Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways

Mitochondrial division inhibitor 1 (mdivi-1) enhances death receptor-mediated apoptosis in human ovarian cancer cells

(2015) Jingnan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth

(2015) Carmela Guido et al.   Oncotarget

Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells

(2015) Wei Qian et al.   Oncotarget

CD147 promotes reprogramming of glucose metabolism and cell proliferation in HCC cells by inhibiting the p53-dependent signaling pathway

(2014) Qichao Huang et al.   JOURNAL OF HEPATOLOGY

Hexabromocyclododecane and polychlorinated biphenyls increase resistance of hepatocellular carcinoma cells to cisplatin through the phosphatidylinositol 3-kinase/protein kinase B pathway

(2014) Jing An et al.   TOXICOLOGY LETTERS

Blocking autophagy enhances the apoptosis effect of bufalin on human hepatocellular carcinoma cells through endoplasmic reticulum stress and JNK activation

(2013) Fengli Hu et al.   APOPTOSIS

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

(2013) Abhishek D. Garg et al.   Autophagy

Mitochondrial fission facilitates mitophagy inSaccharomyces cerevisiae

(2013) Kai Mao et al.   Autophagy

Cytoplasmic Irradiation Results in Mitochondrial Dysfunction and DRP1-Dependent Mitochondrial Fission

(2013) B. Zhang et al.   CANCER RESEARCH

Depletion of mitochondrial fission factor DRP1 causes increased apoptosis in human colon cancer cells

(2012) Akane Inoue-Yamauchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alterations of TP53 are associated with a poor outcome for patients with hepatocellular carcinoma: Evidence from a systematic review and meta-analysis

(2012) Jiangbo Liu et al.   EUROPEAN JOURNAL OF CANCER

Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer

(2012) Jalees Rehman et al.   FASEB JOURNAL

miR-375 Inhibits Autophagy and Reduces Viability of Hepatocellular Carcinoma Cells Under Hypoxic Conditions

(2012) Ying Chang et al.   GASTROENTEROLOGY

Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress

(2012) W. Qian et al.   JOURNAL OF CELL SCIENCE

Inactivation of Bcl-2 through IκB kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE)

(2012) Cagri Bodur et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondrial dynamics regulates migration and invasion of breast cancer cells

(2012) J Zhao et al.   ONCOGENE

Mitochondrial outer membrane permeabilization during apoptosis: The role of mitochondrial fission

(2011) Thomas Landes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of Drp1, a Key Mitochondrial Fission Protein, in Neuropathic Pain

(2011) L. F. Ferrari et al.   JOURNAL OF NEUROSCIENCE

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING

Anti-tumour efficacy of mitofusin-2 in urinary bladder carcinoma

(2010) Baiye Jin et al.   MEDICAL ONCOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

(2010) Sudha B. Singh et al.   NATURE CELL BIOLOGY

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cross talk between stimulated NF-κB and the tumor suppressor p53

(2010) G Schneider et al.   ONCOGENE

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt

(2009) Dong Bai et al.   INTERNATIONAL JOURNAL OF CANCER

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear expression of dynamin-related protein 1 in lung adenocarcinomas

(2009) Yung-Yen Chiang et al.   MODERN PATHOLOGY

Mitochondrial Dynamics in Mammalian Health and Disease

(2009) Marc Liesa et al.   PHYSIOLOGICAL REVIEWS

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

AKT and Oxidative Stress Team Up to Kill Cancer Cells

(2008) Ignacio Dolado et al.   CANCER CELL

Mechanisms of ROS modulated cell survival during carcinogenesis

(2008) J.S. Clerkin et al.   CANCER LETTERS

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species

(2008) Tianzheng Yu et al.   CARDIOVASCULAR RESEARCH

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

A Chemical Inhibitor of DRP1 Uncouples Mitochondrial Fission and Apoptosis

(2008) Atsushi Tanaka et al.   MOLECULAR CELL

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL