Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
出版年份 2022 全文链接
标题
Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
作者
关键词
-
出版物
Journal of Hematology & Oncology
Volume 15, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-07-18
DOI
10.1186/s13045-022-01313-4
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy
- (2022) Zhe Zhang et al. EMBO Molecular Medicine
- Therapeutic applications of mitochondrial transplantation
- (2022) Oner Ulger et al. BIOCHIMIE
- Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications
- (2022) Jin Feng et al. PHARMACOLOGICAL RESEARCH
- A minimalist and robust chemo-photothermal nanoplatform capable of augmenting autophagy-modulated immune response against breast cancer
- (2022) Hui Ming et al. Materials Today Bio
- Harnessing redox signaling to overcome therapeutic-resistant cancer dormancy
- (2022) Siyuan Qin et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- The potential value of dequalinium chloride in the treatment of cancer: Focus on malignant glioma
- (2021) Yuehai Pan et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Dihydropyridine Calcium Channel Blockers Suppress the Transcription of PD-L1 by Inhibiting the Activation of STAT1
- (2021) Xiaohui Pan et al. Frontiers in Pharmacology
- Metformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells
- (2021) Marika Rossini et al. Frontiers in Cell and Developmental Biology
- Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming
- (2021) Jennyfer Levoux et al. Cell Metabolism
- AMPK inhibits Smad3‐mediated autoinduction of TGF‐β1 in gastric cancer cells
- (2021) Junrong Zou et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance
- (2021) Marco Tigano et al. NATURE
- The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity
- (2021) Petra Kameritsch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glycolysis-induced drug resistance in tumors—A response to danger signals?
- (2021) Fabrizio Marcucci et al. NEOPLASIA
- Medicinal applications and molecular targets of dequalinium chloride
- (2021) Christian Bailly BIOCHEMICAL PHARMACOLOGY
- The proliferation effects of fluoxetine and amitriptyline on human breast cancer cells and the underlying molecular mechanisms
- (2021) Bingli Lei et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Differential Cytotoxicity Mechanisms of Copper Complexed with Disulfiram in Oral Cancer Cells
- (2021) Ssu-Yu Chen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mitochondria: Insights into Crucial Features to Overcome Cancer Chemoresistance
- (2021) Ilaria Genovese et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
- (2021) Lucille Stuani et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS
- (2021) Alexis A. Jourdain et al. MOLECULAR CELL
- Mito‐Bomb: Targeting Mitochondria for Cancer Therapy
- (2021) Xiaolu Guo et al. ADVANCED MATERIALS
- Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics
- (2021) Yanjie Guan et al. Cancer Cell International
- Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair
- (2021) Rui Liu et al. Cell Metabolism
- Use of antidepressants and endometrial-cancer risk: a nationwide nested case–control study
- (2021) Cecilie D Sperling et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Melatonin reshapes the mitochondrial network and promotes intercellular mitochondrial transfer via tunneling nanotubes after ischemic‐like injury in hippocampal HT22 cells
- (2021) Maria Gemma Nasoni et al. JOURNAL OF PINEAL RESEARCH
- VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases
- (2021) Thomas L. Ekstrom et al. MOLECULAR CANCER THERAPEUTICS
- Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets
- (2021) Rui Liu et al. MOLECULAR CELL
- Elesclomol induces copper‐dependent ferroptosis in colorectal cancer cells via degradation of ATP7A
- (2021) Wei Gao et al. Molecular Oncology
- Microemulsion for Prolonged Release of Fenretinide in the Mammary Tissue and Prevention of Breast Cancer Development
- (2021) Giovanna Cassone Salata et al. MOLECULAR PHARMACEUTICS
- Targeting cancer stem cells by nutraceuticals for cancer therapy
- (2021) Man Chu et al. SEMINARS IN CANCER BIOLOGY
- Dual-Functional Peptide Driven Liposome Codelivery System for Efficient Treatment of Doxorubicin-Resistant Breast Cancer
- (2021) Kamel S Ahmed et al. Drug Design Development and Therapy
- Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors
- (2021) Christina M. Dieli-Conwright et al. Scientific Reports
- SIRT1/PGC-1α/PPAR-γ Correlate With Hypoxia-Induced Chemoresistance in Non-Small Cell Lung Cancer
- (2021) Rui Xu et al. Frontiers in Oncology
- MCL1 participates in leptin-promoted mitochondrial fusion and contributes to drug resistance in gallbladder cancer
- (2021) Wei-Jan Wang et al. JCI Insight
- Effect of Chronic Stress Present in Fibroblasts Derived from Patients with a Sporadic Form of AD on Mitochondrial Function and Mitochondrial Turnover
- (2021) Karolina Drabik et al. Antioxidants
- CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma
- (2021) Jingyue Yao et al. Autophagy
- NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis
- (2021) Mi Kyung Park et al. Cell Metabolism
- Upgrade of an old drug: Auranofin in innovative cancer therapies to overcome drug resistance and to increase drug effectiveness
- (2021) Tania Gamberi et al. MEDICINAL RESEARCH REVIEWS
- Targeting cancer metabolism in the era of precision oncology
- (2021) Zachary E. Stine et al. NATURE REVIEWS DRUG DISCOVERY
- A review on pharmacological activities and synergistic effect of quercetin with small molecule agents
- (2021) Haoyang Zou et al. PHYTOMEDICINE
- Redox-sensitive cyclophilin A elicits chemoresistance through realigning cellular oxidative status in colorectal cancer
- (2021) Liyuan Peng et al. Cell Reports
- Redox Control of the Dormant Cancer Cell Life Cycle
- (2021) Bowen Li et al. Cells
- The GLP-1R Agonist Exendin-4 Attenuates Hyperglycemia-Induced Chemoresistance in Human Endometrial Cancer Cells Through ROS-Mediated Mitochondrial Pathway
- (2021) Yu Zhang et al. Frontiers in Oncology
- Mitochondrial calcium exchange in physiology and disease
- (2021) Joanne F. Garbincius et al. PHYSIOLOGICAL REVIEWS
- Mitochondria-Associated Membranes (MAMs): A Novel Therapeutic Target for Treating Metabolic Syndrome
- (2020) Ming Yang et al. CURRENT MEDICINAL CHEMISTRY
- Toward a Rational Design of Polyamine-Based Zinc-Chelating Agents for Cancer Therapies
- (2020) Cristina Galiana-Roselló et al. JOURNAL OF MEDICINAL CHEMISTRY
- New drug approvals in oncology
- (2020) Razelle Kurzrock et al. Nature Reviews Clinical Oncology
- The cell biology of mitochondrial membrane dynamics
- (2020) Marta Giacomello et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Machine and deep learning approaches for cancer drug repurposing
- (2020) Naiem T. Issa et al. SEMINARS IN CANCER BIOLOGY
- Non-secretory renin reduces oxidative stress and increases cardiomyoblast survival during glucose and oxygen deprivation
- (2020) Heike Wanka et al. Scientific Reports
- Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module
- (2020) Laura Di Magno et al. Cell Reports
- Tumor- and mitochondria-targeted nanoparticles eradicate drug resistant lung cancer through mitochondrial pathway of apoptosis
- (2020) He Wang et al. JOURNAL OF NANOBIOTECHNOLOGY
- Metabolic Symbiosis in Chemoresistance: Refocusing the Role of Aerobic Glycolysis
- (2020) Lisi Ma et al. Frontiers in Oncology
- Perimitochondrial Enzymatic Self-Assembly for Selective Targeting the Mitochondria of Cancer Cells
- (2020) Hongjian He et al. ACS Nano
- Anionic Polymers Promote Mitochondrial Targeting of Delocalized Lipophilic Cations
- (2020) Ziwen Jiang et al. BIOCONJUGATE CHEMISTRY
- Econazole Induces p53-Dependent Apoptosis and Decreases Metastasis Ability in Gastric Cancer Cells
- (2020) Eun Kyoung Choi et al. Biomolecules & Therapeutics
- Response and Resistance to BCR-ABL1-Targeted Therapies
- (2020) Theodore P. Braun et al. CANCER CELL
- Overcoming Endocrine Resistance in Breast Cancer
- (2020) Ariella B. Hanker et al. CANCER CELL
- Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer
- (2020) Yan Xing et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Repurposing leflunomide for relapsed/refractory multiple myeloma: a phase 1 study
- (2020) Michael Rosenzweig et al. LEUKEMIA & LYMPHOMA
- Transfer of healthy fibroblast-derived mitochondria to HeLa ρ0 and SAS ρ0 cells recovers the proliferation capabilities of these cancer cells under conventional culture medium, but increase their sensitivity to cisplatin-induced apoptotic death
- (2020) Amaneh Mohammadi Roushandeh et al. MOLECULAR BIOLOGY REPORTS
- Rational drug repurposing for cancer by inclusion of the unbiased molecular dynamics simulation in the structure-based virtual screening approach: Challenges and breakthroughs
- (2020) Farzin Sohraby et al. SEMINARS IN CANCER BIOLOGY
- Prazosin inhibits the proliferation, migration and invasion, but promotes the apoptosis of U251 and U87 cells via the PI3K/AKT/mTOR signaling pathway
- (2020) Jing Zhang et al. Experimental and Therapeutic Medicine
- Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer
- (2020) Mariela A. Moreno Ayala et al. Scientific Reports
- Utilizing Synergistic Potential of Mitochondria-Targeting Drugs for Leukemia Therapy
- (2020) Svetlana B. Panina et al. Frontiers in Oncology
- Mitochondrial-derived peptides in energy metabolism
- (2020) Troy L. Merry et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Moonlighting Metabolic Enzymes in Cancer: New Perspectives on the Redox Code
- (2020) Jingwen Jiang et al. ANTIOXIDANTS & REDOX SIGNALING
- Mitochondria-targeted drug delivery in cancers
- (2020) Hana Cho et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Synergistic Induction of Apoptosis by the Combination of an Axl Inhibitor and Auranofin in Human Breast Cancer Cells
- (2020) Yeon-Sang Ryu et al. Biomolecules & Therapeutics
- Bromocoumarinplatin, targeting simultaneously mitochondria and nuclei with p53 apoptosis pathway to overcome cisplatin resistance
- (2020) Jing Ma et al. BIOORGANIC CHEMISTRY
- Mitochondrial Metabolism as a Target for Cancer Therapy
- (2020) Karthik Vasan et al. Cell Metabolism
- Antimycin A shows selective antiproliferation to oral cancer cells by oxidative stress‐mediated apoptosis and DNA damage
- (2020) Tzu‐Jung Yu et al. ENVIRONMENTAL TOXICOLOGY
- Phospholipid ebb and flow makes mitochondria go
- (2020) Michelle Grace Acoba et al. JOURNAL OF CELL BIOLOGY
- Ca2+ Fluxes and Cancer
- (2020) Saverio Marchi et al. MOLECULAR CELL
- Clinical development and potential of photothermal and photodynamic therapies for cancer
- (2020) Xingshu Li et al. Nature Reviews Clinical Oncology
- Itraconazole inhibits the Hedgehog signaling pathway thereby inducing autophagy-mediated apoptosis of colon cancer cells
- (2020) Huiming Deng et al. Cell Death & Disease
- Isocitrate dehydrogenase 2 deficiency aggravates prolonged high-fat diet intake-induced hypertension
- (2020) Mi Ra Noh et al. Redox Biology
- Deferiprone (DFP) Targets Cancer Stem Cell (CSC) Propagation by Inhibiting Mitochondrial Metabolism and Inducing ROS Production
- (2020) Marco Fiorillo et al. Cells
- The Role of Mitochondrial Dynamics and Mitophagy in Carcinogenesis, Metastasis and Therapy
- (2020) Yigang Wang et al. Frontiers in Cell and Developmental Biology
- Targeted Delivery of the Mitochondrial Target Domain of Noxa to Tumor Tissue via Synthetic Secretion System in E. coli
- (2020) Daejin Lim et al. Frontiers in Bioengineering and Biotechnology
- Precisely Assembled Nanoparticles against Cisplatin Resistance via Cancer-Specific Targeting of Mitochondria and Imaging-Guided Chemo-Photothermal Therapy
- (2020) Gang-Gang Yang et al. ACS Applied Materials & Interfaces
- Inter and Intracellular mitochondrial trafficking in health and disease
- (2020) Santhanam Shanmughapriya et al. AGEING RESEARCH REVIEWS
- Activatable Mitochondria‐Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy
- (2020) Xiangjie Luo et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Aspirin in the Prevention of Colorectal Neoplasia
- (2020) David A. Drew et al. Annual Review of Medicine
- BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation
- (2020) Simone C. da Silva Rosa et al. Autophagy
- Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective
- (2020) Samik Bindu et al. BIOCHEMICAL PHARMACOLOGY
- Associations of aspirin, statins, and metformin with lung cancer risk and related mortality: time-dependent analysis of population-based nationally representative data
- (2020) Jihun Kang et al. Journal of Thoracic Oncology
- Nanoenabled Intracellular Calcium Bursting for Safe and Efficient Reversal of Drug Resistance in Tumor Cells
- (2020) Junjie Liu et al. NANO LETTERS
- Photoacoustic-immune therapy with a multi-purpose black phosphorus-based nanoparticle
- (2020) Fanchu Zeng et al. Nano Research
- Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspase‑dependent apoptosis
- (2020) Xia Cui et al. ONCOLOGY REPORTS
- Investigation of cancer drug resistance mechanisms by phosphoproteomics
- (2020) Joelle C. Boulos et al. PHARMACOLOGICAL RESEARCH
- Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone
- (2020) Gang Cheng et al. Scientific Reports
- Cancer metabolism and mitochondria: Finding novel mechanisms to fight tumours
- (2020) Sonia Missiroli et al. EBioMedicine
- Metformin Overcomes Acquired Resistance to EGFR TKIs in EGFR-Mutant Lung Cancer via AMPK/ERK/NF-κB Signaling Pathway
- (2020) Ling Li et al. Frontiers in Oncology
- Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2R1441G mice
- (2020) Huifang Liu et al. Autophagy
- Reduced reticulum–mitochondria Ca2+ transfer is an early and reversible trigger of mitochondrial dysfunctions in diabetic cardiomyopathy
- (2020) Maya Dia et al. BASIC RESEARCH IN CARDIOLOGY
- Role of Nrf2 and mitochondria in cancer stem cells; in carcinogenesis, tumor progression, and chemoresistance
- (2020) Zahra Payandeh et al. BIOCHIMIE
- Novel artemisinin derivatives with potent anticancer activities and the anti-colorectal cancer effect by the mitochondria-mediated pathway
- (2020) Lan Lin et al. BIOORGANIC CHEMISTRY
- Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification
- (2020) Bowen Li et al. DRUG RESISTANCE UPDATES
- MSC extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS
- (2020) Johnatas Dutra Silva et al. EUROPEAN RESPIRATORY JOURNAL
- PGC1α regulates mitochondrial oxidative phosphorylation involved in cisplatin resistance in ovarian cancer cells via nucleo-mitochondrial transcriptional feedback
- (2020) Luyan Shen et al. EXPERIMENTAL CELL RESEARCH
- Mitophagy promotes sorafenib resistance through hypoxia-inducible ATAD3A dependent Axis
- (2020) Hong Wu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Leflunomide Suppresses the Growth of LKB1-Inactivated Tumors in the Immune-Competent Host and Attenuates Distant Cancer Metastasis
- (2020) Rui Jin et al. MOLECULAR CANCER THERAPEUTICS
- Targeting cancer-cell mitochondria and metabolism to improve radiotherapy response
- (2020) Emma McCann et al. Translational Oncology
- Quercetin Induces Apoptosis via Downregulation of Vascular Endothelial Growth Factor/Akt Signaling Pathway in Acute Myeloid Leukemia Cells
- (2020) Huan Shi et al. Frontiers in Pharmacology
- Miro1-mediated mitochondrial positioning supports subcellular redox status
- (2020) Haya Alshaabi et al. Redox Biology
- Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response
- (2020) Radha Desai et al. Science Advances
- Mitochondrial transplantation therapy inhibit carbon tetrachloride‐induced liver injury through scavenging free radicals and protecting hepatocytes
- (2020) Zizhen Zhao et al. Bioengineering & Translational Medicine
- Cell penetrating peptides: A versatile vector for co-delivery of drug and genes in cancer
- (2020) Muhammad Muzamil Khan et al. JOURNAL OF CONTROLLED RELEASE
- Chemical structure modifications and nano-technology applications for improving ADME-Tox properties, a review
- (2019) Faten Farouk et al. ARCHIV DER PHARMAZIE
- CD38-driven mitochondrial trafficking promotes bioenergetic plasticity in multiple myeloma
- (2019) Christopher R. Marlein et al. CANCER RESEARCH
- Hydrogel Dressings for Advanced Wound Management
- (2019) Antonio Francesko et al. CURRENT MEDICINAL CHEMISTRY
- Mitochondrial proteins: from biogenesis to functional networks
- (2019) Nikolaus Pfanner et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Targeting Metabolic–Redox Circuits for Cancer Therapy
- (2019) Kui Wang et al. TRENDS IN BIOCHEMICAL SCIENCES
- Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression
- (2019) Dengke Bao et al. ONCOGENE
- Mitochondrial GPT2 plays a pivotal role in metabolic adaptation to the perturbation of mitochondrial glutamine metabolism
- (2019) Minjoong Kim et al. ONCOGENE
- Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma
- (2019) Yufeng Shi et al. NATURE
- Facile formulation of near-infrared light-triggered hollow mesoporous silica nanoparticles based on mitochondria targeting for on-demand chemo/photothermal/photodynamic therapy
- (2019) Cui-E Shi et al. NANOTECHNOLOGY
- Protective effects of atorvastatin on high glucose-induced oxidative stress and mitochondrial apoptotic signaling pathways in cultured chondrocytes
- (2019) Azam Hosseinzadeh et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Mitochondrial transplantation regulates antitumour activity, chemoresistance and mitochondrial dynamics in breast cancer
- (2019) Jui-Chih Chang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2
- (2019) Lili Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial transplantation as a potential and novel master key for treatment of various incurable diseases
- (2019) Amaneh Mohammadi Roushandeh et al. CYTOTECHNOLOGY
- LATS2 overexpression attenuates the therapeutic resistance of liver cancer HepG2 cells to sorafenib-mediated death via inhibiting the AMPK–Mfn2 signaling pathway
- (2019) Jie Song et al. Cancer Cell International
- Deficiency of Mitophagy Receptor FUNDC1 Impairs Mitochondrial Quality and Aggravates Dietary-Induced Obesity and Metabolic Syndrome
- (2019) Hao Wu et al. Autophagy
- Mitochondria-Targeted and Ultrasound-Activated Nanodroplets for Enhanced Deep-Penetration Sonodynamic Cancer Therapy
- (2019) Liang Zhang et al. ACS Applied Materials & Interfaces
- Quercetin-Modified Metal–Organic Frameworks for Dual Sensitization of Radiotherapy in Tumor Tissues by Inhibiting the Carbonic Anhydrase IX
- (2019) Tengchuang Ma et al. ACS Nano
- Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma
- (2019) Jingwen Jiang et al. Autophagy
- LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in KRAS-mutant lung adenocarcinoma
- (2019) Ana Galan-Cobo et al. CANCER RESEARCH
- Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non–Small Cell Lung Cancer Cells
- (2019) Sagar Sohoni et al. CANCER RESEARCH
- PGC-1α Controls Mitochondrial Biogenesis in Drug-Resistant Colorectal Cancer Cells by Regulating Endoplasmic Reticulum Stress
- (2019) Chul Won Yun et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Indomethacin impairs mitochondrial dynamics by activating the PKCζ–p38–DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells
- (2019) Somnath Mazumder et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The roles of glucose metabolic reprogramming in chemo- and radio-resistance
- (2019) Jinguan Lin et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Mitochondrial metabolism promotes adaptation to proteotoxic stress
- (2019) Peter Tsvetkov et al. Nature Chemical Biology
- Repurposing Disulfiram as an Anti-Cancer Agent: Updated Review on Literature and Patents
- (2019) Elmira Ekincia et al. Recent Patents on Anti-Cancer Drug Discovery
- Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma
- (2019) Liang Zhang et al. Science Translational Medicine
- Regulation of succinate dehydrogenase and role of succinate in cancer
- (2019) Elisa Dalla Pozza et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- γ-Tocotrienol inhibits oxidative phosphorylation and triggers apoptosis by inhibiting mitochondrial complex I subunit NDUFB8 and complex II subunit SDHB
- (2019) HaiXia Wang et al. TOXICOLOGY
- Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment
- (2019) Xufeng Chen et al. Cancer Discovery
- Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes
- (2019) Poliana Camila Marinello et al. Scientific Reports
- Fenton reaction assisted photodynamic therapy for cancer with multifunctional magnetic nanoparticles
- (2019) Huabo Hou et al. ACS Applied Materials & Interfaces
- 2D Nanomaterials for Cancer Theranostic Applications
- (2019) Liang Cheng et al. ADVANCED MATERIALS
- PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis
- (2019) Chaojun Yan et al. Autophagy
- Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug
- (2019) Xiaonan Zhang et al. BIOCHIMIE
- Drug repurposing to overcome resistance to various therapies for colorectal cancer
- (2019) Winnie Fong et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
- (2019) Marjorie Reyes-Farias et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mitochondrial Involvement in Cisplatin Resistance
- (2019) Veronica Cocetta et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Adipocyte and lipid metabolism in cancer drug resistance
- (2019) Yihai Cao JOURNAL OF CLINICAL INVESTIGATION
- Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy
- (2019) Aamod S. Dekhne et al. MOLECULAR CANCER THERAPEUTICS
- Cyclic Cell-Penetrating Peptides As Efficient Intracellular Drug Delivery Tools
- (2019) Shang Eun Park et al. MOLECULAR PHARMACEUTICS
- Insights into new mechanisms and models of cancer stem cell multidrug resistance
- (2019) Y. Garcia-Mayea et al. SEMINARS IN CANCER BIOLOGY
- Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
- (2019) Gang Cheng et al. Nature Communications
- Exploiting Mitochondrial Vulnerabilities to Trigger Apoptosis Selectively in Cancer Cells
- (2019) Christopher Nguyen et al. Cancers
- The Anticancer Agent Elesclomol Has Direct Effects on Mitochondrial Bioenergetic Function in Isolated Mammalian Mitochondria
- (2019) Modica-Napolitano et al. Biomolecules
- MOTS‐c: A Mitochondrial‐Encoded Regulator of the Nucleus
- (2019) Bérénice A. Benayoun et al. BIOESSAYS
- CRAF methylation by PRMT6 regulates aerobic glycolysis driven hepatocarcinogenesis via ERK‐dependent PKM2 nuclear relocalization and activation
- (2019) Tin‐Lok Wong et al. HEPATOLOGY
- A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells
- (2019) Isabella Orienti et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Mitochondria-targeted delocalized lipophilic cation complexed with human serum albumin for tumor cell imaging and treatment
- (2019) Kun Qian et al. Nanomedicine-Nanotechnology Biology and Medicine
- α-Ketoglutarate links p53 to cell fate during tumour suppression
- (2019) John P. Morris et al. NATURE
- Disulfiram’s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase
- (2019) Zdenek Skrott et al. ONCOGENE
- Mitochondrial fission causes cisplatin resistance under hypoxic conditions via ROS in ovarian cancer cells
- (2019) Youngjin Han et al. ONCOGENE
- Computer-aided drug repurposing for cancer therapy: Approaches and opportunities to challenge anticancer targets
- (2019) Carla Mottini et al. SEMINARS IN CANCER BIOLOGY
- MCT1 relieves osimertinib-induced CRC suppression by promoting autophagy through the LKB1/AMPK signaling
- (2019) Ping Jin et al. Cell Death & Disease
- Effect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone in Patients With Epidermal Growth Factor Receptor–Mutated Lung Adenocarcinoma
- (2019) Oscar Arrieta et al. JAMA Oncology
- Mitochondrial Dynamics and Its Involvement in Disease
- (2019) David C. Chan Annual Review of Pathology-Mechanisms of Disease
- Cell penetrating peptides: the potent multi-cargo intracellular carriers
- (2019) Kimia Kardani et al. Expert Opinion on Drug Delivery
- Mitochondrial fragmentation, elevated mitochondrial superoxide and respiratory supercomplexes disassembly is connected with the tamoxifen-resistant phenotype of breast cancer cells
- (2019) Veronika Tomková et al. FREE RADICAL BIOLOGY AND MEDICINE
- Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism
- (2019) Aamod S. Dekhne et al. MOLECULAR PHARMACOLOGY
- The great escape: tumour cell plasticity in resistance to targeted therapy
- (2019) Soufiane Boumahdi et al. NATURE REVIEWS DRUG DISCOVERY
- Mitochondria as multifaceted regulators of cell death
- (2019) Florian J. Bock et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion
- (2019) Peter Kreuzaler et al. Molecular Metabolism
- Targeting mitochondria as an anticancer strategy
- (2019) Lanfeng Dong et al. Cancer Communications
- Mitochondrial transplantation enhances murine lung viability and recovery after ischemia-reperfusion injury
- (2019) Kamila Moskowitzova et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy
- (2019) Weidong Nie et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Defeating relapsed and refractory malignancies through a nano-enabled mitochondria-mediated respiratory inhibition and damage pathway
- (2019) Zhengyang Yang et al. BIOMATERIALS
- Mitochondrial dysfunction and oxidative stress in heart disease
- (2019) Jessica N. Peoples et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Lercanidipine Synergistically Enhances Bortezomib Cytotoxicity in Cancer Cells via Enhanced Endoplasmic Reticulum Stress and Mitochondrial Ca2+ Overload
- (2019) A Reum Lee et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mitochondria-targeting nanomedicine self-assembled from GSH-responsive paclitaxel-ss-berberine conjugate for synergetic cancer treatment with enhanced cytotoxicity
- (2019) Yu Cheng et al. JOURNAL OF CONTROLLED RELEASE
- π-Extended Benzoporphyrin-Based Metal–Organic Framework for Inhibition of Tumor Metastasis
- (2018) Jin-Yue Zeng et al. ACS Nano
- MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation
- (2018) Tingting Ren et al. ANTIOXIDANTS & REDOX SIGNALING
- Reactive Oxygen Species and Mitochondrial Homeostasis as Regulators of Stem Cell Fate and Function
- (2018) Darren Q. Tan et al. ANTIOXIDANTS & REDOX SIGNALING
- Tumor acidity activating multifunctional nanoplatform for NIR-mediated multiple enhanced photodynamic and photothermal tumor therapy
- (2018) Junjie Liu et al. BIOMATERIALS
- Anti-tumoural actions of cannabinoids
- (2018) Burkhard Hinz et al. BRITISH JOURNAL OF PHARMACOLOGY
- Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics And Tumor Cell Movements
- (2018) Jae Ho Seo et al. CANCER RESEARCH
- RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+Uptake and Promotes Colorectal Oncogenesis
- (2018) Fanxin Zeng et al. CANCER RESEARCH
- New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathways
- (2018) Thuy Giang Lam et al. CANCER SCIENCE
- Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance
- (2018) Hideki Iwamoto et al. Cell Metabolism
- The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
- (2018) Kyung Hwa Kim et al. Cell Metabolism
- AMPK: Sensing Glucose as well as Cellular Energy Status
- (2018) Sheng-Cai Lin et al. Cell Metabolism
- Organic molecule-based photothermal agents: an expanding photothermal therapy universe
- (2018) Hyo Sung Jung et al. CHEMICAL SOCIETY REVIEWS
- A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid Leukemia
- (2018) Timothy S. Pardee et al. CLINICAL CANCER RESEARCH
- Targeting NAD+/PARP DNA Repair Pathway as a Novel Therapeutic Approach toSDHB-Mutated Cluster I Pheochromocytoma and Paraganglioma
- (2018) Ying Pang et al. CLINICAL CANCER RESEARCH
- Metabolic flexibility as an adaptation to energy resources and requirements in health and disease
- (2018) Reuben L Smith et al. ENDOCRINE REVIEWS
- Tumour microenvironment on mitochondrial dynamics and chemoresistance in cancer
- (2018) Youngjin Han et al. FREE RADICAL RESEARCH
- Nuclear genes involved in mitochondrial diseases caused by instability of mitochondrial DNA
- (2018) Joanna Rusecka et al. JOURNAL OF APPLIED GENETICS
- Different mitochondrial response to cisplatin and hyperthermia treatment in human AGS, Caco-2 and T3M4 cancer cell lines
- (2018) Sonata Trumbeckaite et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer
- (2018) Ke Gong et al. JOURNAL OF CLINICAL INVESTIGATION
- Enzymatic Cleavage of Branched Peptides for Targeting Mitochondria
- (2018) Hongjian He et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Complex roles of the old drug aspirin in cancer chemoprevention and therapy
- (2018) Hui Hua et al. MEDICINAL RESEARCH REVIEWS
- Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs
- (2018) Denise R. Minton et al. MOLECULAR CELL
- Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis
- (2018) Yajuan Zhang et al. MOLECULAR CELL
- Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
- (2018) Verónica Eisner et al. NATURE CELL BIOLOGY
- An inhibitor of oxidative phosphorylation exploits cancer vulnerability
- (2018) Jennifer R. Molina et al. NATURE MEDICINE
- p53 and glucose metabolism: an orchestra to be directed in cancer therapy
- (2018) Ana Sara Gomes et al. PHARMACOLOGICAL RESEARCH
- Prazosin but Not Tamsulosin Sensitises PC-3 and LNCaP Prostate Cancer Cells to Docetaxel
- (2018) Briohny H. Spencer et al. PHARMACOLOGY
- Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions
- (2018) György Csordás et al. TRENDS IN CELL BIOLOGY
- Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer
- (2018) Jutaek Nam et al. Nature Communications
- Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
- (2018) Yasuhito Onodera et al. Nature Communications
- Mitochondria-Targeted Artificial “Nano-RBCs” for Amplified Synergistic Cancer Phototherapy by a Single NIR Irradiation
- (2018) Liang Zhang et al. Advanced Science
- IDH2 deficiency increases the liver susceptibility to ischemia-reperfusion injury via increased mitochondrial oxidative injury
- (2018) Sang Jun Han et al. Redox Biology
- Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria
- (2018) Julia Chalker et al. Redox Biology
- A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds
- (2018) Balaraman Kalyanaraman et al. Redox Biology
- Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification
- (2018) Svitlana Melnik et al. Cell Discovery
- Low-dose X-ray radiotherapy–radiodynamic therapy via nanoscale metal–organic frameworks enhances checkpoint blockade immunotherapy
- (2018) Kuangda Lu et al. Nature Biomedical Engineering
- A Mitochondrial-Derived Peptide Exercises the Nuclear Option
- (2018) Kailash C. Mangalhara et al. Cell Metabolism
- Mitochondrial-targeted penetrating peptide delivery for cancer therapy
- (2018) Jiao Wu et al. Expert Opinion on Drug Delivery
- OXPHOS, Pyrimidine Nucleotides, and Alzheimer's Disease: A Pharmacogenomics Approach
- (2018) Alba Pesini et al. JOURNAL OF ALZHEIMERS DISEASE
- CerS6 regulates cisplatin resistance in oral squamous cell carcinoma by altering mitochondrial fission and autophagy
- (2018) Shengjiao Li et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance
- (2018) Kwon-Ho Song et al. JOURNAL OF CLINICAL INVESTIGATION
- OUP accepted manuscript
- (2018) JNCI-Journal of the National Cancer Institute
- Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial
- (2018) J Michael Gaziano et al. LANCET
- Auranofin Enhances Ibrutinib's Anticancer Activity in EGFR-Mutant Lung Adenocarcinoma
- (2018) Jing Hu et al. MOLECULAR CANCER THERAPEUTICS
- Characterizing the protective effects of SHLP2, a mitochondrial-derived peptide, in macular degeneration
- (2018) Sonali Nashine et al. Scientific Reports
- Tricyclic Antidepressants Modulate Stressed Mitochondria in Glioblastoma Multiforme Cells
- (2018) Anna M. Bielecka-Wajdman et al. Cancer Control
- Artesunate-induced mitophagy alters cellular redox status
- (2018) Jianbin Zhang et al. Redox Biology
- Possible Roles of Mitochondrial Dynamics and the Effects of Pharmacological Interventions in Chemoresistant Ovarian Cancer
- (2018) Chalita Kingnate et al. EBioMedicine
- Glutamine Deprivation Enhances Acetyl-CoA Carboxylase Inhibitor-induced Death of Human Pancreatic Cancer Cells
- (2018) KOJI NISHI et al. ANTICANCER RESEARCH
- Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy
- (2018) Hong Cheng et al. BIOMATERIALS
- Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis
- (2018) Bo Zhou et al. CELL RESEARCH
- The Combination of Metformin and Valproic Acid Has a Greater Anti-tumoral Effect on Prostate Cancer Growth In Vivo than Either Drug Alone
- (2018) LINH N.K. TRAN et al. IN VIVO
- Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma
- (2018) Yan Chen et al. JOURNAL OF HEPATOLOGY
- Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and Ca2+
- (2018) Ping Zhao et al. MOLECULES
- Drug repurposing: progress, challenges and recommendations
- (2018) Sudeep Pushpakom et al. NATURE REVIEWS DRUG DISCOVERY
- A Novel Self-Assembled Mitochondria-Targeting Protein Nanoparticle Acting as Theranostic Platform for Cancer
- (2018) Xin-Jie Zhu et al. Small
- Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption
- (2018) Sven de Mey et al. Frontiers in Pharmacology
- Perturbation in cellular redox homeostasis: Decisive regulator of T cell mediated immune responses
- (2018) Lokesh Gambhir et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Inhibition of mitochondrial translation as a therapeutic strategy for human ovarian cancer to overcome chemoresistance
- (2018) Bo Hu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cyclometalated iridium(III)-guanidinium complexes as mitochondria-targeted anticancer agents
- (2017) Xing-Dong Song et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Macrophage conditioned medium induced cellular network formation in MCF-7 cells through enhanced tunneling nanotube formation and tunneling nanotube mediated release of viable cytoplasmic fragments
- (2017) Pooja Patheja et al. EXPERIMENTAL CELL RESEARCH
- Hexokinase II–derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells
- (2017) Abiy D. Woldetsadik et al. FASEB JOURNAL
- Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain
- (2017) Sarah Preston et al. FASEB JOURNAL
- Store-Operated Ca 2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming
- (2017) Martin Vaeth et al. IMMUNITY
- P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models
- (2017) Lluis Lopez-Barcons et al. INTERNATIONAL JOURNAL OF CANCER
- Disrupting mitochondrial Ca2+ homeostasis causes tumor-selective TRAIL sensitization through mitochondrial network abnormalities
- (2017) Yohei Ohshima et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Mitochondrial Ca2+ removal amplifies TRAIL cytotoxicity toward apoptosis-resistant tumor cells via promotion of multiple cell death modalities
- (2017) Natsuhiko Takata et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators
- (2017) Clint A. Stalnecker et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metformin-induced alterations in nucleotide metabolism cause 5-fluorouracil resistance but gemcitabine susceptibility in oesophageal squamous cell carcinoma
- (2017) Charissa Mynhardt et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer
- (2017) M. Cecilia Caino et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of autophagy enhances the selective anti-cancer activity of tigecycline to overcome drug resistance in the treatment of chronic myeloid leukemia
- (2017) Ziyuan Lu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions
- (2017) Amelie V. Guitart et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mitochondrially derived peptides as novel regulators of metabolism
- (2017) Su-Jeong Kim et al. JOURNAL OF PHYSIOLOGY-LONDON
- Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light
- (2017) Mahdi Karimi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
- (2017) Peter W Stacpoole JNCI-Journal of the National Cancer Institute
- Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis
- (2017) Bruno R da Costa et al. LANCET
- Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin: a subgroup analysis of SOCRATES, a randomised, double-blind, controlled trial
- (2017) Pierre Amarenco et al. LANCET NEUROLOGY
- Maintenance of cellular respiration indicates drug resistance in acute myeloid leukemia
- (2017) Katharina Henkenius et al. LEUKEMIA RESEARCH
- Functional nanosome for enhanced mitochondria-targeted gene delivery and expression
- (2017) Yoonhee Bae et al. MITOCHONDRION
- Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration
- (2017) Max-Hinderk Schuler et al. MOLECULAR BIOLOGY OF THE CELL
- Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer
- (2017) Ke Chen et al. Molecular Cancer
- AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
- (2017) Daniel Garcia et al. MOLECULAR CELL
- Mitochondrial Gene Therapy: Advances in Mitochondrial Gene Cloning, Plasmid Production, and Nanosystems Targeted to Mitochondria
- (2017) Eduarda Coutinho et al. MOLECULAR PHARMACEUTICS
- Glucose feeds the TCA cycle via circulating lactate
- (2017) Sheng Hui et al. NATURE
- Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
- (2017) Rodrigo Romero et al. NATURE MEDICINE
- Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
- (2017) Elodie M Kuntz et al. NATURE MEDICINE
- The Drug Repurposing Hub: a next-generation drug library and information resource
- (2017) Steven M Corsello et al. NATURE MEDICINE
- Scientific advice — is drug repurposing missing a trick?
- (2017) Pan Pantziarka Nature Reviews Clinical Oncology
- Inhibition of prostate cancer proliferation by Deferiprone
- (2017) Rui V. Simões et al. NMR IN BIOMEDICINE
- Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma
- (2017) Gregory S. Ducker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Repurposing itraconazole for the treatment of cancer
- (2017) Rachel Pounds et al. Oncology Letters
- Repurposing itraconazole as an anticancer agent
- (2017) Hiroshi Tsubamoto et al. Oncology Letters
- Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
- (2017) Thomas Farge et al. Cancer Discovery
- PGC1α induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells
- (2017) Boyun Kim et al. Oncotarget
- Sequential Delivery of Cyclopeptide RA-V and Doxorubicin for Combination Therapy on Resistant Tumor and In Situ Monitoring of Cytochrome c Release
- (2017) Huachao Chen et al. Theranostics
- Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells
- (2017) Elodie Villa et al. Cell Reports
- The emerging role and targetability of the TCA cycle in cancer metabolism
- (2017) Nicole M. Anderson et al. Protein & Cell
- Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells
- (2017) Lan-Feng Dong et al. eLife
- Optical nanoprobes for biomedical applications: shining a light on upconverting and near-infrared emitting nanoparticles for imaging, thermal sensing, and photodynamic therapy
- (2017) E. Hemmer et al. Journal of Materials Chemistry B
- Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
- (2017) Peter W Stacpoole JNCI-Journal of the National Cancer Institute
- High expression of FUNDC1 predicts poor prognostic outcomes and is a promising target to improve chemoradiotherapy effects in patients with cervical cancer
- (2017) Hailing Hou et al. Cancer Medicine
- Piericidin A1 Blocks Yersinia Ysc Type III Secretion System Needle Assembly
- (2017) Jessica M. Morgan et al. mSphere
- Targeting Intracellular Calcium Signaling ([Ca2+]i) to Overcome Acquired Multidrug Resistance of Cancer Cells: A Mini-Overview
- (2017) Dietrich Büsselberg et al. Cancers
- NSAIDs Use and Reduced Metastasis in Cancer Patients: results from a meta-analysis
- (2017) Xiaoping Zhao et al. Scientific Reports
- Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis
- (2016) Sarah A. Head et al. ACS Chemical Biology
- Black Phosphorus Nanosheet-Based Drug Delivery System for Synergistic Photodynamic/Photothermal/Chemotherapy of Cancer
- (2016) Wansong Chen et al. ADVANCED MATERIALS
- Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics
- (2016) Wei Tao et al. ADVANCED MATERIALS
- Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers
- (2016) Laura J. Cobb et al. Aging-US
- Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction
- (2016) Chen Zhang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Maintenance and Expression of Mammalian Mitochondrial DNA
- (2016) Claes M. Gustafsson et al. Annual Review of Biochemistry
- Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function
- (2016) Lena Pernas et al. Annual Review of Physiology
- Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways
- (2016) Qichao Huang et al. Autophagy
- Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress
- (2016) Yingying Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Antibiotic drug levofloxacin inhibits proliferation and induces apoptosis of lung cancer cells through inducing mitochondrial dysfunction and oxidative damage
- (2016) Meijun Song et al. BIOMEDICINE & PHARMACOTHERAPY
- Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy
- (2016) R. Moschoi et al. BLOOD
- Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells
- (2016) Md Maksudul Alam et al. BMC CANCER
- Hexokinase 2 is a determinant of neuroblastoma metastasis
- (2016) Liat Edry Botzer et al. BRITISH JOURNAL OF CANCER
- Impaired mitochondrial function is abrogated by dexrazoxane in doxorubicin-treated childhood acute lymphoblastic leukemia survivors
- (2016) Steven E. Lipshultz et al. CANCER
- Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells
- (2016) Gang Cheng et al. CANCER RESEARCH
- Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets
- (2016) Erik Norberg et al. CELL DEATH AND DIFFERENTIATION
- Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers
- (2016) Xiaojing Liu et al. Cell Metabolism
- Circadian Rhythm Disruption Promotes Lung Tumorigenesis
- (2016) Thales Papagiannakopoulos et al. Cell Metabolism
- Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
- (2016) Shawn M. Davidson et al. Cell Metabolism
- Inhibition of FoxM1-Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis
- (2016) S. Rajamanickam et al. CLINICAL CANCER RESEARCH
- NIK/MAP3K14 Regulates Mitochondrial Dynamics and Trafficking to Promote Cell Invasion
- (2016) Ji-Ung Jung et al. CURRENT BIOLOGY
- Determinants of Anti-Cancer Effect of Mitochondrial Electron Transport Chain Inhibitors: Bioenergetic Profile and Metabolic Flexibility of Cancer Cells
- (2016) Félix Urra et al. CURRENT PHARMACEUTICAL DESIGN
- Ground control to major TOM: mitochondria-nucleus communication
- (2016) Michal Eisenberg-Bord et al. FEBS Journal
- Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors
- (2016) Gao Zhang et al. JOURNAL OF CLINICAL INVESTIGATION
- Asplatin enhances drug efficacy by altering the cellular response
- (2016) Qinqin Cheng et al. Metallomics
- Can you teach old drugs new tricks?
- (2016) Nicola Nosengo NATURE
- Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease
- (2016) Louise A. Hyslop et al. NATURE
- ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells
- (2016) Samantha C. Lewis et al. SCIENCE
- α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease
- (2016) Roberto Di Maio et al. Science Translational Medicine
- Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS
- (2016) Megan V. Jackson et al. STEM CELLS
- A combined in vitro approach to improve the prediction of mitochondrial toxicants
- (2016) Julie Eakins et al. TOXICOLOGY IN VITRO
- Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties
- (2016) Valentina Izzo et al. TRENDS IN CELL BIOLOGY
- Right Time, Right Place: Probing the Functions of Organelle Positioning
- (2016) Petra van Bergeijk et al. TRENDS IN CELL BIOLOGY
- Mitochondrial Dynamics and Metabolic Regulation
- (2016) Timothy Wai et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- ERK/Drp1-dependent mitochondrial fission is involved in the MSC-induced drug resistance of T-cell acute lymphoblastic leukemia cells
- (2016) Jianye Cai et al. Cell Death & Disease
- The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
- (2016) Thomas M. Ashton et al. Nature Communications
- The antidepressant fluoxetine induces necrosis by energy depletion and mitochondrial calcium overload
- (2016) Emilie Charles et al. Oncotarget
- The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration
- (2016) Linda A. Villani et al. Molecular Metabolism
- Galectin-1-Induced Autophagy Facilitates Cisplatin Resistance of Hepatocellular Carcinoma
- (2016) Yu-Chi Su et al. PLoS One
- Deficiency in Cardiolipin Reduces Doxorubicin-Induced Oxidative Stress and Mitochondrial Damage in Human B-Lymphocytes
- (2016) Baikuntha Aryal et al. PLoS One
- Metformin is a novel suppressor for transforming growth factor (TGF)-β1
- (2016) Han Xiao et al. Scientific Reports
- Iron chelators target both proliferating and quiescent cancer cells
- (2016) Mårten Fryknäs et al. Scientific Reports
- Mitochondrially Targeted Vitamin E Succinate Modulates Expression of Mitochondrial DNA Transcripts and Mitochondrial Biogenesis
- (2015) Jaroslav Truksa et al. ANTIOXIDANTS & REDOX SIGNALING
- Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II)
- (2015) Brian B. Hasinoff et al. BIOCHEMICAL PHARMACOLOGY
- Doxorubicin-loaded NaYF4:Yb/Tm–TiO2 inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers
- (2015) Leyong Zeng et al. BIOMATERIALS
- Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner
- (2015) Bing Yan et al. BMC CANCER
- Exogenous normal mammary epithelial mitochondria suppress glycolytic metabolism and glucose uptake of human breast cancer cells
- (2015) Xian-Peng Jiang et al. BREAST CANCER RESEARCH AND TREATMENT
- Mitochondrial ROS Signaling in Organismal Homeostasis
- (2015) Gerald S. Shadel et al. CELL
- Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA
- (2015) An S. Tan et al. Cell Metabolism
- Redox Homeostasis and Mitochondrial Dynamics
- (2015) Peter H.G.M. Willems et al. Cell Metabolism
- Screening and In Vitro Testing of Antifolate Inhibitors of Human Cytosolic Serine Hydroxymethyltransferase
- (2015) Alessandro Paiardini et al. ChemMedChem
- Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics
- (2015) Angelika S. Rambold et al. DEVELOPMENTAL CELL
- Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo
- (2015) Sheau-Yun Yuan et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Combining BRAFV600Einhibition with modulators of the mitochondrial bioenergy metabolism to overcome drug resistance in metastatic melanoma
- (2015) Elisabeth Livingstone et al. EXPERIMENTAL DERMATOLOGY
- Novel cell-penetrating peptide targeting mitochondria
- (2015) Carmine Pasquale Cerrato et al. FASEB JOURNAL
- Roles of Nrf2 in cell proliferation and differentiation
- (2015) Shohei Murakami et al. FREE RADICAL BIOLOGY AND MEDICINE
- Gefitinib-mediated Reactive Oxygen Specie (ROS) Instigates Mitochondrial Dysfunction and Drug Resistance in Lung Cancer Cells
- (2015) Imoh S. Okon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Combination of Targeted Sunitinib Liposomes and Targeted Vinorelbine Liposomes for Treating Invasive Breast Cancer
- (2015) Ji-Feng Shi et al. Journal of Biomedical Nanotechnology
- Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
- (2015) Yan Xiang et al. JOURNAL OF CLINICAL INVESTIGATION
- Metabolic reprogramming: the emerging concept and associated therapeutic strategies
- (2015) Go J. Yoshida JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy
- (2015) Jagadish C. Ghosh et al. JNCI-Journal of the National Cancer Institute
- Transcriptional activation of LON Gene by a new form of mitochondrial stress: A role for the nuclear respiratory factor 2 in StAR overload response (SOR)
- (2015) Assaf Bahat et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Ibuprofen Induces Mitochondrial-Mediated Apoptosis Through Proteasomal Dysfunction
- (2015) Arun Upadhyay et al. MOLECULAR NEUROBIOLOGY
- Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression
- (2015) Ana M. Cardoso et al. MOLECULAR PHARMACEUTICS
- Enhance Cancer Cell Recognition and Overcome Drug Resistance Using Hyaluronic Acid and α-Tocopheryl Succinate Based Multifunctional Nanoparticles
- (2015) Desheng Liang et al. MOLECULAR PHARMACEUTICS
- Metabolic pathways promoting cancer cell survival and growth
- (2015) Lindsey K. Boroughs et al. NATURE CELL BIOLOGY
- Targeting mitochondria metabolism for cancer therapy
- (2015) Samuel E Weinberg et al. Nature Chemical Biology
- Imipramine blue halts head and neck cancer invasion through promoting F-box and leucine-rich repeat protein 14-mediated Twist1 degradation
- (2015) W-H Yang et al. ONCOGENE
- Mitochondrial ROS and cancer drug resistance: Implications for therapy
- (2015) Imoh S. Okon et al. PHARMACOLOGICAL RESEARCH
- MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism
- (2015) Emelyn H. Shroff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion
- (2015) Christof Osman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells
- (2015) Sarah A. Head et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
- (2015) M. Cecilia Caino et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Concise Review: Bullseye: Targeting Cancer Stem Cells to Improve the Treatment of Gliomas by Repurposing Disulfiram
- (2015) Joanna Triscott et al. STEM CELLS
- Clinical use of photodynamic therapy in ocular tumors
- (2015) Eren Cerman et al. SURVEY OF OPHTHALMOLOGY
- Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model
- (2015) Tuomas Komulainen et al. TOXICOLOGY
- The energy blocker inside the power house: mitochondria targeted delivery of 3-bromopyruvate
- (2015) Sean Marrache et al. Chemical Science
- Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents
- (2015) N Yadav et al. Cell Death & Disease
- Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity
- (2015) Ke Tan et al. Nature Communications
- Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation
- (2015) Tomokazu Murakawa et al. Nature Communications
- Mitochondrial reactive oxygen species production mediates ursolic acid-induced mitochondrial uncoupling and glutathione redox cycling, with protection against oxidant injury in H9c2 cells
- (2015) Jihang Chen et al. Food & Function
- High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant
- (2015) Gillian Farnie et al. Oncotarget
- Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer
- (2015) Peng Zou et al. Oncotarget
- Folate-mediated mitochondrial targeting with doxorubicin-polyrotaxane nanoparticles overcomes multidrug resistance
- (2015) He Wang et al. Oncotarget
- Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling
- (2015) Xinqun Chai et al. Scientific Reports
- Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis
- (2015) Takla Griss et al. PLOS BIOLOGY
- Target delivery of β-cyclodextrin/paclitaxel complexed fluorescent carbon nanoparticles: externally NIR light and internally pH sensitive-mediated release of paclitaxel with bio-imaging
- (2015) Shazid Md. Sharker et al. Journal of Materials Chemistry B
- Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy
- (2015) Jagadish C. Ghosh et al. JNCI-Journal of the National Cancer Institute
- Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors
- (2014) Zhilin Song et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Fenretinide induces autophagic cell death in caspase-defective breast cancer cells
- (2014) Barbara Fazi et al. Autophagy
- Itraconazole suppresses the growth of glioblastoma through induction of autophagy
- (2014) Rui Liu et al. Autophagy
- Mitochondrial dysfunction in cancer chemoresistance
- (2014) Nicoletta Guaragnella et al. BIOCHEMICAL PHARMACOLOGY
- Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1 and Oxidative Phosphorylation in Melanoma
- (2014) Y. N. V. Gopal et al. CANCER RESEARCH
- Tissue-Specific Loss of DARS2 Activates Stress Responses Independently of Respiratory Chain Deficiency in the Heart
- (2014) Sukru Anil Dogan et al. Cell Metabolism
- Mitochondria-Targeted Spin Traps: Synthesis, Superoxide Spin Trapping, and Mitochondrial Uptake
- (2014) Micael Hardy et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Functional Nanomaterials for Phototherapies of Cancer
- (2014) Liang Cheng et al. CHEMICAL REVIEWS
- A Phase I Study of the First-in-Class Antimitochondrial Metabolism Agent, CPI-613, in Patients with Advanced Hematologic Malignancies
- (2014) T. S. Pardee et al. CLINICAL CANCER RESEARCH
- OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand
- (2014) D. A. Patten et al. EMBO JOURNAL
- Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation
- (2014) Floris H. Groenendijk et al. INTERNATIONAL JOURNAL OF CANCER
- Valproic acid, an anti-epileptic drug and a histone deacetylase inhibitor, in combination with proteasome inhibitors exerts antiproliferative, pro-apoptotic and chemosensitizing effects in human colorectal cancer cells: Underlying molecular mechanisms
- (2014) MOHAMED-SALAH I. ABAZA et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells
- (2014) XIAO-JIAN HAN et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Calcineurin-NFATc Regulates Type 2 Inositol 1,4,5-Trisphosphate Receptor (InsP3R2) Expression during Cardiac Remodeling
- (2014) Natesan Sankar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The cytotoxicity of the anticancer drug elesclomol is due to oxidative stress indirectly mediated through its complex with Cu(II)
- (2014) Brian B. Hasinoff et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Far-Red Fluorescence Probe for Monitoring Singlet Oxygen during Photodynamic Therapy
- (2014) Sooyeon Kim et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Mitochondrial Induced and Self-Monitored Intrinsic Apoptosis by Antitumor Theranostic Prodrug: In Vivo Imaging and Precise Cancer Treatment
- (2014) Rajesh Kumar et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The Expression of Genes Involved in Hepatocellular Carcinoma Chemoresistance Is Affected by Mitochondrial Genome Depletion
- (2014) Ester Gonzalez-Sanchez et al. MOLECULAR PHARMACEUTICS
- Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
- (2014) Anila K. Madiraju et al. NATURE
- PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
- (2014) Valerie S. LeBleu et al. NATURE CELL BIOLOGY
- Targeting mitochondria in pancreatic cancer
- (2014) Alessia Errico Nature Reviews Clinical Oncology
- Neuroprotective Effect of Diphenyl Diselenide in a Experimental Stroke Model: Maintenance of Redox System in Mitochondria of Brain Regions
- (2014) Fernando Dobrachinski et al. NEUROTOXICITY RESEARCH
- The Parkinson’s gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes
- (2014) C H O'Flanagan et al. ONCOGENE
- Advances in Anticancer Protein Delivery using Micro-/Nanoparticles
- (2014) Wujin Sun et al. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
- Delivery of a Monomeric p53 Subdomain with Mitochondrial Targeting Signals from Pro-Apoptotic Bak or Bax
- (2014) Karina J. Matissek et al. PHARMACEUTICAL RESEARCH
- Synergistic Anti-Cancer Effect of Phenformin and Oxamate
- (2014) W. Keith Miskimins et al. PLoS One
- Mitochondrial Calcium Uniporter Activity Is Dispensable for MDA-MB-231 Breast Carcinoma Cell Survival
- (2014) Duane D. Hall et al. PLoS One
- High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy
- (2014) M Rossi et al. Cell Death & Disease
- Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
- (2014) Xiaonan Zhang et al. Nature Communications
- Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
- (2014) William W Wheaton et al. eLife
- Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts
- (2013) Jin O-Uchi et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Mitochondrial targeting overcomes ABCA1-dependent resistance of lung carcinoma to α-tocopheryl succinate
- (2013) Lubomir Prochazka et al. APOPTOSIS
- The anticancer efficacy of paclitaxel liposomes modified with mitochondrial targeting conjugate in resistant lung cancer
- (2013) Jia Zhou et al. BIOMATERIALS
- Mitochondrial Localization and the Persistent Migration of Epithelial Cancer cells
- (2013) Salil P. Desai et al. BIOPHYSICAL JOURNAL
- PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
- (2013) Francisca Vazquez et al. CANCER CELL
- Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
- (2013) Elisabeth Mémin et al. CANCER RESEARCH
- Activation of cell-penetrating peptides by disulfide bridge formation of truncated precursors
- (2013) Saskia A. Bode et al. CHEMICAL COMMUNICATIONS
- Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma
- (2013) L. Zheng et al. CLINICAL CANCER RESEARCH
- Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells
- (2013) M. Cecilia Caino et al. JOURNAL OF CLINICAL INVESTIGATION
- Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance
- (2013) Jennifer Pasquier et al. Journal of Translational Medicine
- Delivery of Nucleic Acids, Proteins, and Nanoparticles by Arginine-Rich Cell-Penetrating Peptides in Rotifers
- (2013) Betty Revon Liu et al. MARINE BIOTECHNOLOGY
- NSAIDs may regulate EGR-1-mediated induction of reactive oxygen species and non-steroidal anti-inflammatory drug-induced gene (NAG)-1 to initiate intrinsic pathway of apoptosis for the chemoprevention of colorectal cancer
- (2013) Vivek Vaish et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
- (2013) Lucas B. Sullivan et al. MOLECULAR CELL
- Euphorbia formosana Root Extract Induces Apoptosis by Caspase-Dependent Cell Death via Fas and Mitochondrial Pathway in THP-1 Human Leukemic Cells
- (2013) Yi-Jen Hsieh et al. MOLECULES
- Animal Models of Parkinson’s Disease: A Gateway to Therapeutics?
- (2013) Weidong Le et al. Neurotherapeutics
- Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
- (2013) H. A. Hirsch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipids of mitochondria
- (2013) Susanne E. Horvath et al. PROGRESS IN LIPID RESEARCH
- Regulation of autophagy by stress-responsive transcription factors
- (2013) Federico Pietrocola et al. SEMINARS IN CANCER BIOLOGY
- Humanin: a harbinger of mitochondrial-derived peptides?
- (2013) Changhan Lee et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death
- (2013) N Rimmerman et al. Cell Death & Disease
- Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
- (2012) Patrick S. Ward et al. CANCER CELL
- Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25
- (2012) Saverio Marchi et al. CURRENT BIOLOGY
- The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells
- (2012) Masazumi Nagai et al. FREE RADICAL BIOLOGY AND MEDICINE
- Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo
- (2012) Swati Biswas et al. JOURNAL OF CONTROLLED RELEASE
- Constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes
- (2012) Morten B. Hansen et al. JOURNAL OF CONTROLLED RELEASE
- Metformin in cancer: translational challenges
- (2012) Ryan J O Dowling et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Sorafenib-Induced Mitochondrial Complex I Inactivation and Cell Death in Human Neuroblastoma Cells
- (2012) Vibeke Hervik Bull et al. JOURNAL OF PROTEOME RESEARCH
- Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury
- (2012) Mohammad Naimul Islam et al. NATURE MEDICINE
- Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects
- (2012) Arian Emami Riedmaier et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
- (2012) C. Kondapalli et al. Open Biology
- Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
- (2011) Sophia Y. Lunt et al. Annual Review of Cell and Developmental Biology
- Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling
- (2011) Kui Wang et al. Autophagy
- The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells
- (2011) Xiao-Xing Wang et al. BIOMATERIALS
- Enhanced siRNA delivery into cells by exploiting the synergy between targeting ligands and cell-penetrating peptides
- (2011) Christopher J. Cheng et al. BIOMATERIALS
- Antisense inhibition of gene expression and growth in gram-negative bacteria by cell-penetrating peptide conjugates of peptide nucleic acids targeted to rpoD gene
- (2011) Hui Bai et al. BIOMATERIALS
- Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
- (2011) Nadine Rohwer et al. DRUG RESISTANCE UPDATES
- Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy
- (2011) Lan-Feng Dong et al. FREE RADICAL BIOLOGY AND MEDICINE
- Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress
- (2011) R. Bravo et al. JOURNAL OF CELL SCIENCE
- Organosulfur derivatives of the HDAC inhibitor valproic acid sensitize human lung cancer cell lines to apoptosis and to cisplatin cytotoxicity
- (2011) Anna Tesei et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?
- (2011) A Lemarie et al. ONCOGENE
- Development of Novel Peptides for Mitochondrial Drug Delivery: Amino Acids Featuring Delocalized Lipophilic Cations
- (2011) Shana O. Kelley et al. PHARMACEUTICAL RESEARCH
- Mitochondria and Trypanosomatids: Targets and Drugs
- (2011) Lianet Monzote Fidalgo et al. PHARMACEUTICAL RESEARCH
- Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation
- (2011) A. S. Rambold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ER Tubules Mark Sites of Mitochondrial Division
- (2011) J. R. Friedman et al. SCIENCE
- Mechanism-Based Tumor-Targeting Drug Delivery System. Validation of Efficient Vitamin Receptor-Mediated Endocytosis and Drug Release
- (2010) Shuyi Chen et al. BIOCONJUGATE CHEMISTRY
- Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids
- (2010) Eva Gottfried et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1
- (2010) M. J. Seltzer et al. CANCER RESEARCH
- Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations
- (2010) Hsiuchen Chen et al. CELL
- Newly developed strategies for multifunctional mitochondria-targeted agents in cancer therapy
- (2010) Erlong Zhang et al. DRUG DISCOVERY TODAY
- The repositioning of the anti-fungal agent ciclopirox olamine as a novel therapeutic agent for the treatment of haematologic malignancy
- (2010) S. J. Weir et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease
- (2010) Lyndsey Craven et al. NATURE
- The therapeutic potential of carbon monoxide
- (2010) Roberto Motterlini et al. NATURE REVIEWS DRUG DISCOVERY
- Targeting mitochondria for cancer therapy
- (2010) Simone Fulda et al. NATURE REVIEWS DRUG DISCOVERY
- Cannabinoids Inhibit Cellular Respiration of Human Oral Cancer Cells
- (2010) Donna A. Whyte et al. PHARMACOLOGY
- Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
- (2010) D. F. Egan et al. SCIENCE
- Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆
- (2009) Divya Pathania et al. ADVANCED DRUG DELIVERY REVIEWS
- Fluoxetine Induces Apoptosis in Ovarian Carcinoma Cell Line OVCAR-3 Through Reactive Oxygen Species-Dependent Activation of Nuclear Factor-κB
- (2009) Chung Soo Lee et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Elesclomol, counteracted by Akt survival signaling, enhances the apoptotic effect of chemotherapy drugs in breast cancer cells
- (2009) Ying Qu et al. BREAST CANCER RESEARCH AND TREATMENT
- Mitochondrial Uncoupling and the Warburg Effect: Molecular Basis for the Reprogramming of Cancer Cell Metabolism
- (2009) I. Samudio et al. CANCER RESEARCH
- Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy
- (2009) M. H. Kang et al. CLINICAL CANCER RESEARCH
- MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
- (2009) C. V. Dang et al. CLINICAL CANCER RESEARCH
- Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides
- (2009) Todd A. Aguilera et al. Integrative Biology
- Mitochondrial gene replacement in primate offspring and embryonic stem cells
- (2009) Masahito Tachibana et al. NATURE
- Second window for in vivo imaging
- (2009) Andrew M. Smith et al. Nature Nanotechnology
- How mitochondria produce reactive oxygen species
- (2008) Michael P. Murphy BIOCHEMICAL JOURNAL
- SMAC Mimetics Sensitize Nonsteroidal Anti-inflammatory Drug Induced Apoptosis by Promoting Caspase-3 Mediated Cytochrome c Release
- (2008) A. Bank et al. CANCER RESEARCH
- Resveratrol induces apoptosis in K562 (chronic myelogenous leukemia) cells by targeting a key survival protein, heat shock protein 70
- (2008) Prabir K. Chakraborty et al. CANCER SCIENCE
- Comparative pharmacokinetics of breviscapine liposomes in dogs, rabbits and rats
- (2008) Wenli Lv et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Gain-of-function R225Q Mutation in AMP-activated Protein Kinase γ3 Subunit Increases Mitochondrial Biogenesis in Glycolytic Skeletal Muscle
- (2008) Pablo M. Garcia-Roves et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanism of Synergy of N-(4-Hydroxyphenyl)Retinamide and ABT-737 in Acute Lymphoblastic Leukemia Cell Lines: Mcl-1 Inactivation
- (2008) Min H. Kang et al. JNCI-Journal of the National Cancer Institute
- Growth inhibition in antimycin A treated-lung cancer Calu-6 cells via inducing a G1 phase arrest and apoptosis
- (2008) Yong Hwan Han et al. LUNG CANCER
- Elesclomol induces cancer cell apoptosis through oxidative stress
- (2008) J. R. Kirshner et al. MOLECULAR CANCER THERAPEUTICS
- Organelle-Targeted Nanocarriers: Specific Delivery of Liposomal Ceramide to Mitochondria Enhances Its Cytotoxicity in Vitro and in Vivo
- (2008) Sarathi V. Boddapati et al. NANO LETTERS
- Mitofusin 2 tethers endoplasmic reticulum to mitochondria
- (2008) Olga Martins de Brito et al. NATURE
- α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II
- (2008) L-F Dong et al. ONCOGENE
- Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptides
- (2007) Bryan R. Meade et al. ADVANCED DRUG DELIVERY REVIEWS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now