Insulin action in the brain: Roles in energy and glucose homeostasis

Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia

(2017) Taku Tsunekawa et al.   EBioMedicine

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue

(2016) Sophie M. Steculorum et al.   CELL

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

(2016) Cristina García-Cáceres et al.   CELL

Ptp1b deletion in pro-opiomelanocortin neurons increases energy expenditure and impairs endothelial function via TNF-  dependent mechanisms

(2016) T. Bruder-Nascimento et al.   CLINICAL SCIENCE

Central insulin-mediated regulation of hepatic glucose production [Review]

(2016) Hiroshi Inoue   ENDOCRINE JOURNAL

High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons

(2016) P S Dalvi et al.   INTERNATIONAL JOURNAL OF OBESITY

Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling

(2016) A. Kleinridders   JOURNAL OF NEUROENDOCRINOLOGY

A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation

(2016) Gyun Jee Song et al.   Journal of Neuroinflammation

Neurotrophic factor control of satiety and body weight

(2016) Baoji Xu et al.   NATURE REVIEWS NEUROSCIENCE

Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor

(2016) Kumi Kimura et al.   Cell Reports

Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity

(2016) A. Christine Hausen et al.   Cell Reports

Mitochondria in White, Brown, and Beige Adipocytes

(2016) Miroslava Cedikova et al.   Stem Cells International

Flipping the tanycyte switch: how circulating signals gain direct access to the metabolic brain

(2016) Vincent Prevot et al.   Aging-US

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

(2015) Garron T. Dodd et al.   CELL

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

Human Brown Adipose Tissue: What We Have Learned So Far

(2015) Matthias J. Betz et al.   DIABETES

Brown and Beige Fat: Molecular Parts of a Thermogenic Machine

(2015) Paul Cohen et al.   DIABETES

Selective Insulin Resistance in Homeostatic and Cognitive Control Brain Areas in Overweight and Obese Adults

(2015) Stephanie Kullmann et al.   DIABETES CARE

Insulin Action in the Human Brain: Evidence from Neuroimaging Studies

(2015) S. Kullmann et al.   JOURNAL OF NEUROENDOCRINOLOGY

Impaired insulin action in the human brain: causes and metabolic consequences

(2015) Martin Heni et al.   Nature Reviews Endocrinology

Hippocampal insulin resistance and cognitive dysfunction

(2015) Geert Jan Biessels et al.   NATURE REVIEWS NEUROSCIENCE

Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans

(2015) Ellen A. Schur et al.   Obesity

Inconsistencies in the hypophagic action of intracerebroventricular insulin in mice

(2015) Eugenia Mc Allister et al.   PHYSIOLOGY & BEHAVIOR

Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

(2015) Zhong-Yin Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Hypothalamic inflammation and gliosis in obesity

(2015) Mauricio D. Dorfman et al.   Current Opinion in Endocrinology Diabetes and Obesity

Hypothalamic PKA regulates leptin sensitivity and adiposity

(2015) Linghai Yang et al.   Nature Communications

Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons

(2015) Daqing Wang et al.   Frontiers in Neuroanatomy

Central insulin signaling modulates hypothalamus–pituitary–adrenal axis responsiveness

(2015) Angie C.N. Chong et al.   Molecular Metabolism

Type 2 diabetes mellitus

(2015) Ralph A. DeFronzo et al.   Nature Reviews Disease Primers

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

(2014) Kevin W. Williams et al.   Cell Metabolism

Insulin Excites Anorexigenic Proopiomelanocortin Neurons via Activation of Canonical Transient Receptor Potential Channels

(2014) Jian Qiu et al.   Cell Metabolism

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

(2014) Eglantine Balland et al.   Cell Metabolism

Intranasal Insulin Enhanced Resting-State Functional Connectivity of Hippocampal Regions in Type 2 Diabetes

(2014) Hui Zhang et al.   DIABETES

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men

(2014) M. Heni et al.   DIABETES

Hypothalamic Gliosis Associated With High-Fat Diet Feeding Is Reversible in Mice: A Combined Immunohistochemical and Magnetic Resonance Imaging Study

(2014) Kathryn E. Berkseth et al.   ENDOCRINOLOGY

Cerebellar contribution to feedforward control of locomotion

(2014) Iolanda Pisotta et al.   Frontiers in Human Neuroscience

Ventromedial hypothalamus–specific Ptpn1 deletion exacerbates diet-induced obesity in female mice

(2014) Franck Chiappini et al.   JOURNAL OF CLINICAL INVESTIGATION

Mapping glucose-mediated gut-to-brain signalling pathways in humans

(2014) Tanya J. Little et al.   NEUROIMAGE

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia

(2014) Ted M. Hsu et al.   Frontiers in Aging Neuroscience

Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity

(2014) João A.B. Pedroso et al.   Molecular Metabolism

Glut4 expression defines an insulin-sensitive hypothalamic neuronal population

(2014) Hongxia Ren et al.   Molecular Metabolism

Parallel, Redundant Circuit Organization for Homeostatic Control of Feeding Behavior

(2013) J. Nicholas Betley et al.   CELL

How Is the Hungry Brain like a Sieve?

(2013) Martin G. Myers   Cell Metabolism

Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting

(2013) Fanny Langlet et al.   Cell Metabolism

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

Differential effect of glucose ingestion on the neural processing of food stimuli in lean and overweight adults

(2013) Martin Heni et al.   HUMAN BRAIN MAPPING

Effects of Fructose vs Glucose on Regional Cerebral Blood Flow in Brain Regions Involved With Appetite and Reward Pathways

(2013) Kathleen A. Page et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Intranasal Insulin Reduces Olfactory Sensitivity in Normosmic Humans

(2013) Yvonne F. Brünner et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Protein Tyrosine Phosphatase 1B and Insulin Resistance: Role of Endoplasmic Reticulum Stress/Reactive Oxygen Species/Nuclear Factor Kappa B Axis

(2013) Evgeniy Panzhinskiy et al.   PLoS One

Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance

(2013) L. E. Olofsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic tanycytes: potential roles in the control of feeding and energy balance

(2013) Matei Bolborea et al.   TRENDS IN NEUROSCIENCES

Revealing the secrets of neuronal circuits with recombinant rabies virus technology

(2013) Melanie Ginger et al.   Frontiers in Neural Circuits

Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis

(2013) Marianna Sadagurski et al.   Molecular Metabolism

Inconsistencies in the assessment of food intake

(2012) Stephen C. Woods et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

IRS2 Signaling in LepR-b Neurons Suppresses FoxO1 to Control Energy Balance Independently of Leptin Action

(2012) Marianna Sadagurski et al.   Cell Metabolism

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

(2012) Luis Varela et al.   EMBO REPORTS

Deficiency of PTP1B in Leptin Receptor-Expressing Neurons Leads to Decreased Body Weight and Adiposity in Mice

(2012) Ryan C. Tsou et al.   ENDOCRINOLOGY

(Still) longing for food: Insulin reactivity modulates response to food pictures

(2012) Nils B. Kroemer et al.   HUMAN BRAIN MAPPING

Synaptic plasticity in neuronal circuits regulating energy balance

(2012) Lori M Zeltser et al.   NATURE NEUROSCIENCE

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone

(2012) Tiemin Liu et al.   NEURON

Over-Expression of Leptin Receptors in Hypothalamic POMC Neurons Increases Susceptibility to Diet-Induced Obesity

(2012) Kevin M. Gamber et al.   PLoS One

A Physiological Increase of Insulin in the Olfactory Bulb Decreases Detection of a Learned Aversive Odor and Abolishes Food Odor-Induced Sniffing Behavior in Rats

(2012) Pascaline Aimé et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop

(2011) Yunlei Yang et al.   CELL

Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis

(2011) Thomas Scherer et al.   Cell Metabolism

Role for Insulin Signaling in Catecholaminergic Neurons in Control of Energy Homeostasis

(2011) A. Christine Könner et al.   Cell Metabolism

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

(2011) Kim Loh et al.   Cell Metabolism

Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism

(2011) V. Ott et al.   DIABETES OBESITY & METABOLISM

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating insulin stimulates fatty acid retention in white adipose tissue via KATPchannel activation in the central nervous system only in insulin-sensitive mice

(2011) Claudia P. Coomans et al.   JOURNAL OF LIPID RESEARCH

Signalling by insulin and IGF receptors: supporting acts and new players

(2011) Kenneth Siddle   JOURNAL OF MOLECULAR ENDOCRINOLOGY

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons

(2011) Tim Klöckener et al.   NATURE NEUROSCIENCE

Consumption of a high-fat diet induces central insulin resistance independent of adiposity

(2011) Deborah J. Clegg et al.   PHYSIOLOGY & BEHAVIOR

The Insulin-Mediated Modulation of Visually Evoked Magnetic Fields Is Reduced in Obese Subjects

(2011) Martina Guthoff et al.   PLoS One

Sensory circumventricular organs in health and disease

(2010) Sílvia Sisó et al.   ACTA NEUROPATHOLOGICA

The role of the autonomic nervous liver innervation in the control of energy metabolism

(2010) Chun-Xia Yi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

(2010) Jennifer W. Hill et al.   Cell Metabolism

Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men

(2010) C. Benedict et al.   DIABETES

T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis

(2010) Atsushi Fukushima et al.   DIABETES

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

(2010) A. S. Reed et al.   DIABETES

Corticosterone Regulates Synaptic Input Organization of POMC and NPY/AgRP Neurons in Adult Mice

(2010) Erika Gyengesi et al.   ENDOCRINOLOGY

Acute, short-term hyperinsulinemia increases olfactory threshold in healthy subjects

(2010) C Ketterer et al.   INTERNATIONAL JOURNAL OF OBESITY

Pathogenesis of Insulin Resistance in Skeletal Muscle

(2010) Muhammad A. Abdul-Ghani et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

(2010) Ryoichi Banno et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential effects of insulin on sympathetic nerve activity in agouti obese mice

(2010) Donald A Morgan et al.   JOURNAL OF HYPERTENSION

Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity

(2010) M. O. Dietrich et al.   JOURNAL OF NEUROSCIENCE

Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons

(2010) K. W. Williams et al.   JOURNAL OF NEUROSCIENCE

Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance

(2010) Ewan C. McNay et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Memory formation and long-term retention in humans and animals: Convergence towards a transformation account of hippocampal–neocortical interactions

(2010) Gordon Winocur et al.   NEUROPSYCHOLOGIA

Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

(2010) T. L. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically

(2010) S. Stanley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of the lack of anorectic effect of intracerebroventricular insulin in rats

(2009) Lene Jessen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent

(2009) C.A. Grillo et al.   BRAIN RESEARCH

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Hypothalamic Reactive Oxygen Species Are Required for Insulin-Induced Food Intake Inhibition: An NADPH Oxidase-Dependent Mechanism

(2009) T. Jaillard et al.   DIABETES

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

(2009) H. V. Lin et al.   DIABETES

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Insulin Modulates Food-Related Activity in the Central Nervous System

(2009) Martina Guthoff et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin directly regulates NPY and AgRP gene expression via the MAPK MEK/ERK signal transduction pathway in mHypoE-46 hypothalamic neurons

(2009) Christopher M. Mayer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Central cannabinoid signaling mediating food intake: a pharmacological-challenge magnetic resonance imaging and functional histology study in rat

(2009) G.T. Dodd et al.   NEUROSCIENCE

Leptin resistance: a prediposing factor for diet-induced obesity

(2008) Philip J. Scarpace et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

(2008) M. Delibegovic et al.   DIABETES

Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese Rats

(2008) Paty Karoll Picardi et al.   ENDOCRINOLOGY

Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammationin Vivo

(2008) Janice M. Zabolotny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY