Article
Nutrition & Dietetics
Jessica G. Nicanor-Carreon, Neda Seyedsadjadi, Blair Rowitz, Marta Yanina Pepino
Summary: This study explored the association between maladaptive ingestive behaviors and weight regain in women who had undergone metabolic surgery 2-10 years ago. The findings showed that weight regain was specifically linked to increased cravings for sweets, higher scores in eating disorder assessment, and time elapsed since surgery. Additionally, the study indicated a potential interaction between time after surgery and sweet cravings in predicting weight regain.
Article
Fisheries
Leandro S. Costa, Helder O. Guilherme, Raphael N. Bahiense, Fabio A. C. Santos, Pedro G. Gamarano, Jose F. L. Olmeda, Paula A. P. Ribeiro, Ronald K. Luz
Summary: Two experiments were conducted to investigate the influence of protein concentration on Nile tilapia. The results indicate that tilapia can adjust their protein intake and choose the diet that best meets their nutritional needs.
Article
Behavioral Sciences
Justin A. Smith, Sophia A. Eikenberry, Karen A. Scott, Caitlin Baumer-Harrison, Guillaume de Lartigue, Annette D. de Kloet, Eric G. Krause
Summary: Maintaining homeostasis involves accurately assessing external stimuli and being conscious of internal signals. Oxytocin plays a role in social behavior and cardiovascular and gastrointestinal function. Oxytocin signals are transmitted to the brain via the Vagus nerve, influencing cardiometabolic function and social interactions. Autism Spectrum Disorder is associated with atypical social behavior and cardiometabolic dysfunction.
Article
Agriculture, Dairy & Animal Science
Bruna C. K. Gomes, Ines Andretta, Marcio Valk, Candido Pomar, Luciano Hauschild, Alicia Z. Fraga, Marcos Kipper, Luciano Trevizan, Aline Remus
Summary: A study on pig feeding behavior using electronic feeders showed that hunger-regulating mechanisms were slightly stronger than satiety-regulating mechanisms in the studied animals, decreasing as the animals grew. Feeding programs had little influence on the feeding regulating mechanisms, with conventional and precision feeding systems showing slight differences. The study highlights the importance of further research on pig feeding behavior to improve feeding strategies.
Review
Pharmacology & Pharmacy
Diana L. Williams
Summary: GLP-1 receptors in the brain influence feeding behavior through various mechanisms, including suppressing appetite, inhibiting food reward motivation, inducing nausea, and reducing stress-induced hypophagia, but many questions about the organization of this system remain unanswered.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Masato Yayota, Mai Hotokebuchi, Rie Kawata, Yukinori Tani, Shigeru Ohtani
Summary: This study aimed to clarify the differences in ingestive behavior between goats and sheep at the bite scale. Results showed that goats and sheep exhibited different bite behaviors at short swards, with goats taking deeper bites and maintaining bite overlap, resulting in slightly greater bite mass. Sheep, on the other hand, decreased the overlap of bites at short swards. Therefore, this study suggests that goats and sheep implement different bite scale ingestive behaviors when eating short swards.
