Stereodivergent total synthesis of rocaglaol initiated by synergistic dual-metal-catalyzed asymmetric allylation of benzofuran-3(2H)-one

Dispersion and Steric Effects on Enantio-/Diastereoselectivities in Synergistic Dual Transition-Metal Catalysis

(2022) Bo Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperative N-heterocyclic Carbene and Iridium Catalysis Enables Stereoselective and Regiodivergent [3 + 2] and [3 + 3] Annulation Reactions

(2021) Jian Zhang et al.   ACS Catalysis

Stereodivergent Synthesis of Tertiary Fluoride-Tethered Allenes via Copper and Palladium Dual Catalysis

(2021) Shao-Qian Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantio‐ and Diastereodivergent Synthesis of Spirocycles through Dual‐Metal‐Catalyzed [3+2] Annulation of 2‐Vinyloxiranes with Nucleophilic Dipoles

(2021) Youbin Peng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery and synthesis of rocaglaol derivatives inducing apoptosis in HCT116 cells via suppression of MAPK signaling pathway

(2021) Hao-Jie Yang et al.   FITOTERAPIA

Enantio- and Diastereodivergent Construction of 1,3-Nonadjacent Stereocenters Bearing Axial and Central Chirality through Synergistic Pd/Cu Catalysis

(2021) Jiacheng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synergistic Pd/Amine-Catalyzed Stereodivergent Hydroalkylation of 1,3-Dienes with Aldehydes: Reaction Development, Mechanism, and Stereochemical Origins

(2021) Hongfa Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Synthesis of Enantioenriched 2,3-Disubstituted Dihydrobenzofurans via a One-Pot C–H Functionalization/Oxa-Michael Addition Cascade

(2021) Dong-Xing Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Pd/Cu Catalysis for Asymmetric Desymmetric Alkylation of Allylic Geminal Dicarboxylates

(2021) Xiaohong Huo et al.   CCS Chemistry

Stereodivergent Synthesis of Enantioenriched γ‐Butyrolactones Bearing Two Vicinal Stereocenters Enabled by Synergistic Copper and Iridium Catalysis

(2021) Lu Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent Pd/Cu Catalysis for the Dynamic Kinetic Asymmetric Transformation of Racemic Unsymmetrical 1,3-Disubstituted Allyl Acetates

(2020) Rui He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optically Active Flavaglines-Inspired Molecules by a Palladium-Catalyzed Decarboxylative Dearomative Asymmetric Allylic Alkylation

(2020) Meng-Yue Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diastereodivergent Synthesis of β‐Amino Alcohols through Dual‐Metal‐Catalyzed Coupling of Alkoxyallenes with Aldimine Esters

(2020) Weiwei Zi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent Carbon–Carbon Bond Formation between Iminium and Enolate Intermediates by Synergistic Organocatalysis

(2020) Byungjun Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diversified Cycloisomerization/Diels-Alder Reactions of 1,6-Enynes through Bimetallic Relay Asymmetric Catalysis

(2019) Haifeng Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent Construction of Tertiary Fluorides in Vicinal Stereogenic Pairs by Allylic Substitution with Iridium and Copper Catalysts

(2019) Zhi-Tao He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synergetic iridium and amine catalysis enables asymmetric [4+2] cycloadditions of vinyl aminoalcohols with carbonyls

(2019) Mao-Mao Zhang et al.   Nature Communications

Stereodivergent Coupling of 1,3-Dienes with Aldimine Esters Enabled by Synergistic Pd and Cu Catalysis

(2019) Qinglong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Synthesis of Oxa-Bridged Oxazocines through a Catalytic RhII /ZnII Relay [4+3] Cycloaddition Reaction

(2019) Chaoran Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction

(2019) Shi-Ming Xu et al.   Nature Communications

Diastereodivergent synthesis of enantioenriched α,β-disubstituted γ-butyrolactones via cooperative N-heterocyclic carbene and Ir catalysis

(2019) Santanu Singha et al.   Nature Catalysis

Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses

(2018) Christin Müller et al.   ANTIVIRAL RESEARCH

Stereodivergent Catalysis

(2018) Irina P. Beletskaya et al.   CHEMICAL REVIEWS

Chiral Amino Acids-Derived Catalysts and Ligands

(2018) Xiaohua Liu et al.   CHINESE JOURNAL OF CHEMISTRY

Stereodivergent Synthesis of α,α-Disubstituted α-Amino Acids via Synergistic Cu/Ir Catalysis

(2018) Liang Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Allylation of Azaaryl Acetamides and Acetates by Synergistic Iridium and Copper Catalysis

(2018) Xingyu Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters

(2018) Xiaohong Huo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed Asymmetric Allylic Substitution Reactions

(2018) Qiang Cheng et al.   CHEMICAL REVIEWS

The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA

(2018) Shintaro Iwasaki et al.   MOLECULAR CELL

Stereodivergent Coupling of Aldehydes and Alkynes via Synergistic Catalysis Using Rh and Jacobsen’s Amine

(2017) Faben A. Cruz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergence in Asymmetric Catalysis

(2017) Simon Krautwald et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ir/Zn Dual Catalysis: Enantioselective and Diastereodivergent α-Allylation of Unprotected α-Hydroxy Indanones

(2017) Rui He et al.   ORGANIC LETTERS

Gold(I)/ChiralN,N′-Dioxide-Nickel(II) Relay Catalysis for Asymmetric Tandem Intermolecular Hydroalkoxylation/Claisen Rearrangement

(2016) Jun Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Evolution of the Total Synthesis of Rocaglamide

(2016) Zhe Zhou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in the Synthesis of Flavaglines, a Family of Potent Bioactive Natural Compounds Originating from Traditional Chinese Medicine

(2016) Qian Zhao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Flavaglines Ameliorate Experimental Colitis and Protect Against Intestinal Epithelial Cell Apoptosis and Mitochondrial Dysfunction

(2016) Jie Han et al.   INFLAMMATORY BOWEL DISEASES

An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones

(2016) Xiaohong Huo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Allylic Substitutions with Aryl Acetic Acid Esters by Synergistic Iridium and Lewis Base Catalysis

(2016) Xingyu Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Dual Catalytic α-Allylation of Protected α-Amino- and α-Hydroxyacetaldehydes

(2015) Tobias Sandmeier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric γ-Allylation of α,β-Unsaturated Aldehydes by Combined Organocatalysis and Transition-Metal Catalysis

(2015) Line Naesborg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Each Enantiomer of Rocaglamide by Means of a Palladium(0)-Catalyzed Nazarov-Type Cyclization

(2015) Zhe Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Assessment of flavaglines as potential chikungunya virus entry inhibitors

(2015) Phitchayapak Wintachai et al.   MICROBIOLOGY AND IMMUNOLOGY

Ligand Control of Diastereodivergency in Asymmetric Inverse Electron Demand Diels–Alder Reaction

(2015) Xiaoyu Hao et al.   ACS Catalysis

Stereodivergent Total Synthesis of Δ9-Tetrahydrocannabinols

(2014) Michael A. Schafroth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent α-Allylation of Linear Aldehydes with Dual Iridium and Amine Catalysis

(2014) Simon Krautwald et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species

(2014) Li Pan et al.   NATURAL PRODUCT REPORTS

Chiral N,N′-dioxide ligands: synthesis, coordination chemistry and asymmetric catalysis

(2014) Xiaohua Liu et al.   Organic Chemistry Frontiers

Evidence for a Functionally Relevant Rocaglamide Binding Site on the eIF4A–RNA Complex

(2013) Heather Sadlish et al.   ACS Chemical Biology

Flavaglines: potent anticancer drugs that target prohibitins and the helicase eIF4A

(2013) Christine Basmadjian et al.   Future Medicinal Chemistry

Enantio- and Diastereodivergent Dual Catalysis:  -Allylation of Branched Aldehydes

(2013) S. Krautwald et al.   SCIENCE

Flavaglines as Potent Anticancer and Cytoprotective Agents

(2012) Nigel Ribeiro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Formal Synthesis of (±)-Methyl Rocaglate Using an Unprecedented Acetyl Bromide Mediated Nazarov Reaction

(2012) Philip Magnus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Photocycloaddition of 3-Hydroxyflavones: Total Syntheses and Absolute Configuration Assignments of (+)-Ponapensin and (+)-Elliptifoline

(2012) Neil J. Lajkiewicz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ChiralN,N′-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions

(2011) XiaoHua Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biomimetic Photocycloaddition of 3-Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation

(2010) Stéphane P. Roche et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphoramidites: Privileged Ligands in Asymmetric Catalysis

(2010) Johannes F. Teichert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel Flavaglines Displaying Improved Cytotoxicity

(2010) Frédéric Thuaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Analogue of Rocaglaol Displays a Potent and Selective Cytotoxicity in Cancer Cells: Involvement of Apoptosis Inducing Factor and Caspase-12

(2009) Frédéric Thuaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nazarov Cyclization Initiated by Peracid Oxidation: The Total Synthesis of (±)-Rocaglamide

(2009) John A. Malona et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis and Biological Activity of (±)-Rocaglamide and Its 2,3-Di-epi Analogue

(2008) Hongsen Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY