson et al. Cell Metabolism
- Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
- (2008) Jérôme N. Feige et al. Cell Metabolism
- Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice
- (2008) Olesya Vakhrusheva et al. CIRCULATION RESEARCH
- Transcriptional targets of sirtuins in the coordination of mammalian physiology
- (2008) Jerome N Feige et al. CURRENT OPINION IN CELL BIOLOGY
- Tissue-specific regulation of SIRT1 by calorie restriction
- (2008) D. Chen et al. GENES & DEVELOPMENT
- The secretory function of adipocytes in the physiology of white adipose tissue
- (2008) Ping Wang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5
- (2008) Christine Schlicker et al. JOURNAL OF MOLECULAR BIOLOGY
- SIRT2 Suppresses Adipocyte Differentiation by Deacetylating FOXO1 and Enhancing FOXO1's Repressive Interaction with PPARγ
- (2008) Fei Wang et al. MOLECULAR BIOLOGY OF THE CELL
- A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
- (2008) Yi Liu et al. NATURE
- Negative regulation of the deacetylase SIRT1 by DBC1
- (2008) Wenhui Zhao et al. NATURE
- DBC1 is a negative regulator of SIRT1
- (2008) Ja-Eun Kim et al. NATURE
- SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
- (2008) Eriko Michishita et al. NATURE
- Sirtuins — novel therapeutic targets to treat age-associated diseases
- (2008) Siva Lavu et al. NATURE REVIEWS DRUG DISCOVERY
- Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
- (2008) Deborah M. Muoio et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Phosphorylation Regulates SIRT1 Function
- (2008) Tsutomu Sasaki et al. PLoS One
- A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
- (2008) B.-H. Ahn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1
- (2008) A. Coste et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- miR-34a repression of SIRT1 regulates apoptosis
- (2008) M. Yamakuchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sirt1 protects against high-fat diet-induced metabolic damage
- (2008) P. T. Pfluger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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