ANIMAL SCIENCE JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Ivana Maric, Lorena Lopez-Ferreras, Yashaswini Bhat, Mohammed Asker, Stina Borchers, Lauren Bellfy, Suyeun Byun, Janine L. Kwapis, Karolina P. Skibicka
Summary: The stomach-derived hormone ghrelin has a regulatory role in ingestive, motivated, and anxiety-like behaviors by acting in the locus coeruleus, with differences between males and females.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nikki Clauss, Kelsey Brass Allen, Katie D. Billings, Mikayla D. M. Tolliver, Ray Garza, Jennifer Byrd-Craven, Polly Campbell
Summary: This study on mouse model demonstrates that prenatal Western-pattern diet can alleviate the impact of maternal stress on dams and offspring, and sheds light on the relationship between pre- and post-natal nutrition, gene expression, and behaviors that lead to long-term health effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jinhao Zhang, Mi Xiao, Liang Gao, Andrea Alu, Fengwen Wang
Summary: The authors have designed and realized self-bridging metamaterials with Poisson's ratios exceeding the theoretical limits. This finding is of great significance for expanding the range of achievable Poisson's ratios in mechanical systems, with implications for medical stents and soft robots.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Physical
Fangfang Gao, Xiaochen Xun, Xuan Zhao, Liangxu Xu, Qi Li, Bin Zhao, Tian Ouyang, Qingliang Liao, Yue Zhang
Summary: Triboelectric nanogenerators (TENGs) are considered as the energy for the new era, supplying power for freely mobile and distributed electronic equipment from Internet of Things. However, systematic summary of TENG's service behavior is still in its infancy due to the wide selection of materials, diversity of device structures, and complexity of working environment.
Editorial Material
Plant Sciences
Matthew F. McCabe, Mark Tester
Summary: The convergence of autonomous platforms, advances in machine learning, and rapid sequencing for genome description offer new insights and discoveries in plant sciences. Researchers leverage these tools to bridge the gap between field-based phenotyping and genetic loci identification in the lab, highlighting the need for further collaboration across multidisciplinary fields in digital agriculture.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Multidisciplinary Sciences
Hai-Qian Zhou, Liu-Jing Zhuang, Hong-Qiang Bao, Sheng-Ju Li, Feng-Yan Dai, Ping Wang, Qian Li, Dong -Min Yin
Summary: Olfactory behavior is crucial for animal survival, and olfactory dysfunction is commonly seen in various diseases. This study reveals that mature olfactory sensory neurons (OSNs) express high levels of dopamine D2 receptor (Drd2), which can modulate odorant recognition response by inhibiting odor-induced signaling. Furthermore, nasal dopamine and DRD2 receptor are identified as potential peripheral targets for olfactory modulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Materials Science, Multidisciplinary
Bowen Jin, Lizhi Ren, Yanzhuo Gou, Ruihao Ma, Zihui Liang, Zongbao Li, Binghai Dong, Li Zhao, Shimin Wang, Congcong Wu
Summary: By incorporating ethyl cellulose (EC) as a fiber-bridging component, the mechanical properties of perovskite films are significantly improved, with a 3 times higher Young's modulus and robust stability under harsh conditions.
Article
Behavioral Sciences
Ann Jane Tierney, Madelyn Haller, Leah Grossman, Hannah Grote, Natalie Marcus-Bauer
Summary: Serotonin is an important regulator of feeding behavior across different animal species. This study examined the modulation of feeding behavior in crayfish by administering serotonin and two serotonin receptor ligands. The results showed that exogenous serotonin and the ligands significantly reduced appetitive behaviors and food consumption, but had no significant effects on appetitive feeding movements.
BEHAVIORAL NEUROSCIENCE
(2022)
Review
Plant Sciences
Lars Munck, Asmund Rinnan, Bekzod Khakimov, Birthe Moller Jespersen, Soren Balling Engelsen
Summary: The study demonstrates how pleiotropy can be observed as covarying global molecular patterns in a barley mutant seed model, defining each endosperm. Global coherence was found as a covariate coordinator within and between local genotype specific fingerprints.
TRENDS IN PLANT SCIENCE
(2021)
Article
Endocrinology & Metabolism
Linda Tirou, Mariagiovanna Russo, Helene Faure, Giuliana Pellegrino, Clement Demongin, Mathieu Daynac, Ariane Sharif, Jeremy Amosse, Soazig Le Lay, Raphael Denis, Serge Luquet, Mohammed Taouis, Yacir Benomar, Martial Ruat
Summary: This study reveals that activation of the Shh signaling pathway in hypothalamic astrocytes enhances insulin responsiveness, impacting energy metabolism and leading to alterations in body weight and adipose tissues. It also suggests that this signaling pathway may play a crucial role in preventing age- and obesity-related metabolic disorders.
MOLECULAR METABOLISM
(2021)
Article
Multidisciplinary Sciences
Alexandre Prola, Jordan Blondelle, Aymeline Vandestienne, Jerome Piquereau, Raphael G. P. Denis, Stephane Guyot, Hadrien Chauvin, Arnaud Mourier, Marie Maurer, Celine Henry, Nahed Khadhraoui, Cindy Gallerne, Thibaut Molinie, Guillaume Courtin, Laurent Guillaud, Melanie Gressette, Audrey Solgadi, Florent Dumont, Julien Castel, Julien Ternacle, Jean Demarquoy, Alexandra Malgoyre, Nathalie Koulmann, Genevieve Derumeaux, Marie-France Giraud, Frederic Joubert, Vladimir Veksler, Serge Luquet, Frederic Relaix, Laurent Tiret, Fanny Pilot-Storck
Summary: Mice deficient for a muscle-specific enzyme of very-long-chain fatty acid synthesis displayed increased basal energy expenditure and protection against high-fat diet-induced obesity. Muscle-specific modulation of the very-long-chain fatty acid pathway was associated with a reduced content of inner mitochondrial membrane phospholipid cardiolipin and a blunted coupling efficiency between the respiratory chain and ATP synthase, which was restored by cardiolipin enrichment. Selective increase of lipid oxidative capacities in skeletal muscle, through the cardiolipin-dependent lowering of mitochondrial ATP production, provides an effective option against obesity at the whole-body level.
Letter
Cell Biology
Jelle R. Dalenberg, Raphael Denis, Serge Luquet, Dana M. Small
Review
Endocrinology & Metabolism
Giles S. H. Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M. Koerperich, Mark D. Ericson, Stephanie E. Simonds, Courtney M. Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clement, Michael A. Cowley, Carrie Haskell-Luevano, Lex Van der Ploeg, Roger A. H. Adan
Summary: Insights from human and mouse genetics have highlighted the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, leading to the approval of setmelanotide as a drug for individuals with severe obesity due to specific genetic deficiencies. This research provides a template for drug discovery in complex disorders, showing how a single gene target can eventually lead to the development of an approved drug after 25 years of study.
MOLECULAR METABOLISM
(2021)
Correction
Multidisciplinary Sciences
Pierre-Alexandre Just, Sara Charawi, Raphael G. P. Denis, Mathilde Savall, Massire Traore, Marc Foretz, Sultan Bastu, Salimata Magassa, Nadia Senni, Pierre Sohier, Maud Wursmer, Mireille Vasseur-Cognet, Alain Schmitt, Morgane Le Gall, Marjorie Leduc, Francois Guillonneau, Jean-Pascal De Bandt, Patrick Mayeux, Beatrice Romagnolo, Serge Luquet, Pascale Bossard, Christine Perret
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Camilla Pramfalk, Osman Ahmed, Matteo Pedrelli, Mirko E. Minniti, Serge Luquet, Raphael Gp Denis, Maria Olin, Jennifer Hardfeldt, Lise-Lotte Vedin, Knut R. Steffensen, Mikael Ryden, Leanne Hodson, Mats Eriksson, Paolo Parini
Summary: This study reveals that depletion of the cholesterol ester synthesis enzyme Soat2 improves metabolic control in mice by partitioning lipids into secretory and oxidative pathways, reducing hepatic steatosis.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chloe Berland, Julien Castel, Romano Terrasi, Enrica Montalban, Ewout Foppen, Claire Martin, Giulio G. Muccioli, Serge Luquet, Giuseppe Gangarossa
Summary: This study explores the functional connection between the gut-brain axis and the reward and homeostatic brain structures using a physiologically relevant binge eating (BE) mouse model and multiscale in vivo approaches. The results reveal that compensatory adaptations in response to BE require the gut-to-brain axis, which relies on the permissive actions of peripheral endocannabinoids (eCBs) signaling through the vagus nerve. Inhibition of peripheral CB1 receptors increases hypothalamic activity, modulates metabolic efficiency, and dampens mesolimbic dopamine circuit activity, suppressing palatable eating. This study provides compelling evidence for a yet unappreciated physiological integrative mechanism involving peripheral eCBs and the vagus nerve in regulating homeostatic and reward-driven feeding.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Enrica Montalban, Albert Giralt, Lieng Taing, Evelien H. S. Schut, Laura F. Supiot, Laia Castell, Yuki Nakamura, Benoit de Pins, Assunta Pelosi, Laurence Goutebroze, Pola Tuduri, Wei Wang, Katrina Daila Neiburga, Letizia Vestito, Julien Castel, Serge Luquet, Angus C. Nairn, Denis Herve, Nathaniel Heintz, Claire Martin, Paul Greengard, Emmanuel Valjent, Frank J. Meye, Nicolas Gambardella, Jean-Pierre Roussarie, Jean-Antoine Girault
Summary: Forebrain dopamine-sensitive neurons play important roles in movement, action selection, motivation, and working memory. This study compares different populations of dopaminoceptive neurons and identifies differences in gene expression between them. Additionally, it reveals the potential role of prostaglandin E2 as a neuromodulator in the striatum and a potential therapeutic target.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Clarisse Dumont, Guangping Li, Julien Castel, Serge Luquet, Giuseppe Gangarossa
Summary: The regulation of food intake and energy balance relies on the integration of signals monitoring nutritional, metabolic, cognitive, and emotional states. The paraventricular thalamus (PVT) is a central hub that may contribute to the regulation of feeding and homeostatic/allostatic processes. This study reveals the role of catecholaminergic (CA) inputs from the hindbrain to the PVT in scaling feeding and metabolic efficiency, as well as the modulation of downstream hypothalamic neuron activity.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Multidisciplinary Sciences
Matthieu Leuillier, Thomas Duflot, Severine Menoret, Hind Messaoudi, Zoubir Djerada, Deborah Groussard, Raphael G. P. Denis, Laurence Chevalier, Ahmed Karoui, Baptiste Panthu, Pierre-Alain Thiebaut, Isabelle Schmitz-Afonso, Severine Nobis, Cynthia Campart, Tiphaine Henry, Camille Sautreuil, Serge H. Luquet, Olivia Beseme, Catherine Feliu, Helene Peyret, Lionel Nicol, Jean-Paul Henry, Sylvanie Renet, Paul Mulder, Debin Wan, Laurent Tesson, Jean-Marie Heslan, Angeline Duche, Sebastien Jacques, Frederic Ziegler, Valery Brunel, Gilles J. P. Rautureau, Christelle Monteil, Jean-Luc do Rego, Jean-Claude do Rego, Carlos Afonso, Bruce Hammock, Anne-Marie Madec, Florence Pinet, Vincent Richard, Ignacio Anegon, Christophe Guignabert, Christophe Morisseau, Jeremy Bellien
Summary: The physiological role of the N-terminal phosphatase activity (sEH-P) of soluble epoxide hydrolase (sEH-H) was investigated using CRISPR/Cas9 to generate a knock-in (KI) rat line lacking sEH-P activity. The study found that sEH-P KI rats exhibited decreased metabolism of lysophosphatidic acids, decreased weight and fat mass gain, and increased insulin sensitivity. Moreover, sEH-P KI rats showed increased lipolysis and enhanced energy expenditure, which potentiated brown adipose thermogenesis. Additionally, sEH-P KI rats fed a high-fat diet did not experience weight gain, fat mass accumulation, insulin resistance, or hepatic steatosis, and they also exhibited enhanced cardiac mitochondrial activity and protection against ischemia-reperfusion injury. Overall, the findings highlight the importance of sEH-P in energy and fat metabolism and its potential therapeutic significance in the management of obesity and cardiac complications.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Cell Biology
Monica Imbernon, Chiara Saponaro, Hans Christian Cederberg Helms, Manon Duquenne, Daniela Fernandois, Eleonora Deligia, Raphael G. P. Denis, Daniela Herrera Moro Chao, Sowmyalakshmi Rasika, Bart Staels, Francois Pattou, Frank W. Pfrieger, Birger Brodin, Serge Luquet, Caroline Bonner, Vincent Prevot
Summary: Liraglutide is transported to the hypothalamus by specialized ependymoglial cells called tanycytes, bypassing the blood-brain barrier. Silencing GLP1R in tanycytes or inhibiting tanycytic transport blocks the effects of liraglutide on hypothalamic neurons and its anti-obesity effects.
