Editorial Material
Multidisciplinary Sciences
Jeffrey M. Perkel
Summary: Computational environments and management tools enable researchers to produce code that is reproducible, documented, and shareable.
Article
Pharmacology & Pharmacy
Anna Tavridou, Dolca Rogers, Milton Bonelli, Anja Schiel, Ana Hidalgo-Simon
Summary: Seeking scientific advice earlier and more frequently can help advanced therapy medicinal product developers avoid delays at the marketing authorisation stage. Carefully addressing quality and nonclinical issues before entering the pivotal development phase will pave the way for smooth clinical development and successful marketing authorisation.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Multidisciplinary Sciences
Ningna Weng, Zhe Zhang, Yunhan Tan, Xiaoyue Zhang, Xiawei Wei, Qing Zhu
Summary: This article summarizes the background, aim, and key scientific concepts of repurposing antifungal drugs for cancer therapy, and discusses the challenges and perspectives for their future development and clinical applications.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Computer Science, Information Systems
Tobias D. Weickert, Adam Joinson, Barnaby Craggs
Summary: The idea of forming positive security habits is gaining attention among security practitioners. The literature on habits in psychology has not been fully utilized in the context of security. Through analysis, it was found that habit construct is discussed in relation to other models rather than on its own, indicating limited depth of discussion. The lack of discussion on habit formation methods and the role of cues in triggering habitual behaviors in cybersecurity literature suggests a potential research avenue.
COMPUTERS & SECURITY
(2023)
Review
Pharmacology & Pharmacy
Yihui Song, Xiaoke Yang, Bin Yu
Summary: Drug repurposing is an attractive strategy for finding new indications for existing drugs. Three approved antidepressants have shown potential in clinical trials for cancer treatment. By conducting further medicinal chemistry research, several TCP-based inhibitors of the histone lysine specific demethylase 1 enzyme have been discovered, showing promise for cancer treatment. Repurposing antidepressants could be a promising strategy for cancer treatment.
DRUG DISCOVERY TODAY
(2022)
Review
Pharmacology & Pharmacy
Vigneshwaran Namasivayam, Senthikumar Palaniappan, Murugesan Vanangamudi
Summary: Researchers face challenges in developing treatments for emerging and re-emerging epidemic infections. Drug repurposing is a reliable strategy for discovering new antiviral agents quickly and reducing the need for clinical trials.
DRUG DISCOVERY TODAY
(2022)
Review
Biochemical Research Methods
Ziaurrehman Tanoli, Umair Seemab, Andreas Scherer, Krister Wennerberg, Jing Tang, Markus Vaha-Koskela
Summary: Drug repurposing involves hypothesis building, understanding relevant data, and facing challenges in selecting databases, which is further complicated by the lack of data overview.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Engineering, Chemical
Francisco Javier Somolinos, Carlos Leon, Sara Guerrero-Aspizua
Summary: Drug repositioning is a strategy to identify new uses for existing drugs by utilizing computational methods and biological network models. By leveraging characteristics such as acting on multiple targets and molecular similarities, drug repurposing holds great potential.
Article
Biochemistry & Molecular Biology
Ryo Okuyama
Summary: This study aimed to uncover recent trends in drug repurposing approaches and new technologies for predicting drug efficacy in psychiatric drug development based on animal models. Drug repurposing has been increasingly applied to recently approved psychiatric drugs. The development concepts of psychiatric drugs developed through drug repurposing over the past 20 years were divided into six categories. SmartCube(®), an artificial intelligence-based tool, was developed to predict human drug efficacy from animal phenotypes and produce novel drugs with clinical efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Debarati Ghosh, Karan Sehgal, Babasaheb Sodnar, Nikhil Bhosale, Deepaneeta Sarmah, Aishika Datta, Antra Chaudhary, Kiran Kalia, Xin Wang, Pallab Bhattacharya
Summary: Despite advanced interventions, stroke remains a significant cause of mortality and morbidity worldwide. Drug repurposing offers a novel approach to broaden treatment options for stroke.
DRUG DISCOVERY TODAY
(2022)
Article
Biochemistry & Molecular Biology
Lucia Prieto Santamaria, Esther Ugarte Carro, Marina Diaz Uzquiano, Ernestina Menasalvas Ruiz, Yuliana Perez Gallardo, Alejandro Rodriguez-Gonzalez
Summary: Drug repurposing is an effective strategy to find new treatments by utilizing existing drugs for new indications. Research has shown significant differences between repurposing and non-repurposing data, indicating the potential for identifying new drug repurposing hypotheses. Computational methods using modern biomedical data play a crucial role in accelerating the drug repurposing process.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Biology
Siddhant Doshi, Sundeep Prabhakar Chepuri
Summary: Drug repurposing is a method of finding new medical indications for approved drugs. This study introduces a graph neural network drug repurposing model called GDRnet, which efficiently screens a database of approved drugs and predicts potential treatments for novel diseases.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Genetics & Heredity
Dimitri Guala, Erik L. L. Sonnhammer
Summary: The need for systematic drug repurposing has increased in recent years, especially for addressing unexpected pandemics. With the abundance of functional interaction data, network-based drug repurposing has become more favorable. This study evaluated the performance of network crosstalk-based approaches for drug repurposing and found that they can rival or even outperform state-of-the-art methods.
