The promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors

Identifying pathways regulating the oncogenic p53 family member ΔNp63 provides therapeutic avenues for squamous cell carcinoma

(2022) Zuzana Pokorna et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

A randomized phase 2 study of bicalutamide with or without metformin for biochemical recurrence in overweight or obese prostate cancer patients (BIMET-1)

(2022) Marijo Bilusic et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Quercetin potential effects against SARS‐CoV ‐2 infection and COVID ‐19‐associated cancer progression by inhibiting mTOR and hypoxia‐inducible factor‐1α ( HIF ‐1α)

(2022) Hamidreza Zalpoor et al.   PHYTOTHERAPY RESEARCH

Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines

(2021) Wenqing Liang et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Autocrine TGF-β in Cancer: Review of the Literature and Caveats in Experimental Analysis

(2021) Hendrik Ungefroren   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The cancer metabolic reprogramming and immune response

(2021) Longzheng Xia et al.   Molecular Cancer

Oncometabolite in Cancer: Current Understanding and Challenges

(2021) Yang Liu et al.   CANCER RESEARCH

Worenine reverses the Warburg effect and inhibits colon cancer cell growth by negatively regulating HIF-1α

(2021) Lijiang Ji et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The Role of Cancer-Associated Fibroblasts in Tumor Progression

(2021) Rushikesh S. Joshi et al.   Cancers

A randomized controlled trial of metformin in women with components of metabolic syndrome: intervention feasibility and effects on adiposity and breast density

(2021) Edgar Tapia et al.   BREAST CANCER RESEARCH AND TREATMENT

Metformin Decreases 2-HG Production through the MYC-PHGDH Pathway in Suppressing Breast Cancer Cell Proliferation

(2021) Sehyun Oh et al.   Metabolites

Targeting of the tumor immune microenvironment by metformin

(2021) Zihong Wu et al.   Journal of Cell Communication and Signaling

Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

(2020) Floriane Pelon et al.   Nature Communications

Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells

(2020) Iñigo San-Millán et al.   Frontiers in Oncology

Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma

(2020) Wenzheng Guo et al.   Frontiers in Oncology

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia

(2020) Sylwia Bartoszewska et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Caveolin‐1 in oncogenic metabolic symbiosis

(2020) Martina Raudenska et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

(2020) Lisa M. Butler et al.   ADVANCED DRUG DELIVERY REVIEWS

Heterogeneity of cancer‐associated fibroblasts: Opportunities for precision medicine

(2020) Ryu Kanzaki et al.   CANCER SCIENCE

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling

(2020) Junbin Qian et al.   CELL RESEARCH

Metformin suppresses HIF‐1α expression in cancer‐associated fibroblasts to prevent tumor‐stromal cross talk in breast cancer

(2020) Shan Shao et al.   FASEB JOURNAL

Metabolite sensing and signaling in Cancer

(2020) Yi-Ping Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin Induces Autophagy via the AMPK-mTOR Signaling Pathway in Human Hepatocellular Carcinoma Cells

(2020) Chun Gao et al.   Cancer Management and Research

Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer

(2020) Jason R Brown et al.   JCI Insight

Role of Proton-Coupled Monocarboxylate Transporters in Cancer: From Metabolic Crosstalk to Therapeutic Potential

(2020) Xiangyu Sun et al.   Frontiers in Cell and Developmental Biology

Cancer-Associated Fibroblasts: Accomplices in the Tumor Immune Evasion

(2020) Marc Hilmi et al.   Cancers

Impact of the Tumor Microenvironment on Tumor Heterogeneity and Consequences for Cancer Cell Plasticity and Stemness

(2020) Ralf Hass et al.   Cancers

Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling

(2019) Kexin Sun et al.   EBioMedicine

Fibroblasts rescue oral squamous cancer cell from metformin-induced apoptosis via alleviating metabolic disbalance and inhibiting AMPK pathway

(2019) Zhuoyuan Zhang et al.   CELL CYCLE

Metabolic regulation of cell growth and proliferation

(2019) Jiajun Zhu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The multifaceted effects of metformin on tumor microenvironment

(2019) Ivana Kurelac et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

HIF-1α mediates hyperglycemia-induced pancreatic cancer glycolysis

(2019) Liang Cheng et al.   Anti-Cancer Agents in Medicinal Chemistry

Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways

(2019) José Esparza-López et al.   BMC CANCER

Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy

(2019) Sara Verdura et al.   OncoImmunology

Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis

(2019) America Campos et al.   Biomolecules

Oxidative phosphorylation as a potential therapeutic target for cancer therapy

(2019) Valentina Sica et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

(2019) Tongyan Liu et al.   Journal of Hematology & Oncology

mTOR: Role in cancer, metastasis and drug resistance

(2019) Avaniyapuram Kannan Murugan   SEMINARS IN CANCER BIOLOGY

NK Cell Metabolism and Tumor Microenvironment

(2019) Iñigo Terrén et al.   Frontiers in Immunology

Effect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone in Patients With Epidermal Growth Factor Receptor–Mutated Lung Adenocarcinoma

(2019) Oscar Arrieta et al.   JAMA Oncology

The Acidic Tumor Microenvironment as a Driver of Cancer

(2019) Ebbe Boedtkjer et al.   Annual Review of Physiology

Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer

(2019) Sehui Kim et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals

(2019) Monta Ustinova et al.   PLoS One

Metformin suppresses the proliferation and invasion through NF-kB and MMPs in MCF-7 cell line

(2019) Nail Besli et al.   Turkish Journal of Biochemistry-Turk Biyokimya Dergisi

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

(2019) Tushar D Bhagat et al.   eLife

2-Hydroxyglutarate in Cancer Cells

(2019) Petr Ježek   ANTIOXIDANTS & REDOX SIGNALING

A phase II randomized clinical trial of the effect of metformin versus placebo on progression-free survival in women with metastatic breast cancer receiving standard chemotherapy

(2019) Isabel Pimentel et al.   BREAST

Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner

(2019) Reika Shiratori et al.   Scientific Reports

Transcriptomic changes during TGF-β-mediated differentiation of airway fibroblasts to myofibroblasts

(2019) Erin Joanne Walker et al.   Scientific Reports

Metformin promotes innate immunity through a conserved PMK-1/p38 MAPK pathway

(2019) Yi Xiao et al.   Virulence

Biological Role and Therapeutic Potential of IDH Mutations in Cancer

(2018) Matthew S. Waitkus et al.   CANCER CELL

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response

(2018) Ji Hee Ha et al.   CANCER RESEARCH

The breast tumor microenvironment: role in cancer development, progression and response to therapy

(2018) Suruchi Mittal et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Caveolin-1, cancer and therapy resistance

(2018) Julia Ketteler et al.   INTERNATIONAL JOURNAL OF CANCER

Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells

(2018) Zhenlong Chen et al.   MOLECULAR BIOLOGY OF THE CELL

Metformin Suppresses Tumor Progression by Inactivating Stromal Fibroblasts in Ovarian Cancer

(2018) Sen Xu et al.   MOLECULAR CANCER THERAPEUTICS

Role of the NFκB-signaling pathway in cancer

(2018) Longzheng Xia et al.   OncoTargets and Therapy

Metformin-induced caveolin-1 expression promotes T-DM1 drug efficacy in breast cancer cells

(2018) Yuan-Chiang Chung et al.   Scientific Reports

Cancer-associated Fibroblast-derived IL-6 Promotes Head and Neck Cancer Progression via the Osteopontin-NF-kappa B Signaling Pathway

(2018) Xing Qin et al.   Theranostics

Metabolic Reprogramming of Cancer Associated Fibroblasts: The Slavery of Stromal Fibroblasts

(2018) Angelica Avagliano et al.   Biomed Research International

Metformin blocks myeloid-derived suppressor cell accumulation through AMPK-DACH1-CXCL1 axis

(2018) Guohui Qin et al.   OncoImmunology

D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

(2018) Martin Böttcher et al.   OncoImmunology

Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming

(2018) Victoire Gouirand et al.   Frontiers in Oncology

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

Targeting Mitochondrial Oxidative Phosphorylation Abrogated Irinotecan Resistance in NSCLC

(2018) Soohyun Lee et al.   Scientific Reports

Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma

(2018) Yaping Long et al.   Cancer Medicine

Effects of metformin on the PI3K/AKT/FOXO1 pathway in anaplastic thyroid Cancer cell lines

(2018) Zahra Nozhat et al.   DARU-Journal of Pharmaceutical Sciences

Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy

(2018) Barbara Wegiel et al.   Frontiers in Oncology

Unravelling the Interplay between Extracellular Acidosis and Immune Cells

(2018) Fernando Erra Díaz et al.   MEDIATORS OF INFLAMMATION

The ERK and JNK pathways in the regulation of metabolic reprogramming

(2018) Salvatore Papa et al.   ONCOGENE

Metformin suppresses gastric cancer progression through calmodulin‑like protein�3 secreted from tumor‑associated fibroblasts

(2018) Guangxia Chen et al.   ONCOLOGY REPORTS

Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth

(2018) Yuan Liu et al.   Nature Communications

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

(2018) Don Benjamin et al.   Cell Reports

Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment

(2018) Chunmei Fu et al.   Frontiers in Immunology

Potent immunosuppressive effects of the oncometabolite R-2-hydroxyglutarate

(2018) Lorenzo Galluzzi et al.   OncoImmunology

Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα

(2018) Min Yan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Autophagy and Inflammatory Response in the Tumor Microenvironment

(2017) Daniel Ngabire et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas

(2017) Gary Kohanbash et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin effects on head and neck squamous carcinoma microenvironment: Window of opportunity trial

(2017) Joseph Curry et al.   LARYNGOSCOPE

Metformin inhibits the development, and promotes the resensitization, of treatment-resistant breast cancer

(2017) Gerald Davies et al.   PLoS One

Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development

(2017) Lindsay Wilde et al.   SEMINARS IN ONCOLOGY

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment

(2017) Soumaya Kouidhi et al.   Frontiers in Immunology

Attenuation of CD4 + CD25 + Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

(2017) Yuki Kunisada et al.   EBioMedicine

Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation

(2017) Peiguo Shi et al.   Cell Discovery

Phase II study of metformin for reduction of obesity-associated breast cancer risk: a randomized controlled trial protocol

(2016) Jessica A. Martinez et al.   BMC CANCER

Combinational strategies of metformin and chemotherapy in cancers

(2016) Hui-Hui Zhang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The influence of the pre-metastatic niche on breast cancer metastasis

(2016) Josie Ursini-Siegel et al.   CANCER LETTERS

TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3

(2016) Rachel A. Hesler et al.   CARCINOGENESIS

Caveolin-1 in the regulation of cell metabolism: a cancer perspective

(2016) Zeribe Chike Nwosu et al.   Molecular Cancer

Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets

(2016) Yufang Shi et al.   NATURE REVIEWS DRUG DISCOVERY

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Intratumoral heterogeneity of the therapeutical response to gemcitabine and metformin

(2016) Dietmar Zechner et al.   Oncotarget

Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts

(2016) Alessandro Arcucci et al.   Biomed Research International

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia

(2016) Nicole E. Scharping et al.   Cancer Immunology Research

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

(2016) Stephanos Pavlides et al.   Aging-US

Caveolin interaction governs Kv1.3 lipid raft targeting

(2016) Mireia Pérez-Verdaguer et al.   Scientific Reports

The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor

(2015) Cara J. Valvona et al.   BRAIN PATHOLOGY

Tumors and Mitochondrial Respiration: A Neglected Connection

(2015) Andrea Viale et al.   CANCER RESEARCH

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Effect of Metformin vs Placebo on and Metabolic Factors in NCIC CTG MA.32

(2015) P. J. Goodwin et al.   JNCI-Journal of the National Cancer Institute

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5

(2015) Liraz Levi et al.   Nature Communications

Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype

(2015) Elisabet Cuyàs et al.   Oncotarget

Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1α/VEGF secretion axis

(2015) Jichang Wang et al.   Oncotarget

Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma

(2015) Xinke Zhou et al.   Oncotarget

Effect of Metformin vs Placebo on and Metabolic Factors in NCIC CTG MA.32

(2015) P. J. Goodwin et al.   JNCI-Journal of the National Cancer Institute

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

(2015) Kazuyoshi Shiga et al.   Cancers

A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer

(2014) Nelma Pértega-Gomes et al.   BMC CANCER

Hypoxia-Inducible Factor/MAZ-Dependent Induction of Caveolin-1 Regulates Colon Permeability through Suppression of Occludin, Leading to Hypoxia-Induced Inflammation

(2014) Liwei Xie et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of the GTPase Rac1 Mediates the Antimigratory Effects of Metformin in Prostate Cancer Cells

(2014) B. Dirat et al.   MOLECULAR CANCER THERAPEUTICS

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

TGF-beta in CAF-mediated tumor growth and metastasis

(2014) A. Calon et al.   SEMINARS IN CANCER BIOLOGY

Tumor Microenvironment and Metabolic Synergy in Breast Cancers: Critical Importance of Mitochondrial Fuels and Function

(2014) Ubaldo Martinez-Outschoorn et al.   SEMINARS IN ONCOLOGY

Value of caveolin-1 in cancer progression and prognosis: Emphasis on cancer-associated fibroblasts, human cancer cells and mechanism of caveolin-1 expression (Review)

(2014) DALI CHEN et al.   Oncology Letters

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Anti-inflammatory/antioxidant use in long-term maintenance cancer therapy: a new therapeutic approach to disease progression and recurrence

(2014) Sarah Crawford   Therapeutic Advances in Medical Oncology

Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer

(2013) Cecilia Marini et al.   CELL CYCLE

Glucose promotes breast cancer aggression and reduces metformin efficacy

(2013) Reema Wahdan-Alaswad et al.   CELL CYCLE

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty acids revert the inhibition of respiration caused by the antidiabetic drug metformin to facilitate their mitochondrial β-oxidation

(2012) M. Mar González-Barroso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage

(2012) C. Algire et al.   Cancer Prevention Research

Energy transfer in "parasitic" cancer metabolism

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Mitochondrial metabolism in cancer metastasis

(2012) Federica Sotgia et al.   CELL CYCLE

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

(2012) Carmela Guido et al.   CELL CYCLE

Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects

(2012) M A Pierotti et al.   ONCOGENE

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

(2012) W-Y Shi et al.   Cell Death & Disease

Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment

(2011) Casey Trimmer et al.   CANCER BIOLOGY & THERAPY

The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells

(2011) Alejandro Vazquez-Martin et al.   CELL CYCLE

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells

(2011) Barbara Salani et al.   FASEB JOURNAL

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

(2011) Z. J. Reitman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Glucose metabolism in cancer cells

(2010) Alessandro Annibaldi et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Cancer-associated fibroblasts and tumor growth – bystanders turning into key players

(2009) Arne Östman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT