Gut microbes and food reward: From the gut to the brain

Monogenic obesity syndromes provide insights into the hypothalamic regulation of appetite and associated behaviors

(2022) I. Sadaf Farooqi   BIOLOGICAL PSYCHIATRY

Role of cholecystokinin in satiation: a systematic review and meta-analysis

(2022) Andrew Warrilow et al.   BRITISH JOURNAL OF NUTRITION

Gut microbiome and health: mechanistic insights

(2022) Willem M de Vos et al.   GUT

Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis

(2022) Chloé Berland et al.   MOLECULAR PSYCHIATRY

Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling

(2022) Sevag Hamamah et al.   Biomedicines

Obesity is associated with a distinct brain-gut microbiome signature that connects Prevotella and Bacteroides to the brain’s reward center

(2022) Tien S. Dong et al.   Gut Microbes

Ghrelin and Glucagon-Like Peptide-1: A Gut-Brain Axis Battle for Food Reward

(2021) Lea Decarie-Spain et al.   Nutrients

Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

(2021) Hyo Shin Yoon et al.   Nature Microbiology

Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment

(2021) Stefan Trapp et al.   BRITISH JOURNAL OF PHARMACOLOGY

A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion

(2021) Patrice D. Cani et al.   Cell Metabolism

Bacteroides uniformis CECT 7771 Modulates the Brain Reward Response to Reduce Binge Eating and Anxiety-Like Behavior in Rat

(2021) Ana Agustí et al.   MOLECULAR NEUROBIOLOGY

Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior

(2021) Tyler M. Cook et al.   Molecular Metabolism

The gut–brain axis mediates sugar preference

(2020) Hwei-Ee Tan et al.   NATURE

Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice

(2020) Clara Depommier et al.   Gut Microbes

Alterations of brain endocannabinoidome signaling in germ-free mice

(2020) Claudia Manca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Distinct Brain‐Gut‐Microbiome Profile Exists for Females with Obesity and Food Addiction

(2020) Tien S. Dong et al.   Obesity

Gut microbiome, endocrine control of gut barrier function and metabolic diseases

(2020) Marion Régnier et al.   JOURNAL OF ENDOCRINOLOGY

Microbiota‐gut‐brain axis as a regulator of reward processes

(2020) Rubén García‐Cabrerizo et al.   JOURNAL OF NEUROCHEMISTRY

A Preventive Prebiotic Supplementation Improves the Sweet Taste Perception in Diet-Induced Obese Mice

(2019) Arnaud Bernard et al.   Nutrients

Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis

(2019) Amandine Everard et al.   Nature Communications

Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons – Implications for energy balance and glucose control

(2019) Zhenyan He et al.   Molecular Metabolism

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling

(2019) Claudia Manca et al.   JOURNAL OF LIPID RESEARCH

Rethinking Food Reward

(2019) Ivan E. de Araujo et al.   Annual Review of Psychology

Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4

(2019) Vaibhav R. Konanur et al.   PHYSIOLOGY & BEHAVIOR

Intragastric preloads of l -tryptophan reduce ingestive behavior via oxytocinergic neural mechanisms in male mice

(2018) Sarah N. Gartner et al.   APPETITE

Neurotransmitter modulation by the gut microbiota

(2018) Philip Strandwitz   BRAIN RESEARCH

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism

(2018) Marion Soto et al.   MOLECULAR PSYCHIATRY

Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat

(2018) Léa Décarie-Spain et al.   Molecular Metabolism

Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms

(2018) Kristoffer L. Egerod et al.   Molecular Metabolism

Prebiotics Supplementation Impact on the Reinforcing and Motivational Aspect of Feeding

(2018) Anne-Sophie Delbès et al.   Frontiers in Endocrinology

A Neural Circuit for Gut-Induced Reward

(2018) Wenfei Han et al.   CELL

Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations

(2018) Marcel van de Wouw et al.   JOURNAL OF PHYSIOLOGY-LONDON

A gut-brain neural circuit for nutrient sensory transduction

(2018) Melanie Maya Kaelberer et al.   SCIENCE

Short Term Intrarectal Administration of Sodium Propionate Induces Antidepressant-Like Effects in Rats Exposed to Chronic Unpredictable Mild Stress

(2018) Jianguo Li et al.   Frontiers in Psychiatry

A Neural Circuit for Gut-Induced Reward

(2018) Wenfei Han et al.   CELL

Sugar Addiction: From Evolution to Revolution

(2018) David A. Wiss et al.   Frontiers in Psychiatry

Food-Related Odors Activate Dopaminergic Brain Areas

(2017) Agnieszka Sorokowska et al.   Frontiers in Human Neuroscience

Blaming the Brain for Obesity: Integration of Hedonic and Homeostatic Mechanisms

(2017) Hans-Rudolf Berthoud et al.   GASTROENTEROLOGY

Ghrelin receptors mediate ghrelin-induced excitation of agouti-related protein/neuropeptide Y but not pro-opiomelanocortin neurons

(2017) Shao-Rui Chen et al.   JOURNAL OF NEUROCHEMISTRY

Insulin action in the brain: Roles in energy and glucose homeostasis

(2017) G. T. Dodd et al.   JOURNAL OF NEUROENDOCRINOLOGY

Microbiota-Gut-Brain Axis: Modulator of Host Metabolism and Appetite

(2017) Marcel van de Wouw et al.   JOURNAL OF NUTRITION

Bifidobacterium pseudocatenulatum CECT 7765 Ameliorates Neuroendocrine Alterations Associated with an Exaggerated Stress Response and Anhedonia in Obese Mice

(2017) Ana Agusti et al.   MOLECULAR NEUROBIOLOGY

Commensal bacteria make GPCR ligands that mimic human signalling molecules

(2017) Louis J. Cohen et al.   NATURE

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

(2017) Glenn R. Gibson et al.   Nature Reviews Gastroenterology & Hepatology

Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

(2017) Marisela Morales et al.   NATURE REVIEWS NEUROSCIENCE

Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits

(2017) Benjamin K. Lau et al.   NEUROPHARMACOLOGY

DRD2: Bridging the Genome and Ingestive Behavior

(2017) Xue Sun et al.   TRENDS IN COGNITIVE SCIENCES

Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder

(2017) Alessio Monteleone et al.   Nutrients

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion

(2017) Lorène J. Lebrun et al.   Cell Reports

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

(2017) Lucy Brooks et al.   Molecular Metabolism

Gut microbiome in ADHD and its relation to neural reward anticipation

(2017) Esther Aarts et al.   PLoS One

Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods

(2016) Claire S Byrne et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Formation of propionate and butyrate by the human colonic microbiota

(2016) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells

(2016) Catherine E. Moss et al.   PEPTIDES

Dietary 2’-Fucosyllactose Enhances Operant Conditioning and Long-Term Potentiation via Gut-Brain Communication through the Vagus Nerve in Rodents

(2016) Enrique Vazquez et al.   PLoS One

Gastrointestinal hormones and the gut connectome

(2016) Lihua Ye et al.   Current Opinion in Endocrinology Diabetes and Obesity

Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour

(2015) Lieve Desbonnet et al.   BRAIN BEHAVIOR AND IMMUNITY

The Hunger Genes: Pathways to Obesity

(2015) Agatha A. van der Klaauw et al.   CELL

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

(2015) Christopher S. Reigstad et al.   FASEB JOURNAL

Neural Responses to Macronutrients: Hedonic and Homeostatic Mechanisms

(2015) Alastair J. Tulloch et al.   GASTROENTEROLOGY

Glucagon-Like Peptide 1 Interacts with Ghrelin and Leptin to Regulate Glucose Metabolism and Food Intake through Vagal Afferent Neuron Signaling

(2015) Charlotte C Ronveaux et al.   JOURNAL OF NUTRITION

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Enteroendocrine cells: a review of their role in brain-gut communication

(2015) R. Latorre et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Characterization of attenuated food motivation in high-fat diet-induced obesity: Critical roles for time on diet and reinforcer familiarity

(2015) Andrea L. Tracy et al.   PHYSIOLOGY & BEHAVIOR

Endogenous Glucagon-like Peptide-1 Suppresses High-Fat Food Intake by Reducing Synaptic Drive onto Mesolimbic Dopamine Neurons

(2015) Xue-Feng Wang et al.   Cell Reports

The hypothalamic arcuate nucleus and the control of peripheral substrates

(2014) Aurélie Joly-Amado et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

(2014) Anna Secher et al.   JOURNAL OF CLINICAL INVESTIGATION

Hormonal and neural mechanisms of food reward, eating behaviour and obesity

(2014) Susan Murray et al.   Nature Reviews Endocrinology

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

Neurobiology of food intake in health and disease

(2014) Gregory J. Morton et al.   NATURE REVIEWS NEUROSCIENCE

Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats

(2014) Michèle Crumeyrolle-Arias et al.   PSYCHONEUROENDOCRINOLOGY

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Reward for food odors: an fMRI study of liking and wanting as a function of metabolic state and BMI

(2014) Tao Jiang et al.   Social Cognitive and Affective Neuroscience

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide α-MSH, at the origin of eating disorders

(2014) N Tennoune et al.   Translational Psychiatry

Does liking or wanting determine repeat consumption delay?

(2013) Emily N. Garbinsky et al.   APPETITE

Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit

(2013) Anita Wichmann et al.   Cell Host & Microbe

Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?

(2013) Joshua P. Thaler et al.   DIABETES

Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats

(2013) Nicholas V. DiPatrizio et al.   FASEB JOURNAL

Reversal of dopamine system dysfunction in response to high-fat diet

(2013) JesseLea Carlin et al.   Obesity

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Gut Lipid Messenger Links Excess Dietary Fat to Dopamine Deficiency

(2013) L. A. Tellez et al.   SCIENCE

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

(2012) Luis Varela et al.   EMBO REPORTS

A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin

(2012) Kristoffer L. Egerod et al.   ENDOCRINOLOGY

The Glucagon-Like Peptide 1 (GLP-1) Analogue, Exendin-4, Decreases the Rewarding Value of Food: A New Role for Mesolimbic GLP-1 Receptors

(2012) S. L. Dickson et al.   JOURNAL OF NEUROSCIENCE

The contribution of brain reward circuits to the obesity epidemic

(2012) Eric Stice et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The functional human neuroanatomy of food pleasure cycles

(2012) Morten L. Kringelbach et al.   PHYSIOLOGY & BEHAVIOR

Increased Oral Detection, but Decreased Intestinal Signaling for Fats in Mice Lacking Gut Microbiota

(2012) Frank A. Duca et al.   PLoS One

Implicit wanting and explicit liking are markers for trait binge eating. A susceptible phenotype for overeating

(2011) Graham Finlayson et al.   APPETITE

Up-regulation of intestinal type 1 taste receptor 3 and sodium glucose luminal transporter-1 expression and increased sucrose intake in mice lacking gut microbiota

(2011) T. D. Swartz et al.   BRITISH JOURNAL OF NUTRITION

Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation

(2011) Matthew R. Hayes et al.   Cell Metabolism

Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice

(2011) Amandine Everard et al.   DIABETES

GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake

(2011) Amber L. Alhadeff et al.   ENDOCRINOLOGY

2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans

(2011) Katrine B. Hansen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Circulating glucose levels modulate neural control of desire for high-calorie foods in humans

(2011) Kathleen A. Page et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting gut microbiota in obesity: effects of prebiotics and probiotics

(2011) Nathalie M. Delzenne et al.   Nature Reviews Endocrinology

Common cellular and molecular mechanisms in obesity and drug addiction

(2011) Paul J. Kenny   NATURE REVIEWS NEUROSCIENCE

Chronic High-Fat Diet Drives Postnatal Epigenetic Regulation of μ-Opioid Receptor in the Brain

(2011) Zivjena Vucetic et al.   NEUROPSYCHOPHARMACOLOGY

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlation of the Taq1 dopamine D2 receptor gene and percent body fat in obese and screened control subjects: A preliminary report

(2011) Amanda L. C. Chen et al.   Food & Function

Measuring food reward and the transfer effect of sensory specific satiety

(2010) Sanne Griffioen-Roose et al.   APPETITE

Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor

(2010) Yu Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure

(2010) Linda Rinaman   BRAIN RESEARCH

The G-Protein−Coupled Receptor GPR40 Directly Mediates Long-Chain Fatty Acid−Induced Secretion of Cholecystokinin

(2010) Alice P. Liou et al.   GASTROENTEROLOGY

Reward circuitry responsivity to food predicts future increases in body mass: Moderating effects of DRD2 and DRD4

(2010) Eric Stice et al.   NEUROIMAGE

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Reward, dopamine and the control of food intake: implications for obesity

(2010) Nora D. Volkow et al.   TRENDS IN COGNITIVE SCIENCES

GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

(2009) L. M. Lauffer et al.   DIABETES

The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation

(2009) V Di Marzo et al.   INTERNATIONAL JOURNAL OF OBESITY

GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis

(2009) Hong Lan et al.   JOURNAL OF ENDOCRINOLOGY

Dietary Starch Type Affects Body Weight and Glycemic Control in Freely Fed but Not Energy-Restricted Obese Rats

(2009) Alfred A. Aziz et al.   JOURNAL OF NUTRITION

Reward Processing by the Opioid System in the Brain

(2009) Julie Le Merrer et al.   PHYSIOLOGICAL REVIEWS

Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents

(2008) June Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat.

(2008) Jon F. Davis et al.   BEHAVIORAL NEUROSCIENCE

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Acute Effects of Glucagon-Like Peptide-1 on Hypothalamic Neuropeptide and AMP Activated Kinase Expression in Fasted Rats

(2008) Sanghee SEO et al.   ENDOCRINE JOURNAL

The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat

(2008) Lieve Desbonnet et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele

(2008) E. Stice et al.   SCIENCE

The role of implicit wanting in relation to explicit liking and wanting for food: Implications for appetite control

(2007) Graham Finlayson et al.   APPETITE