FRONTIERS IN GENETICS
(2022)
Review
Pharmacology & Pharmacy
Laura Chaffey, Annabell Roberti, David R. Greaves
Summary: Drug repurposing is a promising approach in drug discovery for cardiovascular disease. Chronic inflammation plays a significant role in cardiovascular pathology, and targeting inflammation is a potential therapeutic strategy. However, challenges remain due to off-target effects and long-term conditions. Assessing repurposed anti-inflammatory drugs in cardiovascular clinical trials has shown mixed successes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemical Research Methods
Yuanchun Zhao, Xingqi Chen, Jiajia Chen, Xin Qi
Summary: The rising global burden of cancer has led to increased research and development efforts for effective anti-cancer drugs. The Connectivity Map (CMap) database has emerged as a promising approach for drug repurposing, with its ability to systematically discover gene-compound-disease associations and elucidate drug mechanisms of action. CMap-based computational drug repurposing is gaining attention for its potential to overcome the constraints of traditional drug discovery. This review article focuses on the applications and approaches of drug repurposing using the CMap database, highlighting its potential in discovering effective anti-cancer drugs.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Pharmacology & Pharmacy
Pan Pantziarka, Lina Ghibelli, Albrecht Reichle
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Ethics
Bishal Gyawali, Gauthier Bouche, Pan Pantziarka, Aaron S. Kesselheim, Ameet Sarpatwari
JOURNAL OF LAW MEDICINE & ETHICS
(2019)
Article
Oncology
Pan Pantziarka, Lydie Meheus
Editorial Material
Oncology
Pan Pantziarka, Ciska Verbaanderd, Lydie Meheus
Article
Oncology
Pan Pantziarka, Ciska Verbaanderd, Isabelle Huys, Gauthier Bouche, Lydie Meheus
Summary: Drug repurposing is a strategy to develop novel cancer treatments by reusing existing medicines developed in other disease areas. Key issues include candidate drug selection, clinical trial development, drug licensing/approval, and clinical adoption.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Oncology
Daniel Heudobler, Florian Lueke, Martin Vogelhuber, Sebastian Klobuch, Tobias Pukrop, Wolfgang Herr, Christopher Gerner, Pan Pantziarka, Lina Ghibelli, Albrecht Reichle
FRONTIERS IN ONCOLOGY
(2019)
Editorial Material
Oncology
Albrecht Reichle, Daniel Heudobler, Christopher Gerner, Pan Pantziarka, Eugenio Martinelli, Ernst Holler, Francesca Corsi, Lina Ghibelli
FRONTIERS IN ONCOLOGY
(2020)
Article
Pharmacology & Pharmacy
Pan Pantziarka, Rica Capistrano, Arno De Potter, Liese Vandeborne, Gauthier Bouche
Summary: Currently, there is no global, unified listing of approved anticancer drugs, but a methodology exists to combine and cleanse relevant data from multiple sources to produce a database specifically for therapeutic antineoplastic purposes, which can be used by researchers as input for further research projects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Liese Vandeborne, Pan Pantziarka, An M. T. Van Nuffel, Gauthier Bouche
Summary: This review summarizes research activities using approved vaccines to treat cancer, with data supporting cancer therapeutic use for 16 vaccines. Clinical trials have been conducted or are ongoing for 10 vaccines, while preclinical evidence supports further evaluation of the remaining 6 vaccines.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Nathalie C. Stoer, Gauthier Bouche, Pan Pantziarka, Erica K. Sloan, Bettina K. Andreassen, Edoardo Botteri
Summary: The study investigates the association between the use of certain drugs and cancer-specific mortality in pancreatic cancer patients. It suggests that statins and non-selective beta-blockers may be associated with reduced pancreatic cancer mortality, supporting the need for randomized clinical trials to further evaluate their potential in pancreatic cancer management.
Letter
Oncology
Gauthier Bouche, Craig Gedye, Lydie Meheus, Pan Pantziarka
Article
Oncology
Andrea Spini, Sandra Donnini, Pan Pantziarka, Sergio Crispino, Marina Ziche
ECANCERMEDICALSCIENCE
(2020)
Review
Oncology
Pan Pantziarka, Gauthier Bouche
Article
Oncology
Pan Pantziarka, Ciska Verbaanderd, Vidula Sukhatme, Rica Capistrano, Sergio Crispino, Bishal Gyawali, Ilse Rooman, An M. T. Van Nuffel, Lydie Meheus, Vikas P. Sukhatme, Gauthier Bouche
ECANCERMEDICALSCIENCE
(2018)
Article
Oncology
Pan Pantziarka, Vidula Sukhatme, Sergio Crispino, Gauthier Bouche, Lydie Meheus, Vikas P. Sukhatme
ECANCERMEDICALSCIENCE
(2018)
