Oxidative phosphorylation as a potential therapeutic target for cancer therapy

CD38-driven mitochondrial trafficking promotes bioenergetic plasticity in multiple myeloma

(2019) Christopher R. Marlein et al.   CANCER RESEARCH

Mitochondrial complex III is essential for suppressive function of regulatory T cells

(2019) Samuel E. Weinberg et al.   NATURE

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

(2019) Yuting Sun et al.   Cell Reports

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

(2019) Grant M. Fischer et al.   Cancer Discovery

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma

(2019) Yufeng Shi et al.   NATURE

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

(2019) Frank Madeo et al.   Cell Metabolism

AIF-regulated oxidative phosphorylation supports lung cancer development

(2019) Shuan Rao et al.   CELL RESEARCH

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

(2019) Liang Zhang et al.   Science Translational Medicine

Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate

(2019) Valentina Sica et al.   Cell Reports

Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

(2019) Ivan Perrot et al.   Cell Reports

Crizotinib-induced immunogenic cell death in non-small cell lung cancer

(2019) Peng Liu et al.   Nature Communications

Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer

(2018) Lifeng Li et al.   CANCER RESEARCH

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

(2018) Sona Hubackova et al.   CELL DEATH AND DIFFERENTIATION

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

(2018) Thomas M. Ashton et al.   CLINICAL CANCER RESEARCH

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

(2018) Yonathan Lissanu Deribe et al.   NATURE MEDICINE

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

(2018) Dannielle DeWaal et al.   Nature Communications

BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose

(2018) Federico Lucantoni et al.   Oncotarget

Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation

(2018) Kathleen A. Boyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

Mitochondria-driven elimination of cancer and senescent cells

(2018) Sona Hubackova et al.   BIOLOGICAL CHEMISTRY

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

(2018) Martina Bajzikova et al.   Cell Metabolism

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

(2018) Daniel A. Pollyea et al.   NATURE MEDICINE

Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies

(2018) Jan Skoda et al.   PHARMACOLOGICAL RESEARCH

Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study

(2018) Cristian Scatena et al.   Frontiers in Oncology

Phase Ib study of the mitochondrial inhibitor ME-344 plus topotecan in patients with previously treated, locally advanced or metastatic small cell lung, ovarian and cervical cancers

(2017) Jennifer R. Diamond et al.   INVESTIGATIONAL NEW DRUGS

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

(2017) Elodie M Kuntz et al.   NATURE MEDICINE

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

Hallmarks of cancer stem cell metabolism

(2016) Patricia Sancho et al.   BRITISH JOURNAL OF CANCER

Cancer metabolism at a glance

(2016) Alexei Vazquez et al.   JOURNAL OF CELL SCIENCE

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Immunological off-target effects of imatinib

(2016) Laurence Zitvogel et al.   Nature Reviews Clinical Oncology

Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties

(2016) Valentina Izzo et al.   TRENDS IN CELL BIOLOGY

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

(2015) N. Jacque et al.   BLOOD

Mitochondrial DNA Variation in Human Radiation and Disease

(2015) Douglas C. Wallace   CELL

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis

(2015) Emilie Hangen et al.   MOLECULAR CELL

Immune-mediated antitumor effect by type 2 diabetes drug, metformin

(2015) Shingo Eikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PROGgeneV2: enhancements on the existing database

(2015) Chirayu Pankaj Goswami et al.   BMC CANCER

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

(2014) Xiaonan Zhang et al.   Nature Communications

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance

(2013) Laurence Zitvogel et al.   IMMUNITY

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I

(2013) Peter Ellinghaus et al.   Cancer Medicine

Mitochondrially targeted compounds and their impact on cellular bioenergetics

(2013) Colin Reily et al.   Redox Biology

Signaling in Control of Cell Growth and Metabolism

(2012) P. S. Ward et al.   Cold Spring Harbor Perspectives in Biology

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL