FUCCI-Based Live Imaging Platform Reveals Cell Cycle Dynamics and Identifies Pro-proliferative Compounds in Human iPSC-Derived Cardiomyocytes

Cardioids reveal self-organizing principles of human cardiogenesis

(2021) Pablo Hofbauer et al.   CELL

Ki-67 gene expression

(2021) Sigrid Uxa et al.   CELL DEATH AND DIFFERENTIATION

Metformin accelerates zebrafish heart regeneration by inducing autophagy

(2021) Fangjing Xie et al.   npj Regenerative Medicine

Polyploidy in Cardiomyocytes

(2020) Wouter Derks et al.   CIRCULATION RESEARCH

Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration

(2020) Lu Han et al.   DEVELOPMENTAL CELL

Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine

(2020) Elaheh Karbassi et al.   Nature Reviews Cardiology

Capsaicin Alleviates the Deteriorative Mitochondrial Function by Upregulating 14-3-3η in Anoxic or Anoxic/Reoxygenated Cardiomyocytes

(2020) Yang Qiao et al.   Oxidative Medicine and Cellular Longevity

TRPV1 activation mitigates hypoxic injury in mouse cardiomyocytes by inducing autophagy through the AMPK signaling pathway

(2020) Jinyu Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cardiomyocyte Maturation

(2020) Yuxuan Guo et al.   CIRCULATION RESEARCH

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes

(2020) Jan W. Buikema et al.   Cell Stem Cell

Evidence for hormonal control of heart regenerative capacity during endothermy acquisition

(2019) Kentaro Hirose et al.   SCIENCE

Advances in heart regeneration based on cardiomyocyte proliferation and regenerative potential of binucleated cardiomyocytes and polyploidization

(2019) Marina Leone et al.   CLINICAL SCIENCE

Ki-67: more than a proliferation marker

(2018) Xiaoming Sun et al.   CHROMOSOMA

Early Regenerative Capacity in the Porcine Heart

(2018) Lei Ye et al.   CIRCULATION

Midbody Positioning and Distance Between Daughter Nuclei Enable Unequivocal Identification of Cardiomyocyte Cell Division in Mice

(2018) Michael Hesse et al.   CIRCULATION RESEARCH

Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis

(2018) Lisa K. Kutsche et al.   Cell Systems

Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI)

(2018) Roberto Alvarez et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The extracellular matrix protein agrin promotes heart regeneration in mice

(2017) Elad Bassat et al.   NATURE

Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration

(2017) Michaela Patterson et al.   NATURE GENETICS

Myocardial stress and autophagy: mechanisms and potential therapies

(2017) Lea M. D. Delbridge et al.   Nature Reviews Cardiology

Cardiac regeneration strategies: Staying young at heart

(2017) Eldad Tzahor et al.   SCIENCE

Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations

(2015) Marina Leone et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Transgenic systems for unequivocal identification of cardiac myocyte nuclei and analysis of cardiomyocyte cell cycle status

(2015) Alexandra Raulf et al.   BASIC RESEARCH IN CARDIOLOGY

Analysis of cardiomyocyte movement in the developing murine heart

(2015) Hisayuki Hashimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice

(2015) Kanar Alkass et al.   CELL

Dynamics of Cell Generation and Turnover in the Human Heart

(2015) Olaf Bergmann et al.   CELL

Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells

(2015) C. W. van den Berg et al.   DEVELOPMENT

FUCCI sensors: powerful new tools for analysis of cell proliferation

(2015) N. Zielke et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response

(2014) Bao N. Puente et al.   CELL

Fucci2a:A bicistronic cell cycle reporter that allows Cre mediated tissue specific expression in mice

(2014) Richard Lester Mort et al.   CELL CYCLE

Alpha-2 adrenoceptors and imidazoline receptors in cardiomyocytes mediate counterbalancing effect of agmatine on NO synthesis and intracellular calcium handling

(2014) Alexander V. Maltsev et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte

(2014) Hisayuki Hashimoto et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Chemically defined generation of human cardiomyocytes

(2014) Paul W Burridge et al.   NATURE METHODS

Cardiac regeneration in vivo: Mending the heart from within?

(2014) Olaf Bergmann et al.   Stem Cell Research

Alpha-1–Adrenergic Receptors in Heart Failure

(2013) Brian C. Jensen et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Mammalian heart renewal by pre-existing cardiomyocytes

(2012) Samuel E. Senyo et al.   NATURE

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

(2012) Xiaojun Lian et al.   Nature Protocols

Drug-induced cell cycle modulation leading to cell-cycle arrest, nuclear mis-segregation, or endoreplication

(2011) Asako Sakaue-Sawano et al.   BMC CELL BIOLOGY

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Limitations of conventional approaches to identify myocyte nuclei in histologic sections of the heart

(2010) Keng-Leong Ang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover

(2010) Olaf Bergmann et al.   EXPERIMENTAL CELL RESEARCH

α-1-Adrenergic Receptor Agonist Activity of Clinical α-Adrenergic Receptor Agonists Interferes with α-2-Mediated Analgesia

(2009) Daniel W. Gil et al.   ANESTHESIOLOGY

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

The Role of Cardiac Troponin T Quantity and Function in Cardiac Development and Dilated Cardiomyopathy

(2008) Ferhaan Ahmad et al.   PLoS One