Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
出版年份 2021 全文链接
标题
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
作者
关键词
-
出版物
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 218, Issue 5, Pages -
出版商
Rockefeller University Press
发表日期
2021-03-24
DOI
10.1084/jem.20200924
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Molecular mechanisms mediating relapse following ivosidenib monotherapy in IDH1-mutant relapsed or refractory AML
- (2020) Sung Choe et al. Blood Advances
- Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy
- (2019) Vera Mugoni et al. CELL RESEARCH
- Enasidenib, an inhibitor of mutant IDH2 proteins, induces durable remissions in older patients with newly diagnosed acute myeloid leukemia
- (2019) Daniel A. Pollyea et al. LEUKEMIA
- Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
- (2019) Irène Baccelli et al. CANCER CELL
- Genetic characterization of ABT-199 sensitivity in human AML
- (2019) Richard Bisaillon et al. LEUKEMIA
- In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site
- (2019) Anuhar Chaturvedi et al. LEUKEMIA
- Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response
- (2019) David Sharon et al. Science Translational Medicine
- Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia
- (2019) Gail J. Roboz et al. BLOOD
- Glutaminolysis is a metabolic dependency in FLT3ITDacute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition
- (2018) Paolo Gallipoli et al. BLOOD
- Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia
- (2018) Mark A. Gregory et al. EXPERIMENTAL HEMATOLOGY
- An inhibitor of oxidative phosphorylation exploits cancer vulnerability
- (2018) Jennifer R. Molina et al. NATURE MEDICINE
- Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib
- (2018) Lynn Quek et al. NATURE MEDICINE
- Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML
- (2018) Courtney D. DiNardo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis
- (2018) Kate E.R. Hollinshead et al. Cell Reports
- Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress
- (2018) Susan J. Gelman et al. Cell Reports
- Persistent IDH1/2 mutation in remission can predict relapse in patients with acute myeloid leukemia
- (2018) Chi Young Ok et al. HAEMATOLOGICA
- Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm
- (2018) Guangyao Kong et al. LEUKEMIA
- Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
- (2018) Andrew M. Intlekofer et al. NATURE
- Molecular remission and response patterns in patients with mutant-IDH2 acute myeloid leukemia treated with enasidenib
- (2018) Eytan M. Stein et al. BLOOD
- A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
- (2018) Livnat Jerby-Arnon et al. CELL
- Large-Scale Modeling Approach Reveals Functional Metabolic Shifts during Hepatic Differentiation
- (2018) Nathalie Poupin et al. JOURNAL OF PROTEOME RESEARCH
- Functional genomic landscape of acute myeloid leukaemia
- (2018) Jeffrey W. Tyner et al. NATURE
- Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition
- (2018) James J. Harding et al. Cancer Discovery
- Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo
- (2017) A Chaturvedi et al. LEUKEMIA
- Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence
- (2017) Sevin Turcan et al. NATURE GENETICS
- The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
- (2017) Nina Fenouille et al. NATURE MEDICINE
- Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
- (2017) Thomas Farge et al. Cancer Discovery
- AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
- (2017) Katharine Yen et al. Cancer Discovery
- Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH -Mutant Molecular Profiles
- (2017) Farshad Farshidfar et al. Cell Reports
- IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation
- (2017) Bin Jiang et al. Cell Reports
- Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2
- (2016) Satoshi Inoue et al. CANCER CELL
- The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
- (2016) Nicole E. Scharping et al. IMMUNITY
- Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia
- (2016) Héléna Boutzen et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53
- (2016) Romain Riscal et al. MOLECULAR CELL
- Genomic Classification and Prognosis in Acute Myeloid Leukemia
- (2016) Elli Papaemmanuil et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia
- (2016) M. Konopleva et al. Cancer Discovery
- Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes
- (2016) Polina Matre et al. Oncotarget
- Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion
- (2015) Kensuke Tateishi et al. CANCER CELL
- An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis
- (2015) Kıvanç Birsoy et al. CELL
- Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells
- (2015) Lucas B. Sullivan et al. CELL
- 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling
- (2015) Xudong Fu et al. Cell Metabolism
- NADP+-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance
- (2015) Feng Li et al. MOLECULAR CELL
- Insulator dysfunction and oncogene activation in IDH mutant gliomas
- (2015) William A. Flavahan et al. NATURE
- Metabolic pathways promoting cancer cell survival and growth
- (2015) Lindsey K. Boroughs et al. NATURE CELL BIOLOGY
- New IDH1 mutant inhibitors for treatment of acute myeloid leukemia
- (2015) Ujunwa C Okoye-Okafor et al. Nature Chemical Biology
- Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
- (2015) Steven M Chan et al. NATURE MEDICINE
- Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype
- (2015) Elisabet Cuyàs et al. Oncotarget
- IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism
- (2014) A. R. Grassian et al. CANCER RESEARCH
- Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance
- (2014) Lev M. Kats et al. Cell Stem Cell
- Tyrosine Kinase Inhibition in Leukemia Induces an Altered Metabolic State Sensitive to Mitochondrial Perturbations
- (2014) F. Alvarez-Calderon et al. CLINICAL CANCER RESEARCH
- Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis
- (2014) M R Corces-Zimmerman et al. LEUKEMIA
- Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
- (2014) Liran I. Shlush et al. NATURE
- Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
- (2014) Andrea Viale et al. NATURE
- Glioma Cells with the IDH1 Mutation Modulate Metabolic Fractional Flux through Pyruvate Carboxylase
- (2014) Jose L. Izquierdo-Garcia et al. PLoS One
- Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex
- (2013) Ji-Hong Lim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells
- (2013) S Scotland et al. LEUKEMIA
- A community-driven global reconstruction of human metabolism
- (2013) Ines Thiele et al. NATURE BIOTECHNOLOGY
- Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
- (2013) NEW ENGLAND JOURNAL OF MEDICINE
- (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
- (2013) J.-A. Losman et al. SCIENCE
- An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
- (2013) D. Rohle et al. SCIENCE
- Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation
- (2013) F. Wang et al. SCIENCE
- Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2
- (2013) Paul Guilhamon et al. Nature Communications
- D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
- (2012) M. Sasaki et al. GENES & DEVELOPMENT
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways
- (2012) Ioannis S. Vlachos et al. NUCLEIC ACIDS RESEARCH
- Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia
- (2011) Marko Škrtić et al. CANCER CELL
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- PGC1 Promotes Tumor Growth by Inducing Gene Expression Programs Supporting Lipogenesis
- (2011) K. Bhalla et al. CANCER RESEARCH
- The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+
- (2011) Zachary Gerhart-Hines et al. MOLECULAR CELL
- iMAT: an integrative metabolic analysis tool
- (2010) Hadas Zur et al. BIOINFORMATICS
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- IDH1andIDH2Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study
- (2010) Guido Marcucci et al. JOURNAL OF CLINICAL ONCOLOGY
- Computational reconstruction of tissue-specific metabolic models: application to human liver metabolism
- (2010) Livnat Jerby et al. Molecular Systems Biology
- Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
- (2009) Ismael Samudio et al. JOURNAL OF CLINICAL INVESTIGATION
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
- (2009) Elaine R. Mardis et al. NEW ENGLAND JOURNAL OF MEDICINE
- Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling
- (2008) R. G.W. Verhaak et al. HAEMATOLOGICA
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started