Article
Endocrinology & Metabolism
Omar Al-Massadi, Paolo Parini, Johan Ferno, Serge Luquet, Mar Quinones
Summary: The growth hormone/insulin growth factor-1 axis plays a crucial role in regulating metabolism through its actions on peripheral tissues and the brain. It is involved in controlling food intake, energy expenditure, and glycemia, and interacts with the central nervous system. Dysregulation of this hepatic axis can lead to metabolic disorders such as obesity, type 2 diabetes, or liver disease. Possible therapeutic applications based on the components of this hepatic axis are discussed.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Cell Biology
Sabrina J. P. Huwart, Alice de Wouters d'Oplinter, Marialetizia Rastelli, Matthias Van Hul, Willem M. de Vos, Serge Luquet, Patrice D. Cani, Amandine Everard
Summary: Reward system dysregulations during obesity are associated with inflammation and alterations in the blood-brain barrier. The gut microbiota Akkermansia muciniphila may improve reward behavior dysregulations in obesity by decreasing activation of inflammatory pathways and lipid-sensing ability in the striatum.
Article
Cell Biology
Daniela Herrera Moro Chao, Matthew K. Kirchner, Cuong Pham, Ewout Foppen, Raphael G. P. Denis, Julien Castel, Chloe Morel, Enrica Montalban, Rim Hassouna, Linh-Chi Bui, Justine Renault, Christine Mouffle, Cristina Garcia-Caceres, Matthias H. Tschop, Dongdong Li, Claire Martin, Javier E. Stern, Serge H. Luquet
Summary: The hypothalamic astrocytes play an important role in the control of systemic metabolism, and their activity is altered in obesity. Manipulation of astrocyte activity can affect neighboring neuron activity, autonomic outflow, glucose metabolism, and energy balance. This study suggests that targeting astrocytes may be a potential strategy for anti-obesity interventions.
Article
Cell Biology
Wineke Bakker, Monica Imbernon, Casper Gravesen Salinas, Daniela Herrera Moro Chao, Rim Hassouna, Chloe Morel, Claire Martin, Caroline Leger, Raphael G. P. Denis, Julien Castel, Andreas Peter, Martin Heni, Walter Maetzler, Heidi Solvang Nielsen, Manon Duquenne, Markus Schwaninger, Sofia Lundh, Wouter Frederic Johan Hogendorf, Giuseppe Gangarossa, Anna Secher, Jacob Hecksher-Sorensen, Thomas Askov Pedersen, Vincent Prevot, Serge Luquet
Summary: A study found that insulin-induced hypoglycemia enhances the entry of GLP-1R agonists into the brain, leading to increased whole-body fat oxidation. This phenomenon relies partially on the release of tanycyctic vascular endothelial growth factor A, which is selectively impaired after exposure to a high-calorie diet. In humans, low blood glucose also enhances the passage of insulin into the brain through the blood-brain barrier. Therefore, preventing hyperglycemia is crucial for fully harnessing the benefits of GLP-1R agonists in the brain.
