期刊
MOLECULAR METABOLISM
卷 10, 期 -, 页码 1-13出版社
ELSEVIER
DOI: 10.1016/j.molmet.2018.01.018
关键词
Diet-induced obesity; Dietary fatty acids; Nuclear factor kappa-b; Neuroinflammation; Depression; Anxiety; Food reward
资金
- MDRC/Sunlife grant
- CIHR [MOP115042]
- FRQS
- CIHR Neuroinflammation Training Program
- MITACS Summer Internship
- FRQS Salary Award
- CIHR New Investigator Award
Objective: The incidence of depression is significantly compounded by obesity. Obesity arising from excessive intake of high-fat food provokes anxiodepressive behavior and elicits molecular adaptations in the nucleus accumbens (NAc), a region well-implicated in the hedonic deficits associated with depression and in the control of food-motivated behavior. To determine the etiology of diet-induced depression, we studied the impact of different dietary lipids on anxiodepressive behavior and metabolic and immune outcomes and the contribution of NAc immune activity. Methods: Adult C57Bl/6 mice were subjected to isocaloric high-fat/high-sucrose diets (HFD), enriched in either saturated or monounsaturated fat, or a control low-fat diet (LFD). Metabolic responses, anxiodepressive behavior, and plasma and NAc inflammatory markers were assessed after 12 weeks. In separate experiments, an adenoviral construct inhibiting IKK beta, an upstream component of the nuclear factor kappa-b (NFk beta) pathway, was a priori injected into the NAc. Results: Both HFDs resulted in obesity and hyperleptinemia; however, the saturated HFD uniquely triggered anxiety-like behavior, behavioral despair, hyperinsulinemia, glucose intolerance, peripheral inflammation, and multiple pro-inflammatory signs in the NAc, including reactive gliosis, increased expression of cytokines, antigen-presenting markers and NF kappa B transcriptional activity. Selective NAc IKK beta inhibition reversed the upregulated expression of inflammatory markers, prevented anxiodepressive behavior and blunted compulsive sucrose-seeking in mice fed the saturated HFD. Conclusions: Metabolic inflammation and NF kappa B-mediated neuroinflammatory responses in the NAc contribute to the expression of anxiodepressive behavior and heightened food cravings caused by a diet high in saturated fat and sugar. (C) 2018 The Authors. Published by Elsevier GmbH.
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