Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways
出版年份 2019 全文链接
标题
Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways
作者
关键词
Breast Cancer, Epithelial-mesenchymal transition, Metformin, STAT3, NF-κB, AMPK
出版物
BMC CANCER
Volume 19, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-07-23
DOI
10.1186/s12885-019-5945-1
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Association of Metformin with Breast Cancer Incidence and Mortality in Patients with Type II Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis
- (2018) Grace H. Tang et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Pre-clinical effects of metformin and aspirin on the cell lines of different breast cancer subtypes
- (2018) Maria Eduarda Azambuja Amaral et al. INVESTIGATIONAL NEW DRUGS
- Metformin suppresses the invasive ability of pancreatic cancer cells by blocking autocrine TGF‑β1 signaling
- (2018) Wanxing Duan et al. ONCOLOGY REPORTS
- Silencing Snail suppresses tumor cell proliferation and invasion by reversing epithelial-to-mesenchymal transition and arresting G2/M phase in non-small cell lung cancer
- (2017) Xueying Yang et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Metformin: Insights into its anticancer potential with special reference to AMPK dependent and independent pathways
- (2017) Shoeb Ikhlas et al. LIFE SCIENCES
- EMT and inflammation: inseparable actors of cancer progression
- (2017) Meggy Suarez-Carmona et al. Molecular Oncology
- Metformin reverses prostate cancer resistance to enzalutamide by targeting TGF-β1/STAT3 axis-regulated EMT
- (2017) Qiuli Liu et al. Cell Death & Disease
- Metformin reverses bFGF-induced epithelial-mesenchymal transition in HCC cells
- (2017) Wang Chengye et al. Oncotarget
- Differential role of Interleukin-1 and Interleukin-6 in K-Ras-driven pancreatic carcinoma undergoing mesenchymal transition
- (2017) Imran Siddiqui et al. OncoImmunology
- Primary breast cancer cell culture yields intra-tumor heterogeneous subpopulations expressing exclusive patterns of receptor tyrosine kinases
- (2016) José Esparza-López et al. BMC CANCER
- Distinctive properties of metastasis-initiating cells
- (2016) Toni Celià-Terrassa et al. GENES & DEVELOPMENT
- The phenomenon of acquired resistance to metformin in breast cancer cells: The interaction of growth pathways and estrogen receptor signaling
- (2016) Alexander M. Scherbakov et al. IUBMB LIFE
- Metformin induces apoptosis via a mitochondria-mediated pathway in human breast cancer cells in vitro
- (2016) ZHEN-YUAN GAO et al. Experimental and Therapeutic Medicine
- Cytokine patterns in cancer patients: A review of the correlation between interleukin 6 and prognosis
- (2016) Bodo E. Lippitz et al. OncoImmunology
- Metformin inhibits thyroid cancer cell growth, migration, and EMT through the mTOR pathway
- (2015) Baiyu Han et al. TUMOR BIOLOGY
- IL-6 originated from breast cancer tissue-derived mesenchymal stromal cells may contribute to carcinogenesis
- (2015) Özlem Sağlam et al. TUMOR BIOLOGY
- Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis
- (2015) Takla Griss et al. PLOS BIOLOGY
- Metformin Does Not Affect Cancer Risk: A Cohort Study in the U.K. Clinical Practice Research Datalink Analyzed Like an Intention-to-Treat Trial
- (2014) Konstantinos K. Tsilidis et al. DIABETES CARE
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Interleukin-6 promotes the migration and invasion of nasopharyngeal carcinoma cell lines and upregulates the expression of MMP-2 and MMP-9
- (2014) WEI SUN et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Interleukin-6-induced epithelial-mesenchymal transition through signal transducer and activator of transcription 3 in human cervical carcinoma
- (2014) JIN-WEI MIAO et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Metformin—mode of action and clinical implications for diabetes and cancer
- (2014) Ida Pernicova et al. Nature Reviews Endocrinology
- Metformin Inhibits the IL-6-Induced Epithelial-Mesenchymal Transition and Lung Adenocarcinoma Growth and Metastasis
- (2014) Zhongquan Zhao et al. PLoS One
- Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer
- (2013) Antoinette Hollestelle et al. BREAST CANCER RESEARCH AND TREATMENT
- Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle
- (2013) S. M. Hadad et al. Clinical & Translational Oncology
- Doxorubicin induces atypical NF-κB activation through c-Abl kinase activity in breast cancer cells
- (2013) José Esparza-López et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- M2-polarized tumor-associated macrophages promoted epithelial–mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway
- (2013) Chao-Ying Liu et al. LABORATORY INVESTIGATION
- Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
- (2013) Russell A. Miller et al. NATURE
- Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
- (2013) H. A. Hirsch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Significance of the Correlation Between the Expression of Interleukin 6 and Clinical Features in Patients With Non-Small Cell Lung Cancer
- (2012) Eitetsu Koh et al. INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
- AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
- (2012) Sang-Min Jeon et al. NATURE
- Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC
- (2012) Giovanni Blandino et al. Nature Communications
- Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
- (2011) Irina N. Alimova et al. CELL CYCLE
- Metformin induces unique biological and molecular responses in triple negative breast cancer cells
- (2011) Bolin Liu et al. CELL CYCLE
- Familial diabetes is associated with reduced risk of cancer in diabetic patients: a possible role for metformin
- (2011) Lev M. Berstein et al. MEDICAL ONCOLOGY
- Metformin and cancer: new applications for an old drug
- (2011) Taxiarchis V. Kourelis et al. MEDICAL ONCOLOGY
- Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer
- (2011) Michael K. Wendt et al. MOLECULAR BIOLOGY OF THE CELL
- IL-6 Promotes Head and Neck Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition via the JAK-STAT3-SNAIL Signaling Pathway
- (2011) A. Yadav et al. MOLECULAR CANCER RESEARCH
- Structure of mammalian AMPK and its regulation by ADP
- (2011) Bing Xiao et al. NATURE
- Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance
- (2011) J.-P. Gillet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression
- (2010) Eek Joong Park et al. CELL
- Metformin regulates breast cancer stem cello ntogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status
- (2010) Alejandro Vazquez-Martin et al. CELL CYCLE
- Efficacy of anti-cancer agents in cell lines versus human primary tumour tissue
- (2010) Ian A Cree et al. CURRENT OPINION IN PHARMACOLOGY
- AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3)
- (2010) A. Nerstedt et al. DIABETOLOGIA
- Snail Family Regulation and Epithelial Mesenchymal Transitions in Breast Cancer Progression
- (2010) Antonio Garcia de Herreros et al. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
- Mechanisms of Motility in Metastasizing Cells
- (2010) Mahmut Yilmaz et al. MOLECULAR CANCER RESEARCH
- Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors
- (2009) Heehyoung Lee et al. CANCER CELL
- Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells
- (2009) N J Sullivan et al. ONCOGENE
- Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1
- (2009) I. Ota et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas
- (2008) M Colomiere et al. BRITISH JOURNAL OF CANCER
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