期刊
SCIENCE
卷 364, 期 6436, 页码 184-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aar2038
关键词
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资金
- JSPS Overseas Research Fellowships
- UCSF-IRACDA postdoctoral fellowship
- NIGMS IMSD fellowship
- Hillblom fellowship
- ARC fellowship
- Agence Nationale de Recherche Thyromut2 program [ANR-15-CE14-0011-01]
- Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [1ZIAES102745]
- NIH [R01HL13845, R00HL114738]
- Edward Mallinckrodt Jr. Foundation
- March of Dimes Basil O'Conner Scholar Award
- American Heart Association
- American Federation for Aging Research
- Life Sciences Research Foundation
- Program for Breakthrough Biomedical Research
- UCSF Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research Seed Grant
- UCSF Academic Senate Committee on Research
- REAC Award (Harris Fund)
- Department of Defense
- Cardiovascular Research Institute
- Agence Nationale de la Recherche (ANR) [ANR-15-CE14-0011] Funding Source: Agence Nationale de la Recherche (ANR)
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [ZIAES102745] Funding Source: NIH RePORTER
Tissue regenerative potential displays striking divergence across phylogeny and ontogeny, but the underlying mechanisms remain enigmatic. Loss of mammalian cardiac regenerative potential correlates with cardiomyocyte cell-cycle arrest and polyploidization as well as the development of postnatal endothermy. We reveal that diploid cardiomyocyte abundance across 41 species conforms to Kleiber's law-the 3/4 -power law scaling of metabolism with bodyweight-and inversely correlates with standard metabolic rate, body temperature, and serum thyroxine level. Inactivation of thyroid hormone signaling reduces mouse cardiomyocyte polyploidization, delays cell-cycle exit, and retains cardiac regenerative potential in adults. Conversely, exogenous thyroid hormones inhibit zebrafish heart regeneration. Thus, our findings suggest that loss of heart regenerative capacity in adult mammals is triggered by increasing thyroid hormones and may be a trade-off for the acquisition of endothermy